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Manfred Boehm, M.D.


Principal Investigator thumbnail image

Manfred Boehm
Senior Investigator

P: +1 301 435 7211
F: +1 301 451 7090

Full Publications Listing

Circulating Blood Endothelial Nitric Oxide Synthase Contributes to the Regulation of Systemic Blood Pressure and Nitrite Homeostasis.
Wood KC, Cortese-Krott MM, Kovacic JC, Noguchi A, Liu VB, Wang X, Raghavachari N, Boehm M, Kato GJ, Kelm M, Gladwin MT.
Arterioscler Thromb Vasc Biol. 2013 May 23.
[Text Abstract on PubMed]

The benefits and risks of stem cell technology.
Leventhal A, Chen G, Negro A, Boehm M.
Oral Dis. 2012 Apr;18(3):217-22.
[Text Abstract on PubMed]

Epithelial-to-mesenchymal and endothelial-to-mesenchymal transition: from cardiovascular development to disease.
Kovacic JC, Mercader N, Torres M, Boehm M, Fuster V.
Circulation. 2012 Apr 10;125(14):1795-808.
[Text Abstract on PubMed]

The NIH Undiagnosed Diseases Program: bonding scientists and clinicians.
Gahl WA, Boerkoel CF, Boehm M.
Dis Model Mech. 2012 Jan;5(1):3-5.
[Text Abstract on PubMed]

Perivascular T-cell infiltration leads to sustained pulmonary artery remodeling after endothelial cell damage.
Cuttica MJ, Langenickel T, Noguchi A, Machado RF, Gladwin MT, Boehm M.
Am. J. Respir. Cell Mol. Biol. 2011 Jul;45(1):62-71.
[Text Abstract on PubMed]

Vascular pathology of medial arterial calcifications in NT5E deficiency: implications for the role of adenosine in pseudoxanthoma elasticum.
Markello TC, Pak LK, St Hilaire C, Dorward H, Ziegler SG, Chen MY, Chaganti K, Nussbaum RL, Boehm M, Gahl WA.
Mol. Genet. Metab. 2011 May;103(1):44-50.
[Text Abstract on PubMed]

NT5E mutations and arterial calcifications.
St Hilaire C, Ziegler SG, Markello TC, Brusco A, Groden C, Gill F, Carlson-Donohoe H, Lederman RJ, Chen MY, Yang D, Siegenthaler MP, Arduino C, Mancini C, Freudenthal B, Stanescu HC, Zdebik AA, Chaganti RK, Nussbaum RL, Kleta R, Gahl WA, Boehm M.
N. Engl. J. Med. 2011 Feb 3;364(5):432-42.
[Text Abstract on PubMed]

Conservation and diversification of dileucine signal recognition by adaptor protein (AP) complex variants.
Mattera R, Boehm M, Chaudhuri R, Prabhu Y, Bonifacino JS.
J. Biol. Chem. 2011 Jan 21;286(3):2022-30.
[Text Abstract on PubMed]

It ANKH necessarily so.
Collins MT, Boehm M.
J. Clin. Endocrinol. Metab. 2011 Jan;96(1):72-4.
[Text Abstract on PubMed]

Major histocompatibility complex-I expression on embryonic stem cell-derived vascular progenitor cells is critical for syngeneic transplant survival.
Ma M, Ding S, Lundqvist A, San H, Fang F, Konoplyannikov M, Berry C, Beltran LE, Chen G, Kovacic JC, Boehm M.
Stem Cells. 2010 Sep;28(9):1465-75.
[Text Abstract on PubMed]

Deficiency of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1 accelerates atherogenesis in apolipoprotein E-deficient mice.
Akyürek LM, Boehm M, Olive M, Zhou AX, San H, Nabel EG.
Biochem. Biophys. Res. Commun. 2010 May 28;396(2):359-63.
[Text Abstract on PubMed]

Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice.
Kovacic JC, Gupta R, Lee AC, Ma M, Fang F, Tolbert CN, Walts AD, Beltran LE, San H, Chen G, St Hilaire C, Boehm M.
J. Clin. Invest. 2010 Jan;120(1):303-14.
[Text Abstract on PubMed]

Histone H2AX is integral to hypoxia-driven neovascularization.
Economopoulou M, Langer HF, Celeste A, Orlova VV, Choi EY, Ma M, Vassilopoulos A, Callen E, Deng C, Bassing CH, Boehm M, Nussenzweig A, Chavakis T.
Nat. Med. 2009 May;15(5):553-8.
[Text Abstract on PubMed]

Neuropilin-1 identifies endothelial precursors in human and murine embryonic stem cells before CD34 expression.
Cimato T, Beers J, Ding S, Ma M, McCoy JP, Boehm M, Nabel EG.
Circulation. 2009 Apr 28;119(16):2170-8.
[Text Abstract on PubMed]

Resident vascular progenitor cells: an emerging role for non-terminally differentiated vessel-resident cells in vascular biology.
Kovacic JC, Boehm M.
Stem Cell Res. 2009 Jan;2(1):2-15.
[Text Abstract on PubMed]

KIS protects against adverse vascular remodeling by opposing stathmin-mediated VSMC migration in mice.
Langenickel TH, Olive M, Boehm M, San H, Crook MF, Nabel EG.
J. Clin. Invest. 2008 Dec;118(12):3848-59.
[Text Abstract on PubMed]

VEGFR1/CXCR4-positive progenitor cells modulate local inflammation and augment tissue perfusion by a SDF-1-dependent mechanism.
Wragg A, Mellad JA, Beltran LE, Konoplyannikov M, San H, Boozer S, Deans RJ, Mathur A, Lederman RJ, Kovacic JC, Boehm M.
J. Mol. Med. 2008 Nov;86(11):1221-32.
[Text Abstract on PubMed]

Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells.
Schieke SM, Ma M, Cao L, McCoy, Liu C, Hensel NF, Barrett AJ, Boehm M, Finkel T.
J. Biol. Chem. 2008 Oct 17;283(42):28506-12.
[Text Abstract on PubMed]

p21Cip1 modulates arterial wound repair through the stromal cell-derived factor-1/CXCR4 axis in mice.
Olive M, Mellad JA, Beltran LE, Ma M, Cimato T, Noguchi AC, San H, Childs R, Kovacic JC, Boehm M.
J. Clin. Invest. 2008 Jun;118(6):2050-61.
[Text Abstract on PubMed]

Endothelial progenitor cells, angioblasts, and angiogenesis--old terms reconsidered from a current perspective.
Kovacic JC, Moore J, Herbert A, Ma D, Boehm M, Graham RM.
Trends Cardiovasc. Med. 2008 Feb;18(2):45-51.
[Text Abstract on PubMed]

GA-binding protein regulates KIS gene expression, cell migration, and cell cycle progression.
Crook MF, Olive M, Xue HH, Langenickel TH, Boehm M, Leonard WJ, Nabel EG.
FASEB J. 2008 Jan;22(1):225-35.
[Text Abstract on PubMed]

Heme oxygenase-1 deficiency accelerates formation of arterial thrombosis through oxidative damage to the endothelium, which is rescued by inhaled carbon monoxide.
True AL, Olive M, Boehm M, San H, Westrick RJ, Raghavachari N, Xu X, Lynn EG, Sack MN, Munson PJ, Gladwin MT, Nabel EG.
Circ. Res. 2007 Oct 26;101(9):893-901.
[Text Abstract on PubMed]

The arginine methyltransferase PRMT2 binds RB and regulates E2F function.
Yoshimoto T, Boehm M, Olive M, Crook MF, San H, Langenickel T, Nabel EG.
Exp. Cell Res. 2006 Jul 1;312(11):2040-53.
[Text Abstract on PubMed]

The cell cycle regulator p27Kip1 interacts with MCM7, a DNA replication licensing factor, to inhibit initiation of DNA replication.
Nallamshetty S, Crook M, Boehm M, Yoshimoto T, Olive M, Nabel EG.
FEBS Lett. 2005 Dec 5;579(29):6529-36.
[Text Abstract on PubMed]

Bone marrow-derived immune cells regulate vascular disease through a p27(Kip1)-dependent mechanism.
Boehm M, Olive M, True AL, Crook MF, San H, Qu X, Nabel EG.
J. Clin. Invest. 2004 Aug;114(3):419-26.
[Text Abstract on PubMed]

Retinoic acid causes cell growth arrest and an increase in p27 in F9 wild type but not in F9 retinoic acid receptor beta2 knockout cells.
Li R, Faria TN, Boehm M, Nabel EG, Gudas LJ.
Exp. Cell Res. 2004 Mar 10;294(1):290-300.
[Text Abstract on PubMed]

p21(CIP1) Controls proliferating cell nuclear antigen level in adult cardiomyocytes.
Engel FB, Hauck L, Boehm M, Nabel EG, Dietz R, von Harsdorf R.
Mol. Cell. Biol. 2003 Jan;23(2):555-65.
[Text Abstract on PubMed]

The cell cycle and cardiovascular diseases.
Boehm M, Nabel EG.
Prog Cell Cycle Res. 2003;5:19-30.
[Text Abstract on PubMed]

Angiotensin-converting enzyme 2--a new cardiac regulator.
Boehm M, Nabel EG.
N. Engl. J. Med. 2002 Nov 28;347(22):1795-7.
[Text Abstract on PubMed]

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.
Boehm M, Yoshimoto T, Crook MF, Nallamshetty S, True A, Nabel GJ, Nabel EG.
EMBO J. 2002 Jul 1;21(13):3390-401.
[Text Abstract on PubMed]

Cell cycle signaling and cardiovascular disease.
Nabel EG, Boehm M, Akyurek LM, Yoshimoto T, Crook MF, Olive M, San H, Qu X.
Cold Spring Harb. Symp. Quant. Biol. 2002;67:163-70.
[Text Abstract on PubMed]

Cell cycle and cell migration: new pieces to the puzzle.
Boehm M, Nabel EG.
Circulation. 2001 Jun 19;103(24):2879-81.
[Text Abstract on PubMed]

Heme oxygenase-1 protects against vascular constriction and proliferation.
Duckers HJ, Boehm M, True AL, Yet SF, San H, Park JL, Clinton Webb R, Lee ME, Nabel GJ, Nabel EG.
Nat. Med. 2001 Jun;7(6):693-8.
[Text Abstract on PubMed]

Differential effects of the cyclin-dependent kinase inhibitors p27(Kip1), p21(Cip1), and p16(Ink4) on vascular smooth muscle cell proliferation.
Tanner FC, Boehm M, Akyürek LM, San H, Yang ZY, Tashiro J, Nabel GJ, Nabel EG.
Circulation. 2000 May 2;101(17):2022-5.
[Text Abstract on PubMed]