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James Anderson, M.D., Ph.D.

Publications


Principal Investigator thumbnail image

James Anderson
Senior Investigator

P: +1 301 402 9852
F: +1 301 480 4632
andersonjm@mail.nih.gov


Full Publications Listing

The N and C Termini of ZO-1 Are Surrounded by Distinct Proteins and Functional Protein Networks.
Van Itallie CM, Aponte A, Tietgens AJ, Gucek M, Fredriksson K, Anderson JM.
J Biol Chem. 2013 May 10;288(19):13775-88.
[Text Abstract on PubMed]

Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1.
Rodgers LS, Beam MT, Anderson JM, Fanning AS.
J Cell Sci. 2013 Apr 1;126(Pt 7):1565-75.
[Text Abstract on PubMed]

Phosphorylation of claudin-2 on serine 208 promotes membrane retention and reduces trafficking to lysosomes.
Van Itallie CM, Tietgens AJ, Logrande K, Aponte A, Gucek M, Anderson JM.
J. Cell. Sci. 2012 Oct 15;125(Pt 20):4902-4912.
[Text Abstract on PubMed]

SUMOylation of claudin-2.
Van Itallie CM, Mitic LL, Anderson JM.
Ann. N. Y. Acad. Sci. 2012 Jul;1258:60-4.
[Text Abstract on PubMed]

Caveolin binds independently to claudin-2 and occludin.
Itallie CM, Anderson JM.
Ann. N. Y. Acad. Sci. 2012 Jun;1257:103-7.
[Text Abstract on PubMed]

Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia.
Fanning AS, Van Itallie CM, Anderson JM.
Mol. Biol. Cell. 2012 Feb;23(4):577-90.
[Text Abstract on PubMed]

The Src homology 3 domain is required for junctional adhesion molecule binding to the third PDZ domain of the scaffolding protein ZO-1.
Nomme J, Fanning AS, Caffrey M, Lye MF, Anderson JM, Lavie A.
J. Biol. Chem. 2011 Dec 16;286(50):43352-60.
[Text Abstract on PubMed]

Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion.
Knauf F, Ko N, Jiang Z, Robertson WG, Van Itallie CM, Anderson JM, Aronson PS.
J. Am. Soc. Nephrol. 2011 Dec;22(12):2247-55.
[Text Abstract on PubMed]

Claudin-2 forms homodimers and is a component of a high molecular weight protein complex.
Van Itallie CM, Mitic LL, Anderson JM.
J. Biol. Chem. 2011 Feb 4;286(5):3442-50.
[Text Abstract on PubMed]

Occludin is required for cytokine-induced regulation of tight junction barriers.
Van Itallie CM, Fanning AS, Holmes J, Anderson JM.
J. Cell. Sci. 2010 Aug 15;123(Pt 16):2844-52.
[Text Abstract on PubMed]

Insights into regulated ligand binding sites from the structure of ZO-1 Src homology 3-guanylate kinase module.
Lye MF, Fanning AS, Su Y, Anderson JM, Lavie A.
J. Biol. Chem. 2010 Apr 30;285(18):13907-17.
[Text Abstract on PubMed]

ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton.
Van Itallie CM, Fanning AS, Bridges A, Anderson JM.
Mol. Biol. Cell. 2009 Sep;20(17):3930-40.
[Text Abstract on PubMed]

Claudin-2-dependent changes in noncharged solute flux are mediated by the extracellular domains and require attachment to the PDZ-scaffold.
Van Itallie CM, Holmes J, Bridges A, Anderson JM.
Ann. N. Y. Acad. Sci. 2009 May;1165:82-7.
[Text Abstract on PubMed]

A PDZ-binding motif controls basolateral targeting of syndecan-1 along the biosynthetic pathway in polarized epithelial cells.
Maday S, Anderson E, Chang HC, Shorter J, Satoh A, Sfakianos J, Fölsch H, Anderson JM, Walther Z, Mellman I.
Traffic. 2008 Nov;9(11):1915-24.
[Text Abstract on PubMed]

Tight junction protein ZO-2 expression and relative function of ZO-1 and ZO-2 during mouse blastocyst formation.
Sheth B, Nowak RL, Anderson R, Kwong WY, Papenbrock T, Fleming TP.
Exp. Cell Res. 2008 Nov 1;314(18):3356-68.
[Text Abstract on PubMed]

The density of small tight junction pores varies among cell types and is increased by expression of claudin-2.
Van Itallie CM, Holmes J, Bridges A, Gookin JL, Coccaro MR, Proctor W, Colegio OR, Anderson JM.
J. Cell. Sci. 2008 Feb 1;121(Pt 3):298-305.
[Text Abstract on PubMed]

Structure of the claudin-binding domain of Clostridium perfringens enterotoxin.
Van Itallie CM, Betts L, Smedley, McClane BA, Anderson JM.
J. Biol. Chem. 2008 Jan 4;283(1):268-74.
[Text Abstract on PubMed]

Domain swapping within PDZ2 is responsible for dimerization of ZO proteins.
Fanning AS, Lye MF, Anderson JM, Lavie A.
J. Biol. Chem. 2007 Dec 28;282(52):37710-6.
[Text Abstract on PubMed]

Claudin-18: a dominant tight junction protein in Barrett's esophagus and likely contributor to its acid resistance.
Jovov B, Van Itallie CM, Shaheen NJ, Carson JL, Gambling TM, Anderson JM, Orlando RC.
Am. J. Physiol. Gastrointest. Liver Physiol. 2007 Dec;293(6):G1106-13.
[Text Abstract on PubMed]

Compositional and stoichiometric analysis of Clostridium perfringens enterotoxin complexes in Caco-2 cells and claudin 4 fibroblast transfectants.
Robertson SL, Smedley, Singh U, Chakrabarti G, Van Itallie CM, Anderson JM, McClane BA.
Cell. Microbiol. 2007 Nov;9(11):2734-55.
[Text Abstract on PubMed]

The unique-5 and -6 motifs of ZO-1 regulate tight junction strand localization and scaffolding properties.
Fanning AS, Little BP, Rahner C, Utepbergenov D, Walther Z, Anderson JM.
Mol. Biol. Cell. 2007 Mar;18(3):721-31.
[Text Abstract on PubMed]

Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities.
Van Itallie CM, Rogan S, Yu A, Vidal LS, Holmes J, Anderson JM.
Am. J. Physiol. Renal Physiol. 2006 Dec;291(6):F1288-99.
[Text Abstract on PubMed]

Tricellulin is a tight-junction protein necessary for hearing.
Riazuddin S, Ahmed ZM, Fanning AS, Lagziel A, Kitajiri S, Ramzan K, Khan SN, Chattaraj P, Friedman PL, Anderson JM, Belyantseva IA, Forge A, Riazuddin S, Friedman TB.
Am. J. Hum. Genet. 2006 Dec;79(6):1040-51.
[Text Abstract on PubMed]

Dimerization of the scaffolding protein ZO-1 through the second PDZ domain.
Utepbergenov DI, Fanning AS, Anderson JM.
J. Biol. Chem. 2006 Aug 25;281(34):24671-7.
[Text Abstract on PubMed]

Claudin profiling in the mouse during postnatal intestinal development and along the gastrointestinal tract reveals complex expression patterns.
Holmes JL, Van Itallie CM, Rasmussen JE, Anderson JM.
Gene Expr. Patterns. 2006 Aug;6(6):581-8.
[Text Abstract on PubMed]

Structure of the conserved cytoplasmic C-terminal domain of occludin: identification of the ZO-1 binding surface.
Li Y, Fanning AS, Anderson JM, Lavie A.
J. Mol. Biol. 2005 Sep 9;352(1):151-64.
[Text Abstract on PubMed]

Palmitoylation of claudins is required for efficient tight-junction localization.
Van Itallie CM, Gambling TM, Carson JL, Anderson JM.
J. Cell. Sci. 2005 Apr 1;118(Pt 7):1427-36.
[Text Abstract on PubMed]

The cytoplasmic tails of claudins can influence tight junction barrier properties through effects on protein stability.
Van Itallie CM, Colegio OR, Anderson JM.
J. Membr. Biol. 2004 May 1;199(1):29-38.
[Text Abstract on PubMed]

Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins.
Van Itallie CM, Fanning AS, Anderson JM.
Am. J. Physiol. Renal Physiol. 2003 Dec;285(6):F1078-84.
[Text Abstract on PubMed]

Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration.
Ben-Yosef T, Belyantseva IA, Saunders TL, Hughes ED, Kawamoto K, Van Itallie CM, Beyer LA, Halsey K, Gardner DJ, Wilcox ER, Rasmussen J, Anderson JM, Dolan DF, Forge A, Raphael Y, Camper SA, Friedman TB.
Hum. Mol. Genet. 2003 Aug 15;12(16):2049-61.
[Text Abstract on PubMed]

Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture.
Colegio OR, Van Itallie C, Rahner C, Anderson JM.
Am. J. Physiol., Cell Physiol. 2003 Jun;284(6):C1346-54.
[Text Abstract on PubMed]

Expression, solubilization, and biochemical characterization of the tight junction transmembrane protein claudin-4.
Mitic LL, Unger VM, Anderson JM.
Protein Sci. 2003 Feb;12(2):218-27.
[Text Abstract on PubMed]

Isolation and functional characterization of the actin binding region in the tight junction protein ZO-1.
Fanning AS, Ma TY, Anderson JM.
FASEB J. 2002 Nov;16(13):1835-7.
[Text Abstract on PubMed]

Claudins create charge-selective channels in the paracellular pathway between epithelial cells.
Colegio OR, Van Itallie CM, McCrea HJ, Rahner C, Anderson JM.
Am. J. Physiol., Cell Physiol. 2002 Jul;283(1):C142-7.
[Text Abstract on PubMed]

Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability.
Van Itallie C, Rahner C, Anderson JM.
J. Clin. Invest. 2001 May;107(10):1319-27.
[Text Abstract on PubMed]

Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut.
Rahner C, Mitic LL, Anderson JM.
Gastroenterology. 2001 Feb;120(2):411-22.
[Text Abstract on PubMed]

hCASK and hDlg associate in epithelia, and their src homology 3 and guanylate kinase domains participate in both intramolecular and intermolecular interactions.
Nix SL, Chishti AH, Anderson JM, Walther Z.
J. Biol. Chem. 2000 Dec 29;275(52):41192-200.
[Text Abstract on PubMed]

Occludin localization at the tight junction requires the second extracellular loop.
Medina R, Rahner C, Mitic LL, Anderson JM, Van Itallie CM.
J. Membr. Biol. 2000 Dec 1;178(3):235-47.
[Text Abstract on PubMed]

Granular cells as a marker of early amiodarone hepatotoxicity.
Jain D, Bowlus CL, Anderson JM, Robert ME.
J. Clin. Gastroenterol. 2000 Oct;31(3):241-3.
[Text Abstract on PubMed]

CaCo-2 cells treated with Clostridium perfringens enterotoxin form multiple large complex species, one of which contains the tight junction protein occludin.
Singh U, Van Itallie CM, Mitic LL, Anderson JM, McClane BA.
J. Biol. Chem. 2000 Jun 16;275(24):18407-17.
[Text Abstract on PubMed]

VAP-33 localizes to both an intracellular vesicle population and with occludin at the tight junction.
Lapierre LA, Tuma PL, Navarre J, Goldenring JR, Anderson JM.
J. Cell. Sci. 1999 Nov;112 ( Pt 21):3723-32.
[Text Abstract on PubMed]

Connexin-occludin chimeras containing the ZO-binding domain of occludin localize at MDCK tight junctions and NRK cell contacts.
Mitic LL, Schneeberger EE, Fanning AS, Anderson JM.
J. Cell Biol. 1999 Aug 9;146(3):683-93.
[Text Abstract on PubMed]

The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton.
Fanning AS, Jameson BJ, Jesaitis LA, Anderson JM.
J. Biol. Chem. 1998 Nov 6;273(45):29745-53.
[Text Abstract on PubMed]

The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane.
Chishti AH, Kim AC, Marfatia SM, Lutchman M, Hanspal M, Jindal H, Liu SC, Low PS, Rouleau GA, Mohandas N, Chasis JA, Conboy JG, Gascard P, Takakuwa Y, Huang SC, Benz, Bretscher A, Fehon RG, Gusella JF, Ramesh V, Solomon F, Marchesi VT, Tsukita S, Tsukita S, Hoover KB.
Trends Biochem. Sci. 1998 Aug;23(8):281-2.
[Text Abstract on PubMed]

Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells.
Cohen AR, Woods DF, Marfatia SM, Walther Z, Chishti AH, Anderson JM, Wood DF.
J. Cell Biol. 1998 Jul 13;142(1):129-38.
[Text Abstract on PubMed]

Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition.
Daniels DL, Cohen AR, Anderson JM, Brünger AT.
Nat. Struct. Biol. 1998 Apr;5(4):317-25.
[Text Abstract on PubMed]

Differential distribution of the tight-junction-associated protein ZO-1 isoforms alpha+ and alpha- in guinea pig Sertoli cells: a possible association with F-actin and G-actin.
Pelletier RM, Okawara Y, Vitale ML, Anderson JM.
Biol. Reprod. 1997 Aug;57(2):367-76.
[Text Abstract on PubMed]

Cytoskeletal rearrangement mediates human microvascular endothelial tight junction modulation by cytokines.
Blum MS, Toninelli E, Anderson JM, Balda MS, Zhou J, O'Donnell L, Pardi R, Bender JR.
Am. J. Physiol. 1997 Jul;273(1 Pt 2):H286-94.
[Text Abstract on PubMed]

Tight junction assembly during mouse blastocyst formation is regulated by late expression of ZO-1 alpha+ isoform.
Sheth B, Fesenko I, Collins JE, Moran B, Wild AE, Anderson JM, Fleming TP.
Development. 1997 May;124(10):2027-37.
[Text Abstract on PubMed]

Occludin confers adhesiveness when expressed in fibroblasts.
Van Itallie CM, Anderson JM.
J. Cell. Sci. 1997 May;110 ( Pt 9):1113-21.
[Text Abstract on PubMed]

Recognition of unique carboxyl-terminal motifs by distinct PDZ domains.
Songyang Z, Fanning AS, Fu C, Xu J, Marfatia SM, Chishti AH, Crompton A, Chan AC, Anderson JM, Cantley LC.
Science. 1997 Jan 3;275(5296):73-7.
[Text Abstract on PubMed]

The SH3 domain of the tight junction protein ZO-1 binds to a serine protein kinase that phosphorylates a region C-terminal to this domain.
Balda MS, Anderson JM, Matter K.
FEBS Lett. 1996 Dec 16;399(3):326-32.
[Text Abstract on PubMed]

Localization of the tight junction protein gene TJP1 to human chromosome 15q13, distal to the Prader-Willi/Angelman region, and to mouse chromosome 7.
Mohandas TK, Chen XN, Rowe LB, Birkenmeier EH, Fanning AS, Anderson JM, Korenberg JR.
Genomics. 1995 Dec 10;30(3):594-7.
[Text Abstract on PubMed]

Altered hepatic localization and expression of occludin after common bile duct ligation.
Fallon MB, Brecher AR, Balda MS, Matter K, Anderson JM.
Am. J. Physiol. 1995 Oct;269(4 Pt 1):C1057-62.
[Text Abstract on PubMed]

Effect of cerulein hyperstimulation on the paracellular barrier of rat exocrine pancreas.
Fallon MB, Gorelick FS, Anderson JM, Mennone A, Saluja A, Steer ML.
Gastroenterology. 1995 Jun;108(6):1863-72.
[Text Abstract on PubMed]

Altered expression and function of hepatocyte gap junctions after common bile duct ligation in the rat.
Fallon MB, Nathanson MH, Mennone A, Sáez JC, Burgstahler AD, Anderson JM.
Am. J. Physiol. 1995 May;268(5 Pt 1):C1186-94.
[Text Abstract on PubMed]

Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells.
Van Itallie CM, Balda MS, Anderson JM.
J. Cell. Sci. 1995 Apr;108 ( Pt 4):1735-42.
[Text Abstract on PubMed]

Increased Tyr phosphorylation of ZO-1 during modification of tight junctions between glomerular foot processes.
Kurihara H, Anderson JM, Farquhar MG.
Am. J. Physiol. 1995 Mar;268(3 Pt 2):F514-24.
[Text Abstract on PubMed]

Expression of the leukemia-associated gene, p18, in normal and malignant tissues; inactivation of expression in a patient with cleaved B cell lymphoma/leukemia.
Ghosh PK, Anderson J, Cohen N, Takeshita K, Atweh GF, Lebowitz P.
Oncogene. 1993 Oct;8(10):2869-72.
[Text Abstract on PubMed]

Assembly of the tight junction: the role of diacylglycerol.
Balda MS, Gonzalez-Mariscal L, Matter K, Cereijido M, Anderson JM.
J. Cell Biol. 1993 Oct;123(2):293-302.
[Text Abstract on PubMed]

The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.
Willott E, Balda MS, Fanning AS, Jameson B, Van Itallie C, Anderson JM.
Proc. Natl. Acad. Sci. U.S.A. 1993 Aug 15;90(16):7834-8.
[Text Abstract on PubMed]

Altered expression and localization of the tight junction protein ZO-1 after common bile duct ligation.
Fallon MB, Mennone A, Anderson JM.
Am. J. Physiol. 1993 Jun;264(6 Pt 1):C1439-47.
[Text Abstract on PubMed]

ZO-1 maintains its spatial distribution but dissociates from junctional fibrils during tight junction regulation.
Madara JL, Carlson S, Anderson JM.
Am. J. Physiol. 1993 May;264(5 Pt 1):C1096-101.
[Text Abstract on PubMed]

Two classes of tight junctions are revealed by ZO-1 isoforms.
Balda MS, Anderson JM.
Am. J. Physiol. 1993 Apr;264(4 Pt 1):C918-24.
[Text Abstract on PubMed]

The altered glomerular filtration slits seen in puromycin aminonucleoside nephrosis and protamine sulfate-treated rats contain the tight junction protein ZO-1.
Kurihara H, Anderson JM, Kerjaschki D, Farquhar MG.
Am. J. Pathol. 1992 Oct;141(4):805-16.
[Text Abstract on PubMed]

Polarized functions and permeability properties of rat epididymal epithelial cells in vitro.
Byers SW, Citi S, Anderson JM, Hoxter B.
J. Reprod. Fertil. 1992 Jul;95(2):385-96.
[Text Abstract on PubMed]

Localization and differential expression of two isoforms of the tight junction protein ZO-1.
Willott E, Balda MS, Heintzelman M, Jameson B, Anderson JM.
Am. J. Physiol. 1992 May;262(5 Pt 1):C1119-24.
[Text Abstract on PubMed]

The tight-junction-specific protein ZO-1 is a component of the human and rat blood-brain barriers.
Watson PM, Anderson JM, Vanltallie CM, Doctrow SR.
Neurosci. Lett. 1991 Aug 5;129(1):6-10.
[Text Abstract on PubMed]

The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium.
Schnabel E, Anderson JM, Farquhar MG.
J. Cell Biol. 1990 Sep;111(3):1255-63.
[Text Abstract on PubMed]

Transforming growth factor beta 1 modulates extracellular matrix organization and cell-cell junctional complex formation during in vitro angiogenesis.
Merwin JR, Anderson JM, Kocher O, Van Itallie CM, Madri JA.
J. Cell. Physiol. 1990 Jan;142(1):117-28.
[Text Abstract on PubMed]

Partial deduced sequence of the 110-kD-calmodulin complex of the avian intestinal microvillus shows that this mechanoenzyme is a member of the myosin I family.
Garcia A, Coudrier E, Carboni J, Anderson J, Vandekerkhove J, Mooseker M, Louvard D, Arpin M.
J. Cell Biol. 1989 Dec;109(6 Pt 1):2895-903.
[Text Abstract on PubMed]

Phosphorylation of the tight-junction protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance.
Stevenson BR, Anderson JM, Braun ID, Mooseker MS.
Biochem. J. 1989 Oct 15;263(2):597-9.
[Text Abstract on PubMed]

ZO-1 and cingulin: tight junction proteins with distinct identities and localizations.
Stevenson BR, Heintzelman MB, Anderson JM, Citi S, Mooseker MS.
Am. J. Physiol. 1989 Oct;257(4 Pt 1):C621-8.
[Text Abstract on PubMed]

ZO-1 mRNA and protein expression during tight junction assembly in Caco-2 cells.
Anderson JM, Van Itallie CM, Peterson MD, Stevenson BR, Carew EA, Mooseker MS.
J. Cell Biol. 1989 Sep;109(3):1047-56.
[Text Abstract on PubMed]

Hepatic immunohistochemical localization of the tight junction protein ZO-1 in rat models of cholestasis.
Anderson JM, Glade JL, Stevenson BR, Boyer JL, Mooseker MS.
Am. J. Pathol. 1989 May;134(5):1055-62.
[Text Abstract on PubMed]

Tight junction structure and ZO-1 content are identical in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance.
Stevenson BR, Anderson JM, Goodenough DA, Mooseker MS.
J. Cell Biol. 1988 Dec;107(6 Pt 1):2401-8.
[Text Abstract on PubMed]

Characterization of ZO-1, a protein component of the tight junction from mouse liver and Madin-Darby canine kidney cells.
Anderson JM, Stevenson BR, Jesaitis LA, Goodenough DA, Mooseker MS.
J. Cell Biol. 1988 Apr;106(4):1141-9.
[Text Abstract on PubMed]

Dr. Paul W. Lapidus (1893-1981).
Jahss MH.
Bull Hosp Jt Dis Orthop Inst. 1987 Fall;47(2):100-2.
[Text Abstract on PubMed]

Angiotensin II stimulates phosphorylation of the myosin light chain in cultured vascular smooth muscle cells.
Anderson JM, Gimbrone, Alexander RW.
J. Biol. Chem. 1981 May 25;256(10):4693-6.
[Text Abstract on PubMed]

Structural comparison of several actin-binding macromolecules.
Tyler JM, Anderson JM, Branton D.
J. Cell Biol. 1980 May;85(2):489-95.
[Text Abstract on PubMed]

State of spectrin phosphorylation does not affect erythrocyte shape or spectrin binding to erythrocyte membranes.
Anderson JM, Tyler JM.
J. Biol. Chem. 1980 Feb 25;255(4):1259-65.
[Text Abstract on PubMed]

Structural studies on human spectrin. Comparison of subunits and fragmentation of native spectrin.
Anderson JM.
J. Biol. Chem. 1979 Feb 10;254(3):939-44.
[Text Abstract on PubMed]

Proteolytic fragmentation of spectrin:effect of removal of terminal phosphopeptides on spectrin binding to human erythrocyte membranes.
Anderson JM, Tyler JM.
Prog. Clin. Biol. Res. 1979;30:531-4.
[Text Abstract on PubMed]