Omnibus Grant Solicitations NHLBI

Omnibus Grant Solicitations (for investigator-initiated applications)

Submission date: Standard receipt dates apply (April 5, August 5, December 5 for non-HIV related applications)

The NHLBI accepts investigator-initiated Phase I and Phase II grant applications that are relevant to the NHLBI mission through the Department of Health and Human Services Omnibus SBIR and STTR Grant Solicitations. While the NHLBI has identified some areas of unmet needs of particular interest (please see below), the NHLBI also encourages mission-aligned applications for innovative technologies outside these targeted areas.

Unmet Needs of Particular Interest for Fiscal Year 2012

Topics are listed here to inform potential applicants about areas of particular interest to the NHLBI.

Applications submitted in response to the Omnibus Grant Solicitations are not limited to the research and development areas described below.

For more information, see the NHLBI section image of word document icon

(74 KB) of the Omnibus Grant Solicitation.

Instructions for submitting applications in response to the following areas:

At the beginning of the title, please include the following four characters: HLS- (Important: according to the NIH's SF424 (R&R) Application Guide, NIH limits title character length to 81 characters including the spaces between words and punctuation. Titles in excess of 81 characters will be truncated).
In the first sentence of the abstract, please include the code shown in the last column of the table below. This coding is for internal NHLBI tracking purposes only.

Topic

Code

Animal and Cellular Models:

for rare non-malignant and pre-malignant (MDS & MPD) hematologic disorders
for complications associated with thrombosis
for transfusion of blood products or cell-based therapies

HLS12-01

Research tools: Imaging, reagents, assays Ð including microassays, microfluidics, bioinformatics and nanotechnology for investigations of blood diseases, transfusion and cellular therapies

HLS12-02

Diagnostics: devices, biomarkers, imaging, and assays for non-malignant blood disorders

HLS12-03

Therapeutics: drugs, blood product and cellular therapies, and gene therapy for non-malignant blood disorders

HLS12-04

E-medicine Apps for patients and medical professionals to improve the management of and reduce the impact of non-malignant blood diseases

HLS12-05

Development of molecular imaging reagents/techniques and nanotechnology-based drug delivery systems which would detect and then allow for specific targeting of lung diseases, such as plexiform lesions in PAH and/or microvascular loci susceptible to rarefaction/pruning in obstructive airway diseases like emphysema, or fibrotic triggers in IPF.

HLS12-06

Development of reagents and methods to identify and isolate stem/progenitor cells, and direct differentiation to specific functional organ units. These reagents may include antibodies for stem/progenitor cell detection and sorting, biomaterials for optimizing the microniches of stem/progenitor cells, as well as methods for 3-D regeneration of tissue.

HLS12-07

Development and validation of techniques(or algorithms) to study the microbiome in situ, including, but not limited to:

Sampling the microbiome of different lung or gut segments while minimizing contamination from other locations.
Development of an analytical system to study the metabolic products of the lung and gut microbiome from breath condensate

HLS12-08

Characterization and in vivo / in vitro applications of miRNA panels that target lung-resident mesenchymal or fibroblast cells and promote directly or indirectly lung repair/regeneration

HLS12-09

Development of high throughput methods to apply microfluidics technology in discovery of molecular profiles (DNAs, RNAs, proteins, or metabolites) in a large number of sputum or exhaled breath condensate samples collected from lung disease patients.

HLS12-10

Develop a biocompatible fluid sealant and associated transcatheter technique to permanently seal paravalvular leaks resulting from transcatheter cardiac valve replacement

HLS12-11

Develop smart phone apps and other communication tools to increase accessibility and evaluation of the latest educational materials and trial research on cardiovascular, nutritional and physical activity information for medical professionals and patients (English and non-English speakers)

HLS12-12

Innovative Point-of-Care technologies to guide diagnostic, monitoring or therapeutic efforts in clinical studies of cardiovascular, lung, and blood diseases and disorders

HLS12-13

Improved diagnostics, monitoring technologies and therapeutics for arterial stiffness and peripheral vascular diseases (e.g., aortic aneurysms, venous and lymphatic disorders, and vascular malformations)

HLS12-14

Develop a technology that enables immediate, user-friendly measures of average daily sodium intake. These technologies would replace the current standard of 24-hour urine collection

HLS12-15

For questions, contact us.

Last Updated July 2012