Dear Ms. [ERT participant's first and last
We promised to let you know when there was new
information about the Hormone Program. There are two studies in this
Programyou are in the study of estrogen alone for women who had a
hysterectomy before joining WHI. The enclosed "WHI HRT Update" describes
important news about the other study of estrogen plus progestin for
women who had not had a hysterectomy. Although you are not in the
estrogen plus progestin study, we want you to be aware of the new
The WHI Data and Safety Monitoring Board (DSMB)
has recommended that your study of estrogen alone continue, because it remains
uncertain whether the benefits outweigh the risks. Currently, there is no
increased risk of breast cancer in women taking estrogen alone. The DSMB will
continue to review the data every 6 months and we will inform you immediately
if they have new recommendations.What are we asking you to do?
- Please continue taking your study pills
as you have in the past.
- Continue your regularly scheduled clinic
contacts and annual mammograms.
- Continue to participate in any other WHI
programs you joined.
I have asked the Clinical Coordinating Center to
send you this letter. More information is available in the attached "WHI HRT
Update" and on the World Wide Web at: http://www.whi.org. Please share this
information with your health care provider. Your WHI clinic staff is also
available to answer your questions.
These results are enormously important and will
inform millions of women and their doctors worldwide about the risks and
benefits of estrogen plus progestin. The findings from this study could not
have been predicted when we began in 1993. You are a vital part of this
historic study, which is expected to influence medical care for current and
future generations. Thank you for our dedication, both past and future, to the
WHI Hormone Program.
Claude Lenfant, MD
National Heart, Lung, and Blood