to Independence Award (Parent K99/R00)
(Non-Independent and Newly Independent Investigators)
to Independence (PI) Award is designed to facilitate a timely
transition from a mentored postdoctoral research position
to a stable independent research position with independent
NIH or other independent research support at an earlier stage
than is currently the norm. The PI award will provide up to
5 years of support consisting of two phases. The initial phase
will provide 1-2 years of mentored support for postdoctoral
research scientists. This phase will be followed by up to
3 years of independent support contingent on securing an independent
tenure-track or equivalent research position.
Pathway to Independence Award Web links:
Pathway to Independence Award (PA-14-042)
Qs&As: "New Investigators Program/Pathway
to Independence Award, Questions and Answers"
The NHLBI has developed an additional
document, Fact Sheet:
K99s Transitioning to R00 which provides application instructions for NHLBI K99 awardees
transitioning from the mentored phase of the K99 to the
independent research phase of the R00.
Who is eligible? At the time of application
submission (or resubmission) candidates for this award must
have earned a terminal clinical or research doctorate (including
Ph.D., M.D., D. O., D.C., N.D., D.D.S., D.V.M., Sc.D., D.N.S.,
Pharm. D., or equivalent doctoral degree, or a combined clinical
and research doctoral degree); and have no more than 4 years
(48 months) of research experience since completing the requirements
of the doctoral degree (resubmissions must also comply with
this requirement). The K99/R00 Program Announcement (PA) describes
some exceptions to the 4-year rule; see the PA and associated
"Questions and Answers" document for details. Individuals
whose terminal or research doctorate was awarded more than
48 months before submission of the K99/R00 application are
strongly urged to contact one of the NHLBI Program staff designated
below before submission to determine whether they are eligible
to apply. This confirmation of eligibility should be documented
in a cover letter to accompany the application. Applications
from ineligible individuals will be returned without review.
U.S. citizens and non-U.S. citizens are eligible. There
are additional eligibility criteria detailed in the full K99/R00
Program Announcement; please check carefully before proceeding.
A typical successful candidate will have an impressive record
of research productivity and publications, and will have identified
a unique research direction to pursue after the mentored phase
of the award.
The opportunities? Both mentored research
and independent research support during the early phase of
an investigators' career.
Duration of support? As described above,
up to 5 years of support consisting of two phases. Award of
the independent (R00) phase is not guaranteed.
Where? Domestic for-profit or non-profit
institutions/organizations, or public or private institutions,
such as universities, colleges, hospitals and laboratories,
eligible agencies of the federal government, and NIH intramural
laboratories. All institution/organization types listed above
are eligible for both the mentored and independent phase,
with one exception: ineligible agencies of the Federal government,
such as the NIH intramural program, are eligible only for
the mentored phase. Foreign institutions are not eligible.
New applications are due February 12, June
12, and October 12.
Resubmitted applications are due March 12, July 12, and November
Mentored phase (K99): Salary:
up to $75,000 plus fringe benefits per year. Research Support:
up to $25,000 per year. F&A costs will be provided at
8% of modified direct costs (to extramural sponsoring institutions
Independent investigator phase (R00): Total
cost may not exceed $249,000 per year. This amount includes
salary, fringe benefits, research support allowance and applicable
F&A costs. F&A costs will be reimbursed at the extramural
sponsoring institution’s F&A rate. Facilities and
administrative costs requested by consortium participants
are included in the total cost limitation.
How to apply: Applications submitted in
response to this Funding Opportunity Announcement (FOA) for
Federal assistance must be submitted electronically through
using the SF 424 Research and Related (R&R) forms and
the SF 424 (R&R) Application Guide.
424 (R&R) Application Guide for NIH and Other PHS Agencies includes Part 1.7 Supplemental Instructions to the SF
424 (R&R) for Preparing an Individual Research Career
Development Award (CDA) Application ("K" series).
Page Limitations: All page limitations described in the SF424 (R&R) Application Guide and the Table of Page Limits must be followed.
Resources for K99/R00 Candidates:
The NHLBI Website also lists training
programs under the category Requests
for Applications/Proposals & Program Announcements
with the application receipt date.
NHLBI's Division of Blood Diseases and Resources (DBDR) Program Description
NHLBI's Division of Cardiovascular Sciences (DCVS) Program Description
NHLBI's Division of Lung Diseases (DLD) Program Description
Please contact the following NHLBI staff member if you have
questions about this award:
Direct your questions about NHLBI intramural programmatic
Herbert Geller, Ph.D.
Director, Office of Education
Division of Intramural Research
National Heart, Lung, and Blood Institute
Building 10, Room 6N248
10 Center Drive, MSC 1754
Bethesda , MD 20892-1754
Phone: (301) 451-9440
FAX: (301) 594-8133
Direct your questions about NHLBI extramural programmatic
Helena O. Mishoe, Ph.D., MPH
Office of Research Training and Minority Health
National Heart, Lung, and Blood Institute
6701 Rockledge Drive , Room 9180, MSC 7913
Bethesda , MD 20892-7913
FAX: (301) 480-0862
Revised February 2014