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Clinical Trials

The National Heart, Lung, and Blood Institute (NHLBI) is strongly committed to supporting research aimed at preventing and treating heart, lung, and blood diseases and conditions and sleep disorders.

NHLBI-supported research has led to many advances in medical knowledge and care. For example, this research has uncovered some of the causes of lung diseases and conditions, as well as ways to prevent or treat them.

Many more questions remain about lung diseases and conditions, including pulmonary hypertension (PH). The NHLBI continues to support research aimed at learning more about these diseases and conditions. For example, NHLBI-supported research on PH includes studies that explore:

  • How often people who have sickle cell anemia develop PH
  • Which genetic mutations (changes in the genes) cause PH; an example is the gene for bone morphogenetic receptor, type II (BMPR2)
  • How certain medicines and therapies can help treat PH and improve quality of life for people who have the disease
  • The effects of a rehabilitation exercise program on people with PH
  • Whether inhaled nitric oxide (a gas) can help people with group 3 PH

Much of this research depends on the willingness of volunteers to take part in clinical trials. Clinical trials test new ways to prevent, diagnose, or treat various diseases and conditions.

For example, new treatments for a disease or condition (such as medicines, medical devices, surgeries, or procedures) are tested in volunteers who have the illness. Testing shows whether a treatment is safe and effective in humans before it is made available for widespread use.

By taking part in a clinical trial, you can gain access to new treatments before they're widely available. You also will have the support of a team of health care providers, who will likely monitor your health closely. Even if you don't directly benefit from the results of a clinical trial, the information gathered can help others and add to scientific knowledge.

If you volunteer for a clinical trial, the research will be explained to you in detail. You'll learn about treatments and tests you may receive, and the benefits and risks they may pose. You'll also be given a chance to ask questions about the research. This process is called informed consent.

If you agree to take part in the trial, you'll be asked to sign an informed consent form. This form is not a contract. You have the right to withdraw from a study at any time, for any reason. Also, you have the right to learn about new risks or findings that emerge during the trial.

For more information about clinical trials related to PH, talk with your doctor. You also can visit the following Web sites to learn more about clinical research and to search for clinical trials:

lk with your doctor. You also can visit the following Web sites to learn more about clinical research and to search for clinical trials:

For more information about clinical trials for children, visit the NHLBI's Children and Clinical Studies Web page.

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April 1, 2011