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What Causes Coronary Heart Disease?

Research suggests that coronary heart disease (CHD) starts when certain factors damage the inner layers of the coronary arteries. These factors include:

Plaque might begin to build up where the arteries are damaged. The buildup of plaque in the coronary arteries may start in childhood.

Over time, plaque can harden or rupture (break open). Hardened plaque narrows the coronary arteries and reduces the flow of oxygen-rich blood to the heart. This can cause angina (chest pain or discomfort).

If the plaque ruptures, blood cell fragments called platelets (PLATE-lets) stick to the site of the injury. They may clump together to form blood clots.

Blood clots can further narrow the coronary arteries and worsen angina. If a clot becomes large enough, it can mostly or completely block a coronary artery and cause a heart attack.

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Coronary Heart Disease Clinical Trials

Clinical trials are research studies that explore whether a medical strategy, treatment, or device is safe and effective for humans. To find clinical trials that are currently underway for Coronary Heart Disease, visit www.clinicaltrials.gov.


Know the Facts and Act Fast!

Collage image of new heart attack materials

When a heart attack happens, any delays in treatment can be deadly. 

Knowing the warning symptoms of a heart attack and how to take action can save your life or someone else’s.

The NHLBI has created a new series of informative, easy-to-read heart attack materials to help the public better understand the facts about heart attacks and how to act fast to save a life.

Click the links to download or order the NHLBI's new heart attack materials:

“Don’t Take a Chance With a Heart Attack: Know the Facts and Act Fast” (also available in Spanish)

“Heart Attack: Know the Symptoms. Take Action.”

“Learn What a Heart Attack Feels Like—It Could Save Your Life”


 
September 29, 2014 Last Updated Icon

The NHLBI updates Health Topics articles on a biennial cycle based on a thorough review of research findings and new literature. The articles also are updated as needed if important new research is published. The date on each Health Topics article reflects when the content was originally posted or last revised.