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Michael Beaven, Ph.D.


Principal Investigator thumbnail image

Michael Beaven
Scientist Emeritus

P: +1 301 496 6188
F: +1 301 480 4852

Full Publications Listing

DJ-1 regulates mast cell activation and IgE-mediated allergic responses.
Kim DK, Kim HS, Kim AR, Kim JH, Kim B, Noh G, Kim HS, Beaven MA, Kim YM, Choi WS.
J. Allergy Clin. Immunol. 2012 Nov 22.
[Text Abstract on PubMed]

Stem cell factor programs the mast cell activation phenotype.
Ito T, Smrž D, Jung MY, Bandara G, Desai A, Smržová Š, Kuehn HS, Beaven MA, Metcalfe DD, Gilfillan AM.
J. Immunol. 2012 Jun 1;188(11):5428-37.
[Text Abstract on PubMed]

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases.
Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown AL, Kim MK, Beaven MA, Burgin AB, Manganiello V, Chung JH.
Cell. 2012 Feb 3;148(3):421-33.
[Text Abstract on PubMed]

Distinct PGE2-responder and non-responder phenotypes in human mast cell populations: "all or nothing" enhancement of antigen-dependent mediator release.
Kuehn HS, Jung MY, Beaven MA, Metcalfe DD, Gilfillan AM.
Immunol. Lett. 2011 Dec 30;141(1):45-54.
[Text Abstract on PubMed]

Examination of the role of TRPM8 in human mast cell activation and its relevance to the etiology of cold-induced urticaria.
Medic N, Desai A, Komarow H, Burch LH, Bandara G, Beaven MA, Metcalfe DD, Gilfillan AM.
Cell Calcium. 2011 Nov;50(5):473-80.
[Text Abstract on PubMed]

The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice.
Lee JH, Kim JW, Kim do K, Kim HS, Park HJ, Park DK, Kim AR, Kim B, Beaven MA, Park KL, Kim YM, Choi WS.
J. Immunol. 2011 Aug 15;187(4):1807-15.
[Text Abstract on PubMed]

Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33.
Andrade MV, Iwaki S, Ropert C, Gazzinelli RT, Cunha-Melo JR, Beaven MA.
Eur. J. Immunol. 2011 Mar;41(3):760-72.
[Text Abstract on PubMed]

Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release.
Kuehn HS, Jung MY, Beaven MA, Metcalfe DD, Gilfillan AM.
J. Biol. Chem. 2011 Jan 7;286(1):391-402.
[Text Abstract on PubMed]

Regulators of Ca(2+) signaling in mast cells: potential targets for treatment of mast cell-related diseases?
Ma HT, Beaven MA.
Adv. Exp. Med. Biol. 2011;716:62-90.
[Text Abstract on PubMed]

Regulation of mast cell responses in health and disease.
Gilfillan AM, Beaven MA.
Crit. Rev. Immunol. 2011;31(6):475-529.
[Text Abstract on PubMed]

Interleukin-33 stimulates formation of functional osteoclasts from human CD14(+) monocytes.
Mun SH, Ko NY, Kim HS, Kim JW, Kim do K, Kim AR, Lee SH, Kim YG, Lee CK, Lee SH, Kim BK, Beaven MA, Kim YM, Choi WS.
Cell. Mol. Life Sci. 2010 Nov;67(22):3883-92.
[Text Abstract on PubMed]

Btk-dependent Rac activation and actin rearrangement following FcepsilonRI aggregation promotes enhanced chemotactic responses of mast cells.
Kuehn HS, Rådinger M, Brown JM, Ali K, Vanhaesebroeck B, Beaven MA, Metcalfe DD, Gilfillan AM.
J. Cell. Sci. 2010 Aug 1;123(Pt 15):2576-85.
[Text Abstract on PubMed]

Phospholipase d promotes lipid microdomain-associated signaling events in mast cells.
Lisboa FA, Peng Z, Combs CA, Beaven MA.
J. Immunol. 2009 Oct 15;183(8):5104-12.
[Text Abstract on PubMed]

Src-like adaptor protein (SLAP) is upregulated in antigen-stimulated mast cells and acts as a negative regulator.
Park SK, Qiao H, Beaven MA.
Mol. Immunol. 2009 Jun;46(10):2133-9.
[Text Abstract on PubMed]

Mechanism of upregulation of the inhibitory regulator, src-like adaptor protein (SLAP), by glucocorticoids in mast cells.
Park SK, Beaven MA.
Mol. Immunol. 2009 Jan;46(3):492-7.
[Text Abstract on PubMed]

Our perception of the mast cell from Paul Ehrlich to now.
Beaven MA.
Eur. J. Immunol. 2009 Jan;39(1):11-25.
[Text Abstract on PubMed]

Regulation of Ca2+ signaling with particular focus on mast cells.
Ma HT, Beaven MA.
Crit. Rev. Immunol. 2009;29(2):155-86.
[Text Abstract on PubMed]

Canonical transient receptor potential 5 channel in conjunction with Orai1 and STIM1 allows Sr2+ entry, optimal influx of Ca2+, and degranulation in a rat mast cell line.
Ma HT, Peng Z, Hiragun T, Iwaki S, Gilfillan AM, Beaven MA.
J. Immunol. 2008 Feb 15;180(4):2233-9.
[Text Abstract on PubMed]

Division of labor: specialization of sphingosine kinases in mast cells.
Beaven MA.
Immunity. 2007 Mar;26(3):271-3.
[Text Abstract on PubMed]

Cutting edge: dexamethasone negatively regulates Syk in mast cells by up-regulating SRC-like adaptor protein.
Hiragun T, Peng Z, Beaven MA.
J. Immunol. 2006 Aug 15;177(4):2047-50.
[Text Abstract on PubMed]

Phospholipase D2 acts as an essential adaptor protein in the activation of Syk in antigen-stimulated mast cells.
Lee JH, Kim YM, Kim NW, Kim JW, Her E, Kim BK, Kim JH, Ryu SH, Park JW, Seo DW, Han JW, Beaven MA, Choi WS.
Blood. 2006 Aug 1;108(3):956-64.
[Text Abstract on PubMed]

FcepsilonR1 and toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cells.
Qiao H, Andrade MV, Lisboa FA, Morgan K, Beaven MA.
Blood. 2006 Jan 15;107(2):610-8.
[Text Abstract on PubMed]

An essential role for phospholipase D in the activation of protein kinase C and degranulation in mast cells.
Peng Z, Beaven MA.
J. Immunol. 2005 May 1;174(9):5201-8.
[Text Abstract on PubMed]

Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cells.
Hiragun T, Peng Z, Beaven MA.
Mol. Pharmacol. 2005 Mar;67(3):598-603.
[Text Abstract on PubMed]

Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells.
Hundley TR, Gilfillan AM, Tkaczyk C, Andrade MV, Metcalfe DD, Beaven MA.
Blood. 2004 Oct 15;104(8):2410-7.
[Text Abstract on PubMed]

Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr.
Choi WS, Hiragun T, Lee JH, Kim YM, Kim HP, Chahdi A, Her E, Han JW, Beaven MA.
Mol. Cell. Biol. 2004 Aug;24(16):6980-92.
[Text Abstract on PubMed]

Dexamethasone suppresses antigen-induced activation of phosphatidylinositol 3-kinase and downstream responses in mast cells.
Andrade MV, Hiragun T, Beaven MA.
J. Immunol. 2004 Jun 15;172(12):7254-62.
[Text Abstract on PubMed]

Mastoparan selectively activates phospholipase D2 in cell membranes.
Chahdi A, Choi WS, Kim YM, Beaven MA.
J. Biol. Chem. 2003 Apr 4;278(14):12039-45.
[Text Abstract on PubMed]

Serine/threonine protein kinases synergistically regulate phospholipase D1 and 2 and secretion in RBL-2H3 mast cells.
Chahdi A, Choi WS, Kim YM, Fraundorfer PF, Beaven MA.
Mol. Immunol. 2002 Sep;38(16-18):1269-76.
[Text Abstract on PubMed]

Phospholipases D1 and D2 regulate different phases of exocytosis in mast cells.
Choi WS, Kim YM, Combs C, Frohman MA, Beaven MA.
J. Immunol. 2002 Jun 1;168(11):5682-9.
[Text Abstract on PubMed]

Compound 48/80 activates mast cell phospholipase D via heterotrimeric GTP-binding proteins.
Chahdi A, Fraundorfer PF, Beaven MA.
J. Pharmacol. Exp. Ther. 2000 Jan;292(1):122-30.
[Text Abstract on PubMed]

Thapsigargin-induced secretion is dependent on activation of a cholera toxin-sensitive and phosphatidylinositol-3-kinase-regulated phospholipase D in a mast cell line.
Cissel DS, Fraundorfer PF, Beaven MA.
J. Pharmacol. Exp. Ther. 1998 Apr;285(1):110-8.
[Text Abstract on PubMed]

Mitogen-activated protein (MAP) kinase regulates production of tumor necrosis factor-alpha and release of arachidonic acid in mast cells. Indications of communication between p38 and p42 MAP kinases.
Zhang C, Baumgartner RA, Yamada K, Beaven MA.
J. Biol. Chem. 1997 May 16;272(20):13397-402.
[Text Abstract on PubMed]

Downstream signals initiated in mast cells by Fc epsilon RI and other receptors.
Beaven MA, Baumgartner RA.
Curr. Opin. Immunol. 1996 Dec;8(6):766-72.
[Text Abstract on PubMed]

Constitutive and inducible mechanisms for synthesis and release of cytokines in immune cell lines.
Baumgartner RA, Deramo VA, Beaven MA.
J. Immunol. 1996 Nov 1;157(9):4087-93.
[Text Abstract on PubMed]

Syk-dependent phosphorylation of Shc. A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2.
Jabril-Cuenod B, Zhang C, Scharenberg AM, Paolini R, Numerof R, Beaven MA, Kinet JP.
J. Biol. Chem. 1996 Jul 5;271(27):16268-72.
[Text Abstract on PubMed]

Calcium signalling: sphingosine kinase versus phospholipase C?
Beaven MA.
Curr. Biol. 1996 Jul 1;6(7):798-801.
[Text Abstract on PubMed]

Sustained activation of phospholipase D via adenosine A3 receptors is associated with enhancement of antigen- and Ca(2+)-ionophore-induced secretion in a rat mast cell line.
Ali H, Choi OH, Fraundorfer PF, Yamada K, Gonzaga HM, Beaven MA.
J. Pharmacol. Exp. Ther. 1996 Feb;276(2):837-45.
[Text Abstract on PubMed]

Activation of the mitogen-activated protein kinase/cytosolic phospholipase A2 pathway in a rat mast cell line. Indications of different pathways for release of arachidonic acid and secretory granules.
Hirasawa N, Santini F, Beaven MA.
J. Immunol. 1995 May 15;154(10):5391-402.
[Text Abstract on PubMed]

A requirement for Syk in the activation of the microtubule-associated protein kinase/phospholipase A2 pathway by Fc epsilon R1 is not shared by a G protein-coupled receptor.
Hirasawa N, Scharenberg A, Yamamura H, Beaven MA, Kinet JP.
J. Biol. Chem. 1995 May 5;270(18):10960-7.
[Text Abstract on PubMed]

Antigen and thapsigargin promote influx of Ca2+ in rat basophilic RBL-2H3 cells by ostensibly similar mechanisms that allow filling of inositol 1,4,5-trisphosphate-sensitive and mitochondrial Ca2+ stores.
Ali H, Maeyama K, Sagi-Eisenberg R, Beaven MA.
Biochem. J. 1994 Dec 1;304 ( Pt 2):431-40.
[Text Abstract on PubMed]

Secretion of TNF from a rat mast cell line is a brefeldin A-sensitive and a calcium/protein kinase C-regulated process.
Baumgartner RA, Yamada K, Deramo VA, Beaven MA.
J. Immunol. 1994 Sep 15;153(6):2609-17.
[Text Abstract on PubMed]

Secretion from rat basophilic RBL-2H3 cells is associated with diphosphorylation of myosin light chains by myosin light chain kinase as well as phosphorylation by protein kinase C.
Choi OH, Adelstein RS, Beaven MA.
J. Biol. Chem. 1994 Jan 7;269(1):536-41.
[Text Abstract on PubMed]

Adenosine A3 receptors in mast cells.
Beaven MA, Ramkumar V, Ali H.
Trends Pharmacol. Sci. 1994 Jan;15(1):13-4.
[Text Abstract on PubMed]

Activation of exocytosis by the heterotrimeric G protein Gi3.
Aridor M, Rajmilevich G, Beaven MA, Sagi-Eisenberg R.
Science. 1993 Dec 3;262(5139):1569-72.
[Text Abstract on PubMed]

Antigen and carbachol mobilize calcium by similar mechanisms in a transfected mast cell line (RBL-2H3 cells) that expresses ml muscarinic receptors.
Choi OH, Lee JH, Kassessinoff T, Cunha-Melo JR, Jones SV, Beaven MA.
J. Immunol. 1993 Nov 15;151(10):5586-95.
[Text Abstract on PubMed]

The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells.
Ramkumar V, Stiles GL, Beaven MA, Ali H.
J. Biol. Chem. 1993 Aug 15;268(23):16887-90.
[Text Abstract on PubMed]

Signal transduction by Fc receptors: the Fc epsilon RI case.
Beaven MA, Metzger H.
Immunol. Today. 1993 May;14(5):222-6.
[Text Abstract on PubMed]

Different isozymes of protein kinase C mediate feedback inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells.
Ozawa K, Yamada K, Kazanietz MG, Blumberg PM, Beaven MA.
J. Biol. Chem. 1993 Feb 5;268(4):2280-3.
[Text Abstract on PubMed]

Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells.
Ozawa K, Szallasi Z, Kazanietz MG, Blumberg PM, Mischak H, Mushinski JF, Beaven MA.
J. Biol. Chem. 1993 Jan 25;268(3):1749-56.
[Text Abstract on PubMed]

The role of myosin phosphorylation in RBL-2H3 cell secretion.
Peleg I, Ludowyke RI, Beaven MA, Adelstein RS.
J. Lab. Clin. Med. 1992 Nov;120(5):675-80.
[Text Abstract on PubMed]

Carbachol induces secretion in a mast cell line (RBL-2H3) transfected with the ml muscarinic receptor gene.
Jones SV, Choi OH, Beaven MA.
FEBS Lett. 1991 Sep 2;289(1):47-50.
[Text Abstract on PubMed]

Calcium influx in a rat mast cell (RBL-2H3) line. Use of multivalent metal ions to define its characteristics and role in exocytosis.
Hide M, Beaven MA.
J. Biol. Chem. 1991 Aug 15;266(23):15221-9.
[Text Abstract on PubMed]

Activation of phospholipase C via adenosine receptors provides synergistic signals for secretion in antigen-stimulated RBL-2H3 cells. Evidence for a novel adenosine receptor.
Ali H, Cunha-Melo JR, Saul WF, Beaven MA.
J. Biol. Chem. 1990 Jan 15;265(2):745-53.
[Text Abstract on PubMed]

Antigen-induced secretion of histamine and the phosphorylation of myosin by protein kinase C in rat basophilic leukemia cells.
Ludowyke RI, Peleg I, Beaven MA, Adelstein RS.
J. Biol. Chem. 1989 Jul 25;264(21):12492-501.
[Text Abstract on PubMed]

Differential down-regulation of protein kinase C isozymes.
Huang FL, Yoshida Y, Cunha-Melo JR, Beaven MA, Huang KP.
J. Biol. Chem. 1989 Mar 5;264(7):4238-43.
[Text Abstract on PubMed]

Formation of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate from inositol 1,3,4,5-tetrakisphosphate and their pathways of degradation in RBL-2H3 cells.
Cunha-Melo JR, Dean NM, Ali H, Beaven MA.
J. Biol. Chem. 1988 Oct 5;263(28):14245-50.
[Text Abstract on PubMed]

Assessment of IgE-receptor function through measurement of hydrolysis of membrane inositol phospholipids. New insights on the phenomena of biphasic antigen concentration-response curves and desensitization.
Maeyama K, Hohman RJ, Ali H, Cunha-Melo JR, Beaven MA.
J. Immunol. 1988 Jun 1;140(11):3919-27.
[Text Abstract on PubMed]

Membrane phosphoinositide-activated signals in mast cells and basophils.
Beaven MA, Cunha-Melo JR.
Prog Allergy. 1988;42:123-84.
[Text Abstract on PubMed]

Synergistic signals in the mechanism of antigen-induced exocytosis in 2H3 cells: evidence for an unidentified signal required for histamine release.
Beaven MA, Guthrie DF, Moore JP, Smith GA, Hesketh TR, Metcalfe JC.
J. Cell Biol. 1987 Sep;105(3):1129-36.
[Text Abstract on PubMed]

Mechanism of signal transduction in mast cells and basophils: studies with RBL-2H3 cells.
Beaven MA, Maeyama K, Wolde-Mussie E, Lo TN, Ali H, Cunha-Melo JR.
Agents Actions. 1987 Apr;20(3-4):137-45.
[Text Abstract on PubMed]

Quantitative relationships between aggregation of IgE receptors, generation of intracellular signals, and histamine secretion in rat basophilic leukemia (2H3) cells. Enhanced responses with heavy water.
Maeyama K, Hohman RJ, Metzger H, Beaven MA.
J. Biol. Chem. 1986 Feb 25;261(6):2583-92.
[Text Abstract on PubMed]

Increase in cytosolic calcium and phosphoinositide metabolism induced by angiotensin II and [Arg]vasopressin in vascular smooth muscle cells.
Nabika T, Velletri PA, Lovenberg W, Beaven MA.
J. Biol. Chem. 1985 Apr 25;260(8):4661-70.
[Text Abstract on PubMed]

The mechanism of the calcium signal and correlation with histamine release in 2H3 cells.
Beaven MA, Rogers J, Moore JP, Hesketh TR, Smith GA, Metcalfe JC.
J. Biol. Chem. 1984 Jun 10;259(11):7129-36.
[Text Abstract on PubMed]

The calcium signal and phosphatidylinositol breakdown in 2H3 cells.
Beaven MA, Moore JP, Smith GA, Hesketh TR, Metcalfe JC.
J. Biol. Chem. 1984 Jun 10;259(11):7137-42.
[Text Abstract on PubMed]

Presence of histamine and histamine-metabolizing enzyme in rat and guinea-pig microvascular endothelial cells.
Robinson-White A, Beaven MA.
J. Pharmacol. Exp. Ther. 1982 Nov;223(2):440-5.
[Text Abstract on PubMed]

Histamine synthesis by intact mast cells from canine fundic mucosa and liver.
Beaven MA, Soll AH, Lewin KJ.
Gastroenterology. 1982 Feb;82(2):254-62.
[Text Abstract on PubMed]

Anaphylactoid reactions to anesthetic drugs.
Beaven MA.
Anesthesiology. 1981 Jul;55(1):3-5.
[Text Abstract on PubMed]

Isolation of histamine-containing cells from rat gastric mucosa: biochemical and morphologic differences from mast cells.
Soll AH, Lewin KJ, Beaven MA.
Gastroenterology. 1981 Apr;80(4):717-27.
[Text Abstract on PubMed]

Phylogeny of histamine in vertebrate brain.
Almeida AP, Beaven MA.
Brain Res. 1981 Mar 9;208(1):244-50.
[Text Abstract on PubMed]

Hormonal and hemodynamic profile of an anaphylactic reaction in man.
Moss J, Fahmy NR, Sunder N, Beaven MA.
Circulation. 1981 Jan;63(1):210-3.
[Text Abstract on PubMed]

Isolation of histamine-containing cells from canine fundic mucosa.
Soll AH, Lewin K, Beaven MA.
Gastroenterology. 1979 Dec;77(6):1283-90.
[Text Abstract on PubMed]

Specific allergic sensitsation to filarial antigens in tropical eosinophilia syndrome.
Ottesen EA, Neva FA, Paranjape RS, Tripathy SP, Thiruvengadam KV, Beaven MA.
Lancet. 1979 Jun 2;1(8127):1158-61.
[Text Abstract on PubMed]

Increased sensitivity of the enzymatic isotopic assay of histamine: measurement of histamine in plasma and serum.
Shaff RE, Beaven MA.
Anal. Biochem. 1979 Apr 15;94(2):425-30.
[Text Abstract on PubMed]

Evidence that indomethacin reversibly inhibits cell growth in the G1 phase of the cell cycle.
Bayer BM, Beaven MA.
Biochem. Pharmacol. 1979;28(3):441-3.
[Text Abstract on PubMed]

A microprocedure for the measurement of 14CO2 release from [14C]carboxyl-labeled amino acids.
Beaven MA, Wilcox G, Terpstra GK.
Anal. Biochem. 1978 Feb;84(2):638-41.
[Text Abstract on PubMed]

Histamine: its role in physiological and pathological processes.
Beaven MA.
Monogr Allergy. 1978;13:1-113.
[Text Abstract on PubMed]

Antiproliferative activity of anti-inflammatory drugs in two mammalian cell culture lines.
Hial V, De Mello MC, Horakova Z, Beaven MA.
J. Pharmacol. Exp. Ther. 1977 Aug;202(2):446-54.
[Text Abstract on PubMed]

In vivo studies of the pathogenesis of cold urticaria, cholinergic urticaria, and vibration-induced swelling.
Kaplan AP, Beaven MA.
J. Invest. Dermatol. 1976 Sep;67(3):327-32.
[Text Abstract on PubMed]

Hereditary vibratory angioedema: confirmation of histamine release in a type of physical hypersensitivity.
Metzger WJ, Kaplan AP, Beaven MA, Irons JS, Patterson R.
J. Allergy Clin. Immunol. 1976 Jun;57(6):605-8.
[Text Abstract on PubMed]

Alteration of tumor growth by aspirin and indomethacin: studies with two transplantable tumors in mouse.
Hial V, Horakova Z, Shaff FE, Beaven MA.
Eur. J. Pharmacol. 1976 Jun;37(2):367-76.
[Text Abstract on PubMed]

Turnover and synthesis of diamine oxidase (DAO) in rat tissues. Studies with heparin and cycloheximide.
Shaff RE, Beaven MA.
Biochem. Pharmacol. 1976 May 1;25(9):1057-62.
[Text Abstract on PubMed]

Histamine (second of two parts).
Beaven MA.
N. Engl. J. Med. 1976 Feb 5;294(6):320-5.
[Text Abstract on PubMed]

Histamine (first of two parts).
Beaven MA.
N. Engl. J. Med. 1976 Jan 1;294(1):30-6.
[Text Abstract on PubMed]

In vivo studies of mediator release in cold urticaria and cholinergic urticaria.
Kaplan AP, Gray L, Shaff RE, Horakova Z, Beaven MA.
J. Allergy Clin. Immunol. 1975 Jun;55(6):394-402.
[Text Abstract on PubMed]

Dopa decarboxylase in medullary carcinoma of the thyroid.
Atkins FL, Beaven MA, Keiser HR.
N. Engl. J. Med. 1973 Sep 13;289(11):545-8.
[Text Abstract on PubMed]

Sipple's syndrome: medullary thyroid carcinoma, pheochromocytoma, and parathyroid disease. Studies in a large family. NIH conference.
Keiser HR, Beaven MA, Doppman J, Wells, Buja LM.
Ann. Intern. Med. 1973 Apr;78(4):561-79.
[Text Abstract on PubMed]

Histaminase activity: a biochemical marker for medullary carcinoma of the thyroid.
Baylin SB, Beaven MA, Buja LM, Keiser HR.
Am. J. Med. 1972 Dec;53(6):723-33.
[Text Abstract on PubMed]

Modification of the enzymatic isotopic assay of histamine and its application to measurement of histamine in tissues, serum and urine.
Beaven MA, Jacobsen S, Horáková Z.
Clin. Chim. Acta. 1972 Mar;37:91-103.
[Text Abstract on PubMed]

Serum histaminase and calcitonin levels in medullary carcinoma of the thyroid.
Baylin SB, Beaven MA, Keiser HR, Tashjian, Melvin KE.
Lancet. 1972 Feb 26;1(7748):455-8.
[Text Abstract on PubMed]

A new assay for histaminase activity: measurement of tritiated water from beta (side chain label)-H 3-histamine.
Beaven MA, Jacobsen S.
J. Pharmacol. Exp. Ther. 1971 Jan;176(1):52-64.
[Text Abstract on PubMed]

Elevated histaminase activity in medullary carcinoma of the thyroid gland.
Baylin SB, Beaven MA, Engelman K, Sjoerdsma A.
N. Engl. J. Med. 1970 Dec 3;283(23):1239-44.
[Text Abstract on PubMed]

Selective labeling of histamine in rat gastric mucosa: application to measurement of turnover rate.
Beaven MA, Horakova Z, Severs WB, Brodie BB.
J. Pharmacol. Exp. Ther. 1968 Jun;161(2):320-8.
[Text Abstract on PubMed]

Use of tracers in the study of biogenic amine compartments.
Beaven MA.
Adv Tracer Methodol. 1965;2:243-52.
[Text Abstract on PubMed]

Stereoselectivity of norepinephrine storage sites in heart.
Beaven MA, Maickel RP.
Biochem. Biophys. Res. Commun. 1964;14:509-13.
[Text Abstract on PubMed]

The turnover of norepinephrine in thyrotoxic and nonthyrotoxic mice.
Life Sci. 1963 Apr;4:241-6.
[Text Abstract on PubMed]