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Light Microscopy Core

The Light Microscopy Core provides state-of-the-art equipment, training, and image processing capabilities to assist researchers in experiments involving light microscopy. Equipment within the facility includes several types of confocal microscopes, two multi-photon microscope, an FCS microscope, laser trap microscope, TIRF microscopes, several standard epi-fluorescence wide-field microscopes and specialty microscopes for super-resolution imaging and wide-area confocal imaging. This range of instruments allows for most types of modern imaging techniques from basic wide-field imaging to very high spatial and temporal resolution imaging for fixed and live-cell imaging to imaging organs and tissues in vivo. Image processing capabilities include image quantification, co-localization analysis, deconvolution, and 3D reconstruction as well as a custom in-house image processing programs for specific applications. The main points of contact in Bldg. 10 are Drs. Combs and Malide and Dr. Wu in Bldg. 50.

Instruments

Bldg. 10

  • Leica SP5 Multi-Photon (dual beam with OPO)/Confocal Microscope
  • Zeiss LSM 510 META Confocal Microscope
  • Zeiss LSM 510 UV Confocal Microscope
  • Nikon Widefield Fluorescence Microscope
  • Leica Fluorescence Stereomicroscope
  • Modified Olympus IX81 Microscope (Structured Light, Ratiometric Calcium, Dual-beam TIRF Microscopy)
  • Leica SP1 Confocal Microscope
  • Leica TCS LSI Super-Zoom Confocal
  • Olympus Fluoview 1000 Experimental Microcope


Bldg. 50 

  • Zeiss LSM 510 confocorr2 (FCS) Microscope
  • Zeiss inverted Axiovert 100 Microscope with microinjector
  • Zeiss LSM 510 META Confocal Microscope
  • Zeiss  5 LIVE Confocal  Microscope
  • Zeiss LSM 780 Microscope
  • Zeiss Stereomicroscope  (SteREO Discovery V12)
  • Zeiss up-right Axioplan Microscope
  • Olympus IX 81 TIRF microscope
  • Olympus XI81 with CSU-X1 spinning disk confocal and customer-made Laser Trap
  • Zeiss LSM  710 2P
  • Nikon STORM Super-resolutionMicroscope
  • Coming soon: DeltaVison OMX Structured Light Microscope


Core Staff

The Core staff members are experts in light microscopy. They are happy to provide advice and training as necessary. Please feel free to contact the staff for more information and for scheduling time on the Light Microscopy Core microscopes.

 

Christian Combs
Core Director
Light Microscopy Core


P: +1 301 496 3236
F: +1 301 480 1477
combsc@nhlbi.nih.gov

 

Xufeng Wu
Deputy Director
Light Microscopy Core


P: +1 301 402 4187
F: +1 301 402 1519
wux@nhlbi.nih.gov

 

Daniela Malide
Staff Scientist
Light Microscopy Core


P: +1 301 402 4719
F: +1 301 480 1477
dm343o@nih.gov


Last Updated: December 13, 2012