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Biophysics Core

The Biophysics Facility develops and optimizes methods to study macromolecular interactions, dynamics and stability. The Facility provides professional collaborations, consultation, training, and instrument access for NHLBI researchers.

The Biophysics Facility currently has resources to study oligomeric state of biomolecular assemblies, perform measurements of affinity, stoichiometry, kinetics and thermodynamics of interactions between proteins, DNA and their cognate ligands. Biophysical characterization capabilities include measurements of molecular weight, shape, and conformation of biological macromolecules.


  • Isothermal Titration Calorimetry (ITC)
  • Differential Scanning Calorimetry (DSC)
  • Surface Plasmon Resonance (SPR-Biacore)
  • Analytical Ultracentrifugation
  • Multi Angle Light Scattering (SEC-MALS/QELS)
  • Circular Dichroism (CD)
  • Fluorescence
  • Stopped-flow

Core Staff

The Core staff members are experts in a variety of biophysical methods.  They are happy to provide advice and training on equipment as necessary.


Grzegorz Piszczek
Core Director
Biophysics Core

P: +1 301 435 8082
F: +1 301 496 0599

Last Updated: December 17, 2012