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Workshop on Nitric Oxide as a Potential Therapeutic Agent: Application to Sickle Cell Disease and Other Vascular Diseases

September 5-6, 2000
Lister Hill Auditorium
sponsored by the National Heart, Lung, and Blood Institute,
the NIH Office of Rare Diseases,
and the National Institute of Diabetes, Digestive, and Kidney Diseases

Tuesday, September 5, 2000

8:00 AM Continental Breakfast and Registration

8:30  Introduction
           Dr. Steve Groft, Director, NIH Office of Rare Diseases
           Dr. Barbara Alving, Director, DBDR, NHLBI
           Dr. Greg Evans, DBDR, NHLBI

8:35  Workshop Overview - Why Nitric Oxide in Sickle Cell Disease, and Other Vascular Diseases?
           Alan Schechter, NIDDK,Workshop Chair

8:45  Session I.   Nitric Oxide, Circulatory Physiology, and Therapeutics (Warren Zapol, Chair)

8:50      Jay Zweier - Measurement and Imaging of Nitric Oxide in Biological Tissues.

9:15      Harry Ischiropoulos - Nitric Oxide Modification of Proteins

9:35      Warren Zapol - Nitric Oxide Therapeutics

10:00     discussant - Mark Gladwin

10:20 Break

 10:40 Session II.  Nitric Oxide and Cardiovascular Diseases (Richard Cannon, Chair)

10:45     Richard Cannon -Vascular Effects of Nitric Oxide Inhalation In Humans

11:10      Virginia Miller - The Paradox of Estrogen Replacement: Arterial Protection Versus Venous Thrombosis

11:35      Jonathan Abrams - Nitric Oxide Donors in the Treatment of Cardiovascular Disease

12:00      Joe Vita - Effects of Ascorbic Acid on Endothelial Vasomotor Function

12:25      discussant - Julio Panza

12:45  Lunch, on your own

1:45   Session III. Nitric Oxide and Lung Diseases (Serpil Erzurum, Chair)

1:45       Serpil Erzurum - Endogenous Nitric Oxide and Nitric Oxide Reaction Products in the Human Lung

2:10       Raed Dweik - Oxygen Regulates Nitric Oxide Production in the Lungs

2:35       John Kinsella - The Role of Inhaled Nitric Oxide in Premature Newborns and Bronchopulmonary Dysplasia

3:00   Break

3:15       Steve Abman - The Role of Inhaled Nitric Oxide Therapy in Neonatal Pulmonary Hypertension

3:40       Richard Channick - Chronic Nitric Oxide Inhalation in Adult Patients with Pulmonary Disorders

4:05       discussant - Warren Zapol

4:25   Transportation to Doubletree Hotel via Metro.

5:00   Poster Session at Doubletree Hotel

7:00    Group Dinner at Doubletree Hotel
              After-dinner talk: Griffin Rodgers - Pathophysiology and Treatment of Sickle Cell Disease

Wednesday, September 6, 2000

8:00 AM Continental Breakfast

8:30   Session III. Nitric Oxide and the Kidney/Kidney Diseases (Josie Briggs, Chair)

8:35       Antonio Guasch - Glomerular Effects of Nitric Oxide Inhibition in Humans

9:00       Chris Baylis - Nitric Oxide Deficiency in Chronic Renal Disease

9:25       Chris Wilcox - Nitric Oxide Deficiency in Hypertension

9:50       discussant - Josie Briggs

10:10  Break

10:25  Session V. Nitric Oxide, Hemoglobin, and Sickle Cell Disease (Greg Evans, Chair)

          Nitric Oxide and Hemoglobin
10:30      David Singel - Kinetics of the Oxyhemoglobin Reaction of Nitric Oxide

10:55      Jonathan Stamler - Hemoglobin: a Microcosm of Nitric Oxide Biology

11:20      Celia Bonaventura - Effects of S-Nitrosation on Oxygen Binding by Normal and Sickle Cell Hemoglobin

11:45      Mark Gladwin - Delivery of Nitric Oxide on Hemoglobin

12:10  Lunch, on your own

          Nitric Oxide and Reactive Oxygen Species
1:10       Bruce Freeman - Oxidase and Oxygenase Impairment of Endothelial-Dependent Function in Sickle Cell Disease

          NO and Sickle Cell Disease
1:35       Marie Stuart - Nitric Oxide and Endothelial Activation in Patients with Sickle Cell Disease

2:00       Al Head - Inhaled Nitric Oxide for the Treatment of Sickle Cell Disease

2:25       Alan Schechter - Effect of Nitric Oxide In Vitro and In Vivo in Sickle Cell Disease

2:50    Break

3:05       Claudia Morris - Clinical Studies of Nitric Oxide Donors in Sickle Cell Disease

3:30       discussant - Marie Stuart

3:50   Workshop Summary (Alan Schechter)

4:00    Recommendations from participants for future research on nitric oxide as a therapeutic agent for sickle cell disease         and other vascular diseases (Greg Evans)

4:15   ADJOURN

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