NATIONAL CENTER ON SLEEP DISORDERS RESEARCH
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

Sleep Disorders Research Advisory Board Meeting Minutes

August 27, 2010


TABLE OF CONTENTS

Attendees
Remarks
Introduction
Adoption Of Minutes From The April 14, 2009 SDRAB Meeting
NCSDR Director's Report: Michael Twery, PhD
Trans-NIH and Federal Agency Updates
Closed Session
2011 Sleep Research Plan Overview
Sleep Research Plan: Invited Presentations and Stakeholder Comments
Sleep Research Plan Development and Discussion
Action Items
Future Meeting
Certification


Sleep Disorders Research Advisory Board Page


BOARD MEMBERS PRESENT

Dr. Charles Czeisler, Chair
Ms. Ann Austin
Dr. Mercedes Carnethon
Dr. Ronald Chervin
Ms. Karen Cushing
Dr. Leszek Kubin
Dr. Sairam Parthasarathy
Dr. Daniel Rudic
Dr. Catherine Vena
Dr. Michael Vitiello
Mr. Gagandeep Walia
Mr. Robert Waterman

BOARD MEMBERS ABSENT

None

EX OFFICIO MEMBERS PRESENT

Dr. Michael Twery, NHLBI, Executive Secretary

FEDERAL LIAISON REPRESENTATIVES PRESENT

Dr. Lawrence Baizer, NIAAA, NIH
Dr. Giovanni Cizza, NIDDK, NIH
Dr. Janet Croft, NCCDPHP, CDC
Dr. Harold Gordon, NIDA, NIH
Dr. Robert Greene, VHA, Department of Veterans Affairs
Dr. Lynne Haverkos, NICHD, NIH
Dr. Mack Mackiewicz, NIA, NIH
Dr. Sue Mardin, NINR, NIH
Dr. Paige McDonald, NCI, NIH
Dr. Merrill Mitler, NINDS, NIH
Ms. Andrea Piani, Census Bureau, Department of Commerce
Dr. Roger Rosa, NIOSH, CDC
Dr. Corinne Silva, NIDDK, NIH
Dr. Barbara Sorkin, NCCAM, NIH
Dr. Aleksandra Vicentic, NIMH, NIH
Dr. Nancy Wesensten, MEDCOM, Department of Defense

FEDERAL EMPLOYEES PRESENT

Dr. Beth Ansel, NCMRR/NICHD, NIH
Dr. Carole Davis, FDA
Dr. Rosemarie Filart, NCRR, NIH
Mr. Peyvand Ghofrani, NHLBI, NIH
Ms. Kaitlyn Harrington, NHLBI, NIH
Dr. Indira Jevaji, ORWH, NIH
Dr. Laura Kienker, Office of Naval Research
Dr. Aaron Laposky, NHLBI, NIH
Dr. Daniel Lewin, NHLBI, NIH
Dr. Wilbur Malloy, DOD
Dr. Sheri Parker, Office of Naval Research
Dr. Letitia Presley-Cantrell, CDC
Dr. Nancy Shinowara, NICHD, NIH
Dr. Brad Wise, NIA, NIH

MEMBERS OF THE PUBLIC PRESENT

Mr. David Cloud, NSF
Dr. John Feeney, Vanda Pharma
Dr. Julie Flygare, Wake Up Narcolepsy
Dr. Ed Grand, ASAA
Dr. Patricia Higgins, Narcolepsy Network
Dr. Clark Lee, Health and Homeland Security/University of Maryland
Dr. Jeff Hickman, Virginia Tech Transportation Institute
Dr. Joni Phillips, SELF
Dr. Richard Rosenberg, AASM
Dr. Jim Walsh, SRS
Dr. Phyllis Zee, Northwestern/AAN

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REMARKS: DIRECTOR, DIVISION OF LUNG DISEASES, NHLBI: James Kiley, PhD

  • The National Center on Sleep Disorders Research (NCSDR) is firmly established within NHLBI both scientifically and organizationally. The Center is currently staffed better than at any previous time with 3 Full Time professional staff, 1 Clinical Trials Specialist, and administrative support staff. The Center continues to stimulate programmatic coordination with other divisions of NHLBI, NIH Institutes and Centers, and other government agencies. The revision of the sleep research plan is a priority for NCSDR.

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INTRODUCTION, Michael Twery, PhD

  • The meeting was called into session at 8:30am as previously announced in the Federal Register [FR Doc. 2010-15480]. The Board and audience were notified that the meeting audio would be recorded.
  • The Sleep Disorders Research Advisory Board (SDRAB) is a Federal Advisory Committee established by the NIH Revitalization Act of 1993 (42 USC Sec. 285b-7).
  • Members of the Board were informed of their status as special government employees during the meeting and that conflict of interest guidelines apply to conduct.

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ADOPTION OF MINUTES FROM THE APRIL 14, 2009 SDRAB MEETING, Acting Chair

  • A motion to adopt the minutes of the preceeding in-person meeting on April 14, 2009 without amendment carried unanimously.

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NCSDR DIRECTOR'S REPORT: Michael Twery, PhD

  • NCSDR is located within the NHLBI and fosters the coordination of NIH sleep and circadian research programs through the Trans-NIH Sleep Research Coordinating Committee (SRCC), Federal Agency partners, SDRAB, individual researchers, community organizations, and other constituencies.
  • Preliminary analysis of FY 2010 RCDC Sleep Disorders Research
    • Sleep research is an NIH-wide concern with sleep category grants supported by 23 of 27 NIH Institute and Centers.
    • The success rate of sleep applications from trainees, new investigators, and established investigators was generally similar.
    • Training applications (T, K, F) categorized as sleep are submitted in numbers smaller than expected given the number of full scale research (Rxx, Pxx) applications and when compared to NIH-wide averages.
  • An analysis of FY2010 funding opportunity announcements revealed that initiatives appropriate for consideration by sleep researchers are numerous. Selected examples of FY2010 NIH activities include:
    • Sleep and Social Environment: Basic Biopsychosocial Processes (R21/R01) RFA-HD-11-102, RFA-HD-11-101 (OppNET). Pending review.
    • Reducing Cardiovascular Disease Risk Through Treatment of Obstructive Sleep Apnea (U34) RFA-HL-10-023. Two grants awarded.
    • Circadian-Coupled Cellular Function in Heart, Lung, and Blood Tissue (R01) RFA-HL-09-012. Six grants awarded.
  • Researchers were encouraged to stay informed regarding NIH research directions, and to submit grant applications for NIH competition.

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TRANS-NIH AND FEDERAL AGENCY UPDATES

  • NIH and Federal Agency Representatives described programs and areas of interest within their organization in relation to sleep research. The following institutes and agencies reported: CDC, VA, NINDS, NIA, NIAAA, NCRR, NICHD, NIOSH, NIDDK, NCI, NIMH, NCCAM, NIDA, and DOD. Dr. Czeisler requested that representatives submit brief written reports to the Board through NCSDR.

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CLOSED SESSION

  • The Board met in closed session briefly to consider the election of a new Chair for FY2011. Dr. Charles Czeisler was elected and is expected to serve as Chair for the balance of his term ending June 30, 2011.

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2011 SLEEP RESEARCH PLAN OVERVIEW, Michael Twery, PhD

  • The process, timeline, and format of an updated NIH Sleep Research Plan was described. As called for in legislation (42 USC Sec. 285b-7), the NIH will develop an NIH Sleep Research Plan in consultation with SDRAB and the Director of NCSDR.
  • The current research plan process launched with the publication of a Request for Information (RFI): Sleep Disorders Research Plan (NOT-HL11-107) in June 2010.
    • The RFI response included over 200 comments including patients (40%), researchers (40%), and organizations (20%).
    • Selected highlights noted:
      • The need to enhance the sleep disorder training of health care providers
      • The need to enhance sleep research training and workforce development.
      • The need to improve therapeutic approaches.

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SLEEP RESEARCH PLAN: INVITED PRESENTATIONS AND STAKEHOLDER COMMENTS

  • Sleep Research Society, Dr. James Walsh.
  • Sleep Research Network, Dr. Allan Pack.
  • American Academy of Sleep Medicine, Dr. Patrick Strollo.
  • Society for Research on Biological Rhythms, Dr. Joseph Takahashi.
  • American Sleep Apnea Association, Mr. Edward Grandi.
  • Narcolepsy Network, Ms. Patricia Higgins.
  • National Sleep Foundation, Mr. David Cloud.

Discussion of the public comments and questions included the following:

  • Dr. Phyllis Zee (American Neurological Association) noted the need for standard sleep research measures in large neurological cohort studies.
  • Ms. Julie Flygare (Wake Up Narcolepsy) urged a need for more funding for research and awareness.

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SLEEP RESEARCH PLAN DEVELOPMENT AND DISCUSSION, Chair/Board Members

  • The Board seeks to develop implementable research plan recommendations that could be undertaken over the next 5 years.
  • The Board received and discussed general directions for research identified by the transNIH Sleep Research Coordinating Committee.
  • A consensus platform of five over-arching provisional goals emerged through a roundtable process of discussion among members, stakeholders, and other meeting participants.
    1. Improve understanding of optimal circadian and sleep (CaS) function and mechanisms across the lifespan and the influence of CaS regulatory systems on human health and function; and evaluate the impact of chronic exposure to CaS disorders and dysregulation, including sleep restriction, circadian misalignment, and recurrent displacement of sleep-wake and circadian cycles (i.e., social jet lag), on health and safety.
    2. Define the links between CaS regulation, CaS function and CaS disorders in neural and peripheral tissue and their role in development, health, and disease pathogenesis and disability.
    3. Improve the prevention, diagnosis and personalized and safe treatment of sleep deprivation, circadian misalignment, CaS dysregulation and CaS disorders.
    4. Accelerate the translation and dissemination of CaS concepts (research, health care, policy, community).
    5. Ensure an adequate scientific research workforce to accomplish these goals by strengthening career research training and research mentoring activities in scientific and medical research related to CaS science and CaS dysregulation and disorders.

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ACTION ITEMS

  • TransNIH Sleep Research program staff and representatives from other Federal agency partners are invited to submit statements summarizing sleep research
  • activities.
  • The Board will identify ad hoc consultants and subject matter expert volunteers as needed for background on exceptional opportunities for sleep research in preparation for subsequent Board meeting discussion.
  • NCSDR will discuss with CDC staff the possibility of updating an existing resource listing datasets with sleep information.

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FUTURE MEETING

  • November 12, 2010, conference call [FR Doc. 2010-27318]
  • December 10, 2010, in-person [FR Doc. 2010-27318]
  • January 4, 2011, conference call [FR Doc. 2010-29523]

These Minutes will be presented to the full Board at its next regularly scheduled in person meeting for consideration, amendment as approved, and formal adoption.

CERTIFICATION

I hereby certify that the foregoing minutes are accurate and complete.

Charles Czeisler, PhD, MD
Chair, Sleep Disorders Research Advisory Board

Michael Twery, PhD
Executive Secretary, Sleep Disorders Research Advisory Board

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