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July 12, 2016

Media Availability: Newly discovered features of collagen may help shed light on disease processes

Scientists at the National Institutes of Health are reporting new, unexpected details about the fundamental structure of collagen, the most abundant protein in the human body. In lab experiments, they demonstrated that collagen, once viewed as inert, forms structures that regulate how certain enzymes break down and remodel body tissue. The finding of this regulatory system provides a molecular view of the potential role of physical forces at work in heart disease, cancer, arthritis, and other disease-related processes, they say. The study appears in the current online issue of the Proceedings of the National Academy of Sciences.

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July 20, 2016 : Science Magazine

Researchers are reporting that an experimental drug designed for fighting cancer also shows promise for tackling heart disease.  In the new study, the researchers showed that the experimental drug prevented the buildup of fatty arterial plaques, which can lead to heart attack and stroke, in mouse models of heart disease.  The study, published in the journal Nature, was funded by NHLBI.

July 18, 2016 : University of Michigan Health System

In a finding that could provide a better understanding of deadly diseases that are common in intensive care patients,  scientists are reporting that bacteria that normally live in the gut have been detected in failing lungs.  The scientists observed these gut bacteria in the lungs of 68 human patients with acute respiratory distress syndrome (ARDS) and in mouse models of sepsis, both of which are life-threatening conditions that are common in the intensive care unit (ICU).  In particular, the finding identifies a potential new target, the lung microbiome (bacterial community), for the prevention and treatment of these diseases.  The study, published in the journal Nature Microbiology, was partly funded by NHLBI.

August 2, 2016 to August 3, 2016
The forum will focus on modifiable risk factors that contribute to morbidity and mortality due to HLS diseases among AI/AN/NH youth. The group will be charged with identifying knowledge gaps and research opportunities that can facilitate the prevention and future treatment interventions of HLS disease outcomes among this minority demographic.
August 15, 2016 to August 17, 2016
NIH Clinical Center (Building 10)
The NHLBI Annual Sickle Cell Disease Clinical Research Meetings provide a yearly forum for investigators, practitioners, and interested health care providers to discuss the progress of ongoing clinical trials, hear presentations about new developments in scientific and clinical aspects of SCD, and interact with other investigators and NHLBI Program Staff.