RESEARCH AGENDA ON COMPLICATIONS OF HEMOPHILIA AND OTHER BLEEDING DISORDERS

Harold Varmus, M.D.
Director, NIH
April, 1999

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EXECUTIVE SUMMARY

INTRODUCTION

BACKGROUND

Treatment of Hemophilia and Other Bleeding Disorders

Improvements in Blood Safety

Complications of Hemophilia

Complications of Other Bleeding Disorders

Finding a Cure

RESEARCH ON COMPLICATIONS OF HEMOPHILIA

Mechanisms of Bleeding and Clotting

Antibody/Inhibitor Formation

Gene Therapy for Hemophilia

Blood-Borne Infectious Agents

• Human Immunodeficiency Virus (HIV)
  Hepatitis C Virus (HCV)

Blood Safety

• HIV and Hepatitis
  Creutzfeldt-JakobDisease(CJD)

Behavioral Research

MONITORING THE BLOOD SUPPLY

COORDINATING COMMITTEES

Public Health Service (PHS) Blood Safety Committee

DHHS Advisory Committee on Blood Safety and Availability (ACBSA)

Trans-Angency Hepatitis Working Group

Trans-NIH Hepatitis C Virus Working Group

Other Coordinating Groups

CONCLUSION

8/31/99