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Division of Intramural Research

Hematology Branch

Principal Investigator: Neal S Young, MD

Welcome to the Hematology Branch. The Branch is an intramural research program within the National Heart, Lung, and Blood Institute in Bethesda Maryland. The Chief of the Branch is Neal Young, MD.

Research activities are directed to the investigation of hematologic disease. Activities range from basic biology to applied clinical research and the treatment of patients in experimental protocols. For these purposes, advanced techniques are utilized from molecular biology, cellular biology, immunology, and virology. Individual, investigator-led units focus on bone marrow failure and its mechanism, especially immune suppression of hematopoiesis and the interaction of viruses with hematopoietic cells; bone marrow transplantation, both autologous and allogeneic, with emphases on stem cell isolation and mechanisms of graft-versus-host and graft-versus-leukemia effects; gene therapy, with protocols for gene marking the clinical treatment of Fanconi's anemia; and the use of primate models for gene therapy. Viruses of interest include B19 parvovirus; adeno-associated virus, especially as a vector for gene therapy; retroviruses, including the human immunodeficiency virus; and herpesviruses. Extensive facilities are available for pre-clinical trials in non-human primates and for human gene therapy. The research is focused on the pathogenesis of disease at the molecular and cellular level and the use of laboratory insights to develop novel strategies for treatment.

Information on the clinical research studies being conducted by the Hematology Branch is available. This information, as well as information on other NHLBI clinical studies is also available in the category, Health Related Information, under Studies Seeking Patients.

Last Updated December 2012

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