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Initiative Concepts Presented to the October 2002 NHLBAC

Introduction

At several meetings each year of the National Heart, Lung, and Blood Advisory Council (NHLBAC), NHLBI staff present proposals for future NHLBI scientific initiatives.  The proposals take the form of Requests for Grant Applications (RFAs), Requests for Contract Proposals (RFPs), Broad Agency Announcements (BAAs), Requests for Information (RFIs), Program Announcements (PAs), and Notices.  RFAs, RFPs, and BAAs include a specific set-aside of funds for an initiative.

At the October 2002 NHLBAC meeting, 12 initiatives were presented for the Council's concept review and approval.  The initiatives had been reviewed in September 2002 by a working group of the Council, the Board of Extramural Advisors (BEA).  The NHLBAC was supportive of all of the proposals but made a number of specific recommendations for consideration prior to their release.

The Director of the NHLBI will consider the recommendations of the BEA and the Council and other budgetary and programmatic issues in determining which of the proposed initiatives, if any, will be implemented by the Institute.

Descriptions of the 12 initiative concepts presented at the October 2002 NHLBAC Meeting are provided below in alphabetical order.

Initiatives

Initiative

Purpose

Cardiovascular and Sleep-related Consequences in Temporomandibular Joint (TMJ) Disorders, RFA To conduct epidemiological and clinical studies of sleep and cardiovascular outcomes in TMJ Disorders (TMJD), to study factors associated with upper airway collapsibility and impaired sleep in TMJD, and to elucidate the role of central pathways involved in TMJD- associated autonomic and motor responses affecting sleep and neuromuscular control of upper airway patency.
Cultural Competence Academic Award, RFA To sponsor the development of core curricula and other educational resources that will enhance physicians' ability to deliver culturally sensitive health care to multi-cultural U.S. populations.
Diagnostic Screening Test for Salt Sensitivity, PAR To fund Small Business Innovation Research (SBIR) and Small Business Technology Transfer Research (STTR) projects which develop a non-invasive or minimally invasive, rapid, and practical diagnostic test for salt sensitivity. Ideally, such a test will correlate with long-term changes in blood pressure resulting from a high salt intake.
Hematologic Sequelae of Diabetes, RFA To stimulate basic and clinical research on the hematologic changes occurring with diabetes that result in diabetic related cardiovascular complications.
Improving Resuscitation Outcomes -- NHLBI Clinical Research Consortium, RFA/RFP To establish a consortium to conduct patient-oriented resuscitation research. The investigators, first responders, and community leaders will function cooperatively under one organizational structure in an effort to facilitate the efficient translation of promising experimental strategies into clinical practice.
Long-term Control of Cardiovascular Function in Health and Disease: An Integrated Approach, RFA To promote understanding of how heart and vascular function is coordinated in intact organisms over long periods of time and to identify changes in long-term control that predispose to the onset or maintenance of cardiovascular (CV) diseases, such as hypertension, arrhythmias, and sudden cardiac death.
Mechanisms of HIV-Related Cardiopulmonary and Hemostatic Complications, RFA To encourage innovative research on the roles of co-infections, immune factors, genetic predisposition, metabolic/energetic mechanisms, and neural and hypothalamic-pituitary-adrenal axis influences on HIV related-cardiopulmonary and hemostatic complications. The ultimate goal is to provide a rational basis for prevention and therapy for the cardiopulmonary and hemostatic complications caused by HIV and its related-factors.
Overweight and Obesity Prevention and Control at the Worksite, RFA To support controlled trials which emphasize environmental approaches to obesity prevention at worksites that will test the effectiveness of worksite interventions for preventing or controlling overweight and obesity in adults.
Protein Processing and Degradation in Heart, Lung, and Blood Diseases, RFA To explore the protein folding and quality control pathways operative in cardiovascular, pulmonary, and blood diseases, leading to a better understanding of how these mechanisms contribute to the molecular pathogenesis of disease and development of novel therapeutic interventions.
Recovery of Heart Function with Circulatory Assist, RFA To understand how the use of a circulatory assist device results in clinical recovery of heart function with the hope of optimizing myocardial recovery and elucidating mechanisms that lead to ventricular reverse remodeling and functional recovery during circulatory assist.
Retrovirus Epidemiology Donor Study (REDS), RFP To conduct epidemiological, laboratory, and survey research on volunteer blood donors to ensure the safety and availability of the Nation's blood supply. This includes monitoring known blood-borne infectious agents, rapidly evaluating the impact of emerging pathogens, assessing the safety implications of changes in laboratory and/or blood donor screening protocols, and examining blood supply availability issues.
Somatic Cell Therapy Processing Facilities, RFP To establish centralized facilities for the development of novel cellular therapies which would aid investigators by providing support in areas ranging from basic science through animal studies to proof-of-principle and eventually human trials.

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Last modified: 10/28/02

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