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APPENDIX I.A.2. LITERATURE REVIEW

The results of the literature search are provided below in terms of the population (top) and clinical (bottom) portions of the evidence model. A total of 43,627 records were obtained from the search; the following notes the number of records per topic.

Population model search citations by topic area (22,017 total):

Cardiovascular disease

3,675 citations

Hypertension

93 citations

Diabetes

65 citations

Dyslipidemia

73 citations

Cardiovascular morbidity and mortality

225 citations

Noncardiovascular morbidity and mortality

4,272 citations

Clinical model search citations by topic area (11,268 total):

Cardiovascular disease

1,866 citations

Hypertension

616 citations

Diabetes

380 citations

Dyslipidemia

917 citations

Cardiovascular morbidity

71 citations

Noncardiovascular morbidity and mortality

6,507 citations

Note: The number of citations per topic do not add up to the total citations per top or bottom model or the overall NLM search. The total number includes all of those listed above plus the citations for fitness, weight loss, and abdominal fat

Evidence Model Questions

Population Model (Top)

Arrow Number

 Question

1

Not considered

2

What is the evidence that relates weight to abdominal fat?

3

Not considered

4

What is the evidence that relates abdominal fat to high blood pressure in minority populations?

5

What is the evidence that relates abdominal fat to dyslipidemia in minority populations?

6

What is the evidence that relates abdominal fat to diabetes in minority populations?

7

What is the evidence that relates abdominal fat to cardiovascular disease?

8

What is the evidence that relates abdominal fat to noncardiovascular mortality and morbidity?

9

What is the evidence that relates abdominal fat to cardiovascular mortality and morbidity?

34

What is the evidence that relates weight to high blood pressure in minority populations?

35

 What is the evidence that relates weight to dyslipidemia in minority populations?

36

What is the evidence that relates weight to diabetes in minority populations?

37

What is the evidence that relates weight to cardiovascular disease?

38

What is the evidence that relates weight to noncardiovascular mortality and morbidity?

39

What is the evidence that relates weight to cardiovascular mortality and morbidity?

Clinical Model (Bottom)

Arrow Number

 Question

10

Not considered

11

Not considered

12

What is the evidence that treatment directly affects abdominal fat?

13

What is the evidence that treatment directly affects weight loss?

14

What is the evidence directly relating treatment and fitness?

15

What is the evidence that fitness is directly related to weight loss?

16

What is the evidence that weight loss directly affects abdominal fat?

17

What is the evidence that a reduction of abdominal fat is directly related to cardiovascular disease?

18

What is the evidence that a reduction of abdominal fat is directly related to cardiovascular mortality and morbidity?

19

What is the evidence that a reduction in abdominal fat directly affects high blood pressure?

20

What is the evidence that a reduction in abdominal fat directly affects dyslipidemia (cholesterol)?

21

What is the evidence that a reduction in abdominal fat directly affects glucose tolerance?

22

What is the evidence that weight loss directly affects high blood pressure?

23

What is the evidence that weight loss directly affects dyslipidemia (cholesterol)?

24

What is the evidence that weight loss directly affects glucose tolerance?

25

What is the evidence that fitness directly affects high blood pressure?

26

What is the evidence that fitness directly affects dyslipidemia (cholesterol)?

27

What is the evidence that fitness directly affects glucose tolerance?

28

What is the evidence that fitness is directly related to noncardiovascular mortality?

29

What is the evidence that fitness is directly related to cardiovascular mortality and morbidity?

30

What is the evidence that fitness is directly related to cardiovascular disease?

31

What is the evidence directly relating weight loss and noncardiovascular mortality and morbidity?

32

What is the evidence directly relating weight loss and cardiovascular mortality and morbidity?

33

What is the evidence directly relating weight loss and cardiovascular disease?

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