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Maurice Burg, M.D.

Publications


Principal Investigator thumbnail image

Maurice Burg
Scientist Emeritus

P: +1 301 496 3187
burgm@mail.nih.gov


Full Publications Listing

Mutations that reduce its specific DNA binding inhibit high NaCl-induced nuclear localization of the osmoprotective transcription factor NFAT5.
Izumi Y, Li J, Villers C, Hashimoto K, Burg MB, Ferraris JD.
Am. J. Physiol., Cell Physiol. 2012 Nov 15;303(10):C1061-9.
[Text Abstract on PubMed]

Proteomic analysis of high NaCl-induced changes in abundance of nuclear proteins.
Li J, Ferraris JD, Yu D, Singh T, Izumi Y, Wang G, Gucek M, Burg MB.
Physiol. Genomics. 2012 Nov 2;44(21):1063-71.
[Text Abstract on PubMed]

Salt, skeletons and suicide.
Burg MB, Ferraris JD.
Am. J. Physiol., Cell Physiol. 2012 Oct 24.
[Text Abstract on PubMed]

Water restriction increases renal inner medullary manganese superoxide dismutase (MnSOD).
Zhou X, Burg MB, Ferraris JD.
Am. J. Physiol. Renal Physiol. 2012 Sep;303(5):F674-80.
[Text Abstract on PubMed]

DNA double-strand breaks induced by high NaCl occur predominantly in gene deserts.
Dmitrieva NI, Cui K, Kitchaev DA, Zhao K, Burg MB.
Proc. Natl. Acad. Sci. U.S.A. 2011 Dec 20;108(51):20796-801.
[Text Abstract on PubMed]

Mre11 is expressed in mammalian mitochondria where it binds to mitochondrial DNA.
Dmitrieva NI, Malide D, Burg MB.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 2011 Sep;301(3):R632-40.
[Text Abstract on PubMed]

Rac1/osmosensing scaffold for MEKK3 contributes via phospholipase C-gamma1 to activation of the osmoprotective transcription factor NFAT5.
Zhou X, Izumi Y, Burg MB, Ferraris JD.
Proc. Natl. Acad. Sci. U.S.A. 2011 Jul 19;108(29):12155-60.
[Text Abstract on PubMed]

High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization.
Gallazzini M, Heussler GE, Kunin M, Izumi Y, Burg MB, Ferraris JD.
Mol. Biol. Cell. 2011 Mar 1;22(5):703-14.
[Text Abstract on PubMed]

Increased insensible water loss contributes to aging related dehydration.
Dmitrieva NI, Burg MB.
PLoS ONE. 2011;6(5):e20691.
[Text Abstract on PubMed]

c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP.
Gallazzini M, Yu MJ, Gunaratne R, Burg MB, Ferraris JD.
FASEB J. 2010 Nov;24(11):4325-35.
[Text Abstract on PubMed]

Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP.
Zhou X, Gallazzini M, Burg MB, Ferraris JD.
Proc. Natl. Acad. Sci. U.S.A. 2010 Apr 13;107(15):7072-7.
[Text Abstract on PubMed]

Phospholipase C-gamma1 is involved in signaling the activation by high NaCl of the osmoprotective transcription factor TonEBP/OREBP.
Irarrazabal CE, Gallazzini M, Schnetz MP, Kunin M, Simons BL, Williams CK, Burg MB, Ferraris JD.
Proc. Natl. Acad. Sci. U.S.A. 2010 Jan 12;107(2):906-11.
[Text Abstract on PubMed]

Mediator of DNA damage checkpoint 1 (MDC1) contributes to high NaCl-induced activation of the osmoprotective transcription factor TonEBP/OREBP.
Kunin M, Dmitrieva NI, Gallazzini M, Shen RF, Wang G, Burg MB, Ferraris JD.
PLoS ONE. 2010;5(8):e12108.
[Text Abstract on PubMed]

What's new about osmotic regulation of glycerophosphocholine.
Gallazzini M, Burg MB.
Physiology (Bethesda). 2009 Aug;24:245-9.
[Text Abstract on PubMed]

Knockout of Ku86 accelerates cellular senescence induced by high NaCl.
Dmitrieva NI, Chen HT, Nussenzweig A, Burg MB.
Aging (Albany NY). 2009 Feb;1(2):245-53.
[Text Abstract on PubMed]

Analysis of DNA breaks, DNA damage response, and apoptosis produced by high NaCl.
Dmitrieva NI, Burg MB.
Am. J. Physiol. Renal Physiol. 2008 Dec;295(6):F1678-88.
[Text Abstract on PubMed]

GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC.
Gallazzini M, Ferraris JD, Burg MB.
Proc. Natl. Acad. Sci. U.S.A. 2008 Aug 5;105(31):11026-31.
[Text Abstract on PubMed]

MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta.
Zhou X, Ferraris JD, Dmitrieva NI, Liu Y, Burg MB.
Proc. Natl. Acad. Sci. U.S.A. 2008 Apr 8;105(14):5620-5.
[Text Abstract on PubMed]

Intracellular organic osmolytes: function and regulation.
Burg MB, Ferraris JD.
J. Biol. Chem. 2008 Mar 21;283(12):7309-13.
[Text Abstract on PubMed]

Activator protein-1 contributes to high NaCl-induced increase in tonicity-responsive enhancer/osmotic response element-binding protein transactivating activity.
Irarrazabal CE, Williams CK, Ely MA, Birrer MJ, Garcia-Perez A, Burg MB, Ferraris JD.
J. Biol. Chem. 2008 Feb 1;283(5):2554-63.
[Text Abstract on PubMed]

High NaCl promotes cellular senescence.
Dmitrieva NI, Burg MB.
Cell Cycle. 2007 Dec 15;6(24):3108-13.
[Text Abstract on PubMed]

Cellular response to hyperosmotic stresses.
Burg MB, Ferraris JD, Dmitrieva NI.
Physiol. Rev. 2007 Oct;87(4):1441-74.
[Text Abstract on PubMed]

Proteomic identification of proteins associated with the osmoregulatory transcription factor TonEBP/OREBP: functional effects of Hsp90 and PARP-1.
Chen Y, Schnetz MP, Irarrazabal CE, Shen RF, Williams CK, Burg MB, Ferraris JD.
Am. J. Physiol. Renal Physiol. 2007 Mar;292(3):F981-92.
[Text Abstract on PubMed]

Osmotic stress and DNA damage.
Dmitrieva NI, Burg MB.
Meth. Enzymol. 2007;428:241-52.
[Text Abstract on PubMed]

Tonicity-regulated gene expression.
Ferraris JD, Burg MB.
Meth. Enzymol. 2007;428:279-96.
[Text Abstract on PubMed]

Neuropathy target esterase catalyzes osmoprotective renal synthesis of glycerophosphocholine in response to high NaCl.
Gallazzini M, Ferraris JD, Kunin M, Morris RG, Burg MB.
Proc. Natl. Acad. Sci. U.S.A. 2006 Oct 10;103(41):15260-5.
[Text Abstract on PubMed]

Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells.
Cai Q, Dmitrieva NI, Ferraris JD, Michea LF, Salvador JM, Hollander MC, Fornace, Fenton RA, Burg MB.
Am. J. Physiol. Renal Physiol. 2006 Aug;291(2):F341-9.
[Text Abstract on PubMed]

Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation.
Irarrazabal CE, Burg MB, Ward SG, Ferraris JD.
Proc. Natl. Acad. Sci. U.S.A. 2006 Jun 6;103(23):8882-7.
[Text Abstract on PubMed]

The saltiness of the sea breaks DNA in marine invertebrates: possible implications for animal evolution.
Dmitrieva NI, Ferraris JD, Norenburg JL, Burg MB.
Cell Cycle. 2006 Jun;5(12):1320-3.
[Text Abstract on PubMed]

Mitochondrial reactive oxygen species contribute to high NaCl-induced activation of the transcription factor TonEBP/OREBP.
Zhou X, Ferraris JD, Burg MB.
Am. J. Physiol. Renal Physiol. 2006 May;290(5):F1169-76.
[Text Abstract on PubMed]

Tonicity-dependent regulation of osmoprotective genes in mammalian cells.
Ferraris JD, Burg MB.
Contrib Nephrol. 2006;152:125-41.
[Text Abstract on PubMed]

High NaCl increases TonEBP/OREBP mRNA and protein by stabilizing its mRNA.
Cai Q, Ferraris JD, Burg MB.
Am. J. Physiol. Renal Physiol. 2005 Oct;289(4):F803-7.
[Text Abstract on PubMed]

Ataxia telangiectasia-mutated, a DNA damage-inducible kinase, contributes to high NaCl-induced nuclear localization of transcription factor TonEBP/OREBP.
Zhang Z, Ferraris JD, Irarrazabal CE, Dmitrieva NI, Park JH, Burg MB.
Am. J. Physiol. Renal Physiol. 2005 Sep;289(3):F506-11.
[Text Abstract on PubMed]

Increased reactive oxygen species contribute to high NaCl-induced activation of the osmoregulatory transcription factor TonEBP/OREBP.
Zhou X, Ferraris JD, Cai Q, Agarwal A, Burg MB.
Am. J. Physiol. Renal Physiol. 2005 Aug;289(2):F377-85.
[Text Abstract on PubMed]

Ku86 preserves chromatin integrity in cells adapted to high NaCl.
Dmitrieva NI, Celeste A, Nussenzweig A, Burg MB.
Proc. Natl. Acad. Sci. U.S.A. 2005 Jul 26;102(30):10730-5.
[Text Abstract on PubMed]

DNA damage and osmotic regulation in the kidney.
Dmitrieva NI, Burg MB, Ferraris JD.
Am. J. Physiol. Renal Physiol. 2005 Jul;289(1):F2-7.
[Text Abstract on PubMed]

Hypertonic stress response.
Dmitrieva NI, Burg MB.
Mutat. Res. 2005 Jan 6;569(1-2):65-74.
[Text Abstract on PubMed]

Drying and salting send different messages.
Ferraris JD, Burg MB.
J. Physiol. (Lond.). 2004 Jul 1;558(Pt 1):3.
[Text Abstract on PubMed]

High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8-oxoguanine lesions in their DNA.
Zhang Z, Dmitrieva NI, Park JH, Levine RL, Burg MB.
Proc. Natl. Acad. Sci. U.S.A. 2004 Jun 22;101(25):9491-6.
[Text Abstract on PubMed]

ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP.
Irarrazabal CE, Liu JC, Burg MB, Ferraris JD.
Proc. Natl. Acad. Sci. U.S.A. 2004 Jun 8;101(23):8809-14.
[Text Abstract on PubMed]

Living with DNA breaks is an everyday reality for cells adapted to high NaCl.
Dmitrieva NI, Burg MB.
Cell Cycle. 2004 May;3(5):561-3.
[Text Abstract on PubMed]

Cells adapted to high NaCl have many DNA breaks and impaired DNA repair both in cell culture and in vivo.
Dmitrieva NI, Cai Q, Burg MB.
Proc. Natl. Acad. Sci. U.S.A. 2004 Feb 24;101(8):2317-22.
[Text Abstract on PubMed]

Greater tolerance of renal medullary cells for a slow increase in osmolality is associated with enhanced expression of HSP70 and other osmoprotective genes.
Cai Q, Ferraris JD, Burg MB.
Am. J. Physiol. Renal Physiol. 2004 Jan;286(1):F58-67.
[Text Abstract on PubMed]

Expression of osmotic stress-related genes in tissues of normal and hyposmotic rats.
Zhang Z, Ferraris JD, Brooks HL, Brisc I, Burg MB.
Am. J. Physiol. Renal Physiol. 2003 Oct;285(4):F688-93.
[Text Abstract on PubMed]

High NaCl causes Mre11 to leave the nucleus, disrupting DNA damage signaling and repair.
Dmitrieva NI, Bulavin DV, Burg MB.
Am. J. Physiol. Renal Physiol. 2003 Aug;285(2):F266-74.
[Text Abstract on PubMed]

Toxicity of acetaminophen, salicylic acid, and caffeine for first-passage rat renal inner medullary collecting duct cells.
Cai Q, Dmitrieva NI, Michea LF, Rocha G, Ferguson D, Burg MB.
J. Pharmacol. Exp. Ther. 2003 Jul;306(1):35-42.
[Text Abstract on PubMed]

cAMP-independent role of PKA in tonicity-induced transactivation of tonicity-responsive enhancer/ osmotic response element-binding protein.
Ferraris JD, Persaud P, Williams CK, Chen Y, Burg MB.
Proc. Natl. Acad. Sci. U.S.A. 2002 Dec 24;99(26):16800-5.
[Text Abstract on PubMed]

Three GADD45 isoforms contribute to hypertonic stress phenotype of murine renal inner medullary cells.
Chakravarty D, Cai Q, Ferraris JD, Michea L, Burg MB, Kültz D.
Am. J. Physiol. Renal Physiol. 2002 Nov;283(5):F1020-9.
[Text Abstract on PubMed]

Response of renal inner medullary epithelial cells to osmotic stress.
Burg MB.
Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 2002 Nov;133(3):661-6.
[Text Abstract on PubMed]

Rate of increase of osmolality determines osmotic tolerance of mouse inner medullary epithelial cells.
Cai Q, Michea L, Andrews P, Zhang Z, Rocha G, Dmitrieva N, Burg MB.
Am. J. Physiol. Renal Physiol. 2002 Oct;283(4):F792-8.
[Text Abstract on PubMed]

Proliferation and osmotic tolerance of renal inner medullary epithelial cells in vivo and in cell culture.
Zhang Z, Cai Q, Michea L, Dmitrieva NI, Andrews P, Burg MB.
Am. J. Physiol. Renal Physiol. 2002 Aug;283(2):F302-8.
[Text Abstract on PubMed]

Putative osmolytes in the kidney of the Australian brush-tailed possum, Trichosurus vulpecula.
Bedford JJ, Burg MB, Peters E, Smith RA, Leader JP.
Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 2002 Jul;132(3):635-44.
[Text Abstract on PubMed]

Mitochondrial dysfunction is an early event in high-NaCl-induced apoptosis of mIMCD3 cells.
Michea L, Combs C, Andrews P, Dmitrieva N, Burg MB.
Am. J. Physiol. Renal Physiol. 2002 Jun;282(6):F981-90.
[Text Abstract on PubMed]

Activity of the TonEBP/OREBP transactivation domain varies directly with extracellular NaCl concentration.
Ferraris JD, Williams CK, Persaud P, Zhang Z, Chen Y, Burg MB.
Proc. Natl. Acad. Sci. U.S.A. 2002 Jan 22;99(2):739-44.
[Text Abstract on PubMed]

Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase.
Dmitrieva NI, Bulavin DV, Fornace, Burg MB.
Proc. Natl. Acad. Sci. U.S.A. 2002 Jan 8;99(1):184-9.
[Text Abstract on PubMed]

Cell cycle delay and apoptosis in response to osmotic stress.
Dmitrieva NI, Michea LF, Rocha GM, Burg MB.
Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 2001 Oct;130(3):411-20.
[Text Abstract on PubMed]

Direct toxicity of nonsteroidal antiinflammatory drugs for renal medullary cells.
Rocha GM, Michea LF, Peters EM, Kirby M, Xu Y, Ferguson DR, Burg MB.
Proc. Natl. Acad. Sci. U.S.A. 2001 Apr 24;98(9):5317-22.
[Text Abstract on PubMed]

Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.
Hurwitz AA, Foster BA, Kwon ED, Truong T, Choi EM, Greenberg NM, Burg MB, Allison JP.
Cancer Res. 2000 May 1;60(9):2444-8.
[Text Abstract on PubMed]

Cell cycle delay and apoptosis are induced by high salt and urea in renal medullary cells.
Michea L, Ferguson DR, Peters EM, Andrews PM, Kirby MR, Burg MB.
Am. J. Physiol. Renal Physiol. 2000 Feb;278(2):F209-18.
[Text Abstract on PubMed]

Macromolecular crowding as a cell volume sensor.
Burg MB.
Cell. Physiol. Biochem. 2000;10(5-6):251-6.
[Text Abstract on PubMed]

Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy.
Kwon ED, Foster BA, Hurwitz AA, Madias C, Allison JP, Greenberg NM, Burg MB.
Proc. Natl. Acad. Sci. U.S.A. 1999 Dec 21;96(26):15074-9.
[Text Abstract on PubMed]

Factors affecting counteraction by methylamines of urea effects on aldose reductase.
Burg MB, Peters EM, Bohren KM, Gabbay KH.
Proc. Natl. Acad. Sci. U.S.A. 1999 May 25;96(11):6517-22.
[Text Abstract on PubMed]

Sodium chloride and water transport in the medullary thick ascending limb of Henle: evidence for active chloride transport 1973.
Rocha AS, Kokko JP, Burg MB.
J. Am. Soc. Nephrol. 1999 May;10(5):1145-56.
[Text Abstract on PubMed]

Hyperosmolality causes growth arrest of murine kidney cells. Induction of GADD45 and GADD153 by osmosensing via stress-activated protein kinase 2.
Kültz D, Madhany S, Burg MB.
J. Biol. Chem. 1998 May 29;273(22):13645-51.
[Text Abstract on PubMed]

Effects of glycine betaine and glycerophosphocholine on thermal stability of ribonuclease.
Burg MB, Peters EM.
Am. J. Physiol. 1998 Apr;274(4 Pt 2):F762-5.
[Text Abstract on PubMed]

Intracellular signaling in response to osmotic stress.
Kültz D, Burg MB.
Contrib Nephrol. 1998;123:94-109.
[Text Abstract on PubMed]

Urea and methylamines have similar effects on aldose reductase activity.
Burg MB, Peters EM.
Am. J. Physiol. 1997 Dec;273(6 Pt 2):F1048-53.
[Text Abstract on PubMed]

Renal osmoregulatory transport of compatible organic osmolytes.
Burg MB.
Curr. Opin. Nephrol. Hypertens. 1997 Sep;6(5):430-3.
[Text Abstract on PubMed]

Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer.
Kwon ED, Hurwitz AA, Foster BA, Madias C, Feldhaus AL, Greenberg NM, Burg MB, Allison JP.
Proc. Natl. Acad. Sci. U.S.A. 1997 Jul 22;94(15):8099-103.
[Text Abstract on PubMed]

Distinct regulation of osmoprotective genes in yeast and mammals. Aldose reductase osmotic response element is induced independent of p38 and stress-activated protein kinase/Jun N-terminal kinase in rabbit kidney cells.
Kültz D, Garcia-Perez A, Ferraris JD, Burg MB.
J. Biol. Chem. 1997 May 16;272(20):13165-70.
[Text Abstract on PubMed]

Preparation and study of fragments of single rabbit nephrons.
Burg MB, Grantham J, Abramow M, Orloff J, Schafer JA.
J. Am. Soc. Nephrol. 1997 Apr;8(4):675-83.
[Text Abstract on PubMed]

Regulation of gene expression by hypertonicity.
Burg MB, Kwon ED, Kültz D.
Annu. Rev. Physiol. 1997;59:437-55.
[Text Abstract on PubMed]

Glycerophosphocholine and betaine counteract the effect of urea on pyruvate kinase.
Burg MB, Kwon ED, Peters EM.
Kidney Int. Suppl. 1996 Dec;57:S100-4.
[Text Abstract on PubMed]

Osmotic regulation of gene expression.
Burg MB, Kwon ED, Kültz D.
FASEB J. 1996 Dec;10(14):1598-606.
[Text Abstract on PubMed]

ORE, a eukaryotic minimal essential osmotic response element. The aldose reductase gene in hyperosmotic stress.
Ferraris JD, Williams CK, Jung KY, Bedford JJ, Burg MB, García-Pérez A.
J. Biol. Chem. 1996 Aug 2;271(31):18318-21.
[Text Abstract on PubMed]

Organic osmolyte distribution and levels in the mammalian urinary bladder in diuresis and antidiuresis.
Kwon ED, Dooley JA, Jung KY, Andrews PM, García-Pérez A, Burg MB.
Am. J. Physiol. 1996 Jul;271(1 Pt 2):F230-3.
[Text Abstract on PubMed]

Coordinate regulation of organic osmolytes in renal cells.
Burg MB.
Kidney Int. 1996 Jun;49(6):1684-5.
[Text Abstract on PubMed]

Betaine transporter cDNA cloning and effect of osmolytes on its mRNA induction.
Ferraris JD, Burg MB, Williams CK, Peters EM, García-Pérez A.
Am. J. Physiol. 1996 Feb;270(2 Pt 1):C650-4.
[Text Abstract on PubMed]

Betaine and inositol reduce MDCK cell glycerophosphocholine by stimulating its degradation.
Kwon ED, Zablocki K, Peters EM, Jung KY, García-Pérez A, Burg MB.
Am. J. Physiol. 1996 Jan;270(1 Pt 1):C200-7.
[Text Abstract on PubMed]

CD9 antigen mRNA is induced by hypertonicity in two renal epithelial cell lines.
Sheikh-Hamad D, Ferraris JD, Dragolovich J, Preuss HG, Burg MB, García-Pérez A.
Am. J. Physiol. 1996 Jan;270(1 Pt 1):C253-8.
[Text Abstract on PubMed]

Osmoregulation of GPC:choline phosphodiesterase in MDCK cells: different effects of urea and NaCl.
Kwon ED, Zablocki K, Jung KY, Peters EM, García-Pérez A, Burg MB.
Am. J. Physiol. 1995 Jul;269(1 Pt 1):C35-41.
[Text Abstract on PubMed]

Molecular basis of osmotic regulation.
Burg MB.
Am. J. Physiol. 1995 Jun;268(6 Pt 2):F983-96.
[Text Abstract on PubMed]

Osmotic regulation of synthesis of glycerophosphocholine from phosphatidylcholine in MDCK cells.
Kwon ED, Jung KY, Edsall LC, Kim HY, García-Pérez A, Burg MB.
Am. J. Physiol. 1995 Feb;268(2 Pt 1):C402-12.
[Text Abstract on PubMed]

Cloning, genomic organization, and osmotic response of the aldose reductase gene.
Ferraris JD, Williams CK, Martin BM, Burg MB, García-Pérez A.
Proc. Natl. Acad. Sci. U.S.A. 1994 Oct 25;91(22):10742-6.
[Text Abstract on PubMed]

Induction of gene expression by heat shock versus osmotic stress.
Sheikh-Hamad D, García-Pérez A, Ferraris JD, Peters EM, Burg MB.
Am. J. Physiol. 1994 Jul;267(1 Pt 2):F28-34.
[Text Abstract on PubMed]

Macromolecular crowding and confinement in cells exposed to hypertonicity.
Garner MM, Burg MB.
Am. J. Physiol. 1994 Apr;266(4 Pt 1):C877-92.
[Text Abstract on PubMed]

Molecular basis for osmoregulation of organic osmolytes in renal medullary cells.
Burg MB.
J. Exp. Zool. 1994 Feb 1;268(2):171-5.
[Text Abstract on PubMed]

How tonicity regulates gene expression.
Burg MB, Garcia-Perez A.
J. Am. Soc. Nephrol. 1992 Aug;3(2):121-7.
[Text Abstract on PubMed]

Cloning of the cDNa for a Na+/myo-inositol cotransporter, a hypertonicity stress protein.
Kwon HM, Yamauchi A, Uchida S, Preston AS, Garcia-Perez A, Burg MB, Handler JS.
J. Biol. Chem. 1992 Mar 25;267(9):6297-301.
[Text Abstract on PubMed]

Kidney aldose reductase gene transcription is osmotically regulated.
Smardo, Burg MB, Garcia-Perez A.
Am. J. Physiol. 1992 Mar;262(3 Pt 1):C776-82.
[Text Abstract on PubMed]

Cloning of a Na(+)- and Cl(-)-dependent betaine transporter that is regulated by hypertonicity.
Yamauchi A, Uchida S, Kwon HM, Preston AS, Robey RB, Garcia-Perez A, Burg MB, Handler JS.
J. Biol. Chem. 1992 Jan 5;267(1):649-52.
[Text Abstract on PubMed]

Renal medullary organic osmolytes.
Garcia-Perez A, Burg MB.
Physiol. Rev. 1991 Oct;71(4):1081-115.
[Text Abstract on PubMed]

Accumulation of glycerophosphocholine (GPC) by renal cells: osmotic regulation of GPC:choline phosphodiesterase.
Zablocki K, Miller SP, Garcia-Perez A, Burg MB.
Proc. Natl. Acad. Sci. U.S.A. 1991 Sep 1;88(17):7820-4.
[Text Abstract on PubMed]

Induction of glycinebetaine uptake into Xenopus oocytes by injection of poly(A)+ RNA from renal cells exposed to high extracellular NaCl.
Robey RB, Kwon HM, Handler JS, Garcia-Perez A, Burg MB.
J. Biol. Chem. 1991 Jun 5;266(16):10400-5.
[Text Abstract on PubMed]

Intracellular betaine substitutes for sorbitol in protecting renal medullary cells from hypertonicity.
Moriyama T, Garcia-Perez A, Olson AD, Burg MB.
Am. J. Physiol. 1991 Apr;260(4 Pt 2):F494-7.
[Text Abstract on PubMed]

Renal Na-myo-inositol cotransporter mRNA expression in Xenopus oocytes: regulation by hypertonicity.
Kwon HM, Yamauchi A, Uchida S, Robey RB, Garcia-Perez A, Burg MB, Handler JS.
Am. J. Physiol. 1991 Feb;260(2 Pt 2):F258-63.
[Text Abstract on PubMed]

Role of organic osmolytes in adaptation of renal cells to high osmolality.
Garcia-Perez A, Burg MB.
J. Membr. Biol. 1991 Jan;119(1):1-13.
[Text Abstract on PubMed]

Importance of organic osmolytes for osmoregulation by renal medullary cells.
Garcia-Perez A, Burg MB.
Hypertension. 1990 Dec;16(6):595-602.
[Text Abstract on PubMed]

Factors affecting the ratio of different organic osmolytes in renal medullary cells.
Moriyama T, Garcia-Perez A, Burg MB.
Am. J. Physiol. 1990 Nov;259(5 Pt 2):F847-58.
[Text Abstract on PubMed]

Osmoregulation of betaine transport in mammalian renal medullary cells.
Nakanishi T, Turner RJ, Burg MB.
Am. J. Physiol. 1990 Apr;258(4 Pt 2):F1061-7.
[Text Abstract on PubMed]

Microdissection of kidney tubule segments.
Wright PA, Burg MB, Knepper MA.
Meth. Enzymol. 1990;191:226-31.
[Text Abstract on PubMed]

Effects of NaCl, glucose, and aldose reductase inhibitors on cloning efficiency of renal medullary cells.
Yancey PH, Burg MB, Bagnasco SM.
Am. J. Physiol. 1990 Jan;258(1 Pt 1):C156-63.
[Text Abstract on PubMed]

In vivo osmoregulation of aldose reductase mRNA, protein, and sorbitol in renal medulla.
Cowley, Ferraris JD, Carper D, Burg MB.
Am. J. Physiol. 1990 Jan;258(1 Pt 2):F154-61.
[Text Abstract on PubMed]

Counteracting effects of urea and betaine in mammalian cells in culture.
Yancey PH, Burg MB.
Am. J. Physiol. 1990 Jan;258(1 Pt 2):R198-204.
[Text Abstract on PubMed]

Osmoregulatory fluxes of myo-inositol and betaine in renal cells.
Nakanishi T, Burg MB.
Am. J. Physiol. 1989 Nov;257(5 Pt 1):C964-70.
[Text Abstract on PubMed]

Osmotic regulation of aldose reductase protein synthesis in renal medullary cells.
Moriyama T, Garcia-Perez A, Burg MB.
J. Biol. Chem. 1989 Oct 5;264(28):16810-4.
[Text Abstract on PubMed]

Molecular cloning of cDNA coding for kidney aldose reductase. Regulation of specific mRNA accumulation by NaCl-mediated osmotic stress.
Garcia-Perez A, Martin B, Murphy HR, Uchida S, Murer H, Cowley, Handler JS, Burg MB.
J. Biol. Chem. 1989 Oct 5;264(28):16815-21.
[Text Abstract on PubMed]

Osmoregulation of glycerophosphorylcholine content of mammalian renal cells.
Nakanishi T, Burg MB.
Am. J. Physiol. 1989 Oct;257(4 Pt 1):C795-801.
[Text Abstract on PubMed]

Distribution of major organic osmolytes in rabbit kidneys in diuresis and antidiuresis.
Yancey PH, Burg MB.
Am. J. Physiol. 1989 Oct;257(4 Pt 2):F602-7.
[Text Abstract on PubMed]

Osmoregulatory changes in myo-inositol transport by renal cells.
Nakanishi T, Turner RJ, Burg MB.
Proc. Natl. Acad. Sci. U.S.A. 1989 Aug;86(15):6002-6.
[Text Abstract on PubMed]

Survey of osmolytes in renal cell lines.
Nakanishi T, Balaban RS, Burg MB.
Am. J. Physiol. 1988 Aug;255(2 Pt 1):C181-91.
[Text Abstract on PubMed]

Active NH4+ absorption by the thick ascending limb.
Garvin JL, Burg MB, Knepper MA.
Am. J. Physiol. 1988 Jul;255(1 Pt 2):F57-65.
[Text Abstract on PubMed]

Osmoregulation by slow changes in aldose reductase and rapid changes in sorbitol flux.
Bagnasco SM, Murphy HR, Bedford JJ, Burg MB.
Am. J. Physiol. 1988 Jun;254(6 Pt 1):C788-92.
[Text Abstract on PubMed]

Role of aldose reductase and sorbitol in maintaining the medullary intracellular milieu.
Burg MB.
Kidney Int. 1988 Mar;33(3):635-41.
[Text Abstract on PubMed]

Sorbitol, osmoregulation, and the complications of diabetes.
Burg MB, Kador PF.
J. Clin. Invest. 1988 Mar;81(3):635-40.
[Text Abstract on PubMed]

Disequilibrium pH and ammonia transport in isolated perfused cortical collecting ducts.
Star RA, Kurtz I, Mejia R, Burg MB, Knepper MA.
Am. J. Physiol. 1987 Dec;253(6 Pt 2):F1232-42.
[Text Abstract on PubMed]

Characterization and purification of a mammalian osmoregulatory protein, aldose reductase, induced in renal medullary cells by high extracellular NaCl.
Bedford JJ, Bagnasco SM, Kador PF, Harris, Burg MB.
J. Biol. Chem. 1987 Oct 15;262(29):14255-9.
[Text Abstract on PubMed]

Control of steady-state pH in rabbit proximal straight tubules.
Atkins JL, Burg MB.
Am. J. Physiol. 1987 Aug;253(2 Pt 2):F282-9.
[Text Abstract on PubMed]

Ammonium, urea, and systemic pH regulation.
Knepper MA, Burg MB, Orloff J, Berliner RW, Rector.
Am. J. Physiol. 1987 Jul;253(1 Pt 2):F199-202.
[Text Abstract on PubMed]

Luminal disequilibrium pH and ammonia transport in outer medullary collecting duct [corrected and issued with original paging in Am J Physiol 1987 Aug;253(2 Pt 2)].
Star RA, Burg MB, Knepper MA.
Am. J. Physiol. 1987 Jun;252(6 Pt 2):F1148-57.
[Text Abstract on PubMed]

Induction of aldose reductase and sorbitol in renal inner medullary cells by elevated extracellular NaCl.
Bagnasco SM, Uchida S, Balaban RS, Kador PF, Burg MB.
Proc. Natl. Acad. Sci. U.S.A. 1987 Mar;84(6):1718-20.
[Text Abstract on PubMed]

Osmotically active organic solutes in the renal inner medulla.
Balaban RS, Burg MB.
Kidney Int. 1987 Feb;31(2):562-4.
[Text Abstract on PubMed]

NH3 and NH4+ transport by rabbit renal proximal straight tubules.
Garvin JL, Burg MB, Knepper MA.
Am. J. Physiol. 1987 Feb;252(2 Pt 2):F232-9.
[Text Abstract on PubMed]

Single tubule perfusion techniques.
Burg MB, Knepper MA.
Kidney Int. 1986 Aug;30(2):166-70.
[Text Abstract on PubMed]

Effects of vasopressin and bradykinin on anion transport by the rat cortical collecting duct. Evidence for an electroneutral sodium chloride transport pathway.
Tomita K, Pisano JJ, Burg MB, Knepper MA.
J. Clin. Invest. 1986 Jan;77(1):136-41.
[Text Abstract on PubMed]

Ammonia and bicarbonate transport by rat cortical collecting ducts perfused in vitro.
Knepper MA, Good DW, Burg MB.
Am. J. Physiol. 1985 Dec;249(6 Pt 2):F870-7.
[Text Abstract on PubMed]

Ammonium replaces potassium in supporting sodium transport by the Na-K-ATPase of renal proximal straight tubules.
Garvin JL, Burg MB, Knepper MA.
Am. J. Physiol. 1985 Nov;249(5 Pt 2):F785-8.
[Text Abstract on PubMed]

Bicarbonate transport by isolated perfused rat collecting ducts.
Atkins JL, Burg MB.
Am. J. Physiol. 1985 Oct;249(4 Pt 2):F485-9.
[Text Abstract on PubMed]

Bicarbonate secretion and chloride absorption by rabbit cortical collecting ducts. Role of chloride/bicarbonate exchange.
Star RA, Burg MB, Knepper MA.
J. Clin. Invest. 1985 Sep;76(3):1123-30.
[Text Abstract on PubMed]

Deoxycorticosterone-stimulated bicarbonate secretion in rabbit cortical collecting ducts: effects of luminal chloride removal and in vivo acid loading.
Garcia-Austt J, Good DW, Burg MB, Knepper MA.
Am. J. Physiol. 1985 Aug;249(2 Pt 2):F205-12.
[Text Abstract on PubMed]

Ammonia absorption by the thick ascending limb of Henle's loop.
Good DW, Knepper MA, Burg MB.
Contrib Nephrol. 1985;47:110-5.
[Text Abstract on PubMed]

Mechanism of ammonia secretion by rabbit cortical collecting ducts. Quantitative considerations.
Knepper MA, Good DW, Burg MB.
Contrib Nephrol. 1985;47:116-24.
[Text Abstract on PubMed]

Mechanism of ammonia secretion by cortical collecting ducts of rabbits.
Knepper MA, Good DW, Burg MB.
Am. J. Physiol. 1984 Nov;247(5 Pt 2):F729-38.
[Text Abstract on PubMed]

Aldosterone-stimulated sodium uptake by apical membrane vesicles from A6 cells.
Sariban-Sohraby S, Burg MB, Turner RJ.
J. Biol. Chem. 1984 Sep 25;259(18):11221-5.
[Text Abstract on PubMed]

Ammonia and bicarbonate transport by thick ascending limb of rat kidney.
Good DW, Knepper MA, Burg MB.
Am. J. Physiol. 1984 Jul;247(1 Pt 2):F35-44.
[Text Abstract on PubMed]

Ammonia production by individual segments of the rat nephron.
Good DW, Burg MB.
J. Clin. Invest. 1984 Mar;73(3):602-10.
[Text Abstract on PubMed]

Apical sodium uptake in toad kidney epithelial cell line A6.
Sariban-Sohraby S, Burg MB, Turner RJ.
Am. J. Physiol. 1983 Sep;245(3):C167-71.
[Text Abstract on PubMed]

Thick ascending limb of Henle's loop.
Burg MB.
Kidney Int. 1982 Nov;22(5):454-64.
[Text Abstract on PubMed]

Isolated perfused tubule. Introduction: background and development of microperfusion technique.
Burg MB.
Kidney Int. 1982 Nov;22(5):417-24.
[Text Abstract on PubMed]

Sodium transport in the rabbit connecting tubule.
Almeida AJ, Burg MB.
Am. J. Physiol. 1982 Oct;243(4):F330-4.
[Text Abstract on PubMed]

Increased fluid absorption and cell volume in isolated rabbit proximal straight tubules after in vivo DOCA administration.
Knepper MA, Burg MB.
Am. J. Physiol. 1981 Nov;241(5):F502-8.
[Text Abstract on PubMed]

The significance of nephron heterogeneity.
Burg MB.
Nihon Jinzo Gakkai Shi. 1981 Jul;23(7):957-64.
[Text Abstract on PubMed]

Mineralocorticoid effects on Na-K-ATPase in individual nephron segments.
Garg LC, Knepper MA, Burg MB.
Am. J. Physiol. 1981 Jun;240(6):F536-44.
[Text Abstract on PubMed]

Carbon dioxide permeability of rabbit proximal convoluted tubules.
Schwartz GJ, Weinstein AM, Steele RE, Stephenson JL, Burg MB.
Am. J. Physiol. 1981 Mar;240(3):F231-44.
[Text Abstract on PubMed]

Effect of acid-base status in vivo on bicarbonate transport by rabbit renal tubules in vitro.
Iino Y, Burg MB.
Jpn. J. Physiol. 1981;31(1):99-107.
[Text Abstract on PubMed]

Secretion and reabsorption of bicarbonate in single renal tubules of the rabbit.
Burg MB.
Ann. N. Y. Acad. Sci. 1980;341:225-32.
[Text Abstract on PubMed]

Effect of parathyroid hormone on bicarbonate absorption by proximal tubules in vitro.
Iino Y, Burg MB.
Am. J. Physiol. 1979 Apr;236(4):F387-91.
[Text Abstract on PubMed]

Mineralocorticoid effects on cation transport by cortical collecting tubules in vitro.
Schwartz GJ, Burg MB.
Am. J. Physiol. 1978 Dec;235(6):F576-85.
[Text Abstract on PubMed]

The nephron in transport of sodium, amino acids, and glucose.
Burg MB.
Hosp Pract. 1978 Oct;13(10):99-109.
[Text Abstract on PubMed]

Bicarbonate secretion by rabbit cortical collecting tubules in vitro.
McKinney TD, Burg MB.
J. Clin. Invest. 1978 Jun;61(6):1421-7.
[Text Abstract on PubMed]

Contribution of leaked load to solute transport by renal tubules.
Warnock DG, Patlak CS, Burg MB.
Am. J. Physiol. 1978 Jun;234(6):F480-4.
[Text Abstract on PubMed]

Bicarbonate absorption by rabbit cortical collecting tubules in vitro.
McKinney TD, Burg MB.
Am. J. Physiol. 1978 Feb;234(2):F141-5.
[Text Abstract on PubMed]

Bicarbonate transport by rabbit cortical collecting tubules. Effect of acid and alkali loads in vivo on transport in vitro.
McKinney TD, Burg MB.
J. Clin. Invest. 1977 Sep;60(3):766-8.
[Text Abstract on PubMed]

Biocarbonate and fluid absorption by renal proximal straight tubules.
McKinney TD, Burg MB.
Kidney Int. 1977 Jul;12(1):1-8.
[Text Abstract on PubMed]

Urinary acidification: CO2 transport by the rabbit proximal straight tubule.
Warnock DG, Burg MB.
Am. J. Physiol. 1977 Jan;232(1):F20-5.
[Text Abstract on PubMed]

Role of monovalent ions in the reabsorption of fluid by isolated perfused proximal renal tubules of the rabbit.
Burg MB, Green N.
Kidney Int. 1976 Sep;10(3):221-8.
[Text Abstract on PubMed]

Renal chloride transport and diuretics.
Burg MB.
Circulation. 1976 Apr;53(4):587-8.
[Text Abstract on PubMed]

Tubular chloride transport and the mode of action of some diuretics.
Burg MB.
Kidney Int. 1976 Feb;9(2):189-97.
[Text Abstract on PubMed]

Effect of acid lumen pH on potassium transport in renal cortical collecting tubules.
Boudry JF, Stoner LC, Burg MB.
Am. J. Physiol. 1976 Jan;230(1):239-44.
[Text Abstract on PubMed]

Lack of relationship of potential difference to fluid absorption in the proximal renal tubule.
Cardinal J, Lutz MD, Burg MB, Orloff J.
Kidney Int. 1975 Feb;7(2):94-102.
[Text Abstract on PubMed]

Ion transport in cortical collecting tubule; effect of amiloride.
Stoner LC, Burg MB, Orloff J.
Am. J. Physiol. 1974 Aug;227(2):453-9.
[Text Abstract on PubMed]

Electrical resistance of renal proximal tubule perfused in vitro.
Lutz MD, Cardinal J, Burg MB.
Am. J. Physiol. 1973 Sep;225(3):729-34.
[Text Abstract on PubMed]

Function of the thick ascending limb of Henle's loop.
Burg MB, Green N.
Am. J. Physiol. 1973 Mar;224(3):659-68.
[Text Abstract on PubMed]

Perfusion of isolated renal tubules.
Burg MB.
Yale J Biol Med. 1972 Jun-Aug;45(3-4):321-6.
[Text Abstract on PubMed]

Effect of vasopressin on sodium transport in renal cortical collecting tubules.
Frindt G, Burg MB.
Kidney Int. 1972 Apr;1(4):224-31.
[Text Abstract on PubMed]

Glucose transport by proximal renal tubules.
Tune BM, Burg MB.
Am. J. Physiol. 1971 Aug;221(2):580-5.
[Text Abstract on PubMed]

Effect of vasopressin on electrical resistance of renal cortical collecting tubules.
Helman SI, Grantham JJ, Burg MB.
Am. J. Physiol. 1971 Jun;220(6):1825-32.
[Text Abstract on PubMed]

Characteristics of NaCl and water transport in the renal proximal tubule.
Kokko JP, Burg MB, Orloff J.
J. Clin. Invest. 1971 Jan;50(1):69-76.
[Text Abstract on PubMed]

Electrical potential difference across proximal convoluted tubules.
Burg MB, Orloff J.
Am. J. Physiol. 1970 Dec;219(6):1714-6.
[Text Abstract on PubMed]

Iodopyracet transport by isolated perfused flounder proximal renal tubules.
Burg MB, Weller PF.
Am. J. Physiol. 1969 Oct;217(4):1053-6.
[Text Abstract on PubMed]

Characteristics of p-aminohippurate transport in proximal renal tubules.
Tune BM, Burg MB, Patlak CS.
Am. J. Physiol. 1969 Oct;217(4):1057-63.
[Text Abstract on PubMed]

p-Aminohippurate uptake and exchange by separated renal tubules.
Burg MB, Orloff J.
Am. J. Physiol. 1969 Oct;217(4):1064-8.
[Text Abstract on PubMed]

Paths of transtubular water flow in isolated renal collecting tubules.
Grantham JJ, Ganote CE, Burg MB, Orloff J.
J. Cell Biol. 1969 May;41(2):562-76.
[Text Abstract on PubMed]

Electrical properties of isolated perfused rabbit renal tubules.
Burg MB, Issaacson L, Grantham J, Orloff J.
Am. J. Physiol. 1968 Oct;215(4):788-94.
[Text Abstract on PubMed]

Control of fluid absorption in the renal proximal tubule.
Burg MB, Orloff J.
J. Clin. Invest. 1968 Sep;47(9):2016-24.
[Text Abstract on PubMed]

Ultrastructural studies of vasopressin effect on isolated perfused renal collecting tubules of the rabbit.
Ganote CE, Grantham JJ, Moses HL, Burg MB, Orloff J.
J. Cell Biol. 1968 Feb;36(2):355-67.
[Text Abstract on PubMed]

Chloride flux in rabbit kidney tubules in vitro.
Abramow M, Burg MB, Orloff J.
Am. J. Physiol. 1967 Nov;213(5):1249-53.
[Text Abstract on PubMed]

Localization of tissue sodium and potassium compartments in rabbit renal cortex.
Burg MB, Abramow M.
Am. J. Physiol. 1966 Oct;211(4):1011-7.
[Text Abstract on PubMed]

Effect of temperature and medium K on Na and K fluxes in separated renal tubules.
Burg MB, Orloff J.
Am. J. Physiol. 1966 Oct;211(4):1005-10.
[Text Abstract on PubMed]

Effect of vasopressin and cyclic AMP on permeability of isolated collecting tubules.
Grantham JJ, Burg MB.
Am. J. Physiol. 1966 Jul;211(1):255-9.
[Text Abstract on PubMed]

ACTIVE CATION TRANSPORT BY KIDNEY TUBULES AT O C.
BURG MB, ORLOFF J.
Am. J. Physiol. 1964 Nov;207:983-8.
[Text Abstract on PubMed]

SODIUM AND POTASSIUM FLUX OF SEPARATED RENAL TUBULES.
BURG MB, GROLLMAN EF, ORLOFF J.
Am. J. Physiol. 1964 Mar;206:483-91.
[Text Abstract on PubMed]

Effect of strophanthidin on fluxes of potassium in rabbit kidney slices.
BURG MB, ORLOFF J.
Am. J. Physiol. 1963 Jul;205:139-46.
[Text Abstract on PubMed]

Oxygen consumption and active transport in separated renal tubules.
BURG MB, ORLOFF J.
Am. J. Physiol. 1962 Aug;203:327-30.
[Text Abstract on PubMed]

Effect of strophanthidin on electrolyte content and PAH accumulation of rabbit kidney slices.
BURG MB, ORLOFF J.
Am. J. Physiol. 1962 Mar;202:565-71.
[Text Abstract on PubMed]

The pathogenesis of hyponatremia in congestive heart failure.
ORLOFF J, BURG MB.
Prog Cardiovasc Dis. 1961 May;3:600-10.
[Text Abstract on PubMed]

Factors influencing the diuretic response to ingested water.
BURG MB, PAPPER S, ROSENBAUM JD.
J. Lab. Clin. Med. 1961 Apr;57:533-45.
[Text Abstract on PubMed]

The effect of morphine sulfate upon the renal excretion of water and solute in man.
PAPPER S, SAXON L, BURG MB, SEIFER HW, ROSENBAUM JD.
J. Lab. Clin. Med. 1957 Nov;50(5):692-704.
[Text Abstract on PubMed]

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