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October 26, 2016

Long-term oxygen treatment does not benefit some COPD patients

Newly published data from the Long-Term Oxygen Treatment Trial (LOTT) show that oxygen use is not beneficial for most people with chronic obstructive pulmonary disease (COPD) and moderately low levels of blood oxygen. It neither boosted their survival nor reduced hospital admissions for study participants. Previous research showed that long-term oxygen treatment improves survival in those with COPD and severely low levels of blood oxygen. However, a long-standing question remained whether a different group of COPD patients—those with moderately low levels of blood oxygen—also benefit. The study was funded by the National Heart, Lung, and Blood Institute (NHLBI)—a part of the National Institutes of Health—and the Centers for Medicare & Medicaid Services.

October 24, 2016

Toward Precision Medicine: First Whole Genomes from TOPMed Now Available for Study

In a bold step for precision medicine, researchers at the National, Heart, Lung, and Blood Institute (NHLBI) today announced they are releasing for study nearly 9,000 whole genomes, courtesy of participants in the Institute’s Trans-Omics for Precision Medicine Program (TOPMed). The genomes—an organism’s complete set of DNA—are the first ever to be made available by the program, and researchers hope they one day will lead to treatments tailor-made to the individual, as well as shed light on racial and ethnic health disparities.

September 30, 2016

NHLBI Awards Grants to Help Improve Health Outcomes for Teens, Adults with Sickle Cell Disease

WHAT: The National Heart, Lung, and Blood Institute (NHLBI) recently awarded nearly $36 million in grants to help improve the quality of health care for U.S. teens and adults with sickle cell disease. The grants are the first of their kind dedicated to testing strategies that could boost health outcomes for this group of young adults. The grants were awarded to eight clinical sites across the country as part of the Sickle Cell Disease Implementation Consortium (SCDIC) project.

September 12, 2016

Researchers Discover New Genetic Markers for Blood Pressure

WHAT: A team of researchers led by scientists from the Framingham Heart Study has discovered 31 new genetic markers it says are associated with blood pressure. The large-scale study provides new insight into the genetic underpinnings of high blood pressure and researchers say it could lead to better ways to treat the disease. Their study was published in Nature Genetics.

August 17, 2016

Study Shows Acetaminophen Can Be Tolerated by Young Children With Mild, Persistent Asthma

WHAT: In a study of children with mild, persistent asthma, scientists found that acetaminophen was tolerated without the worsening of asthma, when compared with ibuprofen use. The study, funded by the National Heart, Lung, and Blood Institute’s asthma network (AsthmaNet), appears in the August 18, 2016, issue of the New England Journal of Medicine.

July 12, 2016

Media Availability: Newly discovered features of collagen may help shed light on disease processes

Scientists at the National Institutes of Health are reporting new, unexpected details about the fundamental structure of collagen, the most abundant protein in the human body. In lab experiments, they demonstrated that collagen, once viewed as inert, forms structures that regulate how certain enzymes break down and remodel body tissue. The finding of this regulatory system provides a molecular view of the potential role of physical forces at work in heart disease, cancer, arthritis, and other disease-related processes, they say. The study appears in the current online issue of the Proceedings of the National Academy of Sciences.

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