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Report of the NIH Rat Model Repository Workshop

Lansdowne Conference Center
Lansdowne, Virginia
August 19-20, 1998


Wednesday, August 19, 1998

Plenary Session One

8:30 a.m. Introduction and Charge Dr. Mockrin
8:45 a.m. Rat History and Background Dr. Gill
8:55 a.m. Rat Genome Resources Dr. Jacob
9:15 a.m. Rat Nomenclature and Rat Map Dr. Levan
9:30 a.m. Overview of Major Strains
  • Cardiovascular/Renal
  • Neurobiology/Aging/Mental Health
Dr. Rapp
Dr. Harris
10:00 a.m. Break
10:15 a.m. Overview Major Strains
  • Immunology
  • Cancer
  • Diabetes
  • Transgenesis
Dr. Gill
Dr. Pitot
Dr. Guberski
Dr. Hammer
11:00 a.m. Existing Repository Programs
  • Europe
  • Japan
  • USA
  • Commercial
              Charles River
              Harlan Sprague-Dawley
Dr. Hedrich
Dr. Nomura
Dr. Rall
Dr. Balk
Dr. Russell
12:30 p.m. Lunch
1:30 p.m. Jax Strategies for Mouse Dr. Mobraaten
1:50 p.m. New Strains - Prospects and Promise
Rat ES Cell/Nuclear Transfer
RI Strains
Dr. Iannaccone
Dr. Printz
Dr. Kwitek-Black
Dr. Hammer
3:15 p.m. Breakout Groups
Group 1 Strain Selection
  • Criteria for admission to the repository
  • Finding strains
  • Criteria for animal distribution (academic/commercial)
  • Criteria and number of substrains maintained
  • Costs
Dr. Festing
Group 2 The Repository
  • Central or distributed resource
  • Academic and/or commercial distribution
  • Import/export
  • Existing strains
  • New strains
  • Requirements: spf/naf
  • Quality control
  • Costs
Dr. Cork
Group 3 Maintenance
  • Cryopreserve or maintain breeding colonies
  • Research and development for maintenance and preservation
  • Identify key features for standard protocol/back-up for storage (cryopreservation)
  • Preservation of strains not selected
  • Costs
Drs. Pakes and
Group 4 Operations
  • Advisory group structure, operation, reporting
  • How involved is NIH?
  • Advertising/Marketing
  • Cost Recovery
  • Informatics - Interface with databases
  • Costs
Dr. Hammer
6:00 p.m. Recess
6:30 p.m. Reception
7:00 p.m. Dinner
8:30 p.m. Write up Breakout Group recommendations for handouts in the morning

Thursday, August 20, 1998

Plenary Session II

8:30 a.m. Breakout Group Reports
8:30 a.m. Group 1 Dr. Festing
9:15 a.m. Group 2 Dr. Cork
10:00 a.m. Break
10:15 a.m. Group 3 Dr. Pakes
11:00 a.m. Group 4 Dr. Hammer
11:45 a.m. Lunch
1:00 p.m. Breakout Groups reconvene

Plenary Session II

2:30 p.m. Final Breakout Group Recommendations Presented
  • Group 1
  • Group 2
  • Group 3
  • Group 4
Dr. Festing
Dr. Cork
Drs. Pake and
Dr. Hammer
3:30 p.m. Summary Dr. Gill
4:15 p.m. Adjourn

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