Agenda

Wednesday, October 14, 2009

8:00 - 8:10 a.m.

Welcome and Opening Remarks
Manfred Boehm, M.D. Translational Medicine Branch, Division of Intramural Research, NHLBI

8:10 - 8:30 a.m.

NHLBI Roadmap for Stem Cell Research
Elizabeth G. Nabel, M.D., Director, NHLBI

8:30 - 10:25 a.m.

Session I: Science That Matters: New Advances in Induced Pluripotent and Embryonic Stem Cells
Chairs: Denis B. Buxton, Ph.D., Basic and Early Translational Research Branch, Division of Cardiovascular Sciences, NHLBI
Martin Friedlander, M.D., Ph.D., The Scripps Research Institute

8:30 - 8:35 a.m.

Introduction to topic and speakers – session chairs

8:35 - 8:55 a.m.

Modeling Blood Disease with iPS Cells
George Q. Daley, M.D., Ph.D.
Harvard Medical School/Children’s Hospital Boston

8:55 - 9:15 a.m.

Cardiovascular Derivatives of Embryonic Stem Cells in Cardiac Repair and Drug Discovery
Christine Mummery, Ph.D.
Leiden University Medical Center (The Netherlands)

9:15 - 9:35 a.m.

The Wages of Syn(ergy): Enhancing Vascularization Promotes Cardiac Remuscularization With Human Embryonic Stem Cells
Charles E. Murry, M.D., Ph.D.

University of Washington Medical Center

9:35 - 9:55 a.m.

Zebrafish Heart Regeneration Occurs by Limited Dedifferentiation and Proliferation of Cardiomyocytes
Juan Carlos Izpisúa Belmonte, Ph.D.
Center of Regenerative Medicine, Barcelona (Spain)

9:55 - 10:25 a.m.

Roundtable discussion

10:25 - 10:45 a.m.

Break

10:45-12:40 p.m.

Session II: Cardiac Development: Looking Backward To Move Forward
Chairs: Jonathan A. Epstein, M.D., Hospital of the University of Pennsylvania
Charles E. Murry, M.D., Ph.D., University of Washington Medical Center

10:45 - 10:50 a.m.

Introduction to topic and speakers – session chairs

10:50 - 11:10 a.m.

Developmental Angiogenesis Swims into Focus
Brant M. Weinstein, Ph.D.
National Institute of Child Health and Human Development, NIH

11:10 - 11:30 a.m.

Jagged1 in the Endothelium and Smooth Muscle: The Importance of Heterotypic Cell Interactions
Luisa Iruela-Arispe, Ph.D.
University of California, Los Angeles

11:30 - 11:50 a.m.

Developmental Origin of Post-MI Cardiac Progenitor Cells
Sean M. Wu, M.D., Ph.D.
Massachusetts General Hospital

11:50 - 12:10 p.m.

Convergence of Inductive and Repressive Pathways Defines the Dimensions of the Cardiac Progenitor Pool in Zebrafish
Deborah L. Yelon, Ph.D.
University of California, San Diego

12:10 - 12:40 p.m.

Roundtable discussion

12:40 - 1:30 p.m.

Lunch (on your own)

1:30 - 3:25 p.m.

Session III: The Emerging Concept of Epithelial to Mesenchymal Transition in Health and Disease
Chair(s): Michael Basson, Ph.D., Nature Medicine
Manfred Boehm, M.D., National Heart, Lung, and Blood Institute

1:30 - 1:35 p.m.

Introduction to topic and speakers – session chairs

1:35 - 1:55 p.m.

Mesothelial Progenitors in Development of the Heart and Lungs
William T. Pu, M.D.
Children’s Hospital Boston

1:55 - 2:15 p.m.

Dynamic Regenerative Responses of the Zebrafish Heart
Kenneth D. Poss, Ph.D.
Duke University Medical Center

2:15 - 2:35 p.m.

Alterations in Cellular Ontology Contribute to the Pathogenesis of Aortic Aneurysm in Marfan Syndrome
Hal Dietz, M.D.
Johns Hopkins University School of Medicine

2:35 - 2:55 p.m.

Insights into Cardiac Fibroblasts and Fibrosis
Raghu Kalluri, M.D., Ph.D.
Beth Israel Deaconess Medical Center

2:55 - 3:25 p.m.

Roundtable discussion

3:25 - 3:45 p.m.

Break

3:45 - 5:00 p.m.

Poster Session and Reception



Thursday, October 15, 2009

8:00 - 9:55 a.m.

Session IV: NHLBI Consortium: An Overview of the Progenitor Cell Consortium
Chair: Elizabeth G. Nabel, M.D.
National Heart, Lung, and Blood Institute

8:00 - 8:05 a.m.

Introduction to topic and speakers – session chairs

8:05 - 8:25 a.m.

Notch Signaling in Hematopoiesis: Basic Studies and Clinical Implications
Irwin D. Bernstein, M.D.
Fred Hutchinson Cancer Research Center

8:25 - 8:45 a.m.

The Stanford-Johns Hopkins Research Hub: Basic and Transitional Research to Develop Safe, iPSC-Based Hematologic and Vascular Therapies
Alan D. Friedman, M.D.
Johns Hopkins University School of Medicine

8:45 - 9:05 a.m.

Elucidating the Program of Lung and Pulmonary Vascular Development
Mark Krasnow, M.D., Ph.D.
Stanford University School of Medicine

9:05 - 9:25 a.m.

Kenneth R. Chien, M.D., Ph.D.
Massachusetts General Hospital/Harvard Medical School/Harvard Stem Cell Institute

9:25 - 9:55 a.m.

Roundtable discussion

9:55 - 10:15 a.m.

Break

10:15 - 12:10 p.m.

Session V: Future Outlook: iPSC and ESC, and More
Chairs: Katrina L. Kelner, Ph.D., Science
Stephen G. Ellis, M.D., The Cleveland Clinic

10:15 - 10:20 a.m.

Introduction to topic and speakers – session chairs

10:20 - 10:40 a.m.

Directed Differentiation of Pluripotent Stem Cells to the Cardiovascular Lineages
Gordon Keller, Ph.D
University Health Network (Canada)

10:40 - 11:00 a.m.

A Chemical Approach to Cell Fate Regulation
Sheng Ding. Ph.D.
The Scripps Research Institute

11:00 - 11:20 a.m.

Stimulating Myocardial Regeneration With Cardiomyocyte Proliferation Factors
Bernhard Kühn, M.D.
Harvard Medical School/Children’s Hospital Boston

11:20 - 11:40 a.m.

Cardiomyocyte Renewal in Humans
Jonas Frisén M.D., Ph.D.
Karolinska Institute (Sweden)

11:40 - 12:10 p.m.

Roundtable discussion

12:10 - 1:00 p.m.

Lunch (on your own)

1:00 - 3:15 p.m.

Session VI: Hitting the Highlights From Other Fields
Chairs: Deborah J. Sweet, Ph.D., Cell Stem Cell
Brant M. Weinstein, Ph.D., National Institute on Child Health and Human Development

1:00 - 1:05 p.m.

Introduction to topic and speakers – session chairs

1:05 - 1:25 p.m.

Regenerative Potential of Skeletal Muscle Stem Cells
Amy Wagers, Ph.D.
Harvard Medical School

1:25 - 1:45 p.m.

Transcriptional Control of Fat Cell Identity and Energy Homeostasis
Bruce M. Spiegelman, Ph.D.
Harvard Medical School/Dana-Farber Cancer Institute

1:45 - 2:05 p.m.

Stemming Vision Loss with Stem Cells
Martin Friedlander, M.D., Ph.D.
The Scripps Research Institute

2:05 - 2:25 p.m.

Regulation of Stem Cell Fate
Helen M. Blau, Ph.D.
Stanford University School of Medicine

2:25 - 2:45 p.m.

Using Stem Cells to Understand and Treat Disease
Ronald D.G. McKay, Ph.D.
National Institute of Neurological Disorders and Stroke, NIH

2:45 - 3:15 p.m.

Roundtable Discussion

3:15 - 4:45 p.m.

Session VII: Clinical Trials Roundtable: Where to Now?
Moderators:
Kenneth R. Chien, Massachusetts General Hospital/Harvard Medical School/Harvard Stem Cell Institute
Joshua M. Hare, M.D., F.A.C.C., F.A.H.A., University of Miami School of Medicine

Overview
Stephen G. Ellis, M.D.
The Cleveland Clinic

Panelists
Richard O. Cannon, III, M.D.
National Heart, Lung, and Blood Institute/NIH

George Q. Daley, M.D., Ph.D.
Harvard Medical School/Children’s Hospital Boston

Jonathan A. Epstein, M.D.
Hospital of the University of Pennsylvania

Martin Friedlander, M.D., Ph.D.
The Scripps Research Institute

Valentin Fuster, M.D.
Mount Sinai School of Medicine

Charles E. Murry, M.D., Ph.D.
University of Washington Medical Center

Robert D. Simari, M.D.
Mayo Clinic

4:45 - 5:00 p.m.

Concluding Remarks and Adjournment
Manfred Boehm, M.D.
Translational Medicine Branch, Division of Intramural Research, NHLBI




Last Updated: October 1, 2009


symposium goals


  - To provide an overview of the
    NHLBI roadmap for cardio-
    vascular stem cell research
    going forward.

  - To relate novel insights from
    embryonic cardiovascular
    development to our understand-
    ing of adult cardiovascular
    stem cells.

 - To review the recent break-
    through discovery of induced-
    pluripotent stem cells (iPS-cells),
    and how they might be harness-
    ed for therapeutic applications.

 - To discuss the emerging and
    inter-related field of epithelial
    to mesenchymal transition,
    and the relevance of this to
    cardiovascular and stem cell
    biology.

 - To emphasize recent discover-
    ies that will facilitate the trans-
    lation of this knowledge from
    bench to bedside.
 
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