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In the News |
Recent Advances from the NHLBI |
At a hearing of the House Appropriations Subcommittee on Labor, Health and Human
Services, Education, and related agencies held on March 9, Dr. Zerhouni,
Dr. Nabel, and other NIH directors highlighted specific areas in which the NIH
has made progress and described ongoing activities. Representatives asked questions
about topics such as obesity, cardiovascular complications associated with long-term
use of COX-2 inhibitors, and recent findings from the NHLBI-supported Women’s
Health Study on the use of low-dose aspirin to prevent heart attack and stroke.
At a hearing of the corresponding Senate Appropriations Subcommittee held on April
6, questions focused on the President’s policy on stem cell research and
the new NIH conflict of interest policy.
Members also have introduced resolutions to:
New findings from the Lung Health Study (LHS), supported by the NHLBI, show that smoking cessation can greatly improve long-term survival even among smokers whose lung function is already impaired.
The LHS followed nearly 5,900 middle-aged smokers who had mildly or moderately abnormal lung function but were otherwise healthy. They were assigned to receive either a 10-week intensive smoking cessation program that included behavior modification, use of nicotine gum, and a five-year maintenance program to minimize relapse, or no intervention at all. Five years after the program began, only about 22 percent of people who received intensive intervention were sustained quitters - compared with about 5 percent of those receiving no intervention. Nonetheless, after 14.5 years, the death rate for those in the smoking cessation program was about 15 percent lower than for participants in the non-intervention group.
Diuretics work better than newer therapies in treating high blood pressure and reducing risk of heart disease in both black and non-black patients, according to a long-term, multi-center trial of antihypertensive therapies funded by the NHLBI. An analysis of race-specific data from the ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial) confirms earlier findings on the overall effectiveness of diuretics and emphasizes that diuretics should be preferred as a first therapy for most patients with high blood pressure.
Across both racial subgroups, a substantially higher risk of heart failure - 37 percent - was found among participants taking calcium channel blockers compared with those on diuretics. When compared with ACE inhibitors, diuretics were more effective in preventing cardiovascular disease, especially heart failure, for all participants and more effective in reducing high blood pressure and preventing stroke in black patients.