National Sleep Disorders Research Plan
arrow image Progress Since the 1996 National Sleep Disorders Research Plan


Progress Index:
Sleep-Disordered Breathing (SDB)
Sleep Deprivation
Sleep Education
Sleep Neurobiology


Progress since 1996
Research Recommendations
Research Training

Circadian Biology:

A growing number of "clock genes" have been identified since 1996 that play a critical role in mammalian circadian timing. In addition, there is clear evidence that non- suprachiasmatic nucleus (SCN) tissues have clock genes and can demonstrate circadian rhythms. Thus, circadian modulation is now established to occur both centrally and peripherally, further emphasizing the importance of circadian chronobiology in the timing of sleep and waking as well as a wide variety of physiologic functions. Now these genetic studies are also being applied to humans, in particular patients with advanced sleep phase syndrome.

National Institutes of Health (NIH) Department of Health and Human Services (click here) First Gov Website (Click here)
National Heart Lung and Blood Institute (Click Here) National Center on Sleep Disorders Research (Click Here)