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Robert S. Adelstein, M.D.


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Robert S. Adelstein
Senior Investigator

P: +1 301 496 1865
F: +1 301 402 1542

Full Publications Listing

NMII forms a contractile transcellular sarcomeric network to regulate apical cell junctions and tissue geometry.
Ebrahim S, Fujita T, Millis BA, Kozin E, Ma X, Kawamoto S, Baird MA, Davidson M, Yonemura S, Hisa Y, Conti MA, Adelstein RS, Sakaguchi H, Kachar B.
Curr Biol. 2013 Apr 22;23(8):731-6.
[Text Abstract on PubMed]

Nonmuscle myosin IIB links cytoskeleton to IRE1α signaling during ER stress.
He Y, Beatty A, Han X, Ji Y, Ma X, Adelstein RS, Yates JR 3rd, Kemphues K, Qi L.
Dev Cell. 2012 Dec 11;23(6):1141-52.
[Text Abstract on PubMed]

Non-muscle myosin IIB is essential for cytokinesis during male meiotic cell divisions.
Yang F, Wei Q, Adelstein RS, Wang PJ.
Dev. Biol. 2012 Sep 15;369(2):356-61.
[Text Abstract on PubMed]

Nonmuscle myosin II is required for internalization of the epidermal growth factor receptor and modulation of downstream signaling.
Kim JH, Wang A, Conti MA, Adelstein RS.
J. Biol. Chem. 2012 Aug 10;287(33):27345-58.
[Text Abstract on PubMed]

Micro-environmental control of cell migration--myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics.
Doyle AD, Kutys ML, Conti MA, Matsumoto K, Adelstein RS, Yamada KM.
J. Cell. Sci. 2012 May 1;125(Pt 9):2244-56.
[Text Abstract on PubMed]

Nonmuscle myosin II exerts tension but does not translocate actin in vertebrate cytokinesis.
Ma X, Kovács M, Conti MA, Wang A, Zhang Y, Sellers JR, Adelstein RS.
Proc. Natl. Acad. Sci. U.S.A. 2012 Mar 20;109(12):4509-14.
[Text Abstract on PubMed]

Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A.
Zhang Y, Conti MA, Malide D, Dong F, Wang A, Shmist YA, Liu C, Zerfas P, Daniels MP, Chan CC, Kozin E, Kachar B, Kelley MJ, Kopp JB, Adelstein RS.
Blood. 2012 Jan 5;119(1):238-50.
[Text Abstract on PubMed]

In vivo studies on nonmuscle myosin II expression and function in heart development.
Ma X, Adelstein RS.
Front. Biosci. 2012;17:545-55.
[Text Abstract on PubMed]

LPA(1) -induced migration requires nonmuscle myosin II light chain phosphorylation in breast cancer cells.
Kim JH, Adelstein RS.
J. Cell. Physiol. 2011 Nov;226(11):2881-93.
[Text Abstract on PubMed]

Distinct and redundant roles of the non-muscle myosin II isoforms and functional domains.
Wang A, Ma X, Conti MA, Adelstein RS.
Biochem. Soc. Trans. 2011 Oct;39(5):1131-5.
[Text Abstract on PubMed]

Actin and myosin contribute to mammalian mitochondrial DNA maintenance.
Reyes A, He J, Mao CC, Bailey LJ, Di Re M, Sembongi H, Kazak L, Dzionek K, Holmes JB, Cluett TJ, Harbour ME, Fearnley IM, Crouch RJ, Conti MA, Adelstein RS, Walker JE, Holt IJ.
Nucleic Acids Res. 2011 Jul;39(12):5098-108.
[Text Abstract on PubMed]

Fox-3 and PSF interact to activate neural cell-specific alternative splicing.
Kim KK, Kim YC, Adelstein RS, Kawamoto S.
Nucleic Acids Res. 2011 Apr;39(8):3064-78.
[Text Abstract on PubMed]

Nonmuscle myosin II isoform and domain specificity during early mouse development.
Wang A, Ma X, Conti MA, Liu C, Kawamoto S, Adelstein RS.
Proc. Natl. Acad. Sci. U.S.A. 2010 Aug 17;107(33):14645-50.
[Text Abstract on PubMed]

Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens.
Smutny M, Cox HL, Leerberg JM, Kovacs EM, Conti MA, Ferguson C, Hamilton NA, Parton RG, Adelstein RS, Yap AS.
Nat. Cell Biol. 2010 Jul;12(7):696-702.
[Text Abstract on PubMed]

Conditional ablation of nonmuscle myosin II-B delineates heart defects in adult mice.
Ma X, Takeda K, Singh A, Yu ZX, Zerfas P, Blount A, Liu C, Towbin JA, Schneider MD, Adelstein RS, Wei Q.
Circ. Res. 2009 Nov 20;105(11):1102-9.
[Text Abstract on PubMed]

Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors.
Kim KK, Adelstein RS, Kawamoto S.
J. Biol. Chem. 2009 Nov 6;284(45):31052-61.
[Text Abstract on PubMed]

Non-muscle myosin II takes centre stage in cell adhesion and migration.
Vicente-Manzanares M, Ma X, Adelstein RS, Horwitz AR.
Nat. Rev. Mol. Cell Biol. 2009 Nov;10(11):778-90.
[Text Abstract on PubMed]

Myosin II regulates extension, growth and patterning in the mammalian cochlear duct.
Yamamoto N, Okano T, Ma X, Adelstein RS, Kelley MW.
Development. 2009 Jun;136(12):1977-86.
[Text Abstract on PubMed]

An alternatively spliced isoform of non-muscle myosin II-C is not regulated by myosin light chain phosphorylation.
Jana SS, Kim KY, Mao J, Kawamoto S, Sellers JR, Adelstein RS.
J. Biol. Chem. 2009 Apr 24;284(17):11563-71.
[Text Abstract on PubMed]

Local cortical tension by myosin II guides 3D endothelial cell branching.
Fischer RS, Gardel M, Ma X, Adelstein RS, Waterman CM.
Curr. Biol. 2009 Feb 10;19(3):260-5.
[Text Abstract on PubMed]

Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion.
Babbin BA, Koch S, Bachar M, Conti MA, Parkos CA, Adelstein RS, Nusrat A, Ivanov AI.
Am. J. Pathol. 2009 Feb;174(2):436-48.
[Text Abstract on PubMed]

Rap1 activation in collagen phagocytosis is dependent on nonmuscle myosin II-A.
Arora PD, Conti MA, Ravid S, Sacks DB, Kapus A, Adelstein RS, Bresnick AR, McCulloch CA.
Mol. Biol. Cell. 2008 Dec;19(12):5032-46.
[Text Abstract on PubMed]

The B2 alternatively spliced isoform of nonmuscle myosin II-B lacks actin-activated MgATPase activity and in vitro motility.
Kim KY, Kawamoto S, Bao J, Sellers JR, Adelstein RS.
Biochem. Biophys. Res. Commun. 2008 Apr 25;369(1):124-34.
[Text Abstract on PubMed]

Nonmuscle myosin II moves in new directions.
Conti MA, Adelstein RS.
J. Cell. Sci. 2008 Jan 1;121(Pt 1):11-8.
[Text Abstract on PubMed]

Replacement of nonmuscle myosin II-B with II-A rescues brain but not cardiac defects in mice.
Bao J, Ma X, Liu C, Adelstein RS.
J. Biol. Chem. 2007 Jul 27;282(30):22102-11.
[Text Abstract on PubMed]

The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway.
Chen Z, Naveiras O, Balduini A, Mammoto A, Conti MA, Adelstein RS, Ingber D, Daley GQ, Shivdasani RA.
Blood. 2007 Jul 1;110(1):171-9.
[Text Abstract on PubMed]

Loss of cell adhesion causes hydrocephalus in nonmuscle myosin II-B-ablated and mutated mice.
Ma X, Bao J, Adelstein RS.
Mol. Biol. Cell. 2007 Jun;18(6):2305-12.
[Text Abstract on PubMed]

Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk.
Even-Ram S, Doyle AD, Conti MA, Matsumoto K, Adelstein RS, Yamada KM.
Nat. Cell Biol. 2007 Mar;9(3):299-309.
[Text Abstract on PubMed]

A unique role for nonmuscle myosin heavy chain IIA in regulation of epithelial apical junctions.
Ivanov AI, Bachar M, Babbin BA, Adelstein RS, Nusrat A, Parkos CA.
PLoS ONE. 2007;2(7):e658.
[Text Abstract on PubMed]

A specific isoform of nonmuscle myosin II-C is required for cytokinesis in a tumor cell line.
Jana SS, Kawamoto S, Adelstein RS.
J. Biol. Chem. 2006 Aug 25;281(34):24662-70.
[Text Abstract on PubMed]

A novel guanine nucleotide exchange factor MyoGEF is required for cytokinesis.
Wu D, Asiedu M, Adelstein RS, Wei Q.
Cell Cycle. 2006 Jun;5(11):1234-9.
[Text Abstract on PubMed]

Function of the neuron-specific alternatively spliced isoforms of nonmuscle myosin II-B during mouse brain development.
Ma X, Kawamoto S, Uribe J, Adelstein RS.
Mol. Biol. Cell. 2006 May;17(5):2138-49.
[Text Abstract on PubMed]

Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C.
Kim KY, Kovács M, Kawamoto S, Sellers JR, Adelstein RS.
J. Biol. Chem. 2005 Jun 17;280(24):22769-75.
[Text Abstract on PubMed]

Vertebrate nonmuscle myosin II isoforms rescue small interfering RNA-induced defects in COS-7 cell cytokinesis.
Bao J, Jana SS, Adelstein RS.
J. Biol. Chem. 2005 May 20;280(20):19594-9.
[Text Abstract on PubMed]

Basic mechanism of three-dimensional collagen fibre transport by fibroblasts.
Meshel AS, Wei Q, Adelstein RS, Sheetz MP.
Nat. Cell Biol. 2005 Feb;7(2):157-64.
[Text Abstract on PubMed]

Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice.
Conti MA, Even-Ram S, Liu C, Yamada KM, Adelstein RS.
J. Biol. Chem. 2004 Oct 1;279(40):41263-6.
[Text Abstract on PubMed]

A point mutation in the motor domain of nonmuscle myosin II-B impairs migration of distinct groups of neurons.
Ma X, Kawamoto S, Hara Y, Adelstein RS.
Mol. Biol. Cell. 2004 Jun;15(6):2568-79.
[Text Abstract on PubMed]

Nonmuscle myosin IIb is involved in the guidance of fibroblast migration.
Lo CM, Buxton DB, Chua GC, Dembo M, Adelstein RS, Wang YL.
Mol. Biol. Cell. 2004 Mar;15(3):982-9.
[Text Abstract on PubMed]

Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family.
Golomb E, Ma X, Jana SS, Preston YA, Kawamoto S, Shoham NG, Goldin E, Conti MA, Sellers JR, Adelstein RS.
J. Biol. Chem. 2004 Jan 23;279(4):2800-8.
[Text Abstract on PubMed]

Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain.
Obungu VH, Lee Burns A, Agarwal SK, Chandrasekharapa SC, Adelstein RS, Marx SJ.
Oncogene. 2003 Sep 25;22(41):6347-58.
[Text Abstract on PubMed]

Ablation and mutation of nonmuscle myosin heavy chain II-B results in a defect in cardiac myocyte cytokinesis.
Takeda K, Kishi H, Ma X, Yu ZX, Adelstein RS.
Circ. Res. 2003 Aug 22;93(4):330-7.
[Text Abstract on PubMed]

Induction of nonmuscle myosin heavy chain II-C by butyrate in RAW 264.7 mouse macrophages.
Buxton DB, Golomb E, Adelstein RS.
J. Biol. Chem. 2003 Apr 25;278(17):15449-55.
[Text Abstract on PubMed]

Pitx2a expression alters actin-myosin cytoskeleton and migration of HeLa cells through Rho GTPase signaling.
Wei Q, Adelstein RS.
Mol. Biol. Cell. 2002 Feb;13(2):683-97.
[Text Abstract on PubMed]

Myosin IIB is required for growth cone motility.
Bridgman PC, Dave S, Asnes CF, Tullio AN, Adelstein RS.
J. Neurosci. 2001 Aug 15;21(16):6159-69.
[Text Abstract on PubMed]

A Rho-dependent signaling pathway operating through myosin localizes beta-actin mRNA in fibroblasts.
Latham VM, Yu EH, Tullio AN, Adelstein RS, Singer RH.
Curr. Biol. 2001 Jul 10;11(13):1010-6.
[Text Abstract on PubMed]

Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II-B heavy chain.
Tullio AN, Bridgman PC, Tresser NJ, Chan CC, Conti MA, Adelstein RS, Hara Y.
J. Comp. Neurol. 2001 Apr 23;433(1):62-74.
[Text Abstract on PubMed]

Calcium-dependent threonine phosphorylation of nonmuscle myosin in stimulated RBL-2H3 mast cells.
Buxton DB, Adelstein RS.
J. Biol. Chem. 2000 Nov 3;275(44):34772-9.
[Text Abstract on PubMed]

Conditional expression of a truncated fragment of nonmuscle myosin II-A alters cell shape but not cytokinesis in HeLa cells.
Wei Q, Adelstein RS.
Mol. Biol. Cell. 2000 Oct;11(10):3617-27.
[Text Abstract on PubMed]

Nonmuscle myosin II localizes to the Z-lines and intercalated discs of cardiac muscle and to the Z-lines of skeletal muscle.
Takeda K, Yu ZX, Qian S, Chin TK, Adelstein RS, Ferrans VJ.
Cell Motil. Cytoskeleton. 2000 May;46(1):59-68.
[Text Abstract on PubMed]

Gene dosage affects the cardiac and brain phenotype in nonmuscle myosin II-B-depleted mice.
Uren D, Hwang HK, Hara Y, Takeda K, Kawamoto S, Tullio AN, Yu ZX, Ferrans VJ, Tresser N, Grinberg A, Preston YA, Adelstein RS.
J. Clin. Invest. 2000 Mar;105(5):663-71.
[Text Abstract on PubMed]

Nonmuscle myosin II-B is required for normal development of the mouse heart.
Tullio AN, Accili D, Ferrans VJ, Yu ZX, Takeda K, Grinberg A, Westphal H, Preston YA, Adelstein RS.
Proc. Natl. Acad. Sci. U.S.A. 1997 Nov 11;94(23):12407-12.
[Text Abstract on PubMed]

Xenopus nonmuscle myosin heavy chain isoforms have different subcellular localizations and enzymatic activities.
Kelley CA, Sellers JR, Gard DL, Bui D, Adelstein RS, Baines IC.
J. Cell Biol. 1996 Aug;134(3):675-87.
[Text Abstract on PubMed]