February 22, 2013
: Cell Press
Cell Press webinar: signaling and mitochondria
co-presented by Toren Finkel, M.D., Ph.D., Center for Molecular Medicine
Recent years have witnessed a growing excitement in the field of mitochondrial biology with a dramatic increase in our appreciation of the diversity and complexity of mitochondrial function. Rather than simply acting as isolated energy-generating organelles, as once thought, we now know that these organelles form a dynamic network that is subject to continuous remodeling and is integrated into cellular signaling pathways. This webinar will focus on recent developments in signaling at mitochondria, specifically the role of oxidative stress signalling in metabolism, the regulation of mitochondrial calcium dynamics, and the contribution of the ubiquitin-proteasome system in modulating mitochondrial dynamics.
December 14, 2012
The NAD-dependent deacetylase SIRT2 is required for programmed necrosis
co-authored by Toren Finkel, Elizabeth Murphy, and Michael Sack
Although initially viewed as unregulated, increasing evidence suggests that cellular necrosis often proceeds through a specific molecular program. In particular, death ligands such as tumour necrosis factor (TNF)-α activate necrosis by stimulating the formation of a complex containing receptor-interacting protein 1 (RIP1) and receptor-interacting protein 3 (RIP3). Relatively little is known regarding how this complex formation is regulated. Here, we show that the NAD-dependent deacetylase SIRT2 binds constitutively to RIP3 and that deletion or knockdown of SIRT2 prevents formation of the RIP1–RIP3 complex in mice.
February 12, 2003
NHLBI Study Finds Possible New Indicator of Heart Disease Risk
Levels of a type of adult stem cell in the bloodstream may indicate a person's risk of developing cardiovascular disease, according to a study supported by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health in Bethesda, MD.