September 23, 2013
: Nature Immunology
Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation
co-authored by Keji Zhao, Ph.D., NHLBI Laboratory of Epigenome Biology
This systems biology study cataloged over 1500 long noncoding RNA molecules (lincRNAs) present in T-cells. The findings reveal that lincRNAs have co-evolved with neighboring protein-coding genes, and provide important clues into the function and regulation of these intriguing molecules.
September 27, 2012
Major cancer protein amplifies global gene expression, NIH study finds
Scientists may have discovered why a protein called MYC can provoke a variety of cancers. Like many proteins associated with cancer, MYC helps regulate cell growth. A study carried out by researchers at the National Institutes of Health and colleagues found that, unlike many other cell growth regulators, MYC does not turn genes on or off, but instead boosts the expression of genes that are already turned on.
April 5, 2012
Report of the National Heart, Lung, and Blood Institute Working Group on Epigenetics and Hypertension
coauthored by Gary H. Gibbons, M.D., Ph.D., Weiqun Peng, Ph.D., H. Eser Tolunay, Ph.D., Katherine C. Wood, Ph.D., Keji Zhao, Ph.D., and Zorina S. Galis, Ph.D., with the NHLBI
The working group concluded that epigenetics research should incorporate multispecies comparisons to benefit from evolutionary insights and perspectives. Studies will require coordination of multidisciplinary teams combining expertise in clinical and basic research, as well as in computational and modeling methods.