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HIV-Related Research on Pediatric Heart, Lung, and Blood Diseases
HIV-Focused Research Goals
NHLBI supports research on the effects of HIV on children and young adults. Such research attempts not only to characterize the natural history of the disease from the intrauterine environment through childhood and adolescence, but also to understand the effect of antiretroviral therapy on developing organ systems. Children with HIV have been shown to have accelerated development of cardiovascular risk factors, including lipid abnormalities and abnormal markers of cardiovascular risk. They are also at risk of cardiomyopathy resulting from both viral infection and long-term treatment with antiretroviral therapy.
Previously Funded Studies
In 2005, the Pediatric HIV/AIDS Cohort Study (PHACS) was established to address the long-term safety of fetal and infant exposure to prophylactic antiretroviral (ART) therapy and the effects of perinatally acquired HIV infection in adolescents. This network of 24 clinical sites across 13 states and Puerto Rico runs two major protocols and studies many facets of pediatric HIV. PHACS' goals germane to the NHLBI include characterization of cardiac structural and functional abnormalities in HIV-infected children. This will be achieved by exploring abnormalities in cardiac function related to ART and/or HIV exposure as well as metabolic risk factors for cardiovascular disease, including abnormal glucose metabolism, lipid abnormalities, and body composition.
The Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study (P2C2) was a prospective natural history study at five clinical centers in the United States during the era before antiretroviral therapy was widely available (1990-1997). The P2C2 study helped define the spectrum of cardiovascular and pulmonary disease in HIV-infected children and uninfected children born to HIV-infected mothers.
Stored serum samples from the P2C2 study may be requested by qualified investigators through the NHLBI Biologic Specimen and Data Repository (BioLincc).
Selected Pediatric-Related Publications Supported by the NHLBI AIDS Program