Accessible Search Form           Advanced Search

Richard Hendler, Ph.D.

Publications


Principal Investigator thumbnail image

Richard Hendler
Scientist Emeritus

P: +1 301 572 5017
F: +1 301 402 1519
hendlerr@mail.nih.gov


Full Publications Listing

Further studies with isolated absolute infrared spectra of bacteriorhodopsin photocycle intermediates: conformational changes and possible role of a new proton-binding center.
Hendler RW, Meuse CW, Smith PD, Kakareka JW.
Appl Spectrosc. 2013 Jan;67(1):73-85.
[Text Abstract on PubMed]

Infrared and visible absolute and difference spectra of bacteriorhodopsin photocycle intermediates.
Hendler RW, Meuse CW, Braiman MS, Smith PD, Kakareka JW.
Appl Spectrosc. 2011 Sep;65(9):1029-45.
[Text Abstract on PubMed]

The ability of actinic light to modify the bacteriorhodopsin photocycle revisited: heterogeneity vs photocooperativity.
Hendler RW, Shrager RI, Meuse CW.
Biochemistry. 2008 May 13;47(19):5406-16.
[Text Abstract on PubMed]

Electrogenic proton-pumping capabilities of the m-fast and m-slow photocycles of bacteriorhodopsin.
Hendler RW, Meuse CW.
Biochemistry. 2008 May 13;47(19):5396-405.
[Text Abstract on PubMed]

Simultaneous measurements of fast optical and proton current kinetics in the bacteriorhodopsin photocycle using an enhanced spectrophotometer.
Kakareka JW, Smith PD, Pohida TJ, Hendler RW.
J. Biochem. Biophys. Methods. 2008 Apr 24;70(6):1116-23.
[Text Abstract on PubMed]

An apparent general solution for the kinetic models of the bacteriorhodopsin photocycles.
Hendler RW.
J Phys Chem B. 2005 Sep 1;109(34):16515-28.
[Text Abstract on PubMed]

Interconversions among four M-intermediates in the bacteriorhodopsin photocycle.
Hendler RW, Bose S.
Eur. J. Biochem. 2003 Sep;270(17):3518-24.
[Text Abstract on PubMed]

Purple membrane lipid control of bacteriorhodopsin conformational flexibility and photocycle activity.
Hendler RW, Barnett SM, Dracheva S, Bose S, Levin IW.
Eur. J. Biochem. 2003 May;270(9):1920-5.
[Text Abstract on PubMed]

Importance of lipids for bacteriorhodopsin structure, photocycle, and function.
Hendler RW, Dracheva S.
Biochemistry Mosc. 2001 Nov;66(11):1311-4.
[Text Abstract on PubMed]

Theory and procedures for finding a correct kinetic model for the bacteriorhodopsin photocycle.
Hendler RW, Shrager R, Bose S.
J Phys Chem B. 2001 Apr 26;105(16):3319-28.
[Text Abstract on PubMed]

On the kinetics of voltage formation in purple membranes of Halobacterium salinarium.
Hendler RW, Drachev LA, Bose S, Joshi MK.
Eur. J. Biochem. 2000 Oct;267(19):5879-90.
[Text Abstract on PubMed]

Regulation of the bacteriorhodopsin photocycle and proton pumping in whole cells of Halobacterium salinarium.
Joshi MK, Bose S, Hendler RW.
Biochemistry. 1999 Jul 6;38(27):8786-93.
[Text Abstract on PubMed]

Importance of specific native lipids in controlling the photocycle of bacteriorhodopsin.
Joshi MK, Dracheva S, Mukhopadhyay AK, Bose S, Hendler RW.
Biochemistry. 1998 Oct 13;37(41):14463-70.
[Text Abstract on PubMed]

O2-binding to fully reduced cytochrome aa3 reexamined using SVD analysis of simulated and real data.
Hendler RW, Shrager RI.
Biochem. Mol. Biol. Int. 1998 Aug;45(5):1031-45.
[Text Abstract on PubMed]

Some pitfalls in curve-fitting and how to avoid them: a case in point.
Shrager RI, Hendler RW.
J. Biochem. Biophys. Methods. 1998 Jun 11;36(2-3):157-73.
[Text Abstract on PubMed]

A high speed optical multichannel analyzer.
Cole JW, Hendler RW, Smith PD, Fredrickson HA, Pohida TJ, Friauf WS.
J. Biochem. Biophys. Methods. 1997 Dec 3;35(3):161-74.
[Text Abstract on PubMed]

Multichannel analysis of single-turnover kinetics of cytochrome aa3 reduction of O2.
Bose S, Hendler RW, Shrager RI, Chan SI, Smith PD.
Biochemistry. 1997 Mar 4;36(9):2439-49.
[Text Abstract on PubMed]

A monitoring system for energy transduction by bacteriorhodopsin liposomes.
Hendler RW, Mukhopadhyay AK, Smith PD, Cascio HE.
J. Biochem. Biophys. Methods. 1996 Nov 15;33(2):89-104.
[Text Abstract on PubMed]

Control of the integral membrane proton pump, bacteriorhodopsin, by purple membrane lipids of Halobacterium halobium.
Mukhopadhyay AK, Dracheva S, Bose S, Hendler RW.
Biochemistry. 1996 Jul 16;35(28):9245-52.
[Text Abstract on PubMed]

Chemical and functional studies on the importance of purple membrane lipids in bacteriorhodopsin photocycle behavior.
Dracheva S, Bose S, Hendler RW.
FEBS Lett. 1996 Mar 11;382(1-2):209-12.
[Text Abstract on PubMed]

The ability of actinic light to modify the bacteriorhodopsin photocycle. Heterogeneity and/or photocooperativity?
Shrager RI, Hendler RW, Bose S.
Eur. J. Biochem. 1995 May 1;229(3):589-95.
[Text Abstract on PubMed]

Functional synergism of the magainins PGLa and magainin-2 in Escherichia coli, tumor cells and liposomes.
Westerhoff HV, Zasloff M, Rosner JL, Hendler RW, De Waal A, Vaz Gomes A, Jongsma PM, Riethorst A, Juretic D.
Eur. J. Biochem. 1995 Mar 1;228(2):257-64.
[Text Abstract on PubMed]

Combination of potentiometry and resonance Raman spectroscopy for the analysis of a redox protein.
Harmon PA, Hendler RW, Friauf WS, Levin IW.
Anal. Biochem. 1995 Jan 1;224(1):309-14.
[Text Abstract on PubMed]

Near infrared spectral changes of cytochrome aa3 during potentiometric titrations.
Hendler RW, Harmon PA, Levin IW.
Biophys. J. 1994 Dec;67(6):2493-500.
[Text Abstract on PubMed]

Membrane-mediated control of the bacteriorhodopsin photocycle.
Mukhopadhyay AK, Bose S, Hendler RW.
Biochemistry. 1994 Sep 13;33(36):10889-95.
[Text Abstract on PubMed]

Magainin oligomers reversibly dissipate delta microH+ in cytochrome oxidase liposomes.
Juretic D, Hendler RW, Kamp F, Caughey WS, Zasloff M, Westerhoff HV.
Biochemistry. 1994 Apr 19;33(15):4562-70.
[Text Abstract on PubMed]

Influence of excitation energy on the bacteriorhodopsin photocycle.
Hendler RW, Dancsházy Z, Bose S, Shrager RI, Tokaji Z.
Biochemistry. 1994 Apr 19;33(15):4604-10.
[Text Abstract on PubMed]

Resonance Raman and optical spectroscopic monitoring of heme a redox states in cytochrome c oxidase during potentiometric titrations.
Harmon PA, Hendler RW, Levin IW.
Biochemistry. 1994 Jan 25;33(3):699-707.
[Text Abstract on PubMed]

Deconvolutions based on singular value decomposition and the pseudoinverse: a guide for beginners.
Hendler RW, Shrager RI.
J. Biochem. Biophys. Methods. 1994 Jan;28(1):1-33.
[Text Abstract on PubMed]

Multiwavelength analysis of the kinetics of reduction of cytochrome aa3 by cytochrome c.
Hendler RW, Bose SK, Shrager RI.
Biophys. J. 1993 Sep;65(3):1307-17.
[Text Abstract on PubMed]

Redox interactions in cytochrome c oxidase: from the "neoclassical" toward "modern" models.
Hendler RW, Westerhoff HV.
Biophys. J. 1992 Dec;63(6):1586-604.
[Text Abstract on PubMed]

Can ferricyanide oxidize carbon monoxide-liganded cytochrome a3?
Hendler RW.
J. Bioenerg. Biomembr. 1991 Oct;23(5):805-17.
[Text Abstract on PubMed]

Potentiometric and spectral studies with the two-subunit cytochrome aa3 from Paracoccus denitrificans. Comparison with the 13-subunit beef heart enzyme.
Pardhasaradhi K, Ludwig B, Hendler RW.
Biophys. J. 1991 Aug;60(2):408-14.
[Text Abstract on PubMed]

Comparison of energy-transducing capabilities of the two- and three-subunit cytochromes aa3 from Paracoccus denitrificans and the 13-subunit beef heart enzyme.
Hendler RW, Pardhasaradhi K, Reynafarje B, Ludwig B.
Biophys. J. 1991 Aug;60(2):415-23.
[Text Abstract on PubMed]

High voltage redox properties of cytochrome c oxidase.
Hendler RW, Sidhu GS, Pardhasaradhi K.
Biophys. J. 1990 Oct;58(4):957-67.
[Text Abstract on PubMed]

Characterization of two low Em forms of cytochrome a3 and their carbon monoxide complexes in mammalian cytochrome c oxidase.
Sidhu GS, Hendler RW.
Biophys. J. 1990 Jun;57(6):1125-40.
[Text Abstract on PubMed]

Magainins and the disruption of membrane-linked free-energy transduction.
Westerhoff HV, Juretic D, Hendler RW, Zasloff M.
Proc. Natl. Acad. Sci. U.S.A. 1989 Sep;86(17):6597-601.
[Text Abstract on PubMed]

Interactions between a new class of eukaryotic antimicrobial agents and isolated rat liver mitochondria.
Westerhoff HV, Hendler RW, Zasloff M, Juretic D.
Biochim. Biophys. Acta. 1989 Aug 3;975(3):361-9.
[Text Abstract on PubMed]

Magainin 2 amide and analogues. Antimicrobial activity, membrane depolarization and susceptibility to proteolysis.
Juretic D, Chen HC, Brown JH, Morell JL, Hendler RW, Westerhoff HV.
FEBS Lett. 1989 Jun 5;249(2):219-23.
[Text Abstract on PubMed]

A new high potential redox transition for cytochrome aa3.
Hendler RW, Sidhu GS.
Biophys. J. 1988 Jul;54(1):121-33.
[Text Abstract on PubMed]

Direct measurement of the initial and early ratios of proton extrusion to oxygen uptake accompanying cytochrome c oxidation by rat liver mitoplasts.
Hendler RW, Setty OH.
Biophys. J. 1988 Feb;53(2):205-13.
[Text Abstract on PubMed]

Problems in the experimental determination of substrate-specific H+/O ratios during respiration.
Hendler RW, Shrager RI.
J. Bioenerg. Biomembr. 1987 Oct;19(5):551-69.
[Text Abstract on PubMed]

Direct measurement of the initial proton extrusion to oxygen uptake ratio accompanying succinate oxidation by rat liver mitochondria.
Setty OH, Shrager RI, Bunow B, Reynafarje B, Lehninger AL, Hendler RW.
Biophys. J. 1986 Sep;50(3):391-404.
[Text Abstract on PubMed]

Complete analysis of the cytochrome components of beef heart mitochondria in terms of spectra and redox properties. The c1-cytochromes.
Reddy KV, Hendler RW.
Biophys. J. 1986 Mar;49(3):693-703.
[Text Abstract on PubMed]

Complete analysis of the cytochrome components of beef heart mitochondria in terms of spectra and redox properties. Cytochromes aa3.
Reddy KV, Hendler RW, Bunow B.
Biophys. J. 1986 Mar;49(3):705-15.
[Text Abstract on PubMed]

Analysis of the spectra and redox properties of pure cytochromes aa3.
Hendler RW, Reddy KV, Shrager RI, Caughey WS.
Biophys. J. 1986 Mar;49(3):717-29.
[Text Abstract on PubMed]

Processing and analysis of potentiometric data.
Shrager RI, Hendler RW.
Biophys. J. 1986 Mar;49(3):687-91.
[Text Abstract on PubMed]

The H+/O ratio of proton translocation linked to the oxidation of succinate by mitochondria. Reply to a commentary.
Lehninger AL, Reynafarje B, Hendler RW, Shrager RI.
FEBS Lett. 1985 Nov 18;192(2):173-8.
[Text Abstract on PubMed]

Thermodynamic and kinetic considerations of Q-cycle mechanisms and the oxidant-induced reduction of cytochromes b.
Hendler RW, Bunow B, Rieske JS.
J. Bioenerg. Biomembr. 1985 Feb;17(1):51-64.
[Text Abstract on PubMed]

Instrumentation and procedures for real time measurements of proton motive force, membrane potential, delta pH, proton extrusion, and oxygen uptake in respiring cells and vesicles.
Hendler RW, Setty OH, Shrager RI, Songco DC, Friauf WS.
Rev Sci Instrum. 1983 Dec;54(12):1749-55.
[Text Abstract on PubMed]

Simultaneous measurements of proton motive force, delta pH, membrane potential, and H+/O ratios in intact Escherichia coli.
Setty OH, Hendler RW, Shrager RI.
Biophys. J. 1983 Sep;43(3):371-81.
[Text Abstract on PubMed]

Complete analysis of the cytochrome components of beef heart mitochondria in terms of spectra and redox properties. The b-type cytochromes.
Reddy KV, Hendler RW.
J. Biol. Chem. 1983 Jul 25;258(14):8568-81.
[Text Abstract on PubMed]

A cellular factor involved in the formation of a DNA-synthesizing complex from DNA polymerase I in Escherichia coli.
Scharff R, Hanson MA, Hendler RW.
Biochim. Biophys. Acta. 1983 Apr 15;739(3):265-75.
[Text Abstract on PubMed]

Interference of electron donors in the measurement of the proton gradient and membrane potential by flow dialysis.
Setty OH, Hendler RW.
J. Biochem. Biophys. Methods. 1982 Dec;7(1):35-46.
[Text Abstract on PubMed]

Potentiometric analysis of Escherichia coli cytochromes in the optical absorbance range of 500 nm to 700 nm.
Hendler RW, Shrager RI.
J. Biol. Chem. 1979 Nov 25;254(22):11288-99.
[Text Abstract on PubMed]

Limitations on the use of and interpretation of data from the Aminco--Chance dual-wavelength split-beam recording spectrophotometer and related instruments.
Hendler RW.
Anal. Biochem. 1979 Apr 15;94(2):450-64.
[Text Abstract on PubMed]

Reconstitution of escherichia coli succinoxidase from soluble components.
Reddy TL, Hendler RW.
J. Biol. Chem. 1978 Nov 10;253(21):7972-9.
[Text Abstract on PubMed]

Automated electrodic potentiometry of potassium ferricyanide and respiratory components.
Hendler RW.
Anal. Chem. 1977 Nov;49(13):1914-8.
[Text Abstract on PubMed]

DNA synthesis involving a complexes form of DNA polymerase I in extracts of Escherichia coli.
Hendler RW, Pereira M, Scharff R.
Proc. Natl. Acad. Sci. U.S.A. 1975 Jun;72(6):2099-103.
[Text Abstract on PubMed]

Redox properties of beta-type cytochromes in Escherichia coli and rat liver mitochondria and techniques for their analysis.
Hendler RW, Towne DW, Shrager RI.
Biochim. Biophys. Acta. 1975 Jan 31;376(1):42-62.
[Text Abstract on PubMed]

Fractionation of the electron-transport chain of Escherichia coli.
Hendler RW, Burgess AH.
Biochim. Biophys. Acta. 1974 Aug 23;357(2):215-30.
[Text Abstract on PubMed]

Protein disposition in biological membranes.
Hendler RW.
Biomembranes. 1974;5:251-73.
[Text Abstract on PubMed]

Protein synthesis by membrane-bound polyribosomes.
Hendler RW.
Biomembranes. 1974;5:147-211.
[Text Abstract on PubMed]

Respiration and protein synthesis in Escherichia coli membrane-envelope fragments. VI. Solubilization and characterization of the electron transport chain.
Hendler RW, Burgess AH.
J. Cell Biol. 1972 Nov;55(2):266-81.
[Text Abstract on PubMed]

Improved quantitative assay procedures for lipopolysaccharide and peptidoglycan components of Escherichia coli.
Hendler RW, Burgess AH.
Anal. Biochem. 1972 May;47(1):109-22.
[Text Abstract on PubMed]

Respiration and protein synthesis in Escherichia coli membrane-envelope fragments. IV. Chemical and cytological characterization and biosynthetic capabilities of fragments obtained by mild procedures.
Scharff R, Hendler RW, Nanninga N, Burgess AH.
J. Cell Biol. 1972 Apr;53(1):1-23.
[Text Abstract on PubMed]

Respiration and protein synthesis in Escherichia coli membrane-envelope fragments. V. On the reduction of nonheme iron and the cytochromes by nicotinamide adenine dinucleotide and succinate.
Hendler RW.
J. Cell Biol. 1971 Dec;51(3):664-73.
[Text Abstract on PubMed]

Biological membrane ultrastructure.
Hendler RW.
Physiol. Rev. 1971 Jan;51(1):66-97.
[Text Abstract on PubMed]

Respiration and protein synthesis in Escherichia coli membrane-envelope fragments. 3. Electron microscopy and analysis of the cytochromes.
Hendler RW, Nanninga N.
J. Cell Biol. 1970 Jul;46(1):114-29.
[Text Abstract on PubMed]

Respiration and protein synthesis in Escherichia coli membrane-envelope fragments. II. Effects of fatty acids and albumin on respiration.
Hendler RW, Burgess AH, Scharff R.
J. Cell Biol. 1970 Feb;44(2):376-84.
[Text Abstract on PubMed]

Respiration and protein synthesis in Escherichia coli membrane-envelope fragments. I. Oxidative activities with soluble substrates.
Hendler RW, Burgess AH, Scharff R.
J. Cell Biol. 1969 Sep;42(3):715-32.
[Text Abstract on PubMed]

2,4-Dinitrophenol and azide as inhibitors of protein and ribonucleic acid synthesis in anaerobic yeast.
Jarett L, Hendler RW.
Biochemistry. 1967 Jun;6(6):1693-703.
[Text Abstract on PubMed]

Lipoamino acids as precursors in the synthesis of authentic proteins by homogenates of hen oviduct.
Hendler RW.
Proc. Natl. Acad. Sci. U.S.A. 1965 Oct;54(4):1233-40.
[Text Abstract on PubMed]

Importance of membranes in protein biosynthesis.
Hendler RW.
Nature. 1965 Sep 4;207(5001):1053-4 passim.
[Text Abstract on PubMed]

Uptake of nucleic acid, protein and carbohydrate precursors by hen-oviduct lipids.
Hendler RW.
Biochim. Biophys. Acta. 1965 Jul 7;106(1):184-96.
[Text Abstract on PubMed]

ON THE CYTOLOGICAL UNIT FOR PROTEIN SYNTHESIS IN VIVO IN E. COLI. I. STUDIES WITH SPHEROPLASTS OF TYPE K-12.
TANI J, HENDLER RW.
Biochim. Biophys. Acta. 1964 Feb 17;80:279-93.
[Text Abstract on PubMed]

ON THE CYTOLOGICAL UNIT FOR PROTEIN SYNTHESIS IN VIVO IN E. COLI. III. ELECTRON MICROSCOPIC AND ULTRACENTRIFUGAL EXAMINATION OF INTACT CELLS AND FRACTIONS.
HENDLER RW, BANFIELD WG, TANI J, KUFFEL.
Biochim. Biophys. Acta. 1964 Feb 17;80:307-14.
[Text Abstract on PubMed]

ON THE CYTOLOGICAL UNIT FOR PROTEIN SYNTHESIS IN VIVO IN E. COLI. II. STUDIES WITH INTACT CELLS OF TYPE B.
HENDLER RW, TANI J.
Biochim. Biophys. Acta. 1964 Feb 17;80:294-306.
[Text Abstract on PubMed]

PROCEDURE FOR SIMULTANEOUS ASSAY OF TWO BETA-EMITTING ISOTOPES WITH THE LIQUID SCINTILLATION COUNTING TECHNIQUE.
HENDLER RW.
Anal. Biochem. 1964 Jan;7:110-20.
[Text Abstract on PubMed]

PROTEIN BIOSYNTHESIS: SOME ALTERNATIVE CONSIDERATIONS ON THE CURRENT HYPOTHESIS.
HENDLER RW.
Science. 1963 Oct 18;142(3590):402-5.
[Text Abstract on PubMed]

ISOLATION OF "LIPOPEPTIDES" FROM HEN OVIDUCT.
HENDLER RW.
Biochim. Biophys. Acta. 1963 Sep 10;74:659-66.
[Text Abstract on PubMed]

METABOLIC PROPERTIES OF "LIPOPEPTIDES" ISOLATED FROM HEN OVIDUCT.
HENDLER RW.
Biochim. Biophys. Acta. 1963 Sep 10;74:667-77.
[Text Abstract on PubMed]

On the agreement of amino acid replacement data with code designations for the amino acids.
HENDLER RW.
Proc. Natl. Acad. Sci. U.S.A. 1962 Aug;48:1402-8.
[Text Abstract on PubMed]

Further characterization of an amino acids-lipid complex from hen oviduct.
HENDLER RW.
Biochim. Biophys. Acta. 1962 Jun 18;60:90-7.
[Text Abstract on PubMed]

A model for protein synthesis.
HENDLER RW.
Nature. 1962 Mar 3;193:821-3.
[Text Abstract on PubMed]

Some properties and the possible metabolic significance of amino acid-lipid complexes.
HENDLER RW.
Biochim. Biophys. Acta. 1961 May 13;49:297-307.
[Text Abstract on PubMed]

Self-absorption correction for carbon-14 assay.
KATZ J, HENDLER RW.
Science. 1960 Jun 24;131(3417):1886-7.
[Text Abstract on PubMed]

Self-absorption correction for carbon-14.
HENDLER RW.
Science. 1959 Sep 25;130(3378):772-7.
[Text Abstract on PubMed]

Passage of radioactive amino acids through nonprotein fractions of hen oviduct during incorporation into protein.
HENDLER RW.
J. Biol. Chem. 1959 Jun;234(6):1466-73.
[Text Abstract on PubMed]

Possible involvement of lipids in protein synthesis.
HENDLER RW.
Science. 1958 Jul 18;128(3316):143-4.
[Text Abstract on PubMed]

Passage of radioactivity between protein fractions of a hen oviduct homogenate.
HENDLER RW.
J. Biol. Chem. 1957 Dec;229(2):553-61.
[Text Abstract on PubMed]

Evidence for an intermediate stage in the process of amino acid incorporation into hen oviduct proteins.
HENDLER RW.
Biochim. Biophys. Acta. 1957 Aug;25(2):444-5.
[Text Abstract on PubMed]

A cytological study of the albuminsecreting cells of the hen oviduct.
HENDLER RW, DALTON AJ, GLENNER GG.
J Biophys Biochem Cytol. 1957 May 25;3(3):325-30.
[Text Abstract on PubMed]

A study of carbon dioxide fixation in the hen oviduct.
HENDLER RW.
Biochim. Biophys. Acta. 1957 Apr;24(1):187-92.
[Text Abstract on PubMed]

Studies on the nature of the amino acid incorporation process of hen oviduct tissue.
HENDLER RW.
J. Biol. Chem. 1956 Dec;223(2):831-42.
[Text Abstract on PubMed]

Fixation of carbon dioxide into the carboxyl carbon of glycine.
HENDLER RW.
Nature. 1956 Sep 22;178(4534):651.
[Text Abstract on PubMed]

The synthesis of radioactive L-glutamic acid.
HENDLER RW, HORNING MG, ANFINSEN CB.
Arch. Biochem. Biophys. 1954 Aug;51(2):470-4.
[Text Abstract on PubMed]

On the significance of gamma-glutamyl transpeptidation in peptide biosynthesis.
HENDLER RW, GREENBERG DM.
Biochem. J. 1954 Aug;57(4):641-9.
[Text Abstract on PubMed]

The incorporation of carbon dioxide into both carboxyl groups of glutamic acid.
HENDLER RW, ANFINSEN CB.
J. Biol. Chem. 1954 Jul;209(1):55-62.
[Text Abstract on PubMed]