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Recovery Act Investments in Sleep

Public Health Burden

Sleep deprivation and sleep disorders are pervasive consequences of modern urban lifestyles that increase risk of cardiovascular disease, diabetes, obesity, accidents, and all-cause mortality. Even relatively small decrements in sleep quality or duration are associated with functional and emotional difficulties in family and workplace relationships, diminished cognitive performance, and depression.

Treatment

Although many available treatments appear to reduce the severity of sleep disorders and sleep-related symptoms, their prescription and use in practice vary widely because sleep problems are difficult to measure and rigorous evidence of their efficacy in reducing the risk of disease or death is lacking. Recovery Act-funded grants addressing treatment issues include investigations of:

Basic Research

Chronic sleep insufficiency—whether because of lifestyle choices or untreated sleep disorders—erodes health over time. Sleep duration and sleep pattern strongly influence how well organs work together to maintain health and enable top performance in work, school, or sports. Recent advances indicate that the genes responsible for the timing of sleep and wakefulness in the brain also produce cycles of cell function in tissues such as fat, heart muscle, and liver. A prolonged disruption of such rhythms results in abnormalities associated with disease.  Recovery Act funds are supporting a variety of basic science investigations addressing these topics, such as research on:


  1. 1 RC2 HL101340-01 - Human circadian sensitivity to very short light pulses – Klerman, Elizabeth B (MA)
  2. 1 RC1 HL100046-01 - Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk – Tasali, Esra (IL)
  3. 1 RC1 HL099724-01 - Targeted Therapies for Selected Phenotypes of Obstructive Sleep Apnea – Dempsey, Jerome (WI)
  4. 1 RC2 HL101417-01 - Phase II Trial Of Sleep Apnea Treatment To Reduce Cardiovascular Morbidity – Redline, Susan (OH)
  5. 1 R21 HL092480-02S1 - The Role of Obstructive Sleep Apnea in the Acutely Decompensated Heart Failure, Khayat, Rami N (OH)
  6. 1 R01 HL092140-01A2 - Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration – Carnethon, Mercedes (IL)
  7. 1 R01 HL037379-21A1 - Effects of sex and fat distribution on sleep disordered breathing – Smith, Phillip (MD)
  8. 1 RC1 HL099749-01 - ECG-derived cardiopulmonary coupling biomarkers of sleep, and sleep-breathing – Thomas, Robert (MA)
  9. 1 RC1 HL099701-01 - Biomarker for Sleep Loss: A Proteomic Determination - Naidoo, Nirinjini N (PA)
  10. 1 R01 HL092571-01A1 - Neuropeptidomics of Clock-to-Clock Coupling – Gillette, Martha (IL)
  11. 1 R01 HL088041-01A1 - Biology of the NK cell cytolytic activity rhythm – Sarkar, Dipak (NJ)
  12. 1 R01 HL080492-05S1 - Sleep Apnea: Upper Airway Nerve Injury - Veasey, Sigrid C (PA)
  13. 1 R01 HL080978-04S1 - Circadian & Genetic Evaluation of Extreme Sleep Timing - Duffy, Jeanne F (MA)


Last Updated April 26, 2010





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