Antonina Roll-Mecak and colleagues take a fantastic voyage into the molecular world of microtubules; learning how tubulin acetyltransferase (TAT) labels the insides of these hollow structures. Read more here.
Manfred Boehm's group and colleagues have identified a molecular pathway that contributes to improper vein graft remodeling following bypass surgery, opening avenues to future therapeutic interventions. Read more here.
Justin Taraska’s lab teamed up with researchers at HHMI’s Janelia Farm to develop an imaging technique that aligns the strengths of fluorescent and electron microscopy. The resulting super-resolution images show off target proteins amidst the full context of cell structure. Read more here.
Han Wen and his team report a new, motionless phase contrast x-ray scanning method that lifts the constraints on speed and flexibility imposed by mechanical phase stepping. This could overcome a key barrier to bringing phase contrast x-ray to clinics.
The mission of the NHLBI Division of Intramural Research (DIR) is to perform robust scientific and clinical research leading to a better understanding of biology and clinical pathology. To attain this goal, we have built a strong basic science foundation and coupled it closely with innovative technology development and outstanding clinical research both at the NIH Clinical Center and in partnership with local hospitals.
The purview of our research is broad, encompassing investigations into the basic principles of molecular, cellular, and organ-level biology and their relationship to disease. Some current areas of fundamental interest include single molecule structure; protein assembly; molecular and cell biology; cell signaling and motility; membrane trafficking; physiology; systems biology; engineering and technology development. Insights into disease mechanisms derived from basic studies form the basis for translational research into new diagnostic and therapeutic approaches.
DIR investigators also conduct concept-based clinical studies in the areas of interventional and surgical cardiology; pulmonary medicine; sickle cell anemia; bone marrow transplant; and hematologic disorders. The Center for Population Studies located in Framingham Massachusetts and associated with the Framingham Heart Study focuses on Epidemiology of cardiovascular disease.
Providing state-of-the-art training in basic, translational, and clinical research for the next generation of scientific and clinical leaders is a high priority. This program provides opportunities for scientists and trainees to work together towards a better understanding of molecular machines, the cell, the body, and ultimately the treatment of human diseases.