Frequently Asked Questions for RFA-HL 12-006 and 12-010 Consortium of Lung Repair and Regeneration (U01)

Q: For the Research Centers (HL 12-006), What budget costs are permitted, and how many awards are possible?

A: For this funding opportunity, budgets up to $450,000 direct costs per year and time periods up to 5 years may be requested. For this funding opportunity, NHLBI intends to commit approximately $4.0 million total costs for FY2012 for the Research Centers. It is anticipated that up to 6 Research Center awards will be made through this FOA.

Q: Does the application need to organize investigative teams from multiple institutions?

A: No, multi-institutional collaborations are not required in response to this FOA, but are permitted. This FOA requires that new collaborations are proposed that draw from 2 or more disciplines. The evidence for prior collaborations is not required, and if not previously established through publications should be clearly stated how the collaborative efforts will be managed/ensured. The contributions of each key personnel to the application and to the Consortium as a whole should be presented in the section on “justification of key personnel”. The Consortium will be formed after the review and award of individual applications that are deemed highly meritorious.

Q: Are applications required to provide a research hypothesis to be tested as well as propose 2 or more models/tools/reagents?

A: Yes, both components are required to be responsive to this FOA and should be contained within the 12 page research plan section. The models/tools/reagents that the applicant proposes to develop should not already be in hand, but the applicant should propose what will be developed and why it would contribute to advancing lung cell biology in repair/regeneration.

Q: What is meant by “validation in human studies”?

A: At a minimum studies should be proposed that include use of human cells, tissues, etc. This FOA does not require “clinical studies”.

Q: Are bioengineers required as key personnel in each application?

A: No, bioengineering expertise is not required, but is encouraged with the goal of advancing our understanding of lung regenerative biology. The role and expertise of key personnel proposed in each application should be clearly stated in the key personnel justification section of the application.

Q: If I qualify as an Early Stage Investigator (ESI), will I be given special funding consideration?

A: No, the R01 for this FOA is not eligible for ESI special funding consideration.

Q: Can the same principal investigator submit an application in response to RFA HL10-006 and for the Administrative Coordinating Center RFA HL10-010 simultaneously?

A: No

Q: Can an institution submit more than one application?

A: Yes, but the principal investigator cannot be the same.

Q: Do I need to submit a budget for the skills development core in response to HL12-006?

A: No, not for the Skills Development plan proposed, but the research center budget should support 0.6 month FTE/year for the individual who serves as the research center’s Skills Development Coordinator in all five years of the grant period.

Q: Is there a standing committee that reviews the applications submitted to RFA HL-12-006 and 010?

A: No, there is not a standing committee to review applications in response to these FOAs. A special emphasis panel will be convened specifically for these FOAs.

Q: Do I have to submit a Letter of Intent if I am planning to submit an U01 application?

A: Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review. Prospective applicants are asked to submit a letter of intent. Please refer to section 3.A.1 of RFA HL12-006 and -010 for the specific information to provide in your letter of intent and where to send it.

Q: What should be included in the travel budget?

A: Travel for 2 meetings/year to Washington DC area for PI (one for Steering Committee only, one for annual scientific meeting) and travel to 1 scientific meeting/year for key personnel (likely in the Washington DC area).

Q: For the administrative coordinating center (HL 12-010), does the NHLBI/DLD intend to commit $6.3 million for 1 award in FY 2012 to budgeted all in one year?

A: No, NHLBI/DLD intends to commit $6.3 million for 1 award from FY 2012-FY2015, Requested Direct Costs for the Coordinating Center may not exceed $600,000 in the first year (FY2012) and $900,000 per year in years 2-5 (FY2013-FY2016). Approximately 50% of the Direct Costs should be for administrative coordinating functions and 50% for subcontracts with research centers for collaborative activities.

Q: Regarding the Skills Development Core: Are the Skills Development Coordinator and “representative on the Skills Development Committee” the same position or two different positions?

A: These are the same person.

Q: Calendar Months Percent of Effort: Is the minimum percent of effort (2.4 CM for PI and 0.6 CM for Skills Development) the total combined effort throughout the 5 year grant budget or per year?

A: 2.4 calendar months minimum per year for PI (or sum of multi-PIs) is expected for the entire research application—this isn’t referring to skills development core, though it was placed in that section of the RFA. The skills development coordinator/leader from each research center should have 0.6 mo FTE budgeted for each year of the award to provide input on skills development CORE activities across centers that make up the consortium. First year will primarily include planning, subsequent years planning and implementation of the CORE.

Last update: January 2011

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