NHLBI and Children's National Medical Center have partnered to establish a new Interventional Cardiac Magnetic Resonance suite, which aims to revolutionize the way clinicians diagnose and treat children with heart disease. Read the full press release here.
Keith Horvath of NHLBI's cardiothoracic surgery research program examines some mesenchymal stem cells as part of a new clinical study testing whether these cells can improve blood flow to the heart muscle in patients having heart surgery. Learn more here.
Investigators in the Genetics and Developmental Biology Center uncover how an RNA-binding protein promotes neuronal differentiation (left), while the Protein Trafficking and Organelle Biology lab identifies a novel role for a GTPase family in recruiting key proteins to lysosomes (right). Research featured in latest JCB Biobytes.
The mission of the NHLBI Division of Intramural Research (DIR) is to perform robust scientific and clinical research leading to a better understanding of biology and clinical pathology. To attain this goal, we have built a strong basic science foundation and coupled it closely with innovative technology development and outstanding clinical research both at the NIH Clinical Center and in partnership with local hospitals.
The purview of our research is broad, encompassing investigations into the basic principles of molecular, cellular, and organ-level biology and their relationship to disease. Some current areas of fundamental interest include single molecule structure; protein assembly; molecular and cell biology; cell signaling and motility; membrane trafficking; physiology; systems biology; engineering and technology development. Insights into disease mechanisms derived from basic studies form the basis for translational research into new diagnostic and therapeutic approaches.
DIR investigators also conduct concept-based clinical studies in the areas of interventional and surgical cardiology; pulmonary medicine; sickle cell anemia; bone marrow transplant; and hematologic disorders. The Center for Population Studies located in Framingham Massachusetts and associated with the Framingham Heart Study focuses on Epidemiology of cardiovascular disease.
Providing state-of-the-art training in basic, translational, and clinical research for the next generation of scientific and clinical leaders is a high priority. This program provides opportunities for scientists and trainees to work together towards a better understanding of molecular machines, the cell, the body, and ultimately the treatment of human diseases.