FYI from the NHLBI Index

September 2009: Vol. 10, Issue 2
Research and Resources

NHLBI Research Initiatives

  • Ancillary Studies of Acute Kidney Injury, Chronic Kidney Disease, and End Stage Renal Disease Accessing Information from Clinical Trials, Epidemiological Studies, and Databases
  • Directed Stem Cell Differentiation for Cell-Based Therapies for Heart, Lung, and Blood Diseases
  • Erythropoiesis: Components and Mechanisms (R01)
  • Genetic and Genomic Analyses of Xenopus (R01)
  • Improving Diet and Physical Activity Assessment (R01)
  • Innovations in Biomedical Computational Science and Technology (R01)
  • NHLBI Systems Biology Collaborations
  • Pilot Studies for Studying the Mechanisms of Improvement in Type 2 Diabetes and Cardiovascular Risk Factors or in Cardiovascular, Lung, or Sleep Diseases after Bariatric Surgery (R01)
  • Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships (F31) to Promote Diversity in Health-Related Research
  • Ruth L. Kirschstein National Research Service Awards for Individual Senior Fellows (F33)
  • Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers (U54)
  • Translational Programs in Lung Diseases (P01)

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NHLBI Research Initiatives

From time to time, the NHLBI invites investigators to submit grant applications or contract proposals for specific research programs. We are soliciting applications for the new programs described below. Please visit the URL listed with each program to obtain information about important application dates and deadlines. For full details of these and other current research initiatives, visit www.nhlbi.nih.gov/funding/inits/index.htm.

Ancillary Studies of Acute Kidney Injury, Chronic Kidney Disease, and End Stage Renal Disease Accessing Information from Clinical Trials, Epidemiological Studies, and Databases

  • Initiative Number: PA-09-196
  • Objective: Carry out ancillary studies to ongoing or completed clinical trials, existing administrative and clinical databases, and epidemiological studies of kidney disease, acute kidney injury, and chronic kidney disease in order to extend our understanding of the risk factors for developing kidney disease.

Directed Stem Cell Differentiation for Cell-Based Therapies for Heart, Lung, and Blood Diseases

  • Initiative Number: PA-09-248/249/250
  • Objective: Define the factors that control differentiation of stem cells in vitro or in vivo in order to develop methods to direct differentiation of stem cells to yield replacement cells for clinical use or to develop methods to stimulate differentiation of resident stem cells in vivo for regeneration or repair of the heart, blood vessels, lungs, and blood.

Erythropoiesis: Components and Mechanisms (R01)

  • Initiative Number: PA-09-255
  • Objective: Develop a complete description of the molecular and cellular components of erythropoiesis, including gene expression, protein translation, and post-translational modification.

Genetic and Genomic Analyses of Xenopus (R01)

  • Initiative Number: PAR-09-240/241
  • Objective: Improve the use of the African aquatic clawed frog (genus Xenopus) as a vertebrate model for biomedical research by developing new resources to advance the detection and characterization of genes, pathways, and phenotypes of interest in development, organogenesis, and in cell biological processes such as cell division, signaling, and migration.

Improving Diet and Physical Activity Assessment (R01)

  • Initiative Number: PAR-09-224/225
  • Objective: Improve diet and physical activity measurement through development of novel assessment approaches, improved instruments, new technologies, or statistical/analytical techniques.

Innovations in Biomedical Computational Science and Technology (R01)

  • Initiative Number: PAR-09-218
  • Objective: Conduct research and development in biomedical computing and biomedical information science and technology in order to ensure better management and analysis of biomedical data and better modeling of biological processes.

NHLBI Systems Biology Collaborations

  • Initiative Number: PAR-09-214
  • Objective: Promote the use of collaborative teams of investigators to develop a coordinated systems biology approach to understand the normal physiology and perturbations associated with heart, lung, blood, and sleep disorders.

Pilot Studies for Studying the Mechanisms of Improvement in Type 2 Diabetes and Cardiovascular Risk Factors or in Cardiovascular, Lung, or Sleep Diseases after Bariatric Surgery (R01)

  • Initiative Number: DK-09-012
  • Objective: Determine the optimal research design as well as collect pilot data on feasibility and implementation for a randomized clinical trial of the effects of bariatric surgery on patients with cardiovascular, lung, and sleep diseases. Studies should focus on subjects with a BMI of 30 to 40.

Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships (F31) to Promote Diversity in Health-Related Research

  • Initiative Number: PA-09-209
  • Objective: Improve the diversity of the health-related research workforce by supporting the training of predoctoral students from groups that have been shown to be underrepresented, such as individuals from underrepresented racial and ethnic groups, individuals with disabilities, and individuals from disadvantaged backgrounds.

Ruth L. Kirschstein National Research Service Awards for Individual Senior Fellows (F33)

  • Initiative Number: PA-09-211
  • Objective: Enable experienced scientists who have at least seven years of research experience beyond the doctorate and who have progressed to the stage of independent investigators to make major changes in the direction of their research careers or broaden their scientific backgrounds by acquiring new research capabilities through a program of full-time training for up to two years at the NIH or at other institutions.

Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers (U54)

  • Initiative Number: HD-09-027
  • Objective: Participate in a network of six centers to foster the translation of new scientific findings and technological developments into novel treatments for the muscular dystrophies, a group of hereditary, progressive degenerative disorders causing weakness of the skeletal or voluntary muscles. Each Center may contain a mixture of basic, translational, and/or clinical research, as long as efforts are directed toward therapeutic development.

Translational Programs in Lung Diseases (P01)

  • Initiative Number: PAR-09-185
  • Objective: Encourage interdisciplinary approaches to lung translational research, allowing for potentially high-impact research, which will translate recent findings from basic biomedical research into the development of new prevention, diagnosis, and treatment strategies for pulmonary diseases.

 

Modified 9/3/09
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We are always interested in receiving comments and suggestions from the community. If you or your organizations have questions for me or for the Institute, please contact me at nabele@nhlbi.nih.gov or Dr. Carl Roth at rothc@nhlbi.nih.gov.

Elizabeth G. Nabel, M.D.
Director, NHLBI

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