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Toren Finkel, M.D., Ph.D.

Publications


Principal Investigator thumbnail image

Toren Finkel
Senior Investigator

P: +1 301 402 4081
F: +1 301 402 0888
finkelt@nih.gov


Full Publications Listing

The NAD-dependent deacetylase SIRT2 is required for programmed necrosis.
Narayan N, Lee IH, Borenstein R, Sun J, Wong R, Tong G, Fergusson MM, Liu J, Rovira II, Cheng HL, Wang G, Gucek M, Lombard D, Alt FW, Sack MN, Murphy E, Cao L, Finkel T.
Nature. 2012 Dec 13;492(7428):199-204.
[Text Abstract on PubMed]

Relief with rapamycin: mTOR inhibition protects against radiation-induced mucositis.
Finkel T.
Cell Stem Cell. 2012 Sep 7;11(3):287-8.
[Text Abstract on PubMed]

Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress.
Lee IH, Kawai Y, Fergusson MM, Rovira II, Bishop AJ, Motoyama N, Cao L, Finkel T.
Science. 2012 Apr 13;336(6078):225-8.
[Text Abstract on PubMed]

Guidelines for the use and interpretation of assays for monitoring autophagy.
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, .
Autophagy. 2012 Apr;8(4):445-544.
[Text Abstract on PubMed]

Oncogene-induced senescence results in marked metabolic and bioenergetic alterations.
Quijano C, Cao L, Fergusson MM, Romero H, Liu J, Gutkind S, Rovira II, Mohney RP, Karoly ED, Finkel T.
Cell Cycle. 2012 Apr 1;11(7):1383-92.
[Text Abstract on PubMed]

From sulfenylation to sulfhydration: what a thiolate needs to tolerate.
Finkel T.
Sci Signal. 2012 Mar 13;5(215):pe10.
[Text Abstract on PubMed]

Signal transduction by mitochondrial oxidants.
Finkel T.
J. Biol. Chem. 2012 Feb 10;287(7):4434-40.
[Text Abstract on PubMed]

Mitochondrial metabolism, sirtuins, and aging.
Sack MN, Finkel T.
Cold Spring Harb Perspect Biol. 2012;4(12).
[Text Abstract on PubMed]

Oxidants, metabolism, and stem cell biology.
Liu J, Cao L, Finkel T.
Free Radic. Biol. Med. 2011 Dec 15;51(12):2158-62.
[Text Abstract on PubMed]

A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells.
Shen J, Liu X, Yu WM, Liu J, Nibbelink MG, Guo C, Finkel T, Qu CK.
Mol. Cell. Biol. 2011 Dec;31(24):4902-16.
[Text Abstract on PubMed]

Caenorhabditis elegans UCP4 protein controls complex II-mediated oxidative phosphorylation through succinate transport.
Pfeiffer M, Kayzer EB, Yang X, Abramson E, Kenaston MA, Lago CU, Lo HH, Sedensky MM, Lunceford A, Clarke CF, Wu SJ, McLeod C, Finkel T, Morgan PG, Mills EM.
J. Biol. Chem. 2011 Oct 28;286(43):37712-20.
[Text Abstract on PubMed]

Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes.
Molitoris JK, McColl KS, Swerdlow S, Matsuyama M, Lam M, Finkel TH, Matsuyama S, Distelhorst CW.
J. Biol. Chem. 2011 Aug 26;286(34):30181-9.
[Text Abstract on PubMed]

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent.
Parkhitko A, Myachina F, Morrison TA, Hindi KM, Auricchio N, Karbowniczek M, Wu JJ, Finkel T, Kwiatkowski DJ, Yu JJ, Henske EP.
Proc. Natl. Acad. Sci. U.S.A. 2011 Jul 26;108(30):12455-60.
[Text Abstract on PubMed]

Signal transduction by reactive oxygen species.
Finkel T.
J. Cell Biol. 2011 Jul 11;194(1):7-15.
[Text Abstract on PubMed]

Protection from obesity and diabetes by blockade of TGF-ß/Smad3 signaling.
Yadav H, Quijano C, Kamaraju AK, Gavrilova O, Malek R, Chen W, Zerfas P, Zhigang D, Wright EC, Stuelten C, Sun P, Lonning S, Skarulis M, Sumner AE, Finkel T, Rane SG.
Cell Metab. 2011 Jul 6;14(1):67-79.
[Text Abstract on PubMed]

Genetic links between circulating cells and cardiovascular risk.
Finkel T, Quyyumi AA.
Circ Cardiovasc Genet. 2011 Jun;4(3):218-20.
[Text Abstract on PubMed]

Telomeres and mitochondrial function.
Finkel T.
Circ. Res. 2011 Apr 15;108(8):903-4.
[Text Abstract on PubMed]

Wnt signaling regulates hepatic metabolism.
Liu H, Fergusson MM, Wu JJ, Rovira II, Liu J, Gavrilova O, Lu T, Bao J, Han D, Sack MN, Finkel T.
Sci Signal. 2011;4(158):ra6.
[Text Abstract on PubMed]

BRCA1 is an essential regulator of heart function and survival following myocardial infarction.
Shukla PC, Singh KK, Quan A, Al-Omran M, Teoh H, Lovren F, Cao L, Rovira II, Pan Y, Brezden-Masley C, Yanagawa B, Gupta A, Deng CX, Coles JG, Leong-Poi H, Stanford WL, Parker TG, Schneider MD, Finkel T, Verma S.
Nat Commun. 2011;2:593.
[Text Abstract on PubMed]

Metabolism meets autophagy.
Wu JJ, Quijano C, Wang J, Finkel T.
Cell Cycle. 2010 Dec 15;9(24):4780-1.
[Text Abstract on PubMed]

Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report.
Erzurum S, Rounds SI, Stevens T, Aldred M, Aliotta J, Archer SL, Asosingh K, Balaban R, Bauer N, Bhattacharya J, Bogaard H, Choudhary G, Dorn, Dweik R, Fagan K, Fallon M, Finkel T, Geraci M, Gladwin MT, Hassoun PM, Humbert M, Kaminski N, Kawut SM, Loscalzo J, McDonald D, McMurtry IF, Newman J, Nicolls M, Rabinovitch M, Shizuru J, Oka M, Polgar P, Rodman D, Schumacker P, Stenmark K, Tuder R, Voelkel N, Sullivan E, Weinshilboum R, Yoder MC, Zhao Y, Gail D, Moore TM.
Am. J. Respir. Crit. Care Med. 2010 Dec 15;182(12):1554-62.
[Text Abstract on PubMed]

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.
Bunting SF, Callén E, Wong N, Chen HT, Polato F, Gunn A, Bothmer A, Feldhahn N, Fernandez-Capetillo O, Cao L, Xu X, Deng CX, Finkel T, Nussenzweig M, Stark JM, Nussenzweig A.
Cell. 2010 Apr 16;141(2):243-54.
[Text Abstract on PubMed]

Impact papers on aging in 2009.
Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J.
Aging (Albany NY). 2010 Mar;2(3):111-21.
[Text Abstract on PubMed]

Preview. The Tortoise, the hare, and the FoxO.
Chen E, Finkel T.
Cell Stem Cell. 2009 Nov 6;5(5):451-2.
[Text Abstract on PubMed]

Xanthine oxidoreductase depletion induces renal interstitial fibrosis through aberrant lipid and purine accumulation in renal tubules.
Ohtsubo T, Matsumura K, Sakagami K, Fujii K, Tsuruya K, Noguchi H, Rovira II, Finkel T, Iida M.
Hypertension. 2009 Oct;54(4):868-76.
[Text Abstract on PubMed]

The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine.
Biesecker LG, Mullikin JC, Facio FM, Turner C, Cherukuri PF, Blakesley RW, Bouffard GG, Chines PS, Cruz P, Hansen NF, Teer JK, Maskeri B, Young AC, NISC Comparative Sequencing Program, Manolio TA, Wilson AF, Finkel T, Hwang P, Arai A, Remaley AT, Sachdev V, Shamburek R, Cannon RO, Green ED.
Genome Res. 2009 Sep;19(9):1665-74.
[Text Abstract on PubMed]

A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency.
Cao L, Xu X, Bunting SF, Liu J, Wang RH, Cao LL, Wu JJ, Peng TN, Chen J, Nussenzweig A, Deng CX, Finkel T.
Mol. Cell. 2009 Aug 28;35(4):534-41.
[Text Abstract on PubMed]

Recent progress in the biology and physiology of sirtuins.
Finkel T, Deng CX, Mostoslavsky R.
Nature. 2009 Jul 30;460(7255):587-91.
[Text Abstract on PubMed]

The Krebs cycle meets the cell cycle: mitochondria and the G1-S transition.
Finkel T, Hwang PM.
Proc. Natl. Acad. Sci. U.S.A. 2009 Jul 21;106(29):11825-6.
[Text Abstract on PubMed]

Bmi1 regulates mitochondrial function and the DNA damage response pathway.
Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, Ahn BH, Kumar NG, Rovira II, Xu XL, van Lohuizen M, Motoyama N, Deng CX, Finkel T.
Nature. 2009 May 21;459(7245):387-92.
[Text Abstract on PubMed]

Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy.
Wu JJ, Quijano C, Chen E, Liu H, Cao L, Fergusson MM, Rovira II, Gutkind S, Daniels MP, Komatsu M, Finkel T.
Aging (Albany NY). 2009 Apr;1(4):425-37.
[Text Abstract on PubMed]

Regulation of autophagy by the p300 acetyltransferase.
Lee IH, Finkel T.
J. Biol. Chem. 2009 Mar 6;284(10):6322-8.
[Text Abstract on PubMed]

Breathing lessons: Tor tackles the mitochondria.
Finkel T.
Aging (Albany NY). 2009 Jan;1(1):9-11.
[Text Abstract on PubMed]

Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells.
Schieke SM, Ma M, Cao L, McCoy, Liu C, Hensel NF, Barrett AJ, Boehm M, Finkel T.
J. Biol. Chem. 2008 Oct 17;283(42):28506-12.
[Text Abstract on PubMed]

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.
Wang RH, Zheng Y, Kim HS, Xu X, Cao L, Luhasen T, Lee MH, Xiao C, Vassilopoulos A, Chen W, Gardner K, Man YG, Hung MC, Finkel T, Deng CX.
Mol. Cell. 2008 Oct 10;32(1):11-20.
[Text Abstract on PubMed]

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis.
Ahn BH, Kim HS, Song S, Lee IH, Liu J, Vassilopoulos A, Deng CX, Finkel T.
Proc. Natl. Acad. Sci. U.S.A. 2008 Sep 23;105(38):14447-52.
[Text Abstract on PubMed]

SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism.
Liang XJ, Finkel T, Shen DW, Yin JJ, Aszalos A, Gottesman MM.
Mol. Cancer Res. 2008 Sep;6(9):1499-506.
[Text Abstract on PubMed]

Redox-based regulation of signal transduction: principles, pitfalls, and promises.
Janssen-Heininger YM, Mossman BT, Heintz NH, Forman HJ, Kalyanaraman B, Finkel T, Stamler JS, Rhee SG, van der Vliet A.
Free Radic. Biol. Med. 2008 Jul 1;45(1):1-17.
[Text Abstract on PubMed]

Coordination of mitochondrial bioenergetics with G1 phase cell cycle progression.
Schieke SM, McCoy, Finkel T.
Cell Cycle. 2008 Jun 15;7(12):1782-7.
[Text Abstract on PubMed]

Free radicals and senescence.
Lu T, Finkel T.
Exp. Cell Res. 2008 Jun 10;314(9):1918-22.
[Text Abstract on PubMed]

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.
Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW, Finkel T.
Proc. Natl. Acad. Sci. U.S.A. 2008 Mar 4;105(9):3374-9.
[Text Abstract on PubMed]

The common biology of cancer and ageing.
Finkel T, Serrano M, Blasco MA.
Nature. 2007 Aug 16;448(7155):767-74.
[Text Abstract on PubMed]

Augmented Wnt signaling in a mammalian model of accelerated aging.
Liu H, Fergusson MM, Castilho RM, Liu J, Cao L, Chen J, Malide D, Rovira II, Schimel D, Kuo CJ, Gutkind JS, Hwang PM, Finkel T.
Science. 2007 Aug 10;317(5839):803-6.
[Text Abstract on PubMed]

GAPDH and the search for alternative energy.
Song S, Finkel T.
Nat. Cell Biol. 2007 Aug;9(8):869-70.
[Text Abstract on PubMed]

TOR and aging: less is more.
Schieke SM, Finkel T.
Cell Metab. 2007 Apr;5(4):233-5.
[Text Abstract on PubMed]

Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity.
Cheung KJ, Tzameli I, Pissios P, Rovira I, Gavrilova O, Ohtsubo T, Chen Z, Finkel T, Flier JS, Friedman JM.
Cell Metab. 2007 Feb;5(2):115-28.
[Text Abstract on PubMed]

Cancer gets the Chk'ered flag.
Cao L, Finkel T.
Nat. Med. 2006 Dec;12(12):1354-6.
[Text Abstract on PubMed]

Cell biology: a clean energy programme.
Finkel T.
Nature. 2006 Nov 9;444(7116):151-2.
[Text Abstract on PubMed]

Mitochondrial signaling, TOR, and life span.
Schieke SM, Finkel T.
Biol. Chem. 2006 Oct-Nov;387(10-11):1357-61.
[Text Abstract on PubMed]

The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity.
Schieke SM, Phillips D, McCoy, Aponte AM, Shen RF, Balaban RS, Finkel T.
J. Biol. Chem. 2006 Sep 15;281(37):27643-52.
[Text Abstract on PubMed]

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage.
Wang C, Chen L, Hou X, Li Z, Kabra N, Ma Y, Nemoto S, Finkel T, Gu W, Cress WD, Chen J.
Nat. Cell Biol. 2006 Sep;8(9):1025-31.
[Text Abstract on PubMed]

Intracellular redox regulation by the family of small GTPases.
Finkel T.
Antioxid. Redox Signal. 2006 Sep-Oct;8(9-10):1857-63.
[Text Abstract on PubMed]

Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma.
Khakoo AY, Pati S, Anderson SA, Reid W, Elshal MF, Rovira II, Nguyen AT, Malide D, Combs CA, Hall G, Zhang J, Raffeld M, Rogers TB, Stetler-Stevenson W, Frank JA, Reitz M, Finkel T.
J. Exp. Med. 2006 May 15;203(5):1235-47.
[Text Abstract on PubMed]

Time, tumours and telomeres. Meeting on Cancer and Aging.
Finkel T, Vijg J, Shay JW.
EMBO Rep. 2006 May;7(5):479-83.
[Text Abstract on PubMed]

The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism.
Nemoto S, Combs CA, French S, Ahn BH, Fergusson MM, Balaban RS, Finkel T.
J. Biol. Chem. 2006 Apr 14;281(15):10555-60.
[Text Abstract on PubMed]

Stem cell aging: what bleach can teach.
Liu J, Finkel T.
Nat. Med. 2006 Apr;12(4):383-4.
[Text Abstract on PubMed]

Radical medicine: treating ageing to cure disease.
Finkel T.
Nat. Rev. Mol. Cell Biol. 2005 Dec;6(12):971-6.
[Text Abstract on PubMed]

Redox-dependent transcriptional regulation.
Liu H, Colavitti R, Rovira II, Finkel T.
Circ. Res. 2005 Nov 11;97(10):967-74.
[Text Abstract on PubMed]

Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity.
Smith WW, Norton DD, Gorospe M, Jiang H, Nemoto S, Holbrook NJ, Finkel T, Kusiak JW.
J. Cell Biol. 2005 Apr 25;169(2):331-9.
[Text Abstract on PubMed]

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}.
Nemoto S, Fergusson MM, Finkel T.
J. Biol. Chem. 2005 Apr 22;280(16):16456-60.
[Text Abstract on PubMed]

Reactive oxygen species as mediators of cellular senescence.
Colavitti R, Finkel T.
IUBMB Life. 2005 Apr-May;57(4-5):277-81.
[Text Abstract on PubMed]

Mitochondria, oxidants, and aging.
Balaban RS, Nemoto S, Finkel T.
Cell. 2005 Feb 25;120(4):483-95.
[Text Abstract on PubMed]

Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease.
Powell TM, Paul JD, Hill JM, Thompson M, Benjamin M, Rodrigo M, McCoy JP, Read EJ, Khuu HM, Leitman SF, Finkel T, Cannon.
Arterioscler. Thromb. Vasc. Biol. 2005 Feb;25(2):296-301.
[Text Abstract on PubMed]

Endothelial progenitor cells.
Khakoo AY, Finkel T.
Annu. Rev. Med. 2005;56:79-101.
[Text Abstract on PubMed]

Effect of a histone deacetylase inhibitor on human cardiac mass.
Shizukuda Y, Piekarz RL, Bates SE, Sachdev V, Finkel T, Rosing DR.
Cardiovasc Drugs Ther. 2005 Jan;19(1):89-90.
[Text Abstract on PubMed]

Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.
Nemoto S, Fergusson MM, Finkel T.
Science. 2004 Dec 17;306(5704):2105-8.
[Text Abstract on PubMed]

Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2.
Ohtsubo T, Rovira II, Starost MF, Liu C, Finkel T.
Circ. Res. 2004 Nov 26;95(11):1118-24.
[Text Abstract on PubMed]

Endothelial progenitor cells and endothelial dysfunction.
Hill JM, Finkel T, Quyyumi AA.
Vox Sang. 2004 Jul;87 Suppl 2:31-7.
[Text Abstract on PubMed]

Ageing and the mystery at Arles.
Nemoto S, Finkel T.
Nature. 2004 May 13;429(6988):149-52.
[Text Abstract on PubMed]

Pharmacology: uncoupling the agony from ecstasy.
Mills EM, Banks ML, Sprague JE, Finkel T.
Nature. 2003 Nov 27;426(6965):403-4.
[Text Abstract on PubMed]

Ageing: a toast to long life.
Finkel T.
Nature. 2003 Sep 11;425(6954):132-3.
[Text Abstract on PubMed]

Oxidant signals and oxidative stress.
Finkel T.
Curr. Opin. Cell Biol. 2003 Apr;15(2):247-54.
[Text Abstract on PubMed]

Circulating endothelial progenitor cells, vascular function, and cardiovascular risk.
Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, Finkel T.
N. Engl. J. Med. 2003 Feb 13;348(7):593-600.
[Text Abstract on PubMed]

Neutrophils with a license to kill: permeabilized, not stirred.
Finkel T.
Dev. Cell. 2003 Feb;4(2):146-8.
[Text Abstract on PubMed]

Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor gamma Coactivator-1 alpha (PGC-1alpha).
Ichida M, Nemoto S, Finkel T.
J. Biol. Chem. 2002 Dec 27;277(52):50991-5.
[Text Abstract on PubMed]

Regulation of cellular oncosis by uncoupling protein 2.
Mills EM, Xu D, Fergusson MM, Combs CA, Xu Y, Finkel T.
J. Biol. Chem. 2002 Jul 26;277(30):27385-92.
[Text Abstract on PubMed]

Regulation of the Werner helicase through a direct interaction with a subunit of protein kinase A.
Nguyen DT, Rovira II, Finkel T.
FEBS Lett. 2002 Jun 19;521(1-3):170-4.
[Text Abstract on PubMed]

Redox regulation of Cdc25C.
Savitsky PA, Finkel T.
J. Biol. Chem. 2002 Jun 7;277(23):20535-40.
[Text Abstract on PubMed]

A role for mitochondria as potential regulators of cellular life span.
Xu D, Finkel T.
Biochem. Biophys. Res. Commun. 2002 Jun 7;294(2):245-8.
[Text Abstract on PubMed]

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway.
Nemoto S, Finkel T.
Science. 2002 Mar 29;295(5564):2450-2.
[Text Abstract on PubMed]

Oxidants painting the cysteine chapel: redox regulation of PTPs.
Xu D, Rovira II, Finkel T.
Dev. Cell. 2002 Mar;2(3):251-2.
[Text Abstract on PubMed]

Detection and affinity purification of oxidant-sensitive proteins using biotinylated glutathione ethyl ester.
Sullivan DM, Levine RL, Finkel T.
Meth. Enzymol. 2002;353:101-13.
[Text Abstract on PubMed]

Reactive oxygen species and signal transduction.
Finkel T.
IUBMB Life. 2001 Jul;52(1-2):3-6.
[Text Abstract on PubMed]

Ras regulates NFAT3 activity in cardiac myocytes.
Ichida M, Finkel T.
J. Biol. Chem. 2001 Feb 2;276(5):3524-30.
[Text Abstract on PubMed]

Oxidants, oxidative stress and the biology of ageing.
Finkel T, Holbrook NJ.
Nature. 2000 Nov 9;408(6809):239-47.
[Text Abstract on PubMed]

Role for mitochondrial oxidants as regulators of cellular metabolism.
Nemoto S, Takeda K, Yu ZX, Ferrans VJ, Finkel T.
Mol. Cell. Biol. 2000 Oct;20(19):7311-8.
[Text Abstract on PubMed]

Identification of oxidant-sensitive proteins: TNF-alpha induces protein glutathiolation.
Sullivan DM, Wehr NB, Fergusson MM, Levine RL, Finkel T.
Biochemistry. 2000 Sep 12;39(36):11121-8.
[Text Abstract on PubMed]

Redox-dependent signal transduction.
Finkel T.
FEBS Lett. 2000 Jun 30;476(1-2):52-4.
[Text Abstract on PubMed]

Vascular effects following homozygous disruption of p47(phox) : An essential component of NADPH oxidase.
Hsich E, Segal BH, Pagano PJ, Rey FE, Paigen B, Deleonardis J, Hoyt RF, Holland SM, Finkel T.
Circulation. 2000 Mar 21;101(11):1234-6.
[Text Abstract on PubMed]

Homocysteine accelerates endothelial cell senescence.
Xu D, Neville R, Finkel T.
FEBS Lett. 2000 Mar 17;470(1):20-4.
[Text Abstract on PubMed]

Under new management: A six-month progress report on Circulation Research.
Marbán E, Bolli R, Breitwieser G, Busse R, Dietz H, Endoh M, Finkel T, Kass D, Lowenstein C, Rabinovitch M, Tomaselli G.
Circ. Res. 2000 Feb 4;86(2):111-3.
[Text Abstract on PubMed]

Expression of Rho GTPases using adenovirus vectors.
Sullivan DM, Finkel T.
Meth. Enzymol. 2000;325:303-14.
[Text Abstract on PubMed]

Endothelial progenitor cells as putative targets for angiostatin.
Ito H, Rovira II, Bloom ML, Takeda K, Ferrans VJ, Quyyumi AA, Finkel T.
Cancer Res. 1999 Dec 1;59(23):5875-7.
[Text Abstract on PubMed]

Cytomegalovirus infection of rats increases the neointimal response to vascular injury without consistent evidence of direct infection of the vascular wall.
Zhou YF, Shou M, Guetta E, Guzman R, Unger EF, Yu ZX, Zhang J, Finkel T, Epstein SE.
Circulation. 1999 Oct 5;100(14):1569-75.
[Text Abstract on PubMed]

Relationship of the C242T p22phox gene polymorphism to angiographic coronary artery disease and endothelial function.
Li A, Prasad A, Mincemoyer R, Satorius C, Epstein N, Finkel T, Quyyumi AA.
Am. J. Med. Genet. 1999 Sep 3;86(1):57-61.
[Text Abstract on PubMed]

A role for reactive oxygen species in endothelial cell anoikis.
Li AE, Ito H, Rovira II, Kim KS, Takeda K, Yu ZY, Ferrans VJ, Finkel T.
Circ. Res. 1999 Aug 20;85(4):304-10.
[Text Abstract on PubMed]

Regulation of endothelial cell adherens junctions by a Ras-dependent signal transduction pathway.
Hegland DD, Sullivan DM, Rovira II, Li A, Kovesdi I, Bruder JT, Finkel T.
Biochem. Biophys. Res. Commun. 1999 Jul 5;260(2):371-6.
[Text Abstract on PubMed]

Thinking globally, acting locally. The promise of cardiovascular gene therapy.
Finkel T.
Circ. Res. 1999 Jun 25;84(12):1471-2.
[Text Abstract on PubMed]

Effects of human cytomegalovirus immediate-early proteins on p53-mediated apoptosis in coronary artery smooth muscle cells.
Tanaka K, Zou JP, Takeda K, Ferrans VJ, Sandford GR, Johnson TM, Finkel T, Epstein SE.
Circulation. 1999 Apr 6;99(13):1656-9.
[Text Abstract on PubMed]

Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species.
Lee AC, Fenster BE, Ito H, Takeda K, Bae NS, Hirai T, Yu ZX, Ferrans VJ, Howard BH, Finkel T.
J. Biol. Chem. 1999 Mar 19;274(12):7936-40.
[Text Abstract on PubMed]

Signal transduction by reactive oxygen species in non-phagocytic cells.
Finkel T.
J. Leukoc. Biol. 1999 Mar;65(3):337-40.
[Text Abstract on PubMed]

VEGF stimulates MAPK through a pathway that is unique for receptor tyrosine kinases.
Doanes AM, Hegland DD, Sethi R, Kovesdi I, Bruder JT, Finkel T.
Biochem. Biophys. Res. Commun. 1999 Feb 16;255(2):545-8.
[Text Abstract on PubMed]

The actin cytoskeleton reorganization induced by Rac1 requires the production of superoxide.
Moldovan L, Irani K, Moldovan NI, Finkel T, Goldschmidt-Clermont PJ.
Antioxid. Redox Signal. 1999 Spring;1(1):29-43.
[Text Abstract on PubMed]

Expression of Id1 results in apoptosis of cardiac myocytes through a redox-dependent mechanism.
Tanaka K, Pracyk JB, Takeda K, Yu ZX, Ferrans VJ, Deshpande SS, Ozaki M, Hwang PM, Lowenstein CJ, Irani K, Finkel T.
J. Biol. Chem. 1998 Oct 2;273(40):25922-8.
[Text Abstract on PubMed]

A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy.
Pracyk JB, Tanaka K, Hegland DD, Kim KS, Sethi R, Rovira II, Blazina DR, Lee L, Bruder JT, Kovesdi I, Goldshmidt-Clermont PJ, Irani K, Finkel T.
J. Clin. Invest. 1998 Sep 1;102(5):929-37.
[Text Abstract on PubMed]

A requirement for rac1 in the PDGF-stimulated migration of fibroblasts and vascular smooth cells.
Doanes AM, Irani K, Goldschmidt-Clermont PJ, Finkel T.
Biochem. Mol. Biol. Int. 1998 Jun;45(2):279-87.
[Text Abstract on PubMed]

Protection from reoxygenation injury by inhibition of rac1.
Kim KS, Takeda K, Sethi R, Pracyk JB, Tanaka K, Zhou YF, Yu ZX, Ferrans VJ, Bruder JT, Kovesdi I, Irani K, Goldschmidt-Clermont P, Finkel T.
J. Clin. Invest. 1998 May 1;101(9):1821-6.
[Text Abstract on PubMed]

Bcl-2 regulates nonapoptotic signal transduction: inhibition of c-Jun N-terminal kinase (JNK) activation by IL-1 beta and hydrogen peroxide.
Lee L, Irani K, Finkel T.
Mol. Genet. Metab. 1998 May;64(1):19-24.
[Text Abstract on PubMed]

Oxygen radicals and signaling.
Finkel T.
Curr. Opin. Cell Biol. 1998 Apr;10(2):248-53.
[Text Abstract on PubMed]

Rac1 is required for cell proliferation and G2/M progression.
Moore KA, Sethi R, Doanes AM, Johnson TM, Pracyk JB, Kirby M, Irani K, Goldschmidt-Clermont PJ, Finkel T.
Biochem. J. 1997 Aug 15;326 ( Pt 1):17-20.
[Text Abstract on PubMed]

Inhibition of vascular smooth muscle cell proliferation and neointimal accumulation by adenovirus-mediated gene transfer of cytosine deaminase.
Harrell RL, Rajanayagam S, Doanes AM, Guzman RJ, Hirschowitz EA, Crystal RG, Epstein SE, Finkel T.
Circulation. 1997 Jul 15;96(2):621-7.
[Text Abstract on PubMed]

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts.
Irani K, Xia Y, Zweier JL, Sollott SJ, Der CJ, Fearon ER, Sundaresan M, Finkel T, Goldschmidt-Clermont PJ.
Science. 1997 Mar 14;275(5306):1649-52.
[Text Abstract on PubMed]

Regulation of endothelial cell adhesion by profilin.
Moldovan NI, Milliken EE, Irani K, Chen J, Sohn RH, Finkel T, Goldschmidt-Clermont PJ.
Curr. Biol. 1997 Jan 1;7(1):24-30.
[Text Abstract on PubMed]

rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation.
Sulciner DJ, Irani K, Yu ZX, Ferrans VJ, Goldschmidt-Clermont P, Finkel T.
Mol. Cell. Biol. 1996 Dec;16(12):7115-21.
[Text Abstract on PubMed]

Human cytomegalovirus increases modified low density lipoprotein uptake and scavenger receptor mRNA expression in vascular smooth muscle cells.
Zhou YF, Guetta E, Yu ZX, Finkel T, Epstein SE.
J. Clin. Invest. 1996 Nov 1;98(9):2129-38.
[Text Abstract on PubMed]

The role of infection in restenosis and atherosclerosis: focus on cytomegalovirus.
Epstein SE, Speir E, Zhou YF, Guetta E, Leon M, Finkel T.
Lancet. 1996 Nov;348 Suppl 1:s13-7.
[Text Abstract on PubMed]

Superoxide-mediated actin response in post-hypoxic endothelial cells.
Crawford LE, Milliken EE, Irani K, Zweier JL, Becker LC, Johnson TM, Eissa NT, Crystal RG, Finkel T, Goldschmidt-Clermont PJ.
J. Biol. Chem. 1996 Oct 25;271(43):26863-7.
[Text Abstract on PubMed]

Reactive oxygen species are downstream mediators of p53-dependent apoptosis.
Johnson TM, Yu ZX, Ferrans VJ, Lowenstein RA, Finkel T.
Proc. Natl. Acad. Sci. U.S.A. 1996 Oct 15;93(21):11848-52.
[Text Abstract on PubMed]

Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.
Sundaresan M, Yu ZX, Ferrans VJ, Sulciner DJ, Gutkind JS, Irani K, Goldschmidt-Clermont PJ, Finkel T.
Biochem. J. 1996 Sep 1;318 ( Pt 2):379-82.
[Text Abstract on PubMed]

Apoptosis in vascular disease: opportunities for genetic therapeutic intervention.
Johnson TM, Epstein SE, Finkel T.
Semin Interv Cardiol. 1996 Sep;1(3):195-202.
[Text Abstract on PubMed]

Association between prior cytomegalovirus infection and the risk of restenosis after coronary atherectomy.
Zhou YF, Leon MB, Waclawiw MA, Popma JJ, Yu ZX, Finkel T, Epstein SE.
N. Engl. J. Med. 1996 Aug 29;335(9):624-30.
[Text Abstract on PubMed]

Requirement for generation of H2O2 for platelet-derived growth factor signal transduction.
Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T.
Science. 1995 Oct 13;270(5234):296-9.
[Text Abstract on PubMed]

Gene therapy for vascular disease.
Finkel T, Epstein SE.
FASEB J. 1995 Jul;9(10):843-51.
[Text Abstract on PubMed]

Interaction of human cytomegalovirus with p53: possible role in coronary restenosis.
Speir E, Huang ES, Modali R, Leon MB, Shawl F, Finkel T, Epstein SE.
Scand J Infect Dis Suppl. 1995;99:78-81.
[Text Abstract on PubMed]

In vivo suppression of injury-induced vascular smooth muscle cell accumulation using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene.
Guzman RJ, Hirschowitz EA, Brody SL, Crystal RG, Epstein SE, Finkel T.
Proc. Natl. Acad. Sci. U.S.A. 1994 Oct 25;91(22):10732-6.
[Text Abstract on PubMed]

Ras proteins regulate multiple mitogenic pathways in A10 vascular smooth muscle cells.
Irani K, Herzlinger S, Finkel T.
Biochem. Biophys. Res. Commun. 1994 Aug 15;202(3):1252-8.
[Text Abstract on PubMed]

Potential role of human cytomegalovirus and p53 interaction in coronary restenosis.
Speir E, Modali R, Huang ES, Leon MB, Shawl F, Finkel T, Epstein SE.
Science. 1994 Jul 15;265(5170):391-4.
[Text Abstract on PubMed]

The basis of molecular strategies for treating coronary restenosis after angioplasty.
Epstein SE, Speir E, Unger EF, Guzman RJ, Finkel T.
J. Am. Coll. Cardiol. 1994 May;23(6):1278-88.
[Text Abstract on PubMed]

Dynamic actin structures stabilized by profilin.
Finkel T, Theriot JA, Dise KR, Tomaselli GF, Goldschmidt-Clermont PJ.
Proc. Natl. Acad. Sci. U.S.A. 1994 Feb 15;91(4):1510-4.
[Text Abstract on PubMed]

Efficient gene transfer into myocardium by direct injection of adenovirus vectors.
Guzman RJ, Lemarchand P, Crystal RG, Epstein SE, Finkel T.
Circ. Res. 1993 Dec;73(6):1202-7.
[Text Abstract on PubMed]

Efficient and selective adenovirus-mediated gene transfer into vascular neointima.
Guzman RJ, Lemarchand P, Crystal RG, Epstein SE, Finkel T.
Circulation. 1993 Dec;88(6):2838-48.
[Text Abstract on PubMed]

Do antisense approaches to the problem of restenosis make sense?
Epstein SE, Speir E, Finkel T.
Circulation. 1993 Sep;88(3):1351-3.
[Text Abstract on PubMed]

Detection and modulation in vivo of helix-loop-helix protein-protein interactions.
Finkel T, Duc J, Fearon ER, Dang CV, Tomaselli GF.
J. Biol. Chem. 1993 Jan 5;268(1):5-8.
[Text Abstract on PubMed]

Karyoplasmic interaction selection strategy: a general strategy to detect protein-protein interactions in mammalian cells.
Fearon ER, Finkel T, Gillison ML, Kennedy SP, Casella JF, Tomaselli GF, Morrow JS, Van Dang C.
Proc. Natl. Acad. Sci. U.S.A. 1992 Sep 1;89(17):7958-62.
[Text Abstract on PubMed]

Monoclonal antibody specific for an activated RAS protein.
Carney WP, Petit D, Hamer P, Der CJ, Finkel T, Cooper GM, Lefebvre M, Mobtaker H, Delellis R, Tischler AS.
Proc. Natl. Acad. Sci. U.S.A. 1986 Oct;83(19):7485-9.
[Text Abstract on PubMed]

Biological and biochemical properties of human rasH genes mutated at codon 61.
Der CJ, Finkel T, Cooper GM.
Cell. 1986 Jan 17;44(1):167-76.
[Text Abstract on PubMed]

Activation of ras genes in human tumors does not affect localization, modification, or nucleotide binding properties of p21.
Finkel T, Der CJ, Cooper GM.
Cell. 1984 May;37(1):151-8.
[Text Abstract on PubMed]

Detection of a molecular complex between ras proteins and transferrin receptor.
Finkel T, Cooper GM.
Cell. 1984 Apr;36(4):1115-21.
[Text Abstract on PubMed]