National Sleep Disorders Research Plan
 
   
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APPENDIX C :
NIH SLEEP-RELATED INITIATIVES 1996-2002

The title of each RFA/PA and total funding awarded for each initiative (cumulative through FY 2002) are listed under the relevant research recommendations from the 1996 National Sleep Research Plan. In some instances, an individual initiative applies to more than 1 recommendation and is therefore listed under each relevant recommendation.

1996 SLEEP DISORDERS RESEARCH PLAN RESEARCH RECOMMENDATIONS

Basic Science Research Recommendations

1. Increase efforts to understand the basic mechanisms responsible for sleep by applying molecular biological approaches in concert with techniques of cellular and systems neurobiology

2. Conduct basic studies to understand the brain mechanisms responsible for sleepiness

3. Study basic mechanisms underlying the interaction between the circadian and neurophysiological systems that regulate sleep and wakefulness.

4. Characterize the genetic factors controlling the basic mechanisms of sleep.

5. Increase research efforts to elucidate the fundamental functions of sleep.

Title
Participating Institutes/Centers
Total Costs Awarded (through FY '02)
Interrelationships Between Sleep and Heart, Lung, and Blood Diseases: HL01-009 *; **
NHLBI; NIDA
$1,357,253
Research on Alcohol and Sleep: AA00-005 *; **
NIAAA
$4,512,605
Oxygen Sensing During Intermittent Hypoxia: HL00-004 *
NHLBI
$10,673,975
Nocturnal Asthma, Chronobiology and Sleep: HL99-011*; **
NHLBI
$3,530,381
Phenotypic Characterization of Sleep in Mice: HL99-001
NHLBI; NIMH; NIA; NINDS
$13,512,185
Bioengineering Research Grants: PAR 99-009
NCI; NCRR; NEI; NHGRI; NHLBI; NIA; NIAAA; NIAID; NIAMS; NICHD; NIDA; NIDCD; NIMH; NINDS; NINR; NLM
$546,594
Research on Musculoskeletal Fitness and Sports Medicine: PA97-025 *
NIAMS; NICHD; NINR
$999,146
SCOR in Neurobiology of Sleep & Sleep Apnea: HL96-014 *; **
NHLBI
$18,553,207
Molecular Biology and Genetics of Sleep and Sleep Disorders: HL96-015 *
NHLBI; NIMH; NICHD
$7,335,059
Basic and Clinical Research on Sleep & Wakefulness: PA95-014 *
NIA; NIAAA; NICHD; NIDA; NHLBI; NIMH; NINDS; NINR
$28,384,156

* Also listed under Patient Oriented Research Recommendations
** Also listed under Applied Research Recommendations

Patient-Oriented Research Recommendations

1. Identify the genetic basis of sleep disorders that have a genetic component.

2. Conduct epidemiological research to assess prevalence, risk factors, and long-term consequences of common sleep disorders and determine the role of ethnicity, age, and gender in their causation.

3. Conduct outcomes research and clinical trials on the management of common sleep disorders.

4. Develop new technological approaches for diagnosis of sleep disorders, screening for sleep disorders among high-risk populations in whom sleepiness presents a particular danger (e.g., transportation workers), monitoring the effectiveness of therapy, and detecting abnormalities of sleep as early biological markers of psychiatric illnesses.

5. Elucidate the pathogenesis/pathophysiology of sleep disorders and their consequences.

6. Provide the research infrastructure needed to carry out patient-oriented research.

Title
Participating Institutes/Centers
Total Costs Awarded (through FY '02)
Interrelationships Between Sleep and Heart, Lung, and Blood Diseases: HL01-009 ++
NHLBI; NIDA
$1,357,253
Sleep and Sleep Disorders in Children: HL01-006
NHLBI; NIMH; NINR; NICHD
$1,499,621
Restless Legs Syndrome and Periodic Limb Movement Disorder: PA01-086
NINDS; NHLBI; NIA; NIMH
$334,178
Research on Alcohol and Sleep - AA00-005 +; ++
NIAAA
$4,512,605
Ancillary Studies in Conjunction with SHOW Trial: DK-00-017
NIDDK; NHLBI; NINR; NIAMS, NIDCR
$1,143,165
Oxygen Sensing During Intermittent Hypoxia: HL00-004
NHLBI
$10,673,975
Biobehavioral Research for Effective Sleep: PA00-046 +; ++
NINR; NHLBI; NIA; NIAAA; NICHD; NIDA; NIMH; NCI
$1,717,977
Data Coordinating Center for Sleep Heart Health Study: HL99-014
NHLBI
$2,913,228
Nocturnal Asthma, Chronobiology and Sleep: HL99-011 +; ++
NHLBI
$3,530,381
Occupational Safety and Health Research: PA99-143 ++
NIOSH; NCI; NHLBI; NIA; NIAAA; NIAID; NIAMS; NIDCD; NIEHS
$381,250
Obstructive Sleep Apnea in Children: HL98-004 ++
NHLBI; NIDR; NICHD
$10,826,226
Sleep Academic Award: HL97-015; HL96-021; HL96-006 +++
NHLBI
$4,995,123
Institutional National Research Service Award in Sleep Research: PA97-064 ++
NHLBI; NIA; NIAAA; NICHD; NIDA; NIMH; NINDS; NINR
$737,625
Research on Musculoskeletal Fitness and Sports Medicine: PA97-025 +
NIAMS; NICHD; NINR
$999,146
Molecular Biology and Genetics of Sleep and Sleep Disorders: HL96-015 +
NHLBI; NIMH; NICHD
$7,335,059
SCOR in Neurobiology of Sleep & Sleep Apnea: HL96-014 +; ++
NHLBI
$18,553,207
Basic and Clinical Research on Sleep & Wakefulness PA95-014 +; ++
NHLBI; NIA; NIAAA; NICHD; NIDA; NIMH; NINDS; NINR
$28,384,156

+ Also listed under Basic Science Research Recommendations
++ Also listed under Applied Research Recommendations
+++ Also listed under Research Training Recommendations

Continued on Page Two

  Continued on Page 2

Appendix Sections

APPENDIX A: SLEEP DISORDERS RESEARCH PLAN REVISION TASK FORCE
APPENDIX B: SLEEP DISORDERS RESEARCH ADVISORY BOARD
ABBREVIATIONS
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
National Institutes of Health (NIH) Department of Health and Human Services (click here) First Gov Website (Click here)
National Center on Sleep Disorders Research (Click Here) National Heart Lung and Blood Institute (Click Here)