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Jay H. Chung, Ph.D., M.D.


Principal Investigator thumbnail image

Jay H. Chung
Senior Investigator

P: +1 301 496 3075
F: +1 301 496 9985

Full Publications Listing

Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination.
Um JH, Brown AL, Singh SK, Chen Y, Gucek M, Lee BS, Luckey MA, Kim MK, Park JH, Sleckman BP, Gellert M, Chung JH.
Proc Natl Acad Sci U S A..
[Text Abstract on PubMed]

Resveratrol as a calorie restriction mimetic: therapeutic implications.
Chung JH, Manganiello V, Dyck JR.
Trends Cell Biol. 2012 Oct;22(10):546-54.
[Text Abstract on PubMed]

Metabolic benefits of inhibiting cAMP-PDEs with resveratrol.
Chung JH.
Adipocyte. 2012 Oct 1;1(4):256-258.
[Text Abstract on PubMed]

Epigallocatechin gallate induces expression of heme oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2 that suppresses proinflammatory actions of TNF-a.
Pullikotil P, Chen H, Muniyappa R, Greenberg CC, Yang S, Reiter CE, Lee JW, Chung JH, Quon MJ.
J. Nutr. Biochem. 2012 Sep;23(9):1134-45.
[Text Abstract on PubMed]

Using PDE inhibitors to harness the benefits of calorie restriction: lessons from resveratrol.
Chung JH.
Aging (Albany NY). 2012 Mar;4(3):144-5.
[Text Abstract on PubMed]

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases.
Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown AL, Kim MK, Beaven MA, Burgin AB, Manganiello V, Chung JH.
Cell. 2012 Feb 3;148(3):421-33.
[Text Abstract on PubMed]

Jay H. Chung. Metabolic benefits of inhibiting cAMP-PDEs with resveratrol. Adipocyte 1(4) (2012).

Promyelocytic leukemia inhibits adipogenesis, and loss of promyelocytic leukemia results in fat accumulation in mice.
Kim MK, Yang S, Lee KH, Um JH, Liu M, Kang H, Park SJ, Chung JH.
Am. J. Physiol. Endocrinol. Metab. 2011 Dec;301(6):E1130-42.
[Text Abstract on PubMed]

Peptide switch is essential for Sirt1 deacetylase activity.
Kang H, Suh JY, Jung YS, Jung JW, Kim MK, Chung JH.
Mol. Cell. 2011 Oct 21;44(2):203-13.
[Text Abstract on PubMed]

Glucose deprivation is associated with Chk1 degradation through the ubiquitin-proteasome pathway and effective checkpoint response to replication blocks.
Kim AJ, Kim HJ, Jee HJ, Song N, Kim M, Bae YS, Chung JH, Yun J.
Biochim. Biophys. Acta. 2011 Jun;1813(6):1230-8.
[Text Abstract on PubMed]

AMPK regulates circadian rhythms in a tissue- and isoform-specific manner.
Um JH, Pendergast JS, Springer DA, Foretz M, Viollet B, Brown A, Kim MK, Yamazaki S, Chung JH.
PLoS ONE. 2011;6(3):e18450.
[Text Abstract on PubMed]

Variation in the checkpoint kinase 2 gene is associated with type 2 diabetes in multiple populations.
North KE, Franceschini N, Avery CL, Baird L, Graff M, Leppert M, Chung JH, Zhang J, Hanis C, Boerwinkle E, Volcik KA, Grove ML, Mosley TH, Gu C, Heiss G, Pankow JS, Couper DJ, Ballantyne CM, Linda Kao WH, Weder AB, Cooper RS, Ehret GB, O'Connor AA, Chakravarti A, Hunt SC.
Acta Diabetol. 2010 Dec;47(Suppl 1):199-207.
[Text Abstract on PubMed]

AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol.
Um JH, Park SJ, Kang H, Yang S, Foretz M, McBurney MW, Kim MK, Viollet B, Chung JH.
Diabetes. 2010 Mar;59(3):554-63.
[Text Abstract on PubMed]

The role of mPer2 clock gene in glucocorticoid and feeding rhythms.
Yang S, Liu A, Weidenhammer A, Cooksey RC, McClain D, Kim MK, Aguilera G, Abel ED, Chung JH.
Endocrinology. 2009 May;150(5):2153-60.
[Text Abstract on PubMed]

The association of cell cycle checkpoint 2 variants and kidney function: findings of the Family Blood Pressure Program and the Atherosclerosis Risk In Communities study.
Franceschini N, North KE, Arnett D, Pankow JS, Chung JH, Baird L, Leppert MF, Eckfeldt JH, Boerwinkle E, Gu CC, Lewis CE, Myers RH, Turner ST, Weder A, Kao WH, Mosley TH, Chakravarti A, Kramer H, Zhang J, Hunt SC.
Am. J. Hypertens. 2009 May;22(5):552-8.
[Text Abstract on PubMed]

CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage.
Kang H, Jung JW, Kim MK, Chung JH.
PLoS ONE. 2009;4(8):e6611.
[Text Abstract on PubMed]

Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation.
Lee MY, Kim HJ, Kim MA, Jee HJ, Kim AJ, Bae YS, Park JI, Chung JH, Yun J.
Cell Cycle. 2008 Sep 1;7(17):2705-9.
[Text Abstract on PubMed]

Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2.
Um JH, Yang S, Yamazaki S, Kang H, Viollet B, Foretz M, Chung JH.
J. Biol. Chem. 2007 Jul 20;282(29):20794-8.
[Text Abstract on PubMed]

Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif.
Kim MA, Kim HJ, Brown AL, Lee MY, Bae YS, Park JI, Kwak JY, Chung JH, Yun J.
Exp. Mol. Med. 2007 Apr 30;39(2):205-12.
[Text Abstract on PubMed]

Oxygen tension regulates the stability of insulin receptor substrate-1 (IRS-1) through caspase-mediated cleavage.
Kang SG, Brown AL, Chung JH.
J. Biol. Chem. 2007 Mar 2;282(9):6090-7.
[Text Abstract on PubMed]

ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis.
Joe Y, Jeong JH, Yang S, Kang H, Motoyama N, Pandolfi PP, Chung JH, Kim MK.
J. Biol. Chem. 2006 Sep 29;281(39):28764-71.
[Text Abstract on PubMed]

Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation.
Yang S, Jeong JH, Brown AL, Lee CH, Pandolfi PP, Chung JH, Kim MK.
J. Biol. Chem. 2006 Sep 8;281(36):26645-54.
[Text Abstract on PubMed]

Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining.
Zhuang J, Zhang J, Willers H, Wang H, Chung JH, van Gent DC, Hallahan DE, Powell SN, Xia F.
Cancer Res. 2006 Feb 1;66(3):1401-8.
[Text Abstract on PubMed]

Human T-cell leukemia virus type 1 Tax attenuates gamma-irradiation-induced apoptosis through physical interaction with Chk2.
Park HU, Jeong SJ, Jeong JH, Chung JH, Brady JN.
Oncogene. 2006 Jan 19;25(3):438-47.
[Text Abstract on PubMed]

Human T-cell leukemia virus type 1 Tax interacts with Chk1 and attenuates DNA-damage induced G2 arrest mediated by Chk1.
Park HU, Jeong JH, Chung JH, Brady JN.
Oncogene. 2004 Jun 24;23(29):4966-74.
[Text Abstract on PubMed]

Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair.
Zhang J, Willers H, Feng Z, Ghosh JC, Kim S, Weaver DT, Chung JH, Powell SN, Xia F.
Mol. Cell. Biol. 2004 Jan;24(2):708-18.
[Text Abstract on PubMed]

Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.
O'Neill T, Giarratani L, Chen P, Iyer L, Lee CH, Bobiak M, Kanai F, Zhou BB, Chung JH, Rathbun GA.
J. Biol. Chem. 2002 May 3;277(18):16102-15.
[Text Abstract on PubMed]

The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation.
Lee CH, Chung JH.
J. Biol. Chem. 2001 Aug 10;276(32):30537-41.
[Text Abstract on PubMed]

Diverse functions of BRCA1 in the DNA damage response.
Lee JS, Chung JH.
Expert Rev Mol Med. 2001 May 18;2001:1-11.
[Text Abstract on PubMed]

Erythroid Kruppel-like factor is recruited to the CACCC box in the beta-globin promoter but not to the CACCC box in the gamma-globin promoter: the role of the neighboring promoter elements.
Lee JS, Ngo H, Kim D, Chung JH.
Proc. Natl. Acad. Sci. U.S.A. 2000 Mar 14;97(6):2468-73.
[Text Abstract on PubMed]

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response.
Lee JS, Collins KM, Brown AL, Lee CH, Chung JH.
Nature. 2000 Mar 9;404(6774):201-4.
[Text Abstract on PubMed]

The function of BRCA1 in DNA damage response.
Lee JS, Collins K, Brown A, Lee CH, Chung JH.
Cold Spring Harb. Symp. Quant. Biol. 2000;65:547-52.
[Text Abstract on PubMed]

Targeting a SWI/SNF-related chromatin remodeling complex to the beta-globin promoter in erythroid cells.
Lee CH, Murphy MR, Lee JS, Chung JH.
Proc. Natl. Acad. Sci. U.S.A. 1999 Oct 26;96(22):12311-5.
[Text Abstract on PubMed]

In vivo transcription factor recruitment during thyroid hormone receptor-mediated activation.
Kim MK, Lee JS, Chung JH.
Proc. Natl. Acad. Sci. U.S.A. 1999 Aug 31;96(18):10092-7.
[Text Abstract on PubMed]

The beta-globin promoter is important for recruitment of erythroid Krüppel-like factor to the locus control region in erythroid cells.
Lee JS, Lee CH, Chung JH.
Proc. Natl. Acad. Sci. U.S.A. 1999 Aug 31;96(18):10051-5.
[Text Abstract on PubMed]

A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage.
Brown AL, Lee CH, Schwarz JK, Mitiku N, Piwnica-Worms H, Chung JH.
Proc. Natl. Acad. Sci. U.S.A. 1999 Mar 30;96(7):3745-50.
[Text Abstract on PubMed]

Studying the recruitment of Sp1 to the beta-globin promoter with an in vivo method: protein position identification with nuclease tail (PIN*POINT).
Lee JS, Lee CH, Chung JH.
Proc. Natl. Acad. Sci. U.S.A. 1998 Feb 3;95(3):969-74.
[Text Abstract on PubMed]

The establishment of active chromatin domains.
Bell A, Boyes J, Chung J, Pikaart M, Prioleau MN, Recillas F, Saitoh N, Felsenfeld G.
Cold Spring Harb. Symp. Quant. Biol. 1998;63:509-14.
[Text Abstract on PubMed]

Characterization of the chicken beta-globin insulator.
Chung JH, Bell AC, Felsenfeld G.
Proc. Natl. Acad. Sci. U.S.A. 1997 Jan 21;94(2):575-80.
[Text Abstract on PubMed]

Chromatin structure and gene expression.
Felsenfeld G, Boyes J, Chung J, Clark D, Studitsky V.
Proc. Natl. Acad. Sci. U.S.A. 1996 Sep 3;93(18):9384-8.
[Text Abstract on PubMed]

A soluble transcription factor, Oct-1, is also found in the insoluble nuclear matrix and possesses silencing activity in its alanine-rich domain.
Kim MK, Lesoon-Wood LA, Weintraub BD, Chung JH.
Mol. Cell. Biol. 1996 Aug;16(8):4366-77.
[Text Abstract on PubMed]

Felsenfeld, G., Bresnick, E., Chung, J., and Reitman, M.: Chromatin Structure and the Regulation of Globin Gene Expression. Hemoglobin Switching 1:3-11 (1995).

A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila.
Chung JH, Whiteley M, Felsenfeld G.
Cell. 1993 Aug 13;74(3):505-14.
[Text Abstract on PubMed]

Chromatin structure of transcriptionally active genes.
Clark D, Reitman M, Studitsky V, Chung J, Westphal H, Lee E, Felsenfeld G.
Cold Spring Harb. Symp. Quant. Biol. 1993;58:1-6.
[Text Abstract on PubMed]

In vitro and in vivo analysis of the c-myc RNA polymerase III promoter.
Sussman DJ, Chung J, Leder P.
Nucleic Acids Res. 1991 Sep 25;19(18):5045-52.
[Text Abstract on PubMed]

The c-myc gene encodes superimposed RNA polymerase II and III promoters.
Chung J, Sussman DJ, Zeller R, Leder P.
Cell. 1987 Dec 24;51(6):1001-8.
[Text Abstract on PubMed]

Trans-acting elements modulate expression of the human c-myc gene in Burkitt lymphoma cells.
Chung J, Sinn E, Reed RR, Leder P.
Proc. Natl. Acad. Sci. U.S.A. 1986 Oct;83(20):7918-22.
[Text Abstract on PubMed]