FYI from the NHLBI Index

January 2010: Vol. 10, Issue 3
Research and Resources

NHLBI Research Initiatives

  • Functional Modeling of Pediatric Upper Airway Disorders (R01)
  • Lung Transplantation: Planning Grants for Clinical Trials of Novel Therapies (R34)
  • Bioengineering Nanotechnology Initiative (STTR [R41/R42]) and (SBIR [R43/R44])
  • NHLBI Clinical Trial Pilot Studies (R34)
  • Bioengineering Research Grants (R01 and R21)
  • Cellular and Molecular Mechanisms of Arterial Stiffening and Its Relationship to Development of Hypertension (R01)
  • NHLBI Centers for Cardiovascular Outcomes Research (U01)
  • Obesity Policy Research: Evaluation and Measures (R01)
  • Effectiveness Research on Smoking Cessation in Hospitalized Patients (U01)
  • Selected Topics in Transfusion Medicine (R01/R21)
  • Reducing Cardiovascular Disease Risk Through Treatment of Obstructive Sleep Apnea (U34)
  • Critical Illness and Injury in Aging (R01)
  • Dissemination and Implementation Research in Health (R01)
  • Development of Multifunctional Drug and Gene Delivery Systems (R01)
  • Programs of Excellence in Glycosciences (P01)
  • Systems Biology Approach to the Mechanisms of TB Latency and Reactivation (R01)

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NHLBI Research Initiatives

From time to time, the NHLBI invites investigators to submit grant applications or contract proposals for specific research programs. We are soliciting applications for the new programs described below. Please visit the URL listed with each program to obtain information about important application dates and deadlines. For full details of these and other current research initiatives, visit www.nhlbi.nih.gov/funding/inits/index.htm.

Functional Modeling of Pediatric Upper Airway Disorders (R01)

  • Initiative Number: RFA-HL-10-017
  • Objective: Develop functional computational models of the upper airway in children with multiple types of congenital malformations and acquired syndromes of airway obstruction to identify control points that limit airflow.

Lung Transplantation: Planning Grants for Clinical Trials of Novel Therapies (R34)

  • Initiative Number: RFA-HL-10-016
  • Objective: Propose novel protocols assessing promising new interventions for lung donors and recipients with the goal of improving long-term lung transplant patient outcomes.

Bioengineering Nanotechnology Initiative (STTR [R41/R42]) and (SBIR [R43/R44])

  • Initiative Number: PA-09-266 and -267
  • Objective: Conduct small business projects that develop and apply nanotechnology to biomedicine.

NHLBI Clinical Trial Pilot Studies (R34)

  • Initiative Number: PAR-10-005
  • Objective: Conduct pilot studies to obtain critical data needed to design clinical trials directed at improving the prevention and treatment of heart, lung, blood, and sleep disorders.

Bioengineering Research Grants (R01 and R21)

  • Initiative Number: PA-10-009 and -010
  • Objective: Conduct basic design-directed or hypothesis-driven bioengineering studies in single laboratories or small groups using integrative, systems approaches.

Cellular and Molecular Mechanisms of Arterial Stiffening and Its Relationship to Development of Hypertension (R01)

  • Initiative Number: RFA-HL-10-027
  • Objective: Determine the relationship between arterial stiffening and the development of hypertension with the goal of preventing hypertension and associated target organ damage.

NHLBI Centers for Cardiovascular Outcomes Research (U01)

  • Initiative Number: RFA-HL-10-008 and -018
  • Objective: Generate an improved understanding of the processes involved in translating cardiovascular research findings into practice through the conduct of outcomes and comparative effectiveness research.

Obesity Policy Research: Evaluation and Measures (R01)

  • Initiative Number: PA-10-027 and -028
  • Objective: Conduct research on community and other population-level public policy interventions that may affect diet and physical activity.

Effectiveness Research on Smoking Cessation in Hospitalized Patients (U01)

  • Initiative Number: RFA-HL-10-020 and -025
  • Objective: Conduct studies to determine how to translate smoking cessation interventions for hospitalized patients into effective programs for implementation in routine clinical care and to assess their cost effectiveness.

Selected Topics in Transfusion Medicine (R01/R21)

  • Initiative Number: PAR-10-033 and -034
  • Objective: Conduct research on selected topics related to transfusion medicine, such as alloimmunization and its consequences, infectious disease complications, microchimerism, the development of effective animal models of transfusion complications, and behavioral studies related to blood donor recruitment.

Reducing Cardiovascular Disease Risk Through Treatment of Obstructive Sleep Apnea (U34)

  • Initiative Number: RFA-HL-10-023
  • Objective: Provide preliminary and critical information for the design of a Phase III clinical trial to test whether positive airway pressure treatment of obstructive sleep apnea reduces cardiovascular events.

Critical Illness and Injury in Aging (R01)

  • Initiative Number: PA-10-042, -043, and -044
  • Objective: Study mechanisms and management of critical illness and injury, including trauma and neurotrauma, in aging.

Dissemination and Implementation Research in Health (R01)

  • Initiative Number: PAR-10-038
  • Objective: Identify, develop, and refine methods to test models of dissemination and implementation of health behavior change interventions and evidence-based prevention.

Development of Multifunctional Drug and Gene Delivery Systems (R01)

  • Initiative Number: PAR-10-048
  • Objective: Develop drug and gene delivery systems that can target therapies to particular cells and intracellular components.

Programs of Excellence in Glycosciences (P01)

  • Initiative Number: RFA-HL-10-026
  • Objective: Enhance interdisciplinary research and training in glycosciences in order to translate emerging discoveries in glycosciences into new diagnostics and clinical applications.

Systems Biology Approach to the Mechanisms of TB Latency and Reactivation (R01)

  • Initiative Number: RFA-HL-10-015 and -022
  • Objective: Investigate the mechanisms of latency and reactivation of tuberculosis in the lung using collaborative systems biology approaches based primarily on human studies.

 

Modified 1/15/10
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We are always interested in receiving comments and suggestions from the community. If you or your organizations have questions for me or for the Institute, please contact me at shurinsb@nhlbi.nih.gov or Dr. Carl Roth at rothc@nhlbi.nih.gov.

Susan B. Shurin, M.D.
Acting Director, NHLBI

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