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Clinical Trials

The National Heart, Lung, and Blood Institute (NHLBI) is strongly committed to supporting research aimed at preventing and treating heart, lung, and blood diseases and conditions and sleep disorders.

NHLBI-supported research has led to many advances in medical knowledge and care. For example, this research has uncovered some of the causes of heart diseases and conditions, as well as ways to prevent or treat them.

Many more questions remain about heart diseases and conditions, including heart valve disease. Thus, the NHLBI continues to support research to learn more. For example, NHLBI-supported research on heart valve disease includes studies that explore:

  • New techniques to evaluate mitral valve backflow
  • Whether mitral valve repair or replacement works better for people who have severe backflow through their mitral valves
  • Whether coronary artery bypass grafting alone or with mitral valve repair works better for treating people who have moderate mitral valve backflow and coronary heart disease

Much of this research depends on the willingness of volunteers to take part in clinical trials. Clinical trials test new ways to prevent, diagnose, or treat various diseases and conditions.

For example, new treatments for a disease or condition (such as medicines, medical devices, surgeries, or procedures) are tested in volunteers who have the illness. Testing shows whether a treatment is safe and effective in humans before it is made available for widespread use.

By taking part in a clinical trial, you can gain access to new treatments before they're widely available. You also will have the support of a team of health care providers, who will likely monitor your health closely. Even if you don't directly benefit from the results of a clinical trial, the information gathered can help others and add to scientific knowledge.

If you volunteer for a clinical trial, the research will be explained to you in detail. You'll learn about treatments and tests you may receive, and the benefits and risks they may pose. You'll also be given a chance to ask questions about the research. This process is called informed consent.

If you agree to take part in the trial, you'll be asked to sign an informed consent form. This form is not a contract. You have the right to withdraw from a study at any time, for any reason. Also, you have the right to learn about new risks or findings that emerge during the trial.

For more information about clinical trials related to heart valve disease, talk with your doctor. You also can visit the following Web sites to learn more about clinical research and to search for clinical trials:

For more information about clinical trials for children, visit the NHLBI's Children and Clinical Studies Web page.

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Heart Valve Disease Clinical Trials

Clinical trials are research studies that explore whether a medical strategy, treatment, or device is safe and effective for humans. To find clinical trials that are currently underway for Heart Valve Disease, visit www.clinicaltrials.gov.


Heart Valve Disease in the News

November 18, 2013
Valve repair or replacement offers similar outcomes for severe heart valve disease
Repair or replace? Consumers often ask this question when considering faulty cars, appliances, or other equipment. A new clinical study has now addressed this question for a serious medical decision: how to treat ischemic mitral regurgitation (IMR), a condition in which blood backflows into the heart because the mitral valve becomes leaky after a heart attack. The study compared the two surgical options –re-tightening the leaky mitral valve or replacing it with a prosthetic –and found no significant differences in patient outcomes after a year.

View all Heart Valve Disease Press Releases


 
November 16, 2011 Last Updated Icon

The NHLBI updates Health Topics articles on a biennial cycle based on a thorough review of research findings and new literature. The articles also are updated as needed if important new research is published. The date on each Health Topics article reflects when the content was originally posted or last revised.