FYI from the NHLBI Index
May 2002: Vol. 3, Issue 1
In the News
News from Capitol Hill
Recent Advances from the NHLBI
- Gene Linked to Sudden Cardiac Death Identified
- Heart Assist Device Extends and Improves Lives of Patients with End Stage Heart Failure
- Scientists Use Gene Therapy to Correct Sickle Cell Disease in Mice
- Ozone Alert! Days Can Be Bad for Your Heart
The House and Senate Appropriations Subcommittees on Labor, Health and Human Services, and
Education are working on their respective appropriations bills for the NIH for Fiscal Year (FY) 2003.
Dr. Ruth Kirschstein, Acting Director, NIH, and the Directors of the various NIH Institutes and
Centers, participated in an overview hearings with the House and Senate subcommittees on March 13
and 21, respectively. Dr. Kirschstein and other Directors also met with the House subcommittee for
"theme hearings" on specific topics:
- From Bench to Bedside and Beyond
- Fundamental Research: Biomedical Science in the Future
- Collaborations in Research
- Disease Prevention and Health Promotion
Dr. Lenfant was invited to speak during the Disease Prevention and Health Promotion hearing on
April 16. He presented several examples of NHLBI activities that bring research results to
local communities and described ongoing collaborations to allow the Institute's messages to
reach people of all ages and backgrounds.
Recent Advances from the NHLBI
Gene Linked to Sudden Cardiac Death Identified
Researchers have cloned and identified the role of a gene that, in the presence of heart
failure, appears to cause irregular heart beats that can lead to sudden cardiac death. Although
the study was conducted in mice, the same gene regulates electrical currents that are vital to
sustaining a normal rhythm in the human heart. Study coauthor Dr. Ching-Feng Cheng, University
of California, San Diego, explained that the gene functions like an electrical switch; during
heart failure, the switch disrupts current flow, leading to malignant heart rhythms and sudden
death. He also noted, however, that sudden cardiac death may be caused by a wide spectrum of
underlying mechanisms. "The challenge," he said, "is to identify the key molecular switches that
lead to the disease, and to design new ways to treat complex human cardiac diseases."
Heart Assist Device Extends and Improves Lives of Patients with End Stage Heart Failure
Despite several serious side effects, a type of implantable heart pump, called a left ventricular
assist device, can extend and improve the lives of terminally ill patients with end-stage heart failure
who are not eligible for cardiac transplantation. "This study is an initial step in demonstrating
the feasibility of restoring or replacing heart function for extended periods of time," said Dr. John
Watson, director of the NHLBI Clinical and Molecular Medicine Program and study coauthor. Heart
failure affects an estimated 4.7 million Americans, and 550,000 new cases are diagnosed each year.
Dr. Lenfant commented, "This compelling study shows that even with a high rate of complications, a
left ventricular assistance device can provide a significantly longer and better quality of life in
extremely ill heart failure patients for whom a poor quality of life and death are certain."
Scientists Use Gene Therapy to Correct Sickle Cell Disease in Mice
For the first time scientists have corrected sickle cell disease in mice using gene
therapy. "Scientists have been working to accomplish this since the creation of an animal
model for sickle cell disease several years ago. Although much more research is needed before
human application, this is a significant achievement that brings us closer to human gene therapy
for what is a very serious genetic blood disorder," said Dr. Lenfant. The next step is to see how
safe and effective the gene transfer process is in larger animals more similar to humans.
Currently, the only cure available is bone marrow transplantation, which requires a healthy, matched sibling donor,
and only approximately 18 percent of children with sickle cell disease qualify.
Ozone Alert! Days Can Be Bad for Your Heart
"Code Red," "Ozone Action Day," and other terms describing poor air quality in a community
usually are associated with an increase in respiratory ailments. Now, researchers have shown that
invisible air pollutants so small that they can evade the lungs' normal defense mechanisms and
get into the bloodstream may trigger a heart attack as little as 2 hours after being inhaled.
Although it is too early to predict what medical interventions might be effective in preventing
heart attacks triggered by fine-particle exposure, some recent data suggest that the particles
may cause inflammation and increase levels of certain proteins that cause clots to form.
Year-round processes such as combustion in automobile engines, power plants, and refineries cause
fine-particulate air pollution, but the associated health concerns are largely summer phenomena.
The study's co-author, Douglass W. Dockery, Sc.D., professor of environmental epidemiology at
Harvard School of Public Health, advises people to "avoid outdoor activity on hot, hazy days,"
because when people exercise outside, their increased respiratory activity also increases the
amount of particles that are absorbed into the blood stream. But don't use that as an excuse for
not going to the gym you joined as part of your New Year's Resolution;
air conditioning can reduce indoor concentrations of the pollutants by 30-50 percent.
Please send us your feedback, comments, and questions by using the appropriate link on the page, Contact the NHLBI.
Note to users of screen readers and other assistive technologies: please report your problems here.
PDF Version | Contents | Feature
Articles | In the News | Events and Meetings | Research and Resources
All Issues | FYI Index | NHLBI Express