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Preliminary Agendadashed line

Tuesday, November 16, 2010

Masur Auditorium, Building 10

10:00 a.m.

Welcoming Remarks
Susan B. Shurin, M.D., Acting Director, National Heart, Lung, and
   Blood Institute
Donald A.B. Lindberg, M.D., Director, National Library of Medicine

10:15 a.m.

Session I: Sickle Cell Disease in Historical Perspective

10:15 a.m.

James B. Herrick and his Contributions
Alan N. Schechter, M.D., National Institute of Diabetes and Digestive
   and Kidney Diseases

10:30 a.m.

Panel Discussion: Historical and Cultural Perspectives
Moderator: John Ruffin, Ph.D., Director
                 National Center on Minority Health and Health Disparities

This panel discussion would be preceded by brief comments by each participant and the moderated conversation will cover James B. Herrick and his contributions as well as social and cultural perspectives on the history of sickle cell disease and its relationship to modern science and medicine.

Sickle Cell Anemia and the Vexed Crossroads of Race and
    Disease in America

Stephen Pemberton, Ph.D., New Jersey Institute of Technology

Sickle Cell Patients Are ______? How the Science of Treatment
    Has Shaped What Medical Professionals Think About Their

Carolyn Rouse, Ph.D., Princeton University

Cultural Histories of Mild Sickle Cell Anemia in Senegal,
    West Africa

Duana Fullwiley, Ph.D., Harvard University

12:00 p.m.

Questions and Answers

12:15 p.m.

Lunch (on your own)

1:15 p.m.

Experiences of People With Sickle Cell Disease Seeking Health
   Care for Pain

Mary Catherine Beach, M.D., M.P.H., Johns Hopkins University

1:30 p.m.

Panel Discussion: Personal Perspectives
Moderator: Lanetta B. Jordan, M.D., M.P.H., M.S.P.H., Chief Medical
                  Officer, Sickle Cell Disease Association of America, Inc.,
                  and Memorial Healthcare System, Hollywood, FL

Screening Student Athletes for Sickle Cell Trait: Where Do We Go
   From Here?

Vence L. Bonham, Jr., J.D., National Human Genome Research

Living Life Like It’s Golden
J. Hoxi Jones, Texas Health and Human Services Commission

To Screen or not To Screen? That Is the Question!
Robert F. Murray, Jr., M.D., Howard University School of Medicine

Wanda Whitten-Shurney, M.D., Wayne State University/Children’s
    Hospital of Michigan

2:15 p.m.

Session II: International Perspectives
Moderator: Roger I. Glass, M.D., Ph.D., Director
                 John E. Fogarty International Center for Advanced Study
                    in Health Disparities

2:20 p.m.

Sickle Cell Disease in Africa: History and Disease Burden
Kwaku Ohene-Frempong, M.D., University of Pennsylvania School of
   Medicine/Children’s Hospital of Philadelphia

2:35 p.m.

Sickle Cell Disease: The Contribution From Africa in the Next 100

Julie Makani, M.D., MRCP, Muhimbili University of Health and Allied
   Sciences (Tanzania)

2:50 p.m.

The Caribbean Contribution to Sickle Cell Disease
Graham R. Serjeant, M.D., FRCP, Sickle Cell Trust (Jamaica)

3:05 p.m.

Sickle Cell Disease in the United Kingdom: Epidemiology, Clinical
    Aspects and Morbid Anatomy

Sebastian Lucas, M.D., FRCP, FRCPath, King's College London School
   of Medicine (United Kingdom)

3:20 p.m.

Questions and Answers

3:50 p.m.


4:00 - 5:30 p.m.

Tours of the National Library of Medicine Exhibits and Rare Book
    Collection (Building 38)

6:30 p.m.

Dinner: Tragara Ristorante. We are sorry, but currently we are at capacity and can no longer take registrations or payments for the Networking Dinner.

W. Keith Hoots, M.D., National Heart, Lung, and Blood Institute

Sickle Cell Disease: An Historic Perspective
H. Franklin Bunn, M.D., Brigham and Women’s Hospital/Harvard
   Medical School

Keynote Speech:
Sickle Cell Anemia and the Origins of Molecular Medicine
Sir David Weatherall, M.D., FRCP, FRS, University of Oxford
   (United Kingdom)

Wednesday, November 17, 2010

Natcher Conference Center, Building 45

8:00 a.m.

Welcoming Remarks
Susan B. Shurin, M.D., Acting Director, National Heart, Lung, and
   Blood Institute
Sonja L. Banks, President and Chief Operating Officer, Sickle Cell
   Disease Association of America, Inc.

8:20 a.m.

The NHLBI Sickle Cell Guidelines: A First Look
Barbara Yawn, M.D., M.Sc., University of Minnesota
George Buchanan, M.D., University of Texas Southwestern Medical
    Center at Dallas

8:30 a.m.

Sickle Cell Anemia: Past, Present, and Future
David G. Nathan, M.D., Dana-Farber Cancer Institute

8:45 a.m.

Accelerating the Therapeutic Agenda for the First Molecular

Francis S. Collins, M.D., Ph.D., Director, National Institutes of Health

9:10 a.m.

Session III: Sickle Cell Disease Pathophysiology
Moderator: Eric D. Green, M.D., Ph.D., Director
                 National Human Genome Research Institute

9:15 a.m.

Sickle Cell Anemia: 100 Years later
Griffin P. Rodgers, M.D., M.A.C.P., National Institute of
   Diabetes and Digestive and Kidney Diseases

9:35 a.m.

Evolving Concepts of Brain Vasculopathy and Stroke in Sickle Cell

Robert J. Adams, M.D., Medical University of South Carolina

9:55 a.m.

Genetic Contributions to Pain
Clifford Woolf, MB, B.Ch., Ph.D., Children’s Hospital
   Boston/Massachusetts General Hospital

10:15 a.m.

Lung Disease and Sickle Cell Disease
Elliott Vichinsky, M.D., Children’s Hospital & Research Center

10:35 a.m.

Genetic Modifying Factors in Sickle Cell Disease
Swee Lay Thein, FRCPath., FRCP, D.Sc., F.Med.Sci., King’s
   College London (United Kingdom)

10:55 a.m.


11:15 a.m.

Session IV: Clinical and Social Impact Across the Lifespan
Moderator: Alan Guttmacher, M.D., Director
                 Eunice Kennedy Shriver National Institute of Child Health
                    and Human Development

11:20 a.m.

Sickle Cell Disease: Maternal/Fetal/Neonatal Prospective
John C. Morrison, M.D., University of Mississippi Medical Center

11:40 a.m.

The Triumphs and Challenges of the Study of Sickle Cell Disease
    in Infants, Children and Adolescents

Michael R. DeBaun, M.D., M.P.H., Vanderbilt School of Medicine

12:00 p.m.

Improving the Lives of Adults With Sickle Cell Disease
Sophie Lanzkron, M.D., Johns Hopkins School of Medicine

12:20 p.m.

Are You Listening to Me? Challenges in Sickle Cell Patient-
   Provider Communication

Carlton Haywood, Jr., Ph.D., M.A., Johns Hopkins University School of

12:40 p.m.

Lunch (on your own)

1:20 p.m.

Voices of Patients Video
Introduction: Wally R. Smith, M.D., Virginia Commonwealth University

1:35 p.m.

Session V: Sickle Cell Disease Treatment
Moderator: Walter J. Koroshetz, M.D., Deputy Director
                 National Institute of Neurological Disorders and Stroke

1:40 p.m.

Hematopoietic Stem Cell Transplantation for the Treatment of
   Adults With Sickle Cell Disease

John F. Tisdale, M.D., National Heart, Lung, and Blood Institute

2:00 p.m.

Hydroxyurea for Sickle Cell Disease: Fact, Fiction, and Fantasy
Russell E. Ware, M.D., Ph.D., St. Jude Children's Research Hospital

2:20 p.m.

From Mechanisms of Sickle Pathophysiology to Novel Therapies
Punam Malik, M.D., Cincinnati Children's Hospital Medical Center

2:40 p.m.


2:55 p.m

Session VI: Molecular Studies
Moderator: Griffin P. Rodgers, M.D., Director
                  National Institute of Diabetes and Digestive and                   Kidney Diseases

3:00 p.m.

Transcription Factor Networks and Long Range Interactions
Frank Grosveld, Ph.D., Erasmus MC
   (The Netherlands)

3:20 p.m.

Control of Hemoglobin Switching and HbF Silencing
Stuart H. Orkin, M.D., Harvard Medical School/Dana-Farber Cancer

3:40 p.m.

Inflammation and the Genetically Influenced Systems Biology of
   Sickle Disease

Robert P. Hebbel, M.D., University of Minnesota

4:00 p.m.

Session VII: Future Prospects
Moderator: Stephen C. Groft, Pharm.D., Director
                 Office of Rare Diseases Research

4:05 p.m.

Gene Transfer To Increase Fetal Hemoglobin Production
Arthur W. Nienhuis, M.D., St. Jude Children's Research Hospital

4:25 p.m.

Induced Pluripotent Stem (iPS) Cells and Gene Replacement
    Therapy for Sickle Cell Disease

Tim M. Townes, Ph.D., University of Alabama at Birmingham

4:45 p.m.

Concluding Remarks
Susan B. Shurin, M.D., National Heart, Lung, and Blood Institute

4:50 p.m.


Last updated 11/1/10

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