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Julie G. Donaldson, Ph.D.


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Julie G. Donaldson
Senior Investigator

P: +1 301 402 2907
F: +1 301 402 1519

Full Publications Listing

Microtubule-dependent endosomal sorting of clathrin-independent cargo by Hook1.
Maldonado-Báez L, Cole NB, Krämer H, Donaldson JG.
J Cell Biol. 2013 Apr 15;201(2):233-47.
[Text Abstract on PubMed]

Search for inhibitors of endocytosis: Intended specificity and unintended consequences.
Dutta D, Donaldson JG.
Cell Logist. 2012 Oct 1;2(4):203-208.
[Text Abstract on PubMed]

Releasable SNAP-tag probes for studying endocytosis and recycling.
Cole NB, Donaldson JG.
ACS Chem. Biol. 2012 Mar 16;7(3):464-9.
[Text Abstract on PubMed]

Pitstop 2 is a potent inhibitor of clathrin-independent endocytosis.
Dutta D, Williamson CD, Cole NB, Donaldson JG.
PLoS ONE. 2012;7(9):e45799.
[Text Abstract on PubMed]

MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation.
Eyster CA, Cole NB, Petersen S, Viswanathan K, Früh K, Donaldson JG.
Mol. Biol. Cell. 2011 Sep;22(17):3218-30.
[Text Abstract on PubMed]

ARF family G proteins and their regulators: roles in membrane transport, development and disease.
Donaldson JG, Jackson CL.
Nat. Rev. Mol. Cell Biol. 2011 Jun;12(6):362-75.
[Text Abstract on PubMed]

Regulation of M3 muscarinic receptor expression and function by transmembrane protein 147.
Rosemond E, Rossi M, McMillin SM, Scarselli M, Donaldson JG, Wess J.
Mol. Pharmacol. 2011 Feb;79(2):251-61.
[Text Abstract on PubMed]

Analysis of Arf GTP-binding protein function in cells.
Cohen LA, Donaldson JG.
Curr Protoc Cell Biol. 2010 Sep;Chapter 3:Unit 14.12.1-17.
[Text Abstract on PubMed]

Membrane-Associated RING-CH proteins associate with Bap31 and target CD81 and CD44 to lysosomes.
Bartee E, Eyster CA, Viswanathan K, Mansouri M, Donaldson JG, Früh K.
PLoS ONE. 2010;5(12):e15132.
[Text Abstract on PubMed]

Intracellular assembly and trafficking of MHC class I molecules.
Donaldson JG, Williams DB.
Traffic. 2009 Dec;10(12):1745-52.
[Text Abstract on PubMed]

Myosin Vc is a molecular motor that functions in secretory granule trafficking.
Jacobs DT, Weigert R, Grode KD, Donaldson JG, Cheney RE.
Mol. Biol. Cell. 2009 Nov;20(21):4471-88.
[Text Abstract on PubMed]

Phospholipase D in endocytosis and endosomal recycling pathways.
Donaldson JG.
Biochim. Biophys. Acta. 2009 Sep;1791(9):845-9.
[Text Abstract on PubMed]

Pathways and mechanisms of endocytic recycling.
Grant BD, Donaldson JG.
Nat. Rev. Mol. Cell Biol. 2009 Sep;10(9):597-608.
[Text Abstract on PubMed]

Discovery of new cargo proteins that enter cells through clathrin-independent endocytosis.
Eyster CA, Higginson JD, Huebner R, Porat-Shliom N, Weigert R, Wu WW, Shen RF, Donaldson JG.
Traffic. 2009 May;10(5):590-9.
[Text Abstract on PubMed]

Constitutive internalization of G protein-coupled receptors and G proteins via clathrin-independent endocytosis.
Scarselli M, Donaldson JG.
J. Biol. Chem. 2009 Feb 6;284(6):3577-85.
[Text Abstract on PubMed]

Membrane trafficking heats up in Pavia. Golgi Meeting on Membrane Trafficking in Global Cellular Responses.
Donaldson JG, McPherson PS.
EMBO Rep. 2009 Feb;10(2):132-6.
[Text Abstract on PubMed]

Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
Donaldson JG, Porat-Shliom N, Cohen LA.
Cell. Signal. 2009 Jan;21(1):1-6.
[Text Abstract on PubMed]

Arfs and membrane lipids: sensing, generating and responding to membrane curvature.
Donaldson JG.
Biochem. J. 2008 Sep 1;414(2):e1-2.
[Text Abstract on PubMed]

A unique platform for H-Ras signaling involving clathrin-independent endocytosis.
Porat-Shliom N, Kloog Y, Donaldson JG.
Mol. Biol. Cell. 2008 Mar;19(3):765-75.
[Text Abstract on PubMed]

Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains.
Cohen LA, Honda A, Varnai P, Brown FD, Balla T, Donaldson JG.
Mol. Biol. Cell. 2007 Jun;18(6):2244-53.
[Text Abstract on PubMed]

Somatostatin receptors signal through EFA6A-ARF6 to activate phospholipase D in clonal beta-cells.
Grodnitzky JA, Syed N, Kimber MJ, Day TA, Donaldson JG, Hsu WH.
J. Biol. Chem. 2007 May 4;282(18):13410-8.
[Text Abstract on PubMed]

Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation.
Koo TH, Eipper BA, Donaldson JG.
BMC Cell Biol. 2007;8:29.
[Text Abstract on PubMed]

An effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recycling.
Jovanovic OA, Brown FD, Donaldson JG.
Mol. Biol. Cell. 2006 Jan;17(1):327-35.
[Text Abstract on PubMed]

Arfs, phosphoinositides and membrane traffic.
Donaldson JG.
Biochem. Soc. Trans. 2005 Dec;33(Pt 6):1276-8.
[Text Abstract on PubMed]

Localization and function of Arf family GTPases.
Donaldson JG, Honda A.
Biochem. Soc. Trans. 2005 Aug;33(Pt 4):639-42.
[Text Abstract on PubMed]

Multiple activities for Arf1 at the Golgi complex.
Donaldson JG, Honda A, Weigert R.
Biochim. Biophys. Acta. 2005 Jul 10;1744(3):364-73.
[Text Abstract on PubMed]

Targeting of Arf-1 to the early Golgi by membrin, an ER-Golgi SNARE.
Honda A, Al-Awar OS, Hay JC, Donaldson JG.
J. Cell Biol. 2005 Mar 28;168(7):1039-51.
[Text Abstract on PubMed]

Fluorescent microscopy-based assays to study the role of Rab22a in clathrin-independent endocytosis.
Weigert R, Donaldson JG.
Meth. Enzymol. 2005;403:243-53.
[Text Abstract on PubMed]

Characterization of a nonclathrin endocytic pathway: membrane cargo and lipid requirements.
Naslavsky N, Weigert R, Donaldson JG.
Mol. Biol. Cell. 2004 Aug;15(8):3542-52.
[Text Abstract on PubMed]

Rab22a regulates the recycling of membrane proteins internalized independently of clathrin.
Weigert R, Yeung AC, Li J, Donaldson JG.
Mol. Biol. Cell. 2004 Aug;15(8):3758-70.
[Text Abstract on PubMed]

Recycling of Raft-associated prohormone sorting receptor carboxypeptidase E requires interaction with ARF6.
Arnaoutova I, Jackson CL, Al-Awar OS, Donaldson JG, Loh YP.
Mol. Biol. Cell. 2003 Nov;14(11):4448-57.
[Text Abstract on PubMed]

Multiple roles for Arf6: sorting, structuring, and signaling at the plasma membrane.
Donaldson JG.
J. Biol. Chem. 2003 Oct 24;278(43):41573-6.
[Text Abstract on PubMed]

Myoblasts fuse when loner meets ARF6.
Donaldson JG.
Dev. Cell. 2003 Oct;5(4):527-8.
[Text Abstract on PubMed]

Convergence of non-clathrin- and clathrin-derived endosomes involves Arf6 inactivation and changes in phosphoinositides.
Naslavsky N, Weigert R, Donaldson JG.
Mol. Biol. Cell. 2003 Feb;14(2):417-31.
[Text Abstract on PubMed]

A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane.
Caplan S, Naslavsky N, Hartnell LM, Lodge R, Polishchuk RS, Donaldson JG, Bonifacino JS.
EMBO J. 2002 Jun 3;21(11):2557-67.
[Text Abstract on PubMed]

Immunofluorescence staining.
Donaldson JG.
Curr Protoc Immunol. 2002 May;Chapter 21:Unit 21.3.
[Text Abstract on PubMed]

Arf6 and its role in cytoskeletal modulation.
Donaldson JG.
Methods Mol. Biol. 2002;189:191-8.
[Text Abstract on PubMed]

Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic.
Brown FD, Rozelle AL, Yin HL, Balla T, Donaldson JG.
J. Cell Biol. 2001 Sep 3;154(5):1007-17.
[Text Abstract on PubMed]

Membrane-cytoskeletal dynamics in a new dimension.
Heuser JE, Donaldson JG.
Nat. Cell Biol. 2001 Jun;3(6):E140-2.
[Text Abstract on PubMed]

Immunofluorescence staining.
Donaldson JG.
Curr Protoc Cell Biol. 2001 May;Chapter 4:Unit 4.3.
[Text Abstract on PubMed]

Expression and properties of ADP-ribosylation factor (ARF6) in endocytic pathways.
Donaldson JG, Radhakrishna H.
Meth. Enzymol. 2001;329:247-56.
[Text Abstract on PubMed]

ACAPs are arf6 GTPase-activating proteins that function in the cell periphery.
Jackson TR, Brown FD, Nie Z, Miura K, Foroni L, Sun J, Hsu VW, Donaldson JG, Randazzo PA.
J. Cell Biol. 2000 Oct 30;151(3):627-38.
[Text Abstract on PubMed]

Regulators and effectors of the ARF GTPases.
Donaldson JG, Jackson CL.
Curr. Opin. Cell Biol. 2000 Aug;12(4):475-82.
[Text Abstract on PubMed]

Separation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutant.
Al-Awar O, Radhakrishna H, Powell NN, Donaldson JG.
Mol. Cell. Biol. 2000 Aug;20(16):5998-6007.
[Text Abstract on PubMed]

Sorting and signaling at the Golgi complex.
Donaldson JG, Lippincott-Schwartz J.
Cell. 2000 Jun 23;101(7):693-6.
[Text Abstract on PubMed]

Filling in the GAPs in the ADP-ribosylation factor story.
Donaldson JG.
Proc. Natl. Acad. Sci. U.S.A. 2000 Apr 11;97(8):3792-4.
[Text Abstract on PubMed]

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements.
Radhakrishna H, Al-Awar O, Khachikian Z, Donaldson JG.
J. Cell. Sci. 1999 Mar;112 ( Pt 6):855-66.
[Text Abstract on PubMed]

ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.
Brown MT, Andrade J, Radhakrishna H, Donaldson JG, Cooper JA, Randazzo PA.
Mol. Cell. Biol. 1998 Dec;18(12):7038-51.
[Text Abstract on PubMed]

A requirement for ARF6 in Fcgamma receptor-mediated phagocytosis in macrophages.
Zhang Q, Cox D, Tseng CC, Donaldson JG, Greenberg S.
J. Biol. Chem. 1998 Aug 7;273(32):19977-81.
[Text Abstract on PubMed]

Localization of endogenous ARF6 to sites of cortical actin rearrangement and involvement of ARF6 in cell spreading.
Song J, Khachikian Z, Radhakrishna H, Donaldson JG.
J. Cell. Sci. 1998 Aug;111 ( Pt 15):2257-67.
[Text Abstract on PubMed]

Building a secretory apparatus: role of ARF1/COPI in Golgi biogenesis and maintenance.
Lippincott-Schwartz J, Cole NB, Donaldson JG.
Histochem. Cell Biol. 1998 May-Jun;109(5-6):449-62.
[Text Abstract on PubMed]

Brefeldin A-inhibited guanine nucleotide-exchange activity of Sec7 domain from yeast Sec7 with yeast and mammalian ADP ribosylation factors.
Sata M, Donaldson JG, Moss J, Vaughan M.
Proc. Natl. Acad. Sci. U.S.A. 1998 Apr 14;95(8):4204-8.
[Text Abstract on PubMed]

ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathway.
Radhakrishna H, Donaldson JG.
J. Cell Biol. 1997 Oct 6;139(1):49-61.
[Text Abstract on PubMed]

Characterization of chemical inhibitors of brefeldin A-activated mono-ADP-ribosylation.
Weigert R, Colanzi A, Mironov A, Buccione R, Cericola C, Sciulli MG, Santini G, Flati S, Fusella A, Donaldson JG, Di Girolamo M, Corda D, De Matteis MA, Luini A.
J. Biol. Chem. 1997 May 30;272(22):14200-7.
[Text Abstract on PubMed]

Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase.
Radhakrishna H, Klausner RD, Donaldson JG.
J. Cell Biol. 1996 Aug;134(4):935-47.
[Text Abstract on PubMed]

Overexpression of wild-type and mutant ARF1 and ARF6: distinct perturbations of nonoverlapping membrane compartments.
Peters PJ, Hsu VW, Ooi CE, Finazzi D, Teal SB, Oorschot V, Donaldson JG, Klausner RD.
J. Cell Biol. 1995 Mar;128(6):1003-17.
[Text Abstract on PubMed]

The ARF GTPases: defining roles in membrane traffic and organelle structure.
Donaldson JG, Radhakrishna H, Peters PJ.
Cold Spring Harb. Symp. Quant. Biol. 1995;60:229-34.
[Text Abstract on PubMed]

ARF: a key regulatory switch in membrane traffic and organelle structure.
Donaldson JG, Klausner RD.
Curr. Opin. Cell Biol. 1994 Aug;6(4):527-32.
[Text Abstract on PubMed]

Aluminum fluoride acts on the reversibility of ARF1-dependent coat protein binding to Golgi membranes.
Finazzi D, Cassel D, Donaldson JG, Klausner RD.
J. Biol. Chem. 1994 May 6;269(18):13325-30.
[Text Abstract on PubMed]

An activating mutation in ARF1 stabilizes coatomer binding to Golgi membranes.
Teal SB, Hsu VW, Peters PJ, Klausner RD, Donaldson JG.
J. Biol. Chem. 1994 Feb 4;269(5):3135-8.
[Text Abstract on PubMed]

Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein.
Donaldson JG, Finazzi D, Klausner RD.
Nature. 1992 Nov 26;360(6402):350-2.
[Text Abstract on PubMed]

ADP-ribosylation factor, a small GTP-binding protein, is required for binding of the coatomer protein beta-COP to Golgi membranes.
Donaldson JG, Cassel D, Kahn RA, Klausner RD.
Proc. Natl. Acad. Sci. U.S.A. 1992 Jul 15;89(14):6408-12.
[Text Abstract on PubMed]

Brefeldin A: insights into the control of membrane traffic and organelle structure.
Klausner RD, Donaldson JG, Lippincott-Schwartz J.
J. Cell Biol. 1992 Mar;116(5):1071-80.
[Text Abstract on PubMed]

Binding of ARF and beta-COP to Golgi membranes: possible regulation by a trimeric G protein.
Donaldson JG, Kahn RA, Lippincott-Schwartz J, Klausner RD.
Science. 1991 Nov 22;254(5035):1197-9.
[Text Abstract on PubMed]

Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae.
Orci L, Tagaya M, Amherdt M, Perrelet A, Donaldson JG, Lippincott-Schwartz J, Klausner RD, Rothman JE.
Cell. 1991 Mar 22;64(6):1183-95.
[Text Abstract on PubMed]

Forskolin inhibits and reverses the effects of brefeldin A on Golgi morphology by a cAMP-independent mechanism.
Lippincott-Schwartz J, Glickman J, Donaldson JG, Robbins J, Kreis TE, Seamon KB, Sheetz MP, Klausner RD.
J. Cell Biol. 1991 Feb;112(4):567-77.
[Text Abstract on PubMed]

Guanine nucleotides modulate the effects of brefeldin A in semipermeable cells: regulation of the association of a 110-kD peripheral membrane protein with the Golgi apparatus.
Donaldson JG, Lippincott-Schwartz J, Klausner RD.
J. Cell Biol. 1991 Feb;112(4):579-88.
[Text Abstract on PubMed]

Cultured chick yolk sac epithelium: structure and IgG surface binding.
Donaldson JG, Bogenman E, Roth TF.
Eur. J. Cell Biol. 1990 Dec;53(2):246-54.
[Text Abstract on PubMed]

Dissociation of a 110-kD peripheral membrane protein from the Golgi apparatus is an early event in brefeldin A action.
Donaldson JG, Lippincott-Schwartz J, Bloom GS, Kreis TE, Klausner RD.
J. Cell Biol. 1990 Dec;111(6 Pt 1):2295-306.
[Text Abstract on PubMed]

Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin A suggests an ER recycling pathway.
Lippincott-Schwartz J, Donaldson JG, Schweizer A, Berger EG, Hauri HP, Yuan LC, Klausner RD.
Cell. 1990 Mar 9;60(5):821-36.
[Text Abstract on PubMed]