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Light Microscopy Core


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Light Microscopy Core
Christian Combs, Ph.D.

Full Publications Listing

Nonmuscle myosin II exerts tension but does not translocate actin in vertebrate cytokinesis.
Ma X, Kovács M, Conti MA, Wang A, Zhang Y, Sellers JR, Adelstein RS.
Proc. Natl. Acad. Sci. U.S.A. 2012 Mar 20;109(12):4509-14.
[Text Abstract on PubMed]

Class B scavenger receptor types I and II and CD36 mediate bacterial recognition and proinflammatory signaling induced by Escherichia coli, lipopolysaccharide, and cytosolic chaperonin 60.
Baranova IN, Vishnyakova TG, Bocharov AV, Leelahavanichkul A, Kurlander R, Chen Z, Souza AC, Yuen PS, Star RA, Csako G, Patterson AP, Eggerman TL.
J. Immunol. 2012 Feb 1;188(3):1371-80.
[Text Abstract on PubMed]

Phosphoregulation of STIM1 leads to exclusion of the endoplasmic reticulum from the mitotic spindle.
Smyth JT, Beg AM, Wu S, Putney, Rusan NM.
Curr. Biol. 2012 Aug 21;22(16):1487-93.
[Text Abstract on PubMed]

Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress.
Lee IH, Kawai Y, Fergusson MM, Rovira II, Bishop AJ, Motoyama N, Cao L, Finkel T.
Science. 2012 Apr 13;336(6078):225-8.
[Text Abstract on PubMed]

Glia maturation factor-? mediates neutrophil chemotaxis.
Aerbajinai W, Liu L, Chin K, Zhu J, Parent CA, Rodgers GP.
J. Leukoc. Biol. 2011 Sep;90(3):529-38.
[Text Abstract on PubMed]

Mre11 is expressed in mammalian mitochondria where it binds to mitochondrial DNA.
Dmitrieva NI, Malide D, Burg MB.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 2011 Sep;301(3):R632-40.
[Text Abstract on PubMed]

Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells.
Kim KY, Stevens MV, Akter MH, Rusk SE, Huang RJ, Cohen A, Noguchi A, Springer D, Bocharov AV, Eggerman TL, Suen DF, Youle RJ, Amar M, Remaley AT, Sack MN.
J. Clin. Invest. 2011 Sep;121(9):3701-12.
[Text Abstract on PubMed]

Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing.
Li CC, Kuo JC, Waterman CM, Kiyama R, Moss J, Vaughan M.
Proc. Natl. Acad. Sci. U.S.A. 2011 Nov 29;108(48):19228-33.
[Text Abstract on PubMed]

LPA(1) -induced migration requires nonmuscle myosin II light chain phosphorylation in breast cancer cells.
Kim JH, Adelstein RS.
J. Cell. Physiol. 2011 Nov;226(11):2881-93.
[Text Abstract on PubMed]

JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress.
Liu J, Chung HJ, Vogt M, Jin Y, Malide D, He L, Dundr M, Levens D.
EMBO J. 2011 Mar 2;30(5):846-58.
[Text Abstract on PubMed]

High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization.
Gallazzini M, Heussler GE, Kunin M, Izumi Y, Burg MB, Ferraris JD.
Mol. Biol. Cell. 2011 Mar 1;22(5):703-14.
[Text Abstract on PubMed]

Regulation of growth factor receptor degradation by ADP-ribosylation factor domain protein (ARD) 1.
Meza-Carmen V, Pacheco-Rodriguez G, Kang GS, Kato J, Donati C, Zhang CY, Vichi A, Payne DM, El-Chemaly S, Stylianou M, Moss J, Vaughan M.
Proc. Natl. Acad. Sci. U.S.A. 2011 Jun 28;108(26):10454-9.
[Text Abstract on PubMed]

Limitations of closing percutaneous transthoracic ventricular access ports using a commercial collagen vascular closure device.
Barbash IM, Saikus CE, Ratnayaka K, Faranesh AZ, Kocaturk O, Wu V, Bell JA, Schenke WH, Raman VK, Lederman RJ.
Catheter Cardiovasc Interv. 2011 Jun 1;77(7):1079-85.
[Text Abstract on PubMed]

MAL protein controls protein sorting at the supramolecular activation cluster of human T lymphocytes.
Antón OM, Andrés-Delgado L, Reglero-Real N, Batista A, Alonso MA.
J. Immunol. 2011 Jun 1;186(11):6345-56.
[Text Abstract on PubMed]

Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane.
Bond LM, Peden AA, Kendrick-Jones J, Sellers JR, Buss F.
Mol. Biol. Cell. 2011 Jan 1;22(1):54-65.
[Text Abstract on PubMed]

Erythropoietin-driven proliferation of cells with mutations in the tumor suppressor gene TSC2.
Ikeda Y, Taveira-DaSilva AM, Pacheco-Rodriguez G, Steagall WK, El-Chemaly S, Gochuico BR, May RM, Hathaway OM, Li S, Wang JA, Darling TN, Stylianou M, Moss J.
Am. J. Physiol. Lung Cell Mol. Physiol. 2011 Jan;300(1):L64-72.
[Text Abstract on PubMed]

NT5E mutations and arterial calcifications.
St Hilaire C, Ziegler SG, Markello TC, Brusco A, Groden C, Gill F, Carlson-Donohoe H, Lederman RJ, Chen MY, Yang D, Siegenthaler MP, Arduino C, Mancini C, Freudenthal B, Stanescu HC, Zdebik AA, Chaganti RK, Nussbaum RL, Kleta R, Gahl WA, Boehm M.
N. Engl. J. Med. 2011 Feb 3;364(5):432-42.
[Text Abstract on PubMed]

Transient neutropenia after granulocyte-colony stimulating factor administration is associated with neutrophil accumulation in pulmonary vasculature.
DeJesus CE, Egen J, Metzger M, Alvarez X, Combs CA, Malide D, Yu ZX, Tian X, Donahue RE.
Exp. Hematol. 2011 Feb;39(2):142-50.
[Text Abstract on PubMed]

Optimizing multiphoton fluorescence microscopy light collection from living tissue by noncontact total emission detection (epiTED).
Combs CA, Smirnov A, Chess D, McGavern DB, Schroeder JL, Riley J, Kang SS, Lugar-Hammer M, Gandjbakhche A, Knutson JR, Balaban RS.
J Microsc. 2011 Feb;241(2):153-61.
[Text Abstract on PubMed]

MHC class II upregulation and colocalization with Fas in experimental models of immune-mediated bone marrow failure.
Erie AJ, Samsel L, Takaku T, Desierto MJ, Keyvanfar K, McCoy JP, Young NS, Chen J.
Exp. Hematol. 2011 Aug;39(8):837-49.
[Text Abstract on PubMed]

Fox-3 and PSF interact to activate neural cell-specific alternative splicing.
Kim KK, Kim YC, Adelstein RS, Kawamoto S.
Nucleic Acids Res. 2011 Apr;39(8):3064-78.
[Text Abstract on PubMed]

Vasopressin increases phosphorylation of Ser84 and Ser486 in Slc14a2 collecting duct urea transporters.
Hwang S, Gunaratne R, Rinschen MM, Yu MJ, Pisitkun T, Hoffert JD, Fenton RA, Knepper MA, Chou CL.
Am. J. Physiol. Renal Physiol. 2010 Sep;299(3):F559-67.
[Text Abstract on PubMed]

Major histocompatibility complex-I expression on embryonic stem cell-derived vascular progenitor cells is critical for syngeneic transplant survival.
Ma M, Ding S, Lundqvist A, San H, Fang F, Konoplyannikov M, Berry C, Beltran LE, Chen G, Kovacic JC, Boehm M.
Stem Cells. 2010 Sep;28(9):1465-75.
[Text Abstract on PubMed]

SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity.
Bao J, Scott I, Lu Z, Pang L, Dimond CC, Gius D, Sack MN.
Free Radic. Biol. Med. 2010 Oct 15;49(7):1230-7.
[Text Abstract on PubMed]

Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation.
Iwasaki H, Kovacic JC, Olive M, Beers JK, Yoshimoto T, Crook MF, Tonelli LH, Nabel EG.
Circ. Res. 2010 Oct 15;107(8):992-1001.
[Text Abstract on PubMed]

Hematopoiesis in 3 dimensions: human and murine bone marrow architecture visualized by confocal microscopy.
Takaku T, Malide D, Chen J, Calado RT, Kajigaya S, Young NS.
Blood. 2010 Oct 14;116(15):e41-55.
[Text Abstract on PubMed]

Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors.
Wan Z, Zhi N, Wong S, Keyvanfar K, Liu D, Raghavachari N, Munson PJ, Su S, Malide D, Kajigaya S, Young NS.
J. Clin. Invest. 2010 Oct;120(10):3530-44.
[Text Abstract on PubMed]

Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis.
Ma X, Jana SS, Conti MA, Kawamoto S, Claycomb WC, Adelstein RS.
Mol. Biol. Cell. 2010 Nov 15;21(22):3952-62.
[Text Abstract on PubMed]

c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP.
Gallazzini M, Yu MJ, Gunaratne R, Burg MB, Ferraris JD.
FASEB J. 2010 Nov;24(11):4325-35.
[Text Abstract on PubMed]

Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms.
Bao J, Lu Z, Joseph JJ, Carabenciov D, Dimond CC, Pang L, Samsel L, McCoy, Leclerc J, Nguyen P, Gius D, Sack MN.
J. Cell. Biochem. 2010 May;110(1):238-47.
[Text Abstract on PubMed]

Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice.
Kovacic JC, Gupta R, Lee AC, Ma M, Fang F, Tolbert CN, Walts AD, Beltran LE, San H, Chen G, St Hilaire C, Boehm M.
J. Clin. Invest. 2010 Jan;120(1):303-14.
[Text Abstract on PubMed]

Fluorescence microscopy: a concise guide to current imaging methods.
Combs CA.
Curr Protoc Neurosci. 2010 Jan;Chapter 2:Unit2.1.
[Text Abstract on PubMed]

Phenotypic characterization of disseminated cells with TSC2 loss of heterozygosity in patients with lymphangioleiomyomatosis.
Cai X, Pacheco-Rodriguez G, Fan QY, Haughey M, Samsel L, El-Chemaly S, Wu HP, McCoy JP, Steagall WK, Lin JP, Darling TN, Moss J.
Am. J. Respir. Crit. Care Med. 2010 Dec 1;182(11):1410-8.
[Text Abstract on PubMed]

Female infertility in PDE3A(-/-) mice: polo-like kinase 1 (Plk1) may be a target of protein kinase A (PKA) and involved in meiotic arrest of oocytes from PDE3A(-/-) mice.
Shen W, Ahmad F, Hockman S, Ma J, Omi H, Raghavachari N, Manganiello V.
Cell Cycle. 2010 Dec 1;9(23):4720-34.
[Text Abstract on PubMed]

Quantitative phosphoproteomic analysis reveals cAMP/vasopressin-dependent signaling pathways in native renal thick ascending limb cells.
Gunaratne R, Braucht DW, Rinschen MM, Chou CL, Hoffert JD, Pisitkun T, Knepper MA.
Proc. Natl. Acad. Sci. U.S.A. 2010 Aug 31;107(35):15653-8.
[Text Abstract on PubMed]

Mitochondrial respiration protects against oxygen-associated DNA damage.
Sung HJ, Ma W, Wang PY, Hynes J, O'Riordan TC, Combs CA, McCoy, Bunz F, Kang JG, Hwang PM.
Nat Commun. 2010;1:5.
[Text Abstract on PubMed]

Nitrite therapy after cardiac arrest reduces reactive oxygen species generation, improves cardiac and neurological function, and enhances survival via reversible inhibition of mitochondrial complex I.
Dezfulian C, Shiva S, Alekseyenko A, Pendyal A, Beiser DG, Munasinghe JP, Anderson SA, Chesley CF, Vanden Hoek TL, Gladwin MT.
Circulation. 2009 Sep 8;120(10):897-905.
[Text Abstract on PubMed]

Phospholipase d promotes lipid microdomain-associated signaling events in mast cells.
Lisboa FA, Peng Z, Combs CA, Beaven MA.
J. Immunol. 2009 Oct 15;183(8):5104-12.
[Text Abstract on PubMed]

Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors.
Kim KK, Adelstein RS, Kawamoto S.
J. Biol. Chem. 2009 Nov 6;284(45):31052-61.
[Text Abstract on PubMed]

Conditional ablation of nonmuscle myosin II-B delineates heart defects in adult mice.
Ma X, Takeda K, Singh A, Yu ZX, Zerfas P, Blount A, Liu C, Towbin JA, Schneider MD, Adelstein RS, Wei Q.
Circ. Res. 2009 Nov 20;105(11):1102-9.
[Text Abstract on PubMed]

Bone marrow-derived cells do not repair endothelium in a mouse model of chronic endothelial cell dysfunction.
Perry TE, Song M, Despres DJ, Kim SM, San H, Yu ZX, Raghavachari N, Schnermann J, Cannon, Orlic D.
Cardiovasc. Res. 2009 Nov 1;84(2):317-25.
[Text Abstract on PubMed]

Regulation of autophagy by the p300 acetyltransferase.
Lee IH, Finkel T.
J. Biol. Chem. 2009 Mar 6;284(10):6322-8.
[Text Abstract on PubMed]

Abnormal lymphangiogenesis in idiopathic pulmonary fibrosis with insights into cellular and molecular mechanisms.
El-Chemaly S, Malide D, Zudaire E, Ikeda Y, Weinberg BA, Pacheco-Rodriguez G, Rosas IO, Aparicio M, Ren P, MacDonald SD, Wu HP, Nathan SD, Cuttitta F, McCoy JP, Gochuico BR, Moss J.
Proc. Natl. Acad. Sci. U.S.A. 2009 Mar 10;106(10):3958-63.
[Text Abstract on PubMed]

Resident vascular progenitor cells: an emerging role for non-terminally differentiated vessel-resident cells in vascular biology.
Kovacic JC, Boehm M.
Stem Cell Res. 2009 Jan;2(1):2-15.
[Text Abstract on PubMed]

Systems-level analysis of cell-specific AQP2 gene expression in renal collecting duct.
Yu MJ, Miller RL, Uawithya P, Rinschen MM, Khositseth S, Braucht DW, Chou CL, Pisitkun T, Nelson RD, Knepper MA.
Proc. Natl. Acad. Sci. U.S.A. 2009 Feb 17;106(7):2441-6.
[Text Abstract on PubMed]

Knockout of Ku86 accelerates cellular senescence induced by high NaCl.
Dmitrieva NI, Chen HT, Nussenzweig A, Burg MB.
Aging (Albany NY). 2009 Feb;1(2):245-53.
[Text Abstract on PubMed]

Lymphatics in idiopathic pulmonary fibrosis: new insights into an old disease.
El-Chemaly S, Pacheco-Rodriguez G, Ikeda Y, Malide D, Moss J.
Lymphat Res Biol. 2009 Dec;7(4):197-203.
[Text Abstract on PubMed]

An alternatively spliced isoform of non-muscle myosin II-C is not regulated by myosin light chain phosphorylation.
Jana SS, Kim KY, Mao J, Kawamoto S, Sellers JR, Adelstein RS.
J. Biol. Chem. 2009 Apr 24;284(17):11563-71.
[Text Abstract on PubMed]

Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity.
Puxeddu E, Uhart M, Li CC, Ahmad F, Pacheco-Rodriguez G, Manganiello VC, Moss J, Vaughan M.
Proc. Natl. Acad. Sci. U.S.A. 2009 Apr 14;106(15):6158-63.
[Text Abstract on PubMed]