Dr. Quan thanked the participants and adjourned the meeting at 3:00 p.m.
to Table of Contents
We certify that, to the best of our knowledge, the foregoing minutes are
accurate and complete.
Stuart Quan M.D., Chair
Sleep Disorders Research Advisory Board
Carl E. Hunt, M.D., Executive Secretary
Sleep Disorders Research
to Table of Contents
ADDENDUM TO MINUTES
2003 National Sleep Disorders Research Plan
Research Recommendations as Identified and Ranked By SDRAB
Listed in Order of Decreasing Priority (1 highest, 10 lowest)
(Average Ranking Score)
1: Sleep Duration (3.6)
Identify the full range of psychological, behavioral, and physiological (e.g., cardiovascular) consequences of long-term partial sleep deprivation and their underlying mechanisms, including host defense. Epidemiological longitudinal studies will need to be included to assess the relationships among sleep duration, sleep quality, and health outcomes among vulnerable populations
- Children, adolescents, young adults, shift workers, new parents. prolonged work hours, low socioeconomic status
- Depression, obesity, diabetes, and cardiopulmonary diseases.
Studies are needed to determine the extent to which sleep disturbance and sleep deprivation are related to markers of nonspecific inflammatory responses (e.g., leukocytes, cytokines, C-reactive protein). Studies are needed in transgenic or knock-out animals to identify the functional significance to infection resistance and susceptibility of candidate genes in linkage regions or of newly discovered cytokines, candidate neurohormones, or other molecules.
2: Basic Sleep Science: Sleep and Waking (3.7)
Further characterize the descriptive anatomy and neurochemistry of sleep/wake generating systems by investigating the hierarchies of neurotransmitter interactions within these complex circuits.
- Facilitate the development of drugs to treat sleep and waking disorders
- Better understanding of the neuropharmacology of behavioral states.
3: Altered Sleep and Chronic Disease (4.7)
Identify chronically ill populations at highest risk for sleep disturbances, determine the factors most associated with disturbed sleep, and the best ways to improve such sleep disturbances.
- Understand how sleep disturbances affect adherence to treatments for chronic disease and ways that improving sleep may improve treatment outcomes.
-Study the bidirectional relationship between sleep processes and disease development, progression, and morbidity.
- Determine identifiable, measurable characteristics of sleep quality that could serve as potential indicators of primary disease diagnosis, progression, and severity.
4: Sleep and Aging (4.8)
Investigate the neurobiological mechanisms of the effects of sleep, circadian regulation, and sleep disorders on the aging process and the diseases associated with late age.
- Circadian studies should investigate the neurobiological causes and consequences of age-related changes in circadian rhythm parameters other than period (e.g., amplitude, waveform). Genetic, neuroanatomic, neurophysiologic, and neurochemical approaches may be useful in such studies.
5: Neuropsychiatric Disorders in Children (5.3)
Describe the scope and magnitude of sleep disturbances in children and adolescents with ADHD, including the natural history of sleep disturbances as ADHD progresses into adulthood. Describe the impact of ADHD on sleep-related morbidity, including adverse behavioral outcomes such as injuries and motor vehicle crashes, substance abuse, and academic failure.
Describe risks and protective factors for sleep disturbances, and the impact of potential confounders, such as comorbid psychiatric disorders and medication use.
6-7: Psychiatric and Substance Use Disorders (6.0)
Evaluate whether insomnia and hypersomnia are modifiable risk factors for poor outcomes in mood, anxiety, and psychotic disorders, alcoholism, and substance abuse disorders.
- Investigate whether insomnia and hypersomnia are modifiable risk factors for the development of new-onset psychiatric disorders.
- Investigate whether insomnia or specific EEG sleep characteristics are modifiable risk factors for poor outcomes among individuals with existing psychiatric disorders.
- Elucidate possible mechanisms for the relationship between sleep disturbance and psychiatric disorders in the progression of sleep and psychiatric disorders from childhood into adulthood
6-7: Sleep Disordered Breathing (SDB) (6.0)
Conduct adequately powered clinical trials, particularly in high-risk populations, to assess the impact of therapy of SDB on functional status, psychiatric disorders, neurocognitive function, and other disease processes (hypertension, cardiovascular disease, metabolic syndromes, etc.).
Studies assessing the impact of successful therapy of Cheyne-Stokes respiration on cardiac dysfunction, quality of life and survival are also needed.
8: Genetics and Proteomics (6.2)
Develop new methods to measure sleep, circadian physiology, and sleepiness in large numbers of animal and human subjects.
- Develop and validate surrogate measures.
- Define normal sleep-pattern variation in the general human population.
- Normative data will be critical to define and validate existing or novel sleep disorder phenotypes and to elucidate corresponding genetic factors.
9: Sleep Disordered Breathing (SDB) in Children (6.7)
Develop longitudinal normative data on sleep and cardiorespiratory patterning in children.
10: Narcolepsy and Hypersomnia (7.1)
Conduct basic research on hypocretins in animal models to better define the exact role of this system in the regulation of normal sleep and other behaviors.