Flow Cytometry Core

Publications

Flow Cytometry Core
J. Philip McCoy, Ph.D.

Dynamic clonal analysis of murine hematopoietic stem and progenitor cells marked by five fluorescent proteins using confocal and multiphoton microscopy.
Malide D, Metais JY, Dunbar CE.
Blood. 2012 Sep 20;.
[Text Abstract on PubMed]

Standing surface acoustic wave (SSAW) based multichannel cell sorting.
Ding X, Lin SC, Lapsley MI, Li S, Guo X, Chan CY, Chiang IK, Wang L, McCoy JP, Huang TJ.
Lab Chip. 2012 Nov 7;12(21):4228-31.
[Text Abstract on PubMed]

Standardizing immunophenotyping for the Human Immunology Project.
Maecker HT, McCoy JP, Nussenblatt R.
Nat. Rev. Immunol. 2012 Mar;12(3):191-200.
[Text Abstract on PubMed]

Cytopenia and leukocyte recovery shape cytokine fluctuations after myeloablative allogeneic hematopoietic stem cell transplantation.
Melenhorst JJ, Tian X, Xu D, Sandler NG, Scheinberg P, Biancotto A, Scheinberg P, McCoy, Hensel NF, McIver Z, Douek DC, Barrett AJ.
Haematologica. 2012 Jun;97(6):867-73.
[Text Abstract on PubMed]

An integrated, multiparametric flow cytometry chip using "microfluidic drifting" based three-dimensional hydrodynamic focusing.
Mao X, Nawaz AA, Lin SC, Lapsley MI, Zhao Y, McCoy JP, El-Deiry WS, Huang TJ.
Biomicrofluidics. 2012 Jun;6(2):24113-241139.
[Text Abstract on PubMed]

OMIP-004: in-depth characterization of human T regulatory cells.
Biancotto A, Dagur PK, Fuchs JC, Langweiler M, McCoy.
Cytometry A. 2012 Jan;81(1):15-6.
[Text Abstract on PubMed]

Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia.
Biancotto A, Dagur PK, Fuchs JC, Wiestner A, Bagwell CB, McCoy.
Mod. Pathol. 2012 Feb;25(2):246-59.
[Text Abstract on PubMed]

Apolipoprotein A-I attenuates ovalbumin-induced neutrophilic airway inflammation via a granulocyte colony-stimulating factor-dependent mechanism.
Dai C, Yao X, Keeran KJ, Zywicke GJ, Qu X, Yu ZX, Dagur PK, McCoy JP, Remaley AT, Levine SJ.
Am. J. Respir. Cell Mol. Biol. 2012 Aug;47(2):186-95.
[Text Abstract on PubMed]

Decreased plasma cytokines are associated with low platelet counts in aplastic anemia and immune thrombocytopenic purpura.
Feng X, Scheinberg P, Samsel L, Rios O, Chen J, McCoy, Ghanima W, Bussel JB, Young NS.
J. Thromb. Haemost. 2012 Aug;10(8):1616-23.
[Text Abstract on PubMed]

Evaluation of multiplexed cytokine and inflammation marker measurements: a methodologic study.
Chaturvedi AK, Kemp TJ, Pfeiffer RM, Biancotto A, Williams M, Munuo S, Purdue MP, Hsing AW, Pinto L, McCoy JP, Hildesheim A.
Cancer Epidemiol. Biomarkers Prev. 2011 Sep;20(9):1902-11.
[Text Abstract on PubMed]

Inflammation, TNFa and endothelial dysfunction link lenalidomide to venous thrombosis in chronic lymphocytic leukemia.
Aue G, Nelson Lozier J, Tian X, Cullinane AM, Soto S, Samsel L, McCoy P, Wiestner A.
Am. J. Hematol. 2011 Oct;86(10):835-40.
[Text Abstract on PubMed]

High-content screening: getting more from less.
McCoy.
Nat. Methods. 2011 May;8(5):390-1.
[Text Abstract on PubMed]

Alloreactivity across HLA barriers is mediated by both naïve and antigen-experienced T cells.
Melenhorst JJ, Scheinberg P, Williams A, Ambrozak DR, Keyvanfar K, Smith M, McCoy, Hensel NF, Douek DC, Barrett AJ.
Biol. Blood Marrow Transplant. 2011 Jun;17(6):800-9.
[Text Abstract on PubMed]

High dimensional flow cytometry for comprehensive leukocyte immunophenotyping (CLIP) in translational research.
Biancotto A, Fuchs JC, Williams A, Dagur PK, McCoy.
J. Immunol. Methods. 2011 Jan 5;363(2):245-61.
[Text Abstract on PubMed]

The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia.
Herishanu Y, Pérez-Galán P, Liu D, Biancotto A, Pittaluga S, Vire B, Gibellini F, Njuguna N, Lee E, Stennett L, Raghavachari N, Liu P, McCoy JP, Raffeld M, Stetler-Stevenson M, Yuan C, Sherry R, Arthur DC, Maric I, White T, Marti GE, Munson P, Wilson WH, Wiestner A.
Blood. 2011 Jan 13;117(2):563-74.
[Text Abstract on PubMed]

5A, an apolipoprotein A-I mimetic peptide, attenuates the induction of house dust mite-induced asthma.
Yao X, Dai C, Fredriksson K, Dagur PK, McCoy JP, Qu X, Yu ZX, Keeran KJ, Zywicke GJ, Amar MJ, Remaley AT, Levine SJ.
J. Immunol. 2011 Jan 1;186(1):576-83.
[Text Abstract on PubMed]

Transcriptional profiling of CD133(+) cells in coronary artery disease and effects of exercise on gene expression.
Liu D, Glaser AP, Patibandla S, Blum A, Munson PJ, McCoy JP, Raghavachari N, Cannon RO.
Cytotherapy. 2011 Feb;13(2):227-36.
[Text Abstract on PubMed]

MCAM-expressing CD4(+) T cells in peripheral blood secrete IL-17A and are significantly elevated in inflammatory autoimmune diseases.
Dagur PK, Biancotto A, Wei L, Sen HN, Yao M, Strober W, Nussenblatt RB, McCoy.
J. Autoimmun. 2011 Dec;37(4):319-27.
[Text Abstract on PubMed]

Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types.
Wei G, Abraham BJ, Yagi R, Jothi R, Cui K, Sharma S, Narlikar L, Northrup DL, Tang Q, Paul WE, Zhu J, Zhao K.
Immunity. 2011 Aug 26;35(2):299-311.
[Text Abstract on PubMed]

Thymic stromal lymphopoietin is produced by dendritic cells.
Kashyap M, Rochman Y, Spolski R, Samsel L, Leonard WJ.
J. Immunol. 2011 Aug 1;187(3):1207-11.
[Text Abstract on PubMed]

MHC class II upregulation and colocalization with Fas in experimental models of immune-mediated bone marrow failure.
Erie AJ, Samsel L, Takaku T, Desierto MJ, Keyvanfar K, McCoy JP, Young NS, Chen J.
Exp. Hematol. 2011 Aug;39(8):837-49.
[Text Abstract on PubMed]

Cytokine signature profiles in acquired aplastic anemia and myelodysplastic syndromes.
Feng X, Scheinberg P, Wu CO, Samsel L, Nunez O, Prince C, Ganetzky RD, McCoy, Maciejewski JP, Young NS.
Haematologica. 2011 Apr;96(4):602-6.
[Text Abstract on PubMed]

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ß-Pix in negative regulation of focal adhesion maturation.
Kuo JC, Han X, Hsiao CT, Yates, Waterman CM.
Nat. Cell Biol. 2011 Apr;13(4):383-93.
[Text Abstract on PubMed]

Evaluation of transduction efficiency in macrophage colony-stimulating factor differentiated human macrophages using HIV-1 based lentiviral vectors.
Leyva FJ, Anzinger JJ, McCoy, Kruth HS.
BMC Biotechnol. 2011;11:13.
[Text Abstract on PubMed]

Major histocompatibility complex-I expression on embryonic stem cell-derived vascular progenitor cells is critical for syngeneic transplant survival.
Ma M, Ding S, Lundqvist A, San H, Fang F, Konoplyannikov M, Berry C, Beltran LE, Chen G, Kovacic JC, Boehm M.
Stem Cells. 2010 Sep;28(9):1465-75.
[Text Abstract on PubMed]

Transient upregulation of PGC-1alpha diminishes cardiac ischemia tolerance via upregulation of ANT1.
Lynn EG, Stevens MV, Wong RP, Carabenciov D, Jacobson J, Murphy E, Sack MN.
J. Mol. Cell. Cardiol. 2010 Oct;49(4):693-8.
[Text Abstract on PubMed]

A model for harmonizing flow cytometry in clinical trials.
Maecker HT, McCoy, FOCIS Human Immunophenotyping Consortium, Amos M, Elliott J, Gaigalas A, Wang L, Aranda R, Banchereau J, Boshoff C, Braun J, Korin Y, Reed E, Cho J, Hafler D, Davis M, Fathman CG, Robinson W, Denny T, Weinhold K, Desai B, Diamond B, Gregersen P, Di Meglio P, DiMeglio P, Nestle FO, Nestle F, Peakman M, Villanova F, Villnova F, Ferbas J, Field E, Kantor A, Kawabata T, Komocsar W, Lotze M, Nepom J, Ochs H, O'Lone R, Phippard D, Plevy S, Rich S, Roederer M, Rotrosen D, Yeh JH.
Nat. Immunol. 2010 Nov;11(11):975-8.
[Text Abstract on PubMed]

Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms.
Bao J, Lu Z, Joseph JJ, Carabenciov D, Dimond CC, Pang L, Samsel L, McCoy, Leclerc J, Nguyen P, Gius D, Sack MN.
J. Cell. Biochem. 2010 May;110(1):238-47.
[Text Abstract on PubMed]

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation.
Pasapera AM, Schneider IC, Rericha E, Schlaepfer DD, Waterman CM.
J. Cell Biol. 2010 Mar 22;188(6):877-90.
[Text Abstract on PubMed]

CD146+ T lymphocytes are increased in both the peripheral circulation and in the synovial effusions of patients with various musculoskeletal diseases and display pro-inflammatory gene profiles.
Dagur PK, Tatlici G, Gourley M, Samsel L, Raghavachari N, Liu P, Liu D, McCoy.
Cytometry B Clin Cytom. 2010 Mar;78(2):88-95.
[Text Abstract on PubMed]

Defective nucleolar localization and dominant interfering properties of a parafibromin L95P missense mutant causing the hyperparathyroidism-jaw tumor syndrome.
Panicker LM, Zhang JH, Dagur PK, Gastinger MJ, Simonds WF.
Endocr. Relat. Cancer. 2010 Jun;17(2):513-24.
[Text Abstract on PubMed]

Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice.
Kovacic JC, Gupta R, Lee AC, Ma M, Fang F, Tolbert CN, Walts AD, Beltran LE, San H, Chen G, St Hilaire C, Boehm M.
J. Clin. Invest. 2010 Jan;120(1):303-14.
[Text Abstract on PubMed]

Cutting edge: bortezomib-treated tumors sensitized to NK cell apoptosis paradoxically acquire resistance to antigen-specific T cells.
Lundqvist A, Su S, Rao S, Childs R.
J. Immunol. 2010 Feb 1;184(3):1139-42.
[Text Abstract on PubMed]

Phenotypic characterization of disseminated cells with TSC2 loss of heterozygosity in patients with lymphangioleiomyomatosis.
Cai X, Pacheco-Rodriguez G, Fan QY, Haughey M, Samsel L, El-Chemaly S, Wu HP, McCoy JP, Steagall WK, Lin JP, Darling TN, Moss J.
Am. J. Respir. Crit. Care Med. 2010 Dec 1;182(11):1410-8.
[Text Abstract on PubMed]

Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression.
Majerciak V, Kruhlak M, Dagur PK, McCoy, Zheng ZM.
J. Biol. Chem. 2010 Apr 9;285(15):11297-307.
[Text Abstract on PubMed]

Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury.
Hergenroeder GW, Moore AN, McCoy, Samsel L, Ward, Clifton GL, Dash PK.
J Neuroinflammation. 2010;7:19.
[Text Abstract on PubMed]

Mitochondrial respiration protects against oxygen-associated DNA damage.
Sung HJ, Ma W, Wang PY, Hynes J, O'Riordan TC, Combs CA, McCoy, Bunz F, Kang JG, Hwang PM.
Nat Commun. 2010;1:5.
[Text Abstract on PubMed]

SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance.
Jia R, Li C, McCoy JP, Deng CX, Zheng ZM.
Int. J. Biol. Sci. 2010;6(7):806-26.
[Text Abstract on PubMed]

Lenalidomide-induced upregulation of CD80 on tumor cells correlates with T-cell activation, the rapid onset of a cytokine release syndrome and leukemic cell clearance in chronic lymphocytic leukemia.
Aue G, Njuguna N, Tian X, Soto S, Hughes T, Vire B, Keyvanfar K, Gibellini F, Valdez J, Boss C, Samsel L, McCoy, Wilson WH, Pittaluga S, Wiestner A.
Haematologica. 2009 Sep;94(9):1266-73.
[Text Abstract on PubMed]

Variability of C-reactive protein levels among patients with stable coronary artery disease and on statin therapy.
Blum A, Costello R, Samsel L, Zalos G, McCoy P, Csako G, Waclawiw MA, Cannon.
Isr. Med. Assoc. J. 2009 Oct;11(10):602-5.
[Text Abstract on PubMed]

Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors.
Kim KK, Adelstein RS, Kawamoto S.
J. Biol. Chem. 2009 Nov 6;284(45):31052-61.
[Text Abstract on PubMed]

Abnormal lymphangiogenesis in idiopathic pulmonary fibrosis with insights into cellular and molecular mechanisms.
El-Chemaly S, Malide D, Zudaire E, Ikeda Y, Weinberg BA, Pacheco-Rodriguez G, Rosas IO, Aparicio M, Ren P, MacDonald SD, Wu HP, Nathan SD, Cuttitta F, McCoy JP, Gochuico BR, Moss J.
Proc. Natl. Acad. Sci. U.S.A. 2009 Mar 10;106(10):3958-63.
[Text Abstract on PubMed]

Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells.
Wei G, Wei L, Zhu J, Zang C, Hu-Li J, Yao Z, Cui K, Kanno Y, Roh TY, Watford WT, Schones DE, Peng W, Sun HW, Paul WE, O'Shea JJ, Zhao K.
Immunity. 2009 Jan 16;30(1):155-67.
[Text Abstract on PubMed]

Microarray-based characterization of a colony assay used to investigate endothelial progenitor cells and relevance to endothelial function in humans.
Desai A, Glaser A, Liu D, Raghavachari N, Blum A, Zalos G, Lippincott M, McCoy JP, Munson PJ, Solomon MA, Danner RL, Cannon.
Arterioscler. Thromb. Vasc. Biol. 2009 Jan;29(1):121-7.
[Text Abstract on PubMed]

Systems-level analysis of cell-specific AQP2 gene expression in renal collecting duct.
Yu MJ, Miller RL, Uawithya P, Rinschen MM, Khositseth S, Braucht DW, Chou CL, Pisitkun T, Nelson RD, Knepper MA.
Proc. Natl. Acad. Sci. U.S.A. 2009 Feb 17;106(7):2441-6.
[Text Abstract on PubMed]

Polo-like kinases mediate cell survival in mitochondrial dysfunction.
Matsumoto T, Wang PY, Ma W, Sung HJ, Matoba S, Hwang PM.
Proc. Natl. Acad. Sci. U.S.A. 2009 Aug 25;106(34):14542-6.
[Text Abstract on PubMed]

Neuropilin-1 identifies endothelial precursors in human and murine embryonic stem cells before CD34 expression.
Cimato T, Beers J, Ding S, Ma M, McCoy JP, Boehm M, Nabel EG.
Circulation. 2009 Apr 28;119(16):2170-8.
[Text Abstract on PubMed]

Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6.
Wang X, Wang HK, McCoy JP, Banerjee NS, Rader JS, Broker TR, Meyers C, Chow LT, Zheng ZM.
RNA. 2009 Apr;15(4):637-47.
[Text Abstract on PubMed]

Clinical-grade ex vivo-expanded human natural killer cells up-regulate activating receptors and death receptor ligands and have enhanced cytolytic activity against tumor cells.
Berg M, Lundqvist A, McCoy, Samsel L, Fan Y, Tawab A, Childs R.
Cytotherapy. 2009;11(3):341-55.
[Text Abstract on PubMed]

Targeted antagonism of CXCR4 mobilizes progenitor cells under investigation for cardiovascular disease.
Blum A, Childs RW, Smith A, Patibandla S, Zalos G, Samsel L, McCoy JP, Calandra G, Csako G, Cannon.
Cytotherapy. 2009;11(8):1016-9.
[Text Abstract on PubMed]

Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells.
Schieke SM, Ma M, Cao L, McCoy, Liu C, Hensel NF, Barrett AJ, Boehm M, Finkel T.
J. Biol. Chem. 2008 Oct 17;283(42):28506-12.
[Text Abstract on PubMed]

Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells.
Takahashi Y, Harashima N, Kajigaya S, Yokoyama H, Cherkasova E, McCoy JP, Hanada K, Mena O, Kurlander R, Tawab A, Abdul T, Srinivasan R, Lundqvist A, Malinzak E, Geller N, Lerman MI, Childs RW.
J. Clin. Invest. 2008 Mar;118(3):1099-109.
[Text Abstract on PubMed]

Coordination of mitochondrial bioenergetics with G1 phase cell cycle progression.
Schieke SM, McCoy, Finkel T.
Cell Cycle. 2008 Jun 15;7(12):1782-7.
[Text Abstract on PubMed]

p21Cip1 modulates arterial wound repair through the stromal cell-derived factor-1/CXCR4 axis in mice.
Olive M, Mellad JA, Beltran LE, Ma M, Cimato T, Noguchi AC, San H, Childs R, Kovacic JC, Boehm M.
J. Clin. Invest. 2008 Jun;118(6):2050-61.
[Text Abstract on PubMed]

Unfolded protein response and cell death after depletion of brefeldin A-inhibited guanine nucleotide-exchange protein GBF1.
Citterio C, Vichi A, Pacheco-Rodriguez G, Aponte AM, Moss J, Vaughan M.
Proc. Natl. Acad. Sci. U.S.A. 2008 Feb 26;105(8):2877-82.
[Text Abstract on PubMed]

Regulatory T-cell depletion does not prevent emergence of new CD25+ FOXP3+ lymphocytes after antigen stimulation in culture.
Melenhorst JJ, Scheinberg P, Lu J, Ambrozak DR, Sosa E, Zhao L, Hensel NF, Savani BN, Douek DC, Price DA, Barrett AJ.
Cytotherapy. 2008;10(2):152-64.
[Text Abstract on PubMed]

Process optimization of large-scale production of recombinant adeno-associated vectors using dielectric spectroscopy.
Negrete A, Esteban G, Kotin RM.
Appl. Microbiol. Biotechnol. 2007 Sep;76(4):761-72.
[Text Abstract on PubMed]

Early interstitial lung disease in familial pulmonary fibrosis.
Rosas IO, Ren P, Avila NA, Chow CK, Franks TJ, Travis WD, McCoy, May RM, Wu HP, Nguyen DM, Arcos-Burgos M, MacDonald SD, Gochuico BR.
Am. J. Respir. Crit. Care Med. 2007 Oct 1;176(7):698-705.
[Text Abstract on PubMed]

Mitochondrial DNA sequence heterogeneity of single CD34+ cells after nonmyeloablative allogeneic stem cell transplantation.
Yao YG, Childs RW, Kajigaya S, McCoy, Young NS.
Stem Cells. 2007 Oct;25(10):2670-6.
[Text Abstract on PubMed]

TSC2 loss in lymphangioleiomyomatosis cells correlated with expression of CD44v6, a molecular determinant of metastasis.
Pacheco-Rodriguez G, Steagall WK, Crooks DM, Stevens LA, Hashimoto H, Li S, Wang JA, Darling TN, Moss J.
Cancer Res. 2007 Nov 1;67(21):10573-81.
[Text Abstract on PubMed]

Production of recombinant adeno-associated vectors using two bioreactor configurations at different scales.
Negrete A, Kotin RM.
J. Virol. Methods. 2007 Nov;145(2):155-61.
[Text Abstract on PubMed]

Economized large-scale production of high yield of rAAV for gene therapy applications exploiting baculovirus expression system.
Negrete A, Yang LC, Mendez AF, Levy JR, Kotin RM.
J Gene Med. 2007 Nov;9(11):938-48.
[Text Abstract on PubMed]

Development of recombinant adeno-associated virus vectors carrying small interfering RNA (shHec1)-mediated depletion of kinetochore Hec1 protein in tumor cells.
Li L, Yang L, Scudiero DA, Miller SA, Yu ZX, Stukenberg PT, Shoemaker RH, Kotin RM.
Gene Ther. 2007 May;14(10):814-27.
[Text Abstract on PubMed]

Endothelial progenitor cell mobilization and increased intravascular nitric oxide in patients undergoing cardiac rehabilitation.
Paul JD, Powell TM, Thompson M, Benjamin M, Rodrigo M, Carlow A, Annavajjhala V, Shiva S, Dejam A, Gladwin MT, McCoy JP, Zalos G, Press B, Murphy M, Hill JM, Csako G, Waclawiw MA, Cannon.
J Cardiopulm Rehabil Prev. 2007 Mar-Apr;27(2):65-73.
[Text Abstract on PubMed]

Characterization and expansion of baboon CD4+CD25+ Treg cells for potential use in a non-human primate xenotransplantation model.
Porter CM, Horvath-Arcidiacono JA, Singh AK, Horvath KA, Bloom ET, Mohiuddin MM.
Xenotransplantation. 2007 Jul;14(4):298-308.
[Text Abstract on PubMed]

Mitochondrial DNA sequence variation in single cells from leukemia patients.
Yao YG, Ogasawara Y, Kajigaya S, Molldrem JJ, Falcão RP, Pintão MC, McCoy, Rizzatti EG, Young NS.
Blood. 2007 Jan 15;109(2):756-62.
[Text Abstract on PubMed]

Age-dependent accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background.
Yao YG, Ellison FM, McCoy JP, Chen J, Young NS.
Hum. Mol. Genet. 2007 Feb 1;16(3):286-94.
[Text Abstract on PubMed]

Targeted disruption of Kaposi's sarcoma-associated herpesvirus ORF57 in the viral genome is detrimental for the expression of ORF59, K8alpha, and K8.1 and the production of infectious virus.
Majerciak V, Pripuzova N, McCoy JP, Gao SJ, Zheng ZM.
J. Virol. 2007 Feb;81(3):1062-71.
[Text Abstract on PubMed]

Cellular prion protein (PrPC) protects neuronal cells from the effect of huntingtin aggregation.
Lee KJ, Panzera A, Rogawski D, Greene LE, Eisenberg E.
J. Cell. Sci. 2007 Aug 1;120(Pt 15):2663-71.
[Text Abstract on PubMed]

Reduction of GVHD and enhanced antitumor effects after adoptive infusion of alloreactive Ly49-mismatched NK cells from MHC-matched donors.
Lundqvist A, McCoy JP, Samsel L, Childs R.
Blood. 2007 Apr 15;109(8):3603-6.
[Text Abstract on PubMed]

The transcription factor GABP is a critical regulator of B lymphocyte development.
Xue HH, Bollenbacher-Reilley J, Wu Z, Spolski R, Jing X, Zhang YC, McCoy JP, Leonard WJ.
Immunity. 2007 Apr;26(4):421-31.
[Text Abstract on PubMed]

External contamination in single cell mtDNA analysis.
Yao YG, Bandelt HJ, Young NS.
PLoS ONE. 2007;2(8):e681.
[Text Abstract on PubMed]

A unique population of effector memory lymphocytes identified by CD146 having a distinct immunophenotypic and genomic profile.
Elshal MF, Khan SS, Raghavachari N, Takahashi Y, Barb J, Bailey JJ, Munson PJ, Solomon MA, Danner RL, McCoy.
BMC Immunol. 2007;8:29.
[Text Abstract on PubMed]

The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity.
Schieke SM, Phillips D, McCoy, Aponte AM, Shen RF, Balaban RS, Finkel T.
J. Biol. Chem. 2006 Sep 15;281(37):27643-52.
[Text Abstract on PubMed]

Hematopoietic-specific microRNA expression in human cells.
Ramkissoon SH, Mainwaring LA, Ogasawara Y, Keyvanfar K, McCoy, Sloand EM, Kajigaya S, Young NS.
Leuk. Res. 2006 May;30(5):643-7.
[Text Abstract on PubMed]

The E7 oncoprotein is translated from spliced E6*I transcripts in high-risk human papillomavirus type 16- or type 18-positive cervical cancer cell lines via translation reinitiation.
Tang S, Tao M, McCoy, Zheng ZM.
J. Virol. 2006 May;80(9):4249-63.
[Text Abstract on PubMed]

Overcoming graft rejection in heavily transfused and allo-immunised patients with bone marrow failure syndromes using fludarabine-based haematopoietic cell transplantation.
Srinivasan R, Takahashi Y, McCoy JP, Espinoza-Delgado I, Dorrance C, Igarashi T, Lundqvist A, Barrett AJ, Young NS, Geller N, Childs RW.
Br. J. Haematol. 2006 May;133(3):305-14.
[Text Abstract on PubMed]

Short-term induction and long-term suppression of HPV16 oncogene silencing by RNA interference in cervical cancer cells.
Tang S, Tao M, McCoy, Zheng ZM.
Oncogene. 2006 Mar 30;25(14):2094-104.
[Text Abstract on PubMed]

Robust expansion of viral antigen-specific CD4+ and CD8+ T cells for adoptive T cell therapy using gene-modified activated T cells as antigen presenting cells.
Melenhorst JJ, Solomon SR, Shenoy A, Hensel NF, McCoy, Keyvanfar K, Barrett AJ.
J. Immunother. 2006 Jul-Aug;29(4):436-43; discussion 365-6.
[Text Abstract on PubMed]

Multilineage involvement of the fusion gene in patients with FIP1L1/PDGFRA-positive hypereosinophilic syndrome.
Robyn J, Lemery S, McCoy JP, Kubofcik J, Kim YJ, Pack S, Nutman TB, Dunbar C, Klion AD.
Br. J. Haematol. 2006 Feb;132(3):286-92.
[Text Abstract on PubMed]

Multiplex bead array assays: performance evaluation and comparison of sensitivity to ELISA.
Elshal MF, McCoy JP.
Methods. 2006 Apr;38(4):317-23.
[Text Abstract on PubMed]

Uncoupling proteins 2 and 3 function in concert to augment tolerance to cardiac ischemia.
McLeod CJ, Aziz A, Hoyt, McCoy, Sack MN.
J. Biol. Chem. 2005 Sep 30;280(39):33470-6.
[Text Abstract on PubMed]

LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms.
Kristof AS, Pacheco-Rodriguez G, Schremmer B, Moss J.
J. Pharmacol. Exp. Ther. 2005 Sep;314(3):1134-43.
[Text Abstract on PubMed]

CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood.
Elshal MF, Khan SS, Takahashi Y, Solomon MA, McCoy.
Blood. 2005 Oct 15;106(8):2923-4.
[Text Abstract on PubMed]

Mitochondrial DNA spectra of single human CD34+ cells, T cells, B cells, and granulocytes.
Ogasawara Y, Nakayama K, Tarnowka M, McCoy, Kajigaya S, Levin BC, Young NS.
Blood. 2005 Nov 1;106(9):3271-84.
[Text Abstract on PubMed]

Detection of circulating endothelial cells and endothelial progenitor cells by flow cytometry.
Khan SS, Solomon MA, McCoy.
Cytometry B Clin Cytom. 2005 Mar;64(1):1-8.
[Text Abstract on PubMed]

Persistence of recipient plasma cells and anti-donor isohaemagglutinins in patients with delayed donor erythropoiesis after major ABO incompatible non-myeloablative haematopoietic cell transplantation.
Griffith LM, McCoy, Bolan CD, Stroncek DF, Pickett AC, Linton GF, Lundqvist A, Srinivasan R, Leitman SF, Childs RW.
Br. J. Haematol. 2005 Mar;128(5):668-75.
[Text Abstract on PubMed]

Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.
Zeng R, Spolski R, Finkelstein SE, Oh S, Kovanen PE, Hinrichs CS, Pise-Masison CA, Radonovich MF, Brady JN, Restifo NP, Berzofsky JA, Leonard WJ.
J. Exp. Med. 2005 Jan 3;201(1):139-48.
[Text Abstract on PubMed]

Phenotype and function of a CD56+ peripheral blood monocyte.
Sconocchia G, Keyvanfar K, El Ouriaghli F, Grube M, Rezvani K, Fujiwara H, McCoy, Hensel N, Barrett AJ.
Leukemia. 2005 Jan;19(1):69-76.
[Text Abstract on PubMed]

Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease.
Powell TM, Paul JD, Hill JM, Thompson M, Benjamin M, Rodrigo M, McCoy JP, Read EJ, Khuu HM, Leitman SF, Finkel T, Cannon.
Arterioscler. Thromb. Vasc. Biol. 2005 Feb;25(2):296-301.
[Text Abstract on PubMed]

Increased reactive oxygen species contribute to high NaCl-induced activation of the osmoregulatory transcription factor TonEBP/OREBP.
Zhou X, Ferraris JD, Cai Q, Agarwal A, Burg MB.
Am. J. Physiol. Renal Physiol. 2005 Aug;289(2):F377-85.
[Text Abstract on PubMed]

CD34+ cells cultured in stem cell factor and interleukin-2 generate CD56+ cells with antiproliferative effects on tumor cell lines.
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[Text Abstract on PubMed]

The DNA minor groove binding agents Hoechst 33258 and 33342 enhance recombinant adeno-associated virus (rAAV) transgene expression.
Li L, Yang L, Kotin RM.
J Gene Med. 2005 Apr;7(4):420-31.
[Text Abstract on PubMed]

c-Kit expression and stem cell factor-induced hematopoietic cell proliferation are up-regulated in aged B6D2F1 mice.
Smith AL, Ellison FM, McCoy, Chen J.
J. Gerontol. A Biol. Sci. Med. Sci. 2005 Apr;60(4):448-56.
[Text Abstract on PubMed]

cGMP-independent nitric oxide signaling and regulation of the cell cycle.
Cui X, Zhang J, Ma P, Myers DE, Goldberg IG, Sittler KJ, Barb JJ, Munson PJ, Cintron Adel P, McCoy JP, Wang S, Danner RL.
BMC Genomics. 2005;6:151.
[Text Abstract on PubMed]

Multiplex bead array assays for detection of soluble cytokines: comparisons of sensitivity and quantitative values among kits from multiple manufacturers.
Khan SS, Smith MS, Reda D, Suffredini AF, McCoy.
Cytometry B Clin Cytom. 2004 Sep;61(1):35-9.
[Text Abstract on PubMed]

GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells.
Xue HH, Bollenbacher J, Rovella V, Tripuraneni R, Du YB, Liu CY, Williams A, McCoy JP, Leonard WJ.
Nat. Immunol. 2004 Oct;5(10):1036-44.
[Text Abstract on PubMed]

Mitochondrial DNA sequence heterogeneity in circulating normal human CD34 cells and granulocytes.
Shin MG, Kajigaya S, Tarnowka M, McCoy, Levin BC, Young NS.
Blood. 2004 Jun 15;103(12):4466-77.
[Text Abstract on PubMed]

Enhanced cytotoxicity of allogeneic NK cells with killer immunoglobulin-like receptor ligand incompatibility against melanoma and renal cell carcinoma cells.
Igarashi T, Wynberg J, Srinivasan R, Becknell B, McCoy, Takahashi Y, Suffredini DA, Linehan WM, Caligiuri MA, Childs RW.
Blood. 2004 Jul 1;104(1):170-7.
[Text Abstract on PubMed]

Marked mitochondrial DNA sequence heterogeneity in single CD34+ cell clones from normal adult bone marrow.
Shin MG, Kajigaya S, McCoy, Levin BC, Young NS.
Blood. 2004 Jan 15;103(2):553-61.
[Text Abstract on PubMed]

In vitro and in vivo evidence of PNH cell sensitivity to immune attack after nonmyeloablative allogeneic hematopoietic cell transplantation.
Takahashi Y, McCoy, Carvallo C, Rivera C, Igarashi T, Srinivasan R, Young NS, Childs RW.
Blood. 2004 Feb 15;103(4):1383-90.
[Text Abstract on PubMed]

Molecular and genetic analysis of disseminated neoplastic cells in lymphangioleiomyomatosis.
Crooks DM, Pacheco-Rodriguez G, DeCastro RM, McCoy, Wang JA, Kumaki F, Darling T, Moss J.
Proc. Natl. Acad. Sci. U.S.A. 2004 Dec 14;101(50):17462-7.
[Text Abstract on PubMed]

G-CSF-mobilized CD34+ cells cultured in interleukin-2 and stem cell factor generate a phenotypically novel monocyte.
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[Text Abstract on PubMed]

Bone marrow-derived immune cells regulate vascular disease through a p27(Kip1)-dependent mechanism.
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J. Clin. Invest. 2004 Aug;114(3):419-26.
[Text Abstract on PubMed]