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Who Is at Risk for LAM?

LAM is a rare disease that mostly affects women of childbearing age. Many women who develop LAM are between the ages of 20 and 40 when they begin to have symptoms. LAM can occur in older women as well, although this is less common.

Some women might have LAM and not know it. Many of LAM’s signs and symptoms are the same as those of other diseases, such as asthma, emphysema (em-fih-SE-ma), and bronchitis (brong-KI-tis).

LAM affects about 3 out of every 10 women who have tuberous sclerosis complex (TSC). Some of these women may have mild cases of LAM that don’t cause symptoms. Not everyone who has TSC and LAM has lung symptoms.

In rare cases, LAM has been reported in men.

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LAM Clinical Trials

Clinical trials are research studies that explore whether a medical strategy, treatment, or device is safe and effective for humans. To find clinical trials that are currently underway for LAM, visit

December 26, 2013 Last Updated Icon

The NHLBI updates Health Topics articles on a biennial cycle based on a thorough review of research findings and new literature. The articles also are updated as needed if important new research is published. The date on each Health Topics article reflects when the content was originally posted or last revised.