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Cynthia E. Dunbar, M.D.


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Cynthia E. Dunbar
Senior Investigator

P: +1 301 402 1363
F: +1 301 594 1290

Full Publications Listing

Assessing the Risks of Genotoxicity in the Therapeutic Development of Induced Pluripotent Stem Cells.
Hong SG, Dunbar CE, Winkler T.
Mol. Ther. 2012 Dec 4.
[Text Abstract on PubMed]

An educational infusion: more synergy between Blood and the American Society of Hematology.
Dunbar CE.
Blood. 2012 Nov 29;120(23):4449.
[Text Abstract on PubMed]

High Efficiency Restriction Enzyme-Free Linear Amplification-Mediated Polymerase Chain Reaction Approach for Tracking Lentiviral Integration Sites Does Not Abrogate Retrieval Bias.
Wu C, Jares A, Winkler T, Xie J, Metais JY, Dunbar CE.
Hum. Gene Ther. 2012 Oct 26.
[Text Abstract on PubMed]

Measurement of the absolute immature platelet number reflects marrow production and is not impacted by platelet transfusion.
Bat T, Leitman SF, Calvo KR, Chauvet D, Dunbar CE.
Transfusion. 2012 Oct 9.
[Text Abstract on PubMed]

Thymidine kinase suicide gene-mediated ganciclovir ablation of autologous gene-modified rhesus hematopoiesis.
Barese CN, Krouse AE, Metzger ME, King CA, Traversari C, Marini FC, Donahue RE, Dunbar CE.
Mol. Ther. 2012 Oct;20(10):1932-43.
[Text Abstract on PubMed]

Dynamic clonal analysis of murine hematopoietic stem and progenitor cells marked by five fluorescent proteins using confocal and multiphoton microscopy.
Malide D, Metais JY, Dunbar CE.
Blood. 2012 Sep 20.
[Text Abstract on PubMed]

Eltrombopag and improved hematopoiesis in refractory aplastic anemia.
Olnes MJ, Scheinberg P, Calvo KR, Desmond R, Tang Y, Dumitriu B, Parikh AR, Soto S, Biancotto A, Feng X, Lozier J, Wu CO, Young NS, Dunbar CE.
N. Engl. J. Med. 2012 Jul 5;367(1):11-9.
[Text Abstract on PubMed]

Pharmacological modulation of humoral immunity in a nonhuman primate model of AAV gene transfer for hemophilia B.
Mingozzi F, Chen Y, Murphy SL, Edmonson SC, Tai A, Price SD, Metzger ME, Zhou S, Wright JF, Donahue RE, Dunbar CE, High KA.
Mol. Ther. 2012 Jul;20(7):1410-6.
[Text Abstract on PubMed]

Bone marrow homing and engraftment of human hematopoietic stem and progenitor cells is mediated by a polarized membrane domain.
Larochelle A, Gillette JM, Desmond R, Ichwan B, Cantilena A, Cerf A, Barrett AJ, Wayne AS, Lippincott-Schwartz J, Dunbar CE.
Blood. 2012 Feb 23;119(8):1848-55.
[Text Abstract on PubMed]

Hematopoietic stem cell engineering at a crossroads.
Rivière I, Dunbar CE, Sadelain M.
Blood. 2012 Feb 2;119(5):1107-16.
[Text Abstract on PubMed]

Transient silencing of PTEN in human CD34(+) cells enhances their proliferative potential and ability to engraft immunodeficient mice.
Kim I, Kim YJ, Métais JY, Dunbar CE, Larochelle A.
Exp. Hematol. 2012 Jan;40(1):84-91.
[Text Abstract on PubMed]

BCL2A1a Over-Expression in Murine Hematopoietic Stem and Progenitor Cells Decreases Apoptosis and Results in Hematopoietic Transformation.
Métais JY, Winkler T, Geyer JT, Calado RT, Aplan PD, Eckhaus MA, Dunbar CE.
PLoS ONE. 2012;7(10):e48267.
[Text Abstract on PubMed]

Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity.
Wu C, Dunbar CE.
Front Med. 2011 Dec;5(4):356-71.
[Text Abstract on PubMed]

Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy.
Deichmann A, Brugman MH, Bartholomae CC, Schwarzwaelder K, Verstegen MM, Howe SJ, Arens A, Ott MG, Hoelzer D, Seger R, Grez M, Hacein-Bey-Abina S, Cavazzana-Calvo M, Fischer A, Paruzynski A, Gabriel R, Glimm H, Abel U, Cattoglio C, Mavilio F, Cassani B, Aiuti A, Dunbar CE, Baum C, Gaspar HB, Thrasher AJ, von Kalle C, Schmidt M, Wagemaker G.
Mol. Ther. 2011 Nov;19(11):2031-9.
[Text Abstract on PubMed]

Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia.
Aue G, Du Y, Cleveland SM, Smith SB, Davé UP, Liu D, Weniger MA, Metais JY, Jenkins NA, Copeland NG, Dunbar CE.
Blood. 2011 Oct 27;118(17):4674-81.
[Text Abstract on PubMed]

Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells.
Dar A, Schajnovitz A, Lapid K, Kalinkovich A, Itkin T, Ludin A, Kao WM, Battista M, Tesio M, Kollet O, Cohen NN, Margalit R, Buss EC, Baleux F, Oishi S, Fujii N, Larochelle A, Dunbar CE, Broxmeyer HE, Frenette PS, Lapidot T.
Leukemia. 2011 Aug;25(8):1286-96.
[Text Abstract on PubMed]

Contributions of gene marking to cell and gene therapies.
Barese CN, Dunbar CE.
Hum. Gene Ther. 2011 Jun;22(6):659-68.
[Text Abstract on PubMed]

CD9 up-regulation on CD34+ cells with ingenol 3,20-dibenzoate does not improve homing in NSG mice.
Desmond R, Dunfee A, Racke F, Dunbar CE, Larochelle A.
Blood. 2011 May 26;117(21):5774-6.
[Text Abstract on PubMed]

Patients, hematologists, and time.
Solberg, Dunbar CE.
Blood. 2011 Mar 10;117(10):2753-4.
[Text Abstract on PubMed]

Human and rhesus macaque hematopoietic stem cells cannot be purified based only on SLAM family markers.
Larochelle A, Savona M, Wiggins M, Anderson S, Ichwan B, Keyvanfar K, Morrison SJ, Dunbar CE.
Blood. 2011 Feb 3;117(5):1550-4.
[Text Abstract on PubMed]

Ex vivo expansion of retrovirally transduced primate CD34+ cells results in overrepresentation of clones with MDS1/EVI1 insertion sites in the myeloid lineage after transplantation.
Sellers S, Gomes TJ, Larochelle A, Lopez R, Adler R, Krouse A, Donahue RE, Childs RW, Dunbar CE.
Mol. Ther. 2010 Sep;18(9):1633-9.
[Text Abstract on PubMed]

Repetitive busulfan administration after hematopoietic stem cell gene therapy associated with a dominant HDAC7 clone in a nonhuman primate.
Xie J, Larochelle A, Maric I, Faulhaber M, Donahue RE, Dunbar CE.
Hum. Gene Ther. 2010 Jun;21(6):695-703.
[Text Abstract on PubMed]

Feline leukemia virus integrase and capsid packaging functions do not change the insertion profile of standard Moloney retroviral vectors.
Métais JY, Topp S, Doty RT, Borate B, Nguyen AD, Wolfsberg TG, Abkowitz JL, Dunbar CE.
Gene Ther. 2010 Jun;17(6):799-804.
[Text Abstract on PubMed]

Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer.
Salcido CD, Larochelle A, Taylor BJ, Dunbar CE, Varticovski L.
Br. J. Cancer. 2010 May 25;102(11):1636-44.
[Text Abstract on PubMed]

No evidence for clonal selection due to lentiviral integration sites in human induced pluripotent stem cells.
Winkler T, Cantilena A, Métais JY, Xu X, Nguyen AD, Borate B, Antosiewicz-Bourget JE, Wolfsberg TG, Thomson JA, Dunbar CE.
Stem Cells. 2010 Apr;28(4):687-94.
[Text Abstract on PubMed]

Evaluation of a rapamycin-regulated serotype 2 adeno-associated viral vector in macaque parotid glands.
Zheng C, Voutetakis A, Metzger M, Afione S, Cotrim AP, Eckhaus MA, Rivera VM, Clackson T, Chiorini JA, Donahue RE, Dunbar CE, Baum BJ.
Oral Dis. 2010 Apr;16(3):269-77.
[Text Abstract on PubMed]

Gene therapy activates EVI1, destabilizes chromosomes.
Dunbar CE, Larochelle A.
Nat. Med. 2010 Feb;16(2):163-5.
[Text Abstract on PubMed]

Keeping up with Blood: introducing our CME program.
Vogelsang GB, Dunbar CE.
Blood. 2010 Jan 28;115(4):756.
[Text Abstract on PubMed]

AAV5-mediated gene transfer to the parotid glands of non-human primates.
Voutetakis A, Zheng C, Cotrim AP, Mineshiba F, Afione S, Roescher N, Swaim WD, Metzger M, Eckhaus MA, Donahue RE, Dunbar CE, Chiorini JA, Baum BJ.
Gene Ther. 2010 Jan;17(1):50-60.
[Text Abstract on PubMed]

In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.
Larochelle A, Choi U, Shou Y, Naumann N, Loktionova NA, Clevenger JR, Krouse A, Metzger M, Donahue RE, Kang E, Stewart C, Persons D, Malech HL, Dunbar CE, Sorrentino BP.
J. Clin. Invest. 2009 Jul;119(7):1952-63.
[Text Abstract on PubMed]

Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-transduced CD34+ cells.
Kim YJ, Kim YS, Larochelle A, Renaud G, Wolfsberg TG, Adler R, Donahue RE, Hematti P, Hong BK, Roayaei J, Akagi K, Riberdy JM, Nienhuis AW, Dunbar CE, Persons DA.
Blood. 2009 May 28;113(22):5434-43.
[Text Abstract on PubMed]

Introducing "e-Blood".
Bagby GC, Dunbar CE.
Blood. 2009 May 7;113(19):4488.
[Text Abstract on PubMed]

Genetically modified CD34+ hematopoietic stem cells contribute to turnover of brain perivascular macrophages in long-term repopulated primates.
Soulas C, Donahue RE, Dunbar CE, Persons DA, Alvarez X, Williams KC.
Am. J. Pathol. 2009 May;174(5):1808-17.
[Text Abstract on PubMed]

Intercellular transfer to signalling endosomes regulates an ex vivo bone marrow niche.
Gillette JM, Larochelle A, Dunbar CE, Lippincott-Schwartz J.
Nat. Cell Biol. 2009 Mar;11(3):303-11.
[Text Abstract on PubMed]

'Ghostbusting' at blood.
Dunbar CE, Tallman MS.
Blood. 2009 Jan 15;113(3):502-3.
[Text Abstract on PubMed]

More frequent Blood transfusions.
Dunbar CE.
Blood. 2009 Jan 1;113(1):6.
[Text Abstract on PubMed]

Sorting of transgenic secretory proteins in rhesus macaque parotid glands after adenovirus-mediated gene transfer.
Voutetakis A, Zheng C, Metzger M, Cotrim AP, Donahue RE, Dunbar CE, Baum BJ.
Hum. Gene Ther. 2008 Dec;19(12):1401-5.
[Text Abstract on PubMed]

Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population.
Vasu S, Leitman SF, Tisdale JF, Hsieh MM, Childs RW, Barrett AJ, Fowler DH, Bishop MR, Kang EM, Malech HL, Dunbar CE, Khuu HM, Wesley R, Yau YY, Bolan CD.
Blood. 2008 Sep 1;112(5):2092-100.
[Text Abstract on PubMed]

Reduced genotoxicity of avian sarcoma leukosis virus vectors in rhesus long-term repopulating cells compared to standard murine retrovirus vectors.
Hu J, Renaud G, Gomes TJ, Golmes T, Ferris A, Hendrie PC, Donahue RE, Hughes SH, Wolfsberg TG, Russell DW, Dunbar CE.
Mol. Ther. 2008 Sep;16(9):1617-23.
[Text Abstract on PubMed]

HOXB4 and retroviral vectors: adding fuel to the fire.
Larochelle A, Dunbar CE.
J. Clin. Invest. 2008 Apr;118(4):1350-3.
[Text Abstract on PubMed]

The MDS1-EVI1 gene complex as a retrovirus integration site: impact on behavior of hematopoietic cells and implications for gene therapy.
Métais JY, Dunbar CE.
Mol. Ther. 2008 Mar;16(3):439-49.
[Text Abstract on PubMed]

Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing.
Klion AD, Robyn J, Maric I, Fu W, Schmid L, Lemery S, Noel P, Law MA, Hartsell M, Talar-Williams C, Fay MP, Dunbar CE, Nutman TB.
Blood. 2007 Nov 15;110(10):3552-6.
[Text Abstract on PubMed]

No evidence of clonal dominance in primates up to 4 years following transplantation of multidrug resistance 1 retrovirally transduced long-term repopulating cells.
Bozorgmehr F, Laufs S, Sellers SE, Roeder I, Zeller WJ, Zeller WJ, Dunbar CE, Fruehauf S.
Stem Cells. 2007 Oct;25(10):2610-8.
[Text Abstract on PubMed]

Hematopoietic stem-cell behavior in nonhuman primates.
Shepherd BE, Kiem HP, Lansdorp PM, Dunbar CE, Aubert G, LaRochelle A, Seggewiss R, Guttorp P, Abkowitz JL.
Blood. 2007 Sep 15;110(6):1806-13.
[Text Abstract on PubMed]

Transduction of rhesus macaque hematopoietic stem and progenitor cells with avian sarcoma and leukosis virus vectors.
Hu J, Ferris A, Larochelle A, Krouse AE, Metzger ME, Donahue RE, Hughes SH, Dunbar CE.
Hum. Gene Ther. 2007 Aug;18(8):691-700.
[Text Abstract on PubMed]

Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques.
Seggewiss R, Loré K, Guenaga FJ, Pittaluga S, Mattapallil J, Chow CK, Koup RA, Camphausen K, Nason MC, Meier-Schellersheim M, Donahue RE, Blazar BR, Dunbar CE, Douek DC.
Blood. 2007 Jul 1;110(1):441-9.
[Text Abstract on PubMed]

Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene.
Hsu C, Jones SA, Cohen CJ, Zheng Z, Kerstann K, Zhou J, Robbins PF, Peng PD, Shen X, Gomes TJ, Dunbar CE, Munroe DJ, Stewart C, Cornetta K, Wangsa D, Ried T, Rosenberg SA, Morgan RA.
Blood. 2007 Jun 15;109(12):5168-77.
[Text Abstract on PubMed]

Antibody-mediated cell labeling of peripheral T cells with micron-sized iron oxide particles (MPIOs) allows single cell detection by MRI.
Shapiro EM, Medford-Davis LN, Fahmy TM, Dunbar CE, Koretsky AP.
Contrast Media Mol Imaging. 2007 May-Jun;2(3):147-53.
[Text Abstract on PubMed]

Caffeinated beverage intake and the risk of heart disease mortality in the elderly: a prospective analysis.
Greenberg JA, Dunbar CC, Schnoll R, Kokolis R, Kokolis S, Kassotis J.
Am. J. Clin. Nutr. 2007 Feb;85(2):392-8.
[Text Abstract on PubMed]

Adeno-associated virus serotype 2-mediated gene transfer to the parotid glands of nonhuman primates.
Voutetakis A, Zheng C, Mineshiba F, Cotrim AP, Goldsmith CM, Schmidt M, Afione S, Roescher N, Metzger M, Eckhaus MA, Chiorini JA, Dunbar CE, Donahue RE, Baum BJ.
Hum. Gene Ther. 2007 Feb;18(2):142-50.
[Text Abstract on PubMed]

BM-derived cell therapies for cardiovascular disease.
Cannon, Dunbar CE.
Cytotherapy. 2007;9(4):305-15.
[Text Abstract on PubMed]

The yin and yang of stem cell gene therapy: insights into hematopoiesis, leukemogenesis, and gene therapy safety.
Dunbar CE.
Hematology Am Soc Hematol Educ Program. 2007:460-5.
[Text Abstract on PubMed]

Correction of the disease phenotype in canine leukocyte adhesion deficiency using ex vivo hematopoietic stem cell gene therapy.
Bauer, Hai M, Tuschong LM, Burkholder TH, Gu YC, Sokolic RA, Ferguson C, Dunbar CE, Hickstein DD.
Blood. 2006 Nov 15;108(10):3313-20.
[Text Abstract on PubMed]

In vitro culture during retroviral transduction improves thymic repopulation and output after total body irradiation and autologous peripheral blood progenitor cell transplantation in rhesus macaques.
Loré K, Seggewiss R, Guenaga FJ, Pittaluga S, Donahue RE, Krouse A, Metzger ME, Koup RA, Reilly C, Douek DC, Dunbar CE.
Stem Cells. 2006 Jun;24(6):1539-48.
[Text Abstract on PubMed]

Genotoxicity of retroviral integration in hematopoietic cells.
Nienhuis AW, Dunbar CE, Sorrentino BP.
Mol. Ther. 2006 Jun;13(6):1031-49.
[Text Abstract on PubMed]

Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque.
Seggewiss R, Pittaluga S, Adler RL, Guenaga FJ, Ferguson C, Pilz IH, Ryu B, Sorrentino BP, Young, Donahue RE, von Kalle C, Nienhuis AW, Dunbar CE.
Blood. 2006 May 15;107(10):3865-7.
[Text Abstract on PubMed]

Mobilization as a preparative regimen for hematopoietic stem cell transplantation.
Chen J, Larochelle A, Fricker S, Bridger G, Dunbar CE, Abkowitz JL.
Blood. 2006 May 1;107(9):3764-71.
[Text Abstract on PubMed]

AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates.
Larochelle A, Krouse A, Metzger M, Orlic D, Donahue RE, Fricker S, Bridger G, Dunbar CE, Hematti P.
Blood. 2006 May 1;107(9):3772-8.
[Text Abstract on PubMed]

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.
Ott MG, Schmidt M, Schwarzwaelder K, Stein S, Siler U, Koehl U, Glimm H, Kühlcke K, Schilz A, Kunkel H, Naundorf S, Brinkmann A, Deichmann A, Fischer M, Ball C, Pilz I, Dunbar C, Du Y, Jenkins NA, Copeland NG, Lüthi U, Hassan M, Thrasher AJ, Hoelzer D, von Kalle C, Seger R, Grez M.
Nat. Med. 2006 Apr;12(4):401-9.
[Text Abstract on PubMed]

Combination therapy with rFVIIa and platelets for hemorrhage in patients with severe thrombocytopenia and alloimmunization.
Savani BN, Dunbar CE, Rick ME.
Am. J. Hematol. 2006 Mar;81(3):218-9.
[Text Abstract on PubMed]

A pilot study of nonmyeloablative allogeneic hematopoietic stem cell transplant for advanced systemic mastocytosis.
Nakamura R, Chakrabarti S, Akin C, Robyn J, Bahceci E, Greene A, Childs R, Dunbar CE, Metcalfe DD, Barrett AJ.
Bone Marrow Transplant. 2006 Feb;37(4):353-8.
[Text Abstract on PubMed]

Multilineage involvement of the fusion gene in patients with FIP1L1/PDGFRA-positive hypereosinophilic syndrome.
Robyn J, Lemery S, McCoy JP, Kubofcik J, Kim YJ, Pack S, Nutman TB, Dunbar C, Klion AD.
Br. J. Haematol. 2006 Feb;132(3):286-92.
[Text Abstract on PubMed]

Anti-interleukin-2 receptor antibody (daclizumab) treatment of corticosteroid-refractory autoimmune thrombocytopenic purpura.
Fogarty PF, Seggewiss R, McCloskey DJ, Boss CA, Dunbar CE, Rick ME.
Haematologica. 2006 Feb;91(2):277-8.
[Text Abstract on PubMed]

Hematopoietic stem cell gene therapy: dead or alive?
Ferguson C, Larochelle A, Dunbar CE.
Trends Biotechnol. 2005 Dec;23(12):589-97.
[Text Abstract on PubMed]

Outcomes and risks of granulocyte colony-stimulating factor in patients with coronary artery disease.
Hill JM, Syed MA, Arai AE, Powell TM, Paul JD, Zalos G, Read EJ, Khuu HM, Leitman SF, Horne M, Csako G, Dunbar CE, Waclawiw MA, Cannon.
J. Am. Coll. Cardiol. 2005 Nov 1;46(9):1643-8.
[Text Abstract on PubMed]

Large animal models for stem and progenitor cell analysis.
Donahue RE, Kuramoto K, Dunbar CE.
Curr Protoc Immunol. 2005 Nov;Chapter 22:Unit 22A.1.
[Text Abstract on PubMed]

Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells.
Calmels B, Ferguson C, Laukkanen MO, Adler R, Faulhaber M, Kim HJ, Sellers S, Hematti P, Schmidt M, von Kalle C, Akagi K, Donahue RE, Dunbar CE.
Blood. 2005 Oct 1;106(7):2530-3.
[Text Abstract on PubMed]

Large granular lymphocytic proliferation-associated cyclic thrombocytopenia.
Fogarty PF, Stetler-Stevenson M, Pereira A, Dunbar CE.
Am. J. Hematol. 2005 Aug;79(4):334-6.
[Text Abstract on PubMed]

A new direction for gene therapy: intrathymic T cell-specific lentiviral gene transfer.
Seggewiss R, Dunbar CE.
J. Clin. Invest. 2005 Aug;115(8):2064-7.
[Text Abstract on PubMed]

Stem cell gene transfer: insights into integration and hematopoiesis from primate genetic marking studies.
Dunbar CE.
Ann. N. Y. Acad. Sci. 2005 Jun;1044:178-82.
[Text Abstract on PubMed]

Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner.
Seggewiss R, Loré K, Greiner E, Magnusson MK, Price DA, Douek DC, Dunbar CE, Wiestner A.
Blood. 2005 Mar 15;105(6):2473-9.
[Text Abstract on PubMed]

Prediction and prevention of transplant-related mortality from pulmonary causes after total body irradiation and allogeneic stem cell transplantation.
Savani BN, Montero A, Wu C, Nlonda N, Read E, Dunbar C, Childs R, Solomon S, Barrett AJ.
Biol. Blood Marrow Transplant. 2005 Mar;11(3):223-30.
[Text Abstract on PubMed]

Low-dose total body irradiation causes clonal fluctuation of primate hematopoietic stem and progenitor cells.
Laukkanen MO, Kuramoto K, Calmels B, Takatoku M, von Kalle C, Donahue RE, Dunbar CE.
Blood. 2005 Feb 1;105(3):1010-5.
[Text Abstract on PubMed]

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells.
Hematti P, Hong BK, Ferguson C, Adler R, Hanawa H, Sellers S, Holt IE, Eckfeldt CE, Sharma Y, Schmidt M, von Kalle C, Persons DA, Billings EM, Verfaillie CM, Nienhuis AW, Wolfsberg TG, Dunbar CE, Calmels B.
PLoS Biol. 2004 Dec;2(12):e423.
[Text Abstract on PubMed]

Imatinib-responsive hypereosinophilia in a patient with B cell ALL.
Robyn J, Noel P, Wlodarska I, Choksi M, O'neal P, Arthur D, Dunbar C, Nutman T, Klion A.
Leuk. Lymphoma. 2004 Dec;45(12):2497-501.
[Text Abstract on PubMed]

Workshop on long-term follow-up of participants in human gene transfer research.
Nyberg K, Carter BJ, Chen T, Dunbar C, Flotte TR, Rose S, Rosenblum D, Simek SL, Wilson C.
Mol. Ther. 2004 Dec;10(6):976-80.
[Text Abstract on PubMed]

Gene therapy for hematologic disease: Don't throw the baby out with the bathwater!
Dunbar CE.
Semin. Hematol. 2004 Oct;41(4):1-2.
[Text Abstract on PubMed]

Genetic manipulation of hematopoietic stem cells.
Larochelle A, Dunbar CE.
Semin. Hematol. 2004 Oct;41(4):257-71.
[Text Abstract on PubMed]

The impact of low-dose busulfan on clonal dynamics in nonhuman primates.
Kuramoto K, Follman D, Hematti P, Sellers S, Laukkanen MO, Seggewiss R, Metzger ME, Krouse A, Donahue RE, von Kalle C, Dunbar CE.
Blood. 2004 Sep 1;104(5):1273-80.
[Text Abstract on PubMed]

MRI detection of single particles for cellular imaging.
Shapiro EM, Skrtic S, Sharer K, Hill JM, Dunbar CE, Koretsky AP.
Proc. Natl. Acad. Sci. U.S.A. 2004 Jul 27;101(30):10901-6.
[Text Abstract on PubMed]

Effect of chronic cytokine therapy on clonal dynamics in nonhuman primates.
Kuramoto K, Follmann DA, Hematti P, Sellers S, Agricola BA, Metzger ME, Donahue RE, von Kalle C, Dunbar CE.
Blood. 2004 Jun 1;103(11):4070-7.
[Text Abstract on PubMed]

Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system.
Hanawa H, Hematti P, Keyvanfar K, Metzger ME, Krouse A, Donahue RE, Kepes S, Gray J, Dunbar CE, Persons DA, Nienhuis AW.
Blood. 2004 Jun 1;103(11):4062-9.
[Text Abstract on PubMed]

In vivo gene marking of rhesus macaque long-term repopulating hematopoietic cells using a VSV-G pseudotyped versus amphotropic oncoretroviral vector.
Shi PA, De Angioletti M, Donahue RE, Notaro R, Luzzatto L, Dunbar CE.
J Gene Med. 2004 Apr;6(4):367-73.
[Text Abstract on PubMed]

Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia.
Kiem HP, Sellers S, Thomasson B, Morris JC, Tisdale JF, Horn PA, Hematti P, Adler R, Kuramoto K, Calmels B, Bonifacino A, Hu J, von Kalle C, Schmidt M, Sorrentino B, Nienhuis A, Blau CA, Andrews RG, Donahue RE, Dunbar CE.
Mol. Ther. 2004 Mar;9(3):389-95.
[Text Abstract on PubMed]

Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques that received transplants with hematopoietic stem cells expressing dihydrofolate reductase vectors.
Persons DA, Allay JA, Bonifacino A, Lu T, Agricola B, Metzger ME, Donahue RE, Dunbar CE, Sorrentino BP.
Blood. 2004 Feb 1;103(3):796-803.
[Text Abstract on PubMed]

The presence of the carboxy-terminal fragment of fibronectin allows maintenance of non-human primate long-term hematopoietic repopulating cells during extended ex vivo culture and transduction.
Sellers SE, Tisdale JF, Agricola BA, Donahue RE, Dunbar CE.
Exp. Hematol. 2004 Feb;32(2):163-70.
[Text Abstract on PubMed]

Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome.
Klion AD, Robyn J, Akin C, Noel P, Brown M, Law M, Metcalfe DD, Dunbar C, Nutman TB.
Blood. 2004 Jan 15;103(2):473-8.
[Text Abstract on PubMed]

Stem and progenitor cell therapies: insights from non-human primate models.
Dunbar CE.
Cytotherapy. 2004;6(6):586-8.
[Text Abstract on PubMed]

Direct comparison of RD114-pseudotyped versus amphotropic-pseudotyped retroviral vectors for transduction of rhesus macaque long-term repopulating cells.
Hu J, Kelly P, Bonifacino A, Agricola B, Donahue R, Vanin E, Dunbar CE.
Mol. Ther. 2003 Oct;8(4):611-7.
[Text Abstract on PubMed]

T cell receptor VB repertoire diversity in patients with immune thrombocytopenia following splenectomy.
Fogarty PF, Rick ME, Zeng W, Risitano AM, Dunbar CE, Bussel JB.
Clin. Exp. Immunol. 2003 Sep;133(3):461-6.
[Text Abstract on PubMed]

Serial cardiac magnetic resonance imaging of injected mesenchymal stem cells.
Hill JM, Dick AJ, Raman VK, Thompson RB, Yu ZX, Hinds KA, Pessanha BS, Guttman MA, Varney TR, Martin BJ, Dunbar CE, McVeigh ER, Lederman RJ.
Circulation. 2003 Aug 26;108(8):1009-14.
[Text Abstract on PubMed]

Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells.
Hinds KA, Hill JM, Shapiro EM, Laukkanen MO, Silva AC, Combs CA, Varney TR, Balaban RS, Koretsky AP, Dunbar CE.
Blood. 2003 Aug 1;102(3):867-72.
[Text Abstract on PubMed]

American Society of Gene Therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cells.
Kohn DB, Sadelain M, Dunbar C, Bodine D, Kiem HP, Candotti F, Tisdale J, Riviére I, Blau CA, Richard RE, Sorrentino B, Nolta J, Malech H, Brenner M, Cornetta K, Cavagnaro J, High K, Glorioso J, American Society of Gene Therapy (ASGT).
Mol. Ther. 2003 Aug;8(2):180-7.
[Text Abstract on PubMed]

Resetting the immune system in immune thrombocytopenic purpura: immunoablative strategies.
Fogarty PF, Dunbar CE.
Clin Adv Hematol Oncol. 2003 Jun;1(6):365-71.
[Text Abstract on PubMed]

Cyclosporine is required to prevent severe acute GVHD following T-cell-depleted peripheral blood stem cell transplantation.
Solomon SR, Nakamura R, Read EJ, Leitman SF, Carter C, Childs R, Dunbar CE, Young NS, Barrett AJ.
Bone Marrow Transplant. 2003 May;31(9):783-8.
[Text Abstract on PubMed]

Efficient characterization of retro-, lenti-, and foamyvector-transduced cell populations by high-accuracy insertion site sequencing.
Schmidt M, Glimm H, Wissler M, Hoffmann G, Olsson K, Sellers S, Carbonaro D, Tisdale JF, Leurs C, Hanenberg H, Dunbar CE, Kiem HP, Karlsson S, Kohn DB, Williams D, Von Kalle C.
Ann. N. Y. Acad. Sci. 2003 May;996:112-21.
[Text Abstract on PubMed]

Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: long-term results of the first clinical gene therapy trial.
Muul LM, Tuschong LM, Soenen SL, Jagadeesh GJ, Ramsey WJ, Long Z, Carter CS, Garabedian EK, Alleyne M, Brown M, Bernstein W, Schurman SH, Fleisher TA, Leitman SF, Dunbar CE, Blaese RM, Candotti F.
Blood. 2003 Apr 1;101(7):2563-9.
[Text Abstract on PubMed]

Retroviral transduction efficiency of G-CSF+SCF-mobilized peripheral blood CD34+ cells is superior to G-CSF or G-CSF+Flt3-L-mobilized cells in nonhuman primates.
Hematti P, Sellers SE, Agricola BA, Metzger ME, Donahue RE, Dunbar CE.
Blood. 2003 Mar 15;101(6):2199-205.
[Text Abstract on PubMed]

High-dose cyclophosphamide with autologous lymphocyte-depleted peripheral blood stem cell (PBSC) support for treatment of refractory chronic autoimmune thrombocytopenia.
Huhn RD, Fogarty PF, Nakamura R, Read EJ, Leitman SF, Rick ME, Kimball J, Greene A, Hansmann K, Gratwohl A, Young N, Barrett AJ, Dunbar CE.
Blood. 2003 Jan 1;101(1):71-7.
[Text Abstract on PubMed]

Prolonged multilineage clonal hematopoiesis in a rhesus recipient of CD34 positive cells marked with a RD114 pseudotyped oncoretroviral vector.
Kelly PF, Donahue RE, Vandergriff JA, Takatoku M, Bonifacino AC, Agricola BA, Metzger ME, Dunbar CE, Nienhuis AW, Vanin EF.
Blood Cells Mol. Dis. 2003 Jan-Feb;30(1):132-43.
[Text Abstract on PubMed]

Analysis of origin and optimization of expansion and transduction of circulating peripheral blood endothelial progenitor cells in the rhesus macaque model.
Hu J, Takatoku M, Sellers SE, Agricola BA, Metzger ME, Donahue RE, Dunbar CE.
Hum. Gene Ther. 2002 Nov 20;13(17):2041-50.
[Text Abstract on PubMed]

Polyclonal long-term repopulating stem cell clones in a primate model.
Schmidt M, Zickler P, Hoffmann G, Haas S, Wissler M, Muessig A, Tisdale JF, Kuramoto K, Andrews RG, Wu T, Kiem HP, Dunbar CE, von Kalle C.
Blood. 2002 Oct 15;100(8):2737-43.
[Text Abstract on PubMed]

Update on hematopoietic stem cell gene transfer using non-human primate models.
Hu J, Dunbar CE.
Curr. Opin. Mol. Ther. 2002 Oct;4(5):482-90.
[Text Abstract on PubMed]

Antithymocyte globulin for treatment of the bone marrow failure associated with myelodysplastic syndromes.
Molldrem JJ, Leifer E, Bahceci E, Saunthararajah Y, Rivera M, Dunbar C, Liu J, Nakamura R, Young NS, Barrett AJ.
Ann. Intern. Med. 2002 Aug 6;137(3):156-63.
[Text Abstract on PubMed]

Activity of STI571 in chronic myelomonocytic leukemia with a platelet-derived growth factor beta receptor fusion oncogene.
Magnusson MK, Meade KE, Nakamura R, Barrett J, Dunbar CE.
Blood. 2002 Aug 1;100(3):1088-91.
[Text Abstract on PubMed]

Absence of donor-derived keratinocyte stem cells in skin tissues cultured from patients after mobilized peripheral blood hematopoietic stem cell transplantation.
Hematti P, Sloand EM, Carvallo CA, Albert MR, Yee CL, Fuehrer MM, Blancato JK, Kearns WG, Barrett JA, Childs RW, Vogel JC, Dunbar CE.
Exp. Hematol. 2002 Aug;30(8):943-9.
[Text Abstract on PubMed]

Plasticity and hematopoiesis: Circe's transforming potion?
Tisdale JF, Dunbar CE.
Curr. Opin. Hematol. 2002 Jul;9(4):268-73.
[Text Abstract on PubMed]

Genetic marking as an approach to studying in vivo hematopoiesis: progress in the non-human primate model.
Shi PA, Hematti P, von Kalle C, Dunbar CE.
Oncogene. 2002 May 13;21(21):3274-83.
[Text Abstract on PubMed]

Retroviral transduction and engraftment ability of primate hematopoietic progenitor and stem cells transduced under serum-free versus serum-containing conditions.
Kluge KA, Bonifacino AC, Sellers S, Agricola BA, Donahue RE, Dunbar CE.
Mol. Ther. 2002 Mar;5(3):316-22.
[Text Abstract on PubMed]

Assessment of rapid remobilization intervals with G-CSF and SCF in murine and rhesus macaque models.
Shi PA, Pomper GJ, Metzger ME, Donahue RE, Leitman SF, Dunbar CE.
Transfusion. 2001 Nov;41(11):1438-44.
[Text Abstract on PubMed]

Rabaptin-5 is a novel fusion partner to platelet-derived growth factor beta receptor in chronic myelomonocytic leukemia.
Magnusson MK, Meade KE, Brown KE, Arthur DC, Krueger LA, Barrett AJ, Dunbar CE.
Blood. 2001 Oct 15;98(8):2518-25.
[Text Abstract on PubMed]

Transplant dose of CD34(+) and CD3(+) cells predicts outcome in patients with haematological malignancies undergoing T cell-depleted peripheral blood stem cell transplants with delayed donor lymphocyte add-back.
Nakamura R, Bahceci E, Read EJ, Leitman SF, Carter CS, Childs R, Dunbar CE, Gress R, Altemus R, Young NS, Barrett AJ.
Br. J. Haematol. 2001 Oct;115(1):95-104.
[Text Abstract on PubMed]

In vivo persistence of retrovirally transduced murine long-term repopulating cells is not limited by expression of foreign gene products in the fully or minimally myeloablated setting.
Kang E, Giri N, Wu T, Sellers S, Kirby M, Hanazono Y, Tisdale J, Dunbar CE.
Hum. Gene Ther. 2001 Sep 1;12(13):1663-72.
[Text Abstract on PubMed]

Avoidance of stimulation improves engraftment of cultured and retrovirally transduced hematopoietic cells in primates.
Takatoku M, Sellers S, Agricola BA, Metzger ME, Kato I, Donahue RE, Dunbar CE.
J. Clin. Invest. 2001 Aug;108(3):447-55.
[Text Abstract on PubMed]

Gene therapy approaches for multiple myeloma.
Russell SJ, Dunbar CE.
Semin. Hematol. 2001 Jul;38(3):268-75.
[Text Abstract on PubMed]

Collection of hematopoietic stem cells from patients with autoimmune diseases.
Burt RK, Fassas A, Snowden J, van Laar JM, Kozak T, Wulffraat NM, Nash RA, Dunbar CE, Arnold R, Prentice G, Bingham S, Marmont AM, McSweeney PA.
Bone Marrow Transplant. 2001 Jul;28(1):1-12.
[Text Abstract on PubMed]

The impact of ex vivo cytokine stimulation on engraftment of primitive hematopoietic cells in a non-human primate model.
Dunbar CE, Takatoku M, Donahue RE.
Ann. N. Y. Acad. Sci. 2001 Jun;938:236-44; discussion 244-5.
[Text Abstract on PubMed]

Update on the use of nonhuman primate models for preclinical testing of gene therapy approaches targeting hematopoietic cells.
Donahue RE, Dunbar CE.
Hum. Gene Ther. 2001 Apr 10;12(6):607-17.
[Text Abstract on PubMed]

The use of nonhuman primate models to improve gene transfer into haematopoietic stem cells.
Dunbar CE.
J. Intern. Med. 2001 Apr;249(4):329-38.
[Text Abstract on PubMed]

The effect of multidrug-resistance 1 gene versus neo transduction on ex vivo and in vivo expansion of rhesus macaque hematopoietic repopulating cells.
Sellers SE, Tisdale JF, Agricola BA, Metzger ME, Donahue RE, Dunbar CE, Sorrentino BP.
Blood. 2001 Mar 15;97(6):1888-91.
[Text Abstract on PubMed]

Hematopoietic stem cell gene therapy: towards clinically significant gene transfer efficiency.
Heim DA, Dunbar CE.
Immunol. Rev. 2000 Dec;178:29-38.
[Text Abstract on PubMed]

High-dose cyclophosphamide in severe aplastic anaemia: a randomised trial.
Tisdale JF, Dunn DE, Geller N, Plante M, Nunez O, Dunbar CE, Barrett AJ, Walsh TJ, Rosenfeld SJ, Young NS.
Lancet. 2000 Nov 4;356(9241):1554-9.
[Text Abstract on PubMed]

Tumor-specific recognition of human myeloma cells by idiotype-induced CD8(+) T cells.
Li Y, Bendandi M, Deng Y, Dunbar C, Munshi N, Jagannath S, Kwak LW, Lyerly HK.
Blood. 2000 Oct 15;96(8):2828-33.
[Text Abstract on PubMed]

Primary T lymphocytes as targets for gene therapy.
Hanazono Y, Brown KE, Dunbar CE.
J. Hematother. Stem Cell Res. 2000 Oct;9(5):611-20.
[Text Abstract on PubMed]

Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation.
Childs R, Chernoff A, Contentin N, Bahceci E, Schrump D, Leitman S, Read EJ, Tisdale J, Dunbar C, Linehan WM, Young NS, Barrett AJ.
N. Engl. J. Med. 2000 Sep 14;343(11):750-8.
[Text Abstract on PubMed]

Highlights from the third annual ASGT meeting. American Society of Gene Therapy.
Glorioso JC, Huang L, Dunbar C, Felgner PL.
Mol. Ther. 2000 Aug;2(2):96-100.
[Text Abstract on PubMed]

Many multipotential gene-marked progenitor or stem cell clones contribute to hematopoiesis in nonhuman primates.
Kim HJ, Tisdale JF, Wu T, Takatoku M, Sellers SE, Zickler P, Metzger ME, Agricola BA, Malley JD, Kato I, Donahue RE, Brown KE, Dunbar CE.
Blood. 2000 Jul 1;96(1):1-8.
[Text Abstract on PubMed]

Introduction of a xenogeneic gene via hematopoietic stem cells leads to specific tolerance in a rhesus monkey model.
Heim DA, Hanazono Y, Giri N, Wu T, Childs R, Sellers SE, Muul L, Agricola BA, Metzger ME, Donahue RE, Tisdale JF, Dunbar CE.
Mol. Ther. 2000 Jun;1(6):533-44.
[Text Abstract on PubMed]

Human gene marker/therapy clinical protocols.
Rosenberg SA, Blaese RM, Brenner MK, Deisseroth AB, Ledley FD, Lotze MT, Wilson JM, Nabel GJ, Cornetta K, Economou JS, Freeman SM, Riddell SR, Brenner M, Oldfield E, Gansbacher B, Dunbar C, Walker RE, Schuening FG, Roth JA, Crystal RG, Welsh MJ, Culver K, Heslop HE, Simons J, Wilmott RW, Boucher RC, Siegler HF, Barranger JA, Karlsson S, Kohn D, Galpin JE, Raffel C, Hesdorffer C, Ilan J, Cassileth P, O'Shaughnessy J, Kun LE, Das TK, Wong-Staal F, Sobol RE, Haubrich R, Sznol M, Rubin J, Sorcher EJ, Rosenblatt J, Walker R, Brigham K, Vogelzang N, Hersh E, Eck SL.
Hum. Gene Ther. 2000 Apr 10;11(6):919-79.
[Text Abstract on PubMed]

Prolonged high-level detection of retrovirally marked hematopoietic cells in nonhuman primates after transduction of CD34+ progenitors using clinically feasible methods.
Wu T, Kim HJ, Sellers SE, Meade KE, Agricola BA, Metzger ME, Kato I, Donahue RE, Dunbar CE, Tisdale JF.
Mol. Ther. 2000 Mar;1(3):285-93.
[Text Abstract on PubMed]

CD34+ cell dose predicts relapse and survival after T-cell-depleted HLA-identical haematopoietic stem cell transplantation (HSCT) for haematological malignancies.
Bahçeci E, Read EJ, Leitman S, Childs R, Dunbar C, Young NS, Barrett AJ.
Br. J. Haematol. 2000 Feb;108(2):408-14.
[Text Abstract on PubMed]

Clinical and laboratory evidence for a trilineage haematopoietic defect in patients with refractory Diamond-Blackfan anaemia.
Giri N, Kang E, Tisdale JF, Follman D, Rivera M, Schwartz GN, Kim S, Young NS, Rick ME, Dunbar CE.
Br. J. Haematol. 2000 Jan;108(1):167-75.
[Text Abstract on PubMed]

Human gene marker/therapy clinical protocols.
Rosenberg SA, Blaese RM, Brenner MK, Deisseroth AB, Ledley FD, Lotze MT, Wilson JM, Nabel GJ, Cornetta K, Economou JS, Freeman SM, Riddell SR, Oldfield E, Gansbacher B, Dunbar C, Walker RE, Schuening FG, Roth JA, Crystal RG, Welsh MJ, Culver K, Heslop HE, Simons J, Wilmott RW, Habib NA.
Hum. Gene Ther. 1999 Dec 10;10(18):3067-123.
[Text Abstract on PubMed]

In vivo marking of rhesus monkey lymphocytes by adeno-associated viral vectors: direct comparison with retroviral vectors.
Hanazono Y, Brown KE, Handa A, Metzger ME, Heim D, Kurtzman GJ, Donahue RE, Dunbar CE.
Blood. 1999 Oct 1;94(7):2263-70.
[Text Abstract on PubMed]

Retroviral marking and transplantation of rhesus hematopoietic cells by nonmyeloablative conditioning.
Huhn RD, Tisdale JF, Agricola B, Metzger ME, Donahue RE, Dunbar CE.
Hum. Gene Ther. 1999 Jul 20;10(11):1783-90.
[Text Abstract on PubMed]

Engraftment of MDR1 and NeoR gene-transduced hematopoietic cells after breast cancer chemotherapy.
Moscow JA, Huang H, Carter C, Hines K, Zujewski J, Cusack G, Chow C, Venzon D, Sorrentino B, Chiang Y, Goldspiel B, Leitman S, Read EJ, Abati A, Gottesman MM, Pastan I, Sellers S, Dunbar C, Cowan KH.
Blood. 1999 Jul 1;94(1):52-61.
[Text Abstract on PubMed]

Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients.
Cowan KH, Moscow JA, Huang H, Zujewski JA, O'Shaughnessy J, Sorrentino B, Hines K, Carter C, Schneider E, Cusack G, Noone M, Dunbar C, Steinberg S, Wilson W, Goldspiel B, Read EJ, Leitman SF, McDonagh K, Chow C, Abati A, Chiang Y, Chang YN, Gottesman MM, Pastan I, Nienhuis A.
Clin. Cancer Res. 1999 Jul;5(7):1619-28.
[Text Abstract on PubMed]

CNS interleukin-3 (IL-3) expression and neurological syndrome in antisense-IL-3 transgenic mice.
Sugita Y, Zhao B, Shankar P, Dunbar CE, Doren S, Young HA, Schwartz JP.
J. Neuropathol. Exp. Neurol. 1999 May;58(5):480-8.
[Text Abstract on PubMed]

Expression of interferon-gamma by stromal cells inhibits murine long-term repopulating hematopoietic stem cell activity.
Yu JM, Emmons RV, Hanazono Y, Sellers S, Young NS, Dunbar CE.
Exp. Hematol. 1999 May;27(5):895-903.
[Text Abstract on PubMed]

No discrepancy between in vivo gene marking efficiency assessed in peripheral blood populations compared with bone marrow progenitors or CD34+ cells.
Sellers SE, Tisdale JF, Bodine DM, Williams DA, Karlsson S, Meztger M, Donahue RE, Dunbar CE.
Hum. Gene Ther. 1999 Mar 1;10(4):633-40.
[Text Abstract on PubMed]

Amendment to Clinical Research Project. Project 90-C-195. April 1, 1993. Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with autologous lymphocytes transduced with a human ADA gene.
Dunbar C, Chang L, Mullen C, Ramsey WJ, Carter C, Kohn D, Parkman R, Lenarsky C, Weinberg K, Wara D, Culver KW, Anderson WF, Leitman S, Fleisher T, Klein H, Shearer G, Clerici M, McGarrity G, Bastian J, Hershfield MS.
Hum. Gene Ther. 1999 Feb 10;10(3):477-88.
[Text Abstract on PubMed]

Retroviral transfer of the glucocerebrosidase gene into CD34+ cells from patients with Gaucher disease: in vivo detection of transduced cells without myeloablation.
Dunbar CE, Kohn DB, Schiffmann R, Barton NW, Nolta JA, Esplin JA, Pensiero M, Long Z, Lockey C, Emmons RV, Csik S, Leitman S, Krebs CB, Carter C, Brady RO, Karlsson S.
Hum. Gene Ther. 1998 Nov 20;9(17):2629-40.
[Text Abstract on PubMed]

High incidence of adeno- and polyomavirus-induced hemorrhagic cystitis in bone marrow allotransplantation for hematological malignancy following T cell depletion and cyclosporine.
Childs R, Sanchez C, Engler H, Preuss J, Rosenfeld S, Dunbar C, van Rhee F, Plante M, Phang S, Barrett AJ.
Bone Marrow Transplant. 1998 Nov;22(9):889-93.
[Text Abstract on PubMed]

Molecular and serological examination of the relationship of human herpesvirus 8 to multiple myeloma: orf 26 sequences in bone marrow stroma are not restricted to myeloma patients and other regions of the genome are not detected.
Tisdale JF, Stewart AK, Dickstein B, Little RF, Dubé I, Cappe D, Dunbar CE, Brown KE.
Blood. 1998 Oct 15;92(8):2681-7.
[Text Abstract on PubMed]

Abrogation of TGF-beta activity during retroviral transduction improves murine hematopoietic progenitor and repopulating cell gene transfer efficiency.
Yu J, Soma T, Hanazono Y, Dunbar CE.
Gene Ther. 1998 Sep;5(9):1265-71.
[Text Abstract on PubMed]

Ex vivo expansion of genetically marked rhesus peripheral blood progenitor cells results in diminished long-term repopulating ability.
Tisdale JF, Hanazono Y, Sellers SE, Agricola BA, Metzger ME, Donahue RE, Dunbar CE.
Blood. 1998 Aug 15;92(4):1131-41.
[Text Abstract on PubMed]

Improved amphotropic retrovirus-mediated gene transfer into hematopoietic stem cells.
Bodine DM, Dunbar CE, Girard LJ, Seidel NE, Cline AP, Donahue RE, Orlic D.
Ann. N. Y. Acad. Sci. 1998 Jun 30;850:139-50.
[Text Abstract on PubMed]

Murine bone marrow expressing the neomycin resistance gene has no competitive disadvantage assessed in vivo.
Wu T, Bloom ML, Yu JM, Tisdale JF, Dunbar CE.
Hum. Gene Ther. 1998 May 20;9(8):1157-64.
[Text Abstract on PubMed]

T cell-depleted granulocyte colony-stimulating factor (G-CSF) modified allogenic bone marrow transplantation for hematological malignancy improves graft CD34+ cell content but is associated with delayed pancytopenia.
Mavroudis DA, Read EJ, Molldrem J, Raptis A, Plante M, Carter CS, Phang S, Dunbar CE, Barrett AJ.
Bone Marrow Transplant. 1998 Mar;21(5):431-40.
[Text Abstract on PubMed]

T cell-depleted bone marrow transplantation and delayed T cell add-back to control acute GVHD and conserve a graft-versus-leukemia effect.
Barrett AJ, Mavroudis D, Tisdale J, Molldrem J, Clave E, Dunbar C, Cottler-Fox M, Phang S, Carter C, Okunnieff P, Young NS, Read EJ.
Bone Marrow Transplant. 1998 Mar;21(6):543-51.
[Text Abstract on PubMed]

Human gene marker/therapy clinical protocols.
Rosenberg SA, Blaese RM, Brenner MK, Deisseroth AB, Ledley FD, Lotze MT, Wilson JM, Nabel GJ, Cornetta K, Economou JS, Freeman SM, Riddell SR, Oldfield E, Gansbacher B, Dunbar C, Walker RE, Schuening FG, Roth JA, Crystal RG, Welsh MJ, Culver K, Heslop HE, Simons J, Wilmott RW, Boucher RC.
Hum. Gene Ther. 1997 Dec 10;8(18):2301-38.
[Text Abstract on PubMed]

Murine long-term repopulating ability is compromised by ex vivo culture in serum-free medium despite preservation of committed progenitors.
Sekhar M, Yu JM, Soma T, Dunbar CE.
J Hematother. 1997 Dec;6(6):543-9.
[Text Abstract on PubMed]

Retroviral mediated gene transfer of the Fanconi anemia complementation group C gene to hematopoietic progenitors of group C patients.
Liu JM, Young NS, Walsh CE, Cottler-Fox M, Carter C, Dunbar C, Barrett AJ, Emmons R.
Hum. Gene Ther. 1997 Sep 20;8(14):1715-30.
[Text Abstract on PubMed]

Green fluorescent protein retroviral vectors: low titer and high recombination frequency suggest a selective disadvantage.
Hanazono Y, Yu JM, Dunbar CE, Emmons RV.
Hum. Gene Ther. 1997 Jul 20;8(11):1313-9.
[Text Abstract on PubMed]

Retroviral gene transduction of adult peripheral blood or marrow-derived CD34+ cells for six hours without growth factors or on autologous stroma does not improve marking efficiency assessed in vivo.
Emmons RV, Doren S, Zujewski J, Cottler-Fox M, Carter CS, Hines K, O'Shaughnessy JA, Leitman SF, Greenblatt JJ, Cowan K, Dunbar CE.
Blood. 1997 Jun 1;89(11):4040-6.
[Text Abstract on PubMed]

Hepatitis-associated aplastic anemia.
Brown KE, Tisdale J, Barrett AJ, Dunbar CE, Young NS.
N. Engl. J. Med. 1997 Apr 10;336(15):1059-64.
[Text Abstract on PubMed]

Transduction of hematopoietic stem cells in humans and in nonhuman primates.
Dunbar CE, Tisdale J, Yu JM, Soma T, Zujewski J, Bodine D, Sellers S, Cowan K, Donahue R, Emmons R.
Stem Cells. 1997;15 Suppl 1:135-9; discussion 139-40.
[Text Abstract on PubMed]

Human gene marker/therapy clinical protocols.
Rosenberg SA, Blaese RM, Brenner MK, Deisseroth AB, Ledley FD, Lotze MT, Wilson JM, Nabel GJ, Cornetta K, Economou JS, Freeman SM, Riddell SR, Oldfield E, Gansbacher B, Dunbar C, Walker RE, Schuening FG, Roth JA, Crystal RG, Welsh MJ, Culver K, Heslop HE, Simons J, Wilmott RW, Tiberghien P.
Hum. Gene Ther. 1996 Dec 1;7(18):2287-313.
[Text Abstract on PubMed]

Gene marking and gene therapy directed at primary hematopoietic cells.
Dunbar CE, Young NS.
Curr. Opin. Hematol. 1996 Nov;3(6):430-7.
[Text Abstract on PubMed]

CD34+ cell dose predicts survival, posttransplant morbidity, and rate of hematologic recovery after allogeneic marrow transplants for hematologic malignancies.
Mavroudis D, Read E, Cottler-Fox M, Couriel D, Molldrem J, Carter C, Yu M, Dunbar C, Barrett J.
Blood. 1996 Oct 15;88(8):3223-9.
[Text Abstract on PubMed]

Improved retroviral gene transfer into murine and Rhesus peripheral blood or bone marrow repopulating cells primed in vivo with stem cell factor and granulocyte colony-stimulating factor.
Dunbar CE, Seidel NE, Doren S, Sellers S, Cline AP, Metzger ME, Agricola BA, Donahue RE, Bodine DM.
Proc. Natl. Acad. Sci. U.S.A. 1996 Oct 15;93(21):11871-6.
[Text Abstract on PubMed]

Human gene marker/therapy clinical protocols.
Rosenberg SA, Blaese RM, Brenner MK, Deisseroth AB, Ledley FD, Lotze MT, Wilson JM, Nabel GJ, Cornetta K, Economou JS, Freeman SM, Riddell SR, Oldfield E, Gansbacher B, Dunbar C, Walker RE, Schuening FG, Roth JA, Crystal RG, Welsh MJ, Culver K, Heslop HE, Simons J, Wilmott RW, Aebischer P.
Hum. Gene Ther. 1996 Aug 20;7(13):1621-47.
[Text Abstract on PubMed]

Granulocyte colony-stimulating factor recruitment of CD34+ progenitors to peripheral blood: impaired mobilization in chronic granulomatous disease and adenosine deaminase--deficient severe combined immunodeficiency disease patients.
Sekhsaria S, Fleisher TA, Vowells S, Brown M, Miller J, Gordon I, Blaese RM, Dunbar CE, Leitman S, Malech HL.
Blood. 1996 Aug 1;88(3):1104-12.
[Text Abstract on PubMed]

Early reactivation of cytomegalovirus and high risk of interstitial pneumonitis following T-depleted BMT for adults with hematological malignancies.
Couriel D, Canosa J, Engler H, Collins A, Dunbar C, Barrett AJ.
Bone Marrow Transplant. 1996 Aug;18(2):347-53.
[Text Abstract on PubMed]

Maintenance of murine long-term repopulating stem cells in ex vivo culture is affected by modulation of transforming growth factor-beta but not macrophage inflammatory protein-1 alpha activities.
Soma T, Yu JM, Dunbar CE.
Blood. 1996 Jun 1;87(11):4561-7.
[Text Abstract on PubMed]

Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction.
Emmons RV, Reid DM, Cohen RL, Meng G, Young NS, Dunbar CE, Shulman NR.
Blood. 1996 May 15;87(10):4068-71.
[Text Abstract on PubMed]

Retroviral mediated transfer of the cDNA for human glucocerebrosidase into hematopoietic stem cells of patients with Gaucher disease. A phase I study.
Dunbar C, Kohn D.
Hum. Gene Ther. 1996 Jan 20;7(2):231-53.
[Text Abstract on PubMed]

Gene transfer to hematopoietic stem cells: implications for gene therapy of human disease.
Dunbar CE.
Annu. Rev. Med. 1996;47:11-20.
[Text Abstract on PubMed]

Retroviral transduction of CD34-enriched hematopoietic progenitor cells under serum-free conditions.
Sekhar M, Kotani H, Doren S, Agarwal R, McGarrity G, Dunbar CE.
Hum. Gene Ther. 1996 Jan;7(1):33-8.
[Text Abstract on PubMed]

Improved engraftment of human hematopoietic cells in severe combined immunodeficient (SCID) mice carrying human cytokine transgenes.
Bock TA, Orlic D, Dunbar CE, Broxmeyer HE, Bodine DM.
J. Exp. Med. 1995 Dec 1;182(6):2037-43.
[Text Abstract on PubMed]

Growth factors and stromal support generate very efficient retroviral transduction of peripheral blood CD34+ cells from Gaucher patients.
Xu LC, Kluepfel-Stahl S, Blanco M, Schiffmann R, Dunbar C, Karlsson S.
Blood. 1995 Jul 1;86(1):141-6.
[Text Abstract on PubMed]

Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation.
Dunbar CE, Cottler-Fox M, O'Shaughnessy JA, Doren S, Carter C, Berenson R, Brown S, Moen RC, Greenblatt J, Stewart FM.
Blood. 1995 Jun 1;85(11):3048-57.
[Text Abstract on PubMed]

Long-term in vivo expression of the human glucocerebrosidase gene in nonhuman primates after CD34+ hematopoietic cell transduction with cell-free retroviral vector preparations.
Xu LC, Karlsson S, Byrne ER, Kluepfel-Stahl S, Kessler SW, Agricola BA, Sellers S, Kirby M, Dunbar CE, Brady RO.
Proc. Natl. Acad. Sci. U.S.A. 1995 May 9;92(10):4372-6.
[Text Abstract on PubMed]

In vivo models for studying the role of autocrine or paracrine growth factors in hematologic malignancies.
Soma T, Dunbar CE.
Exp. Hematol. 1995 May;23(5):385-8.
[Text Abstract on PubMed]

Positive selection of CD34+ hematopoietic cells using an immunoaffinity column results in T cell-depletion equivalent to elutriation.
Cottler-Fox M, Cipolone K, Yu M, Berenson R, O'Shaughnessy J, Dunbar C.
Exp. Hematol. 1995 Apr;23(4):320-2.
[Text Abstract on PubMed]

Long-term culture of chronic myelogenous leukemia marrow cells on stem cell factor-deficient stroma favors benign progenitors.
Agarwal R, Doren S, Hicks B, Dunbar CE.
Blood. 1995 Mar 1;85(5):1306-12.
[Text Abstract on PubMed]

Gene transfer into hematopoietic progenitor and stem cells: progress and problems.
Dunbar CE, Emmons RV.
Stem Cells. 1994 Nov;12(6):563-76.
[Text Abstract on PubMed]

Transgenic mice expressing antisense interleukin-3 RNA develop a B-cell lymphoproliferative syndrome or neurologic dysfunction.
Cockayne DA, Bodine DM, Cline A, Nienhuis AW, Dunbar CE.
Blood. 1994 Oct 15;84(8):2699-710.
[Text Abstract on PubMed]

Acquired sideroblastic anaemia following progesterone therapy.
Brodsky RA, Hasegawa S, Fibach E, Dunbar CE, Young NS, Rodgers GP.
Br. J. Haematol. 1994 Aug;87(4):859-62.
[Text Abstract on PubMed]

Retroviral mediated transfer of the human multidrug resistance gene (MDR-1) into hematopoietic stem cells during autologous transplantation after intensive chemotherapy for metastatic breast cancer.
O'Shaughnessy JA, Cowan KH, Nienhuis AW, McDonagh KT, Sorrentino BP, Dunbar CE, Chiang Y, Wilson W, Goldspiel B, Kohler D.
Hum. Gene Ther. 1994 Jul;5(7):891-911.
[Text Abstract on PubMed]

Gene transfer into hematopoietic cells. Implications for cancer therapy.
Dunbar CE, Bodine DM, Sorrentino B, Donahue R, McDonagh K, Cottler-Fox M, O'Shaughnessy J, Cowan K, Carter C, Doren S.
Ann. N. Y. Acad. Sci. 1994 May 31;716:216-24; discussion 224-7.
[Text Abstract on PubMed]

Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with CD34+ selected autologous peripheral blood cells transduced with a human ADA gene. Amendment to clinical research project, Project 90-C-195, January 10, 1992.
Blaese RM, Culver KW, Chang L, Anderson WF, Mullen C, Nienhuis A, Carter C, Dunbar C, Leitman S, Berger M.
Hum. Gene Ther. 1993 Aug;4(4):521-7.
[Text Abstract on PubMed]

Retroviral-mediated transfer of the murine interleukin-3 gene engineered for intracellular retention results in a myeloproliferative syndrome but is associated with circulating interleukin-3 levels.
Orchard PJ, Detrick RA, Gorden K, Dunbar CE, Vallera DA, Taylor P, McIvor RS, Blazar BR.
Exp. Hematol. 1993 Aug;21(9):1245-54.
[Text Abstract on PubMed]

Pilot study of high dose ICE (ifosfamide, carboplatin, etoposide) chemotherapy and autologous bone marrow transplant (ABMT) with neoR-transduced bone marrow and peripheral blood stem cells in patients with metastatic breast cancer.
O'Shaughnessy JA, Cowan KH, Wilson W, Bryant G, Goldspiel B, Gress R, Nienhuis AW, Dunbar C, Sorrentino B, Stewart FM.
Hum. Gene Ther. 1993 Jun;4(3):331-54.
[Text Abstract on PubMed]

Multiple myeloma. New approaches to therapy.
Dunbar CE, Nienhuis AW.
JAMA. 1993 May 12;269(18):2412-6.
[Text Abstract on PubMed]

Retroviral-mediated gene transfer into CD34-enriched human peripheral blood stem cells.
Cassel A, Cottler-Fox M, Doren S, Dunbar CE.
Exp. Hematol. 1993 Apr;21(4):585-91.
[Text Abstract on PubMed]

Amendment to clinical research projects. Genetic marking with retroviral vectors to study the feasibility of stem cell gene transfer and the biology of hematopoietic reconstitution after autologous transplantation in multiple myeloma, chronic myelogenous leukemia, or metastatic breast cancer.
Dunbar CE, Nienhuis AW, Stewart FM, Quesenberry P, O'Shaughnessy J, Cowan K, Cottler-Fox M, Leitman S, Goodman S, Sorrentino BP.
Hum. Gene Ther. 1993 Apr;4(2):205-22.
[Text Abstract on PubMed]

Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer.
Donahue RE, Kessler SW, Bodine D, McDonagh K, Dunbar C, Goodman S, Agricola B, Byrne E, Raffeld M, Moen R.
J. Exp. Med. 1992 Oct 1;176(4):1125-35.
[Text Abstract on PubMed]

Separating the wheat from the chaff: selection of benign hematopoietic cells in chronic myeloid leukemia.
Dunbar CE, Stewart FM.
Blood. 1992 Mar 1;79(5):1107-10.
[Text Abstract on PubMed]

Treatment of Diamond-Blackfan anaemia with haematopoietic growth factors, granulocyte-macrophage colony stimulating factor and interleukin 3: sustained remissions following IL-3.
Dunbar CE, Smith DA, Kimball J, Garrison L, Nienhuis AW, Young NS.
Br. J. Haematol. 1991 Oct;79(2):316-21.
[Text Abstract on PubMed]

Introduction of an activated RAS oncogene into murine bone marrow lymphoid progenitors via retroviral gene transfer results in thymic lymphomas.
Dunbar CE, Crosier PS, Nienhuis AW.
Oncogene Res. 1991;6(1):39-51.
[Text Abstract on PubMed]

Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice.
Brandt SJ, Bodine DM, Dunbar CE, Nienhuis AW.
J. Clin. Invest. 1990 Aug;86(2):592-9.
[Text Abstract on PubMed]

Retroviral-mediated transfer of interleukin-6 into hematopoietic cells of mice results in a syndrome resembling Castleman's disease.
Brandt SJ, Bodine DM, Dunbar CE, Nienhuis AW.
Curr. Top. Microbiol. Immunol. 1990;166:37-41.
[Text Abstract on PubMed]

COOH-terminal-modified interleukin-3 is retained intracellularly and stimulates autocrine growth.
Dunbar CE, Browder TM, Abrams JS, Nienhuis AW.
Science. 1989 Sep 29;245(4925):1493-6.
[Text Abstract on PubMed]

Private and public autocrine loops in neoplastic cells.
Browder TM, Dunbar CE, Nienhuis AW.
Cancer Cells. 1989 Sep;1(1):9-17.
[Text Abstract on PubMed]

5-Azacytidine treatment in a beta (0)-thalassaemic patient unable to be transfused due to multiple alloantibodies.
Dunbar C, Travis W, Kan YW, Nienhuis A.
Br. J. Haematol. 1989 Jul;72(3):467-8.
[Text Abstract on PubMed]

Retrovirus-mediated transfer and expression of the interleukin-3 gene in mouse hematopoietic cells result in a myeloproliferative disorder.
Wong PM, Chung SW, Dunbar CE, Bodine DM, Ruscetti S, Nienhuis AW.
Mol. Cell. Biol. 1989 Feb;9(2):798-808.
[Text Abstract on PubMed]

Transfer of genes in hematopoietic cells with retroviral vectors.
Nienhuis A, Bodine D, Browder T, Chung SW, Dunbar C, Karlsson S, Wong P.
Soc. Gen. Physiol. Ser. 1988;43:79-89.
[Text Abstract on PubMed]