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July 29, 2015

High-resolution 3D images reveal the muscle mitochondrial power grid

A new study overturns longstanding scientific ideas regarding how energy is distributed within muscles for powering movement. Scientists are reporting the first clear evidence that muscle cells distribute energy primarily by the rapid conduction of electrical charges through a vast, interconnected network of mitochondria—the cell’s “powerhouse”—in a way that resembles the wire grid that distributes power throughout a city. The study offers an unprecedented, detailed look at the distribution system that rapidly provides energy throughout the cell where it is needed for muscle contraction.

July 1, 2015

NHLBI Media Availability: Largest Study of Gene Mutations in Aplastic Anemia May Help Optimize Treatment

Scientists have identified a group of genetic mutations in patients with aplastic anemia, which likely will help doctors optimize treatment for this rare and deadly blood condition. The study, appearing in the New England Journal of Medicine, could lead to tailor-made treatment plans for aplastic anemia patients as part of the emerging precision medicine movement. It is the largest study of its kind to examine gene mutations in aplastic anemia, the scientists note.

June 19, 2015

NHLBI Media Availability: Scientists develop method of producing large quantities of selectively labeled RNA molecules

Study opens door to new opportunities in medicine and research

WHAT: Scientists have developed an efficient method of producing substantial quantities of RNA molecules with selectively labeled regions, paving the way for more advanced research and medical applications. RNA — DNA's lesser-known partner molecule — plays a significant role not only in genetic activities but in many other biological functions like enzymatic processes. It also is an important research, medical diagnostic, and therapeutic tool.

June 16, 2015

Media Advisory: NHLBI to hold community forum on sickle cell disease

WHAT: The National Heart, Lung, and Blood Institute (NHLBI) is sponsoring the Sickle Cell Disease Forum, “Engaging the Community: Developing Solutions.” The Forum is designed to assemble members of the sickle cell disease community—including patients and their families, advocates, health care professionals, researchers, community and professional organizations, policymakers, government agencies, and industry—to share insights, experiences and needs and to help chart the future of sickle cell disease research.

May 19, 2015

NHLBI Media Availability: New Form of Interleukin-2 Could Be Fine-Tuned to Fight Disease

WHAT:  Scientists are reporting development of a new way to modify interleukin-2 (IL-2), a substance known as a cytokine that plays key roles in regulating immune system responses, in order to fine-tune its actions.  Harnessing the action of IL-2 in a controllable fashion is of clinical interest with potential benefit in a range of situations, including transplantation and autoimmune disease.

May 5, 2015

NIH statement on World Asthma Day 2015

On World Asthma Day 2015, the National Institutes of Health stands with the international community to renew our commitment to advance our understanding of asthma and develop effective strategies to manage and prevent the disease. Within a broad asthma research portfolio, NIH-supported scientists are making progress in understanding how certain exposures—such as to microbes, allergy-triggering substances (allergens) and pollution—may contribute to the development or worsening of asthma, and are working on new approaches to address these factors.

April 25, 2015

Two treatments yield similar results for children after cardiac arrest

A large-scale, multicenter study has shown that emergency body cooling does not improve survival rates or reduce brain injury in infants and children with out-of-hospital cardiac arrest more than normal temperature control.

Therapeutic hypothermia, or whole body cooling, can improve survival and health outcomes for adults after cardiac arrest and also for newborns with brain injury due to a lack of oxygen at birth.  But, until now, this treatment has not been studied in infants or children admitted to hospitals with cardiac arrest.

April 15, 2015

NIH launches largest clinical trial focused on HIV-related cardiovascular disease

Researchers have begun enrolling participants in a multicenter international clinical trial to test whether statin administration can reduce the risk for major adverse cardiovascular events, such as heart attacks, strokes, and heart disease, in people with HIV infection. The trial is supported by the National Institutes of Health’s National Heart, Lung, and Blood Institute (NHLBI) and National Institute of Allergy and Infectious Diseases (NIAID).

April 8, 2015

No evidence to change current transfusion practices for adults undergoing complex cardiac surgery

A National Institutes of Health-funded study found no statistical difference in the primary clinical measure—which assessed changes in function of six organs from before to seven days after surgery—between complex cardiac surgery patients receiving transfusions of red blood cell units stored for short (up to 10 days) versus long (21 or more days) periods. These findings indicate there is no need to alter how hospitals currently transfuse blood in adults going through complex cardiac surgical procedures.

March 23, 2015

NIH selects awardees to help speed development of health technologies

The National Institutes of Health has selected three new proof-of-concept hubs to help speed the translation of basic biomedical discoveries into commercial products, such as new drugs, devices, and diagnostics, to improve patient care and enhance health. The hubs are part of the NIH-supported Research Evaluation and Commercialization Hubs (REACH) program and will be funded at $9 million over three years.

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