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An NIH Conference on Dietary Supplements, Coagulation,
and Antithrombotic Therapies
Agenda

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Executive Summary

Bibliography

Background

Agenda

Faculty

Logistics

Sponsors

Continuing Education

Planning

January 13-14, 2005
Masur Auditorium, Clinical Center, NIH
Chair: Victor Marder, M.D.

:: Preliminary Agenda ::

Thursday, January 13, 2005
7:30 a.m. Light Refreshment and Registration
8:30 a.m. Welcome and Introduction Ahmed Hasan, M.D., Ph.D.
Barbara Alving, M.D.
Session I: Dietary Supplements That Affect Hemostasis and Antithrombotic Therapies Chair: Victor Marder, M.D.
8:40 a.m. Welcome and Interest by ODS Paul Coates, Ph.D.
8:50 a.m. Opening Remarks Victor Marder, M.D.
9:05 a.m. Overview of Hemostasis and Thrombosis; Current Status of Antithrombotic Therapies McDonald Horne, M.D.
9:35 a.m. Inventory and Impact of Supplement Use Peter De Smet, Pharm.D., Ph.D.
10:05 a.m. Vitamins and Minerals, and Other Supplements that Affect Hemostasis and Antithrombotic Therapies Rebecca Couris Ph.D.,R.Ph.
10:35 a.m. Break
10:55 a.m. Effect of Supplements on Hemostasis; Cardiovascular and Cerebrovascular Implications Mary Palmer, M.D.
11:25 a.m. Questions, Panel Discussion, and Summary
11:55 a.m. Lunch
Session II: Biochemical Effects of Dietary Supplements on Hemostasis Chair: Jack Ansell, M.D.
1:00 p.m. Opening Remarks Jack Ansell, M.D.
1:10 p.m. Effects of Supplements on Coagulation and Platelets C.S. Yuan, M.D.
1:30 p.m. Pharmacology and Pharmacogenetics of Warfarin and Other Anticoagulants When Used with Supplements Brian Gage, M.D.
1:50 p.m. Pharmacology and Pharmacogenetics of Aspirin and Other Antiplatelet Agents as Related to Supplements Kenneth Wu, M.D., Ph.D.
2:10 p.m. Questions, Panel Discussion, and Summary
2:40 p.m. Break
Session III: Clinical Data on Dietary Supplements Affecting Hemostasis and Antithrombotic Therapies Chair: Alice Lichtenstein, D. Sc.
3:00 p.m. Welcome and Interest by NCCAM Margaret Chesney, Ph.D.
3:10 p.m. Opening Remarks Alice Lichtenstein, D. Sc.
3:20 p.m. Clinical Implications for Patients on Antithrombotic Therapy While Taking Supplements Thomas Ortel, M.D.
3:50 p.m. A Systematic Review and Inventory of Supplement Effects on Warfarin and Other Anticoagulants/Fibrinolytics Ann Wittkowsky, Pharm.D.
4:10 p.m. A Systematic Review and Inventory of Supplement Effects on Aspirin and Other Anti-Platelet Agents Ditina Desai, Pharm.D
4:30 p.m. Dilemmas in Herbal Medicine: The Clinician's Viewpoint Alison Lee, M.D.
4:50 p.m. Questions, Panel Discussion, and Summary
5:30 p.m. Adjourn

Friday, January 14, 2005
7:30 a.m. Light Refreshment and Registration
Session IV: New Tools and Methodologies for Research and Clinical Practice Chair: Rick Kingston, Pharm.D.
8:00 a.m. Welcome and Interest by NIH CC David Henderson, M.D.
8:10 a.m. Opening Remarks Rick Kingston, Pharm.D.
8:20 a.m. Synergism, Antagonism, or Additivity of Dietary Supplements: Case studies Christopher J. Borgert, Ph.D.
8:40 a.m. Reverse Herbology: Predicting and Preventing Adverse Herb-Drugs Interactions Steven A. Kliewer, Ph.D.
9:00 a.m. Challenges in Collecting, Accessing, and Evaluating Postmarket Surveillance AERs in Patients Receiving Dietary Supplements Rick Kingston, Pharm.D.
9:20 a.m. Best Practices for Clinical Trial Design Evaluating Dietary Supplements Edzard Ernst, M.D., Ph.D.
9:40 a.m. Questions, Panel Discussion, and Summary
10:10 a.m. Break

Session V:
10:30 a.m.

 Panel of Experts: Opinions and Research Priorities
  • Victor Marder, M.D.
  • Victor Tapson, M.D.
  • Richard Cannon, M.D.
  • Paul Nolan, Pharm.D.
  • Brian Gage, M.D.
  • Scott Penzak, Pharm.D.
  • Sarah Spinler, Pharm.D.
  • Peter De Smet, Pharm.D., Ph.D.
  • Ann Wittkowsky, Pharm.D.
  • Alison Lee, M.D.
  • Gail Provencher, C.R.N.P., M.S.N.
  • Edzard Ernst, M.D., Ph.D.
Moderator:
Henry Bussey, Pharm.D.
11:30 a.m. Questions, Panel Discussion, and Summary
12:00 p.m. Lunch
Session VI: Public Health Concerns: Facts, Fictions, and Gaps in Knowledge Chair: Freddie Ann Hoffman, M.D.
1:00 p.m. Opening Remarks Freddie Ann Hoffman, M.D.
1:05 p.m. Academic Perspectives on Dietary Supplement Use: The Need for New Guidelines Arthur P. Grollman, M.D.
1:30 p.m. FDA Regulatory and Safety Perspectives on Supplement Use by Patients on Antithrombotic Therapy Jason J.Y. Woo, M.D., M.P.H.
Myong-Jin Kim, Pharm.D.
1:55 p.m. Industry Perspectives on Regulation and Safety of Supplements that Affect Antithrombotic Therapy Freddie Ann Hoffman, M.D.
2:20 p.m. Questions, Panel Discussion, and Summary
2:45 p.m. Break
Session VII: Dialogue with Patient Care Organizations Moderator:
Rebecca Costello, Ph.D.
3:00 p.m
  • Joan Young - Platelet Disorder Support Association
  • Rebecca Burkholder - National Consumers League
  • Joseph Cranston, PhD - American Medical Association
  • Thomas Ortel, M.D., Ph.D. - American Society of Hematology
  • Steven Dentali, Ph.D. - American Herbal Products Association
  • Richard Cotter, Ph.D. - American Society of Clinical Nutrition
  • Julie O'Sullivan Maillet, Ph.D. - American Dietetic Association
  • Bruce Hawkins - American Society of Health-System Pharmacists
  • W. Craig Hooper, Ph.D. - Centers for Disease Control and Prevention
4:00 p.m. Questions, Panel Discussion, and Summary
4:30 p.m. Open Discussion
5:00 p.m. Conference Summary and Recommendations
for Research Opportunities		 Victor Marder, M.D.
Ahmed Hasan, M.D., Ph.D.
5:30 p.m. Adjourn
NHLBI - National Heart, Lung, and Blood Institute
ODS - Office of Dietary Supplements
CC - NIH Clinical Center
NCCAM - National Center for Complementary and Alternative Medicine
NINDS - National Institute of Neurological Disorders and Stroke
ORD - Office of Rare Diseases
Foundation for the National Institutes of Health
National Institutes of Health Department of Health and Human Services FirstGov, Your First Click to the US Government