Frequently Asked Questions for RFA-HL-10-026: Programs of Excellence in Glycosciences

  1. Q. Will this RFA involve an electronic or paper submission?
    A. This RFA will use a paper PHS 398 submission. A new version of the paper PHS 398 application form and instructions is now available. The new form and instructions must be used to apply for receipt dates January 25, 2010 and beyond. Please download the new application form and instructions from For more information on how the application is being restructured, please visit
  2. Q. What are the key receipt dates?
    A. Letters of Intent Receipt Date: April 9, 2010, is encouraged but not mandatory or binding. Application Receipt Date: May 10, 2010
  3. Q. When is the earliest start date?
    A. Earliest Anticipated Start Date is April 1, 2011.
  4. Q. Are scientists working in foreign institutions eligible to apply?
    A. Applications originating from foreign institutions as well as Principal Investigators (PIs) of Sub-Projects from foreign institutions are not eligible to apply. Scientific collaborations and interactions are allowed, but funds may not be transferred to foreign sites.
  5. Q. Can an applicant submit more than one PEG application?
    A. An “applicant” which refers to a Principal Investigator (either the P01 Program Director or a Sub-Project PI) cannot apply for more than one application or sub-project.
  6. Q. Since the RFA uses the P01 mechanism, are new investigators or early stage investigators (ESI) with recently awarded R01 grants eligible to participate as Sub-Project PIs?
    A. New or ESIs with recently funded R01s are eligible to participate as Sub-Project PIs. However, the Program Director for the P01 should be a Senior Investigator. Each individual project in a PEG should have a different project leader.
  7. Q. How many years will a single post-doc be funded? Can it be extended?
    A. It is expected that a post-doc will be funded for at least 4 years. This period may be extended on an as needed basis.
  8. Q. Can the post-docs get additional training at another PEG training site other than their own?
    A. Yes. Arrangements of cross-PEG training can be made between the collaborating institutions within the funds awarded.
  9. Q. Will investigators be allowed to come from multiple institutions?
    A. Yes, multiple institutions can come together to form the PEG team since desired combinations of expertise and technologies may not reside at a single institution. However, the application needs to be submitted from the Institution of the P01 Program Director.
  10. Q. What constitutes a PEG (Programs of Excellence in Glycosciences)?
    A. A PEG must have a clearly defined, unifying theme to which each component project relates and to which each research investigator contributes. Each PEG must include a minimum of three interrelated research projects, a Glycosciences Skills Development Core, and a Shared Resources Core. Applications that do not have these components will be judged incomplete and will not be reviewed. The Research Projects will perform cutting-edge multidisciplinary research. The Glycosciences Skills Development Core will provide high quality training through hands-on Experience and formal lectures. The Shared Resources Core will develop and supply glyco- analytical tools and resources, such as glycoconjugates analysis, glycan synthesis, glycan detection and glycan interactions to accelerate the pace of research. The Program should also include an Administrative Core. Other Program-Specific cores may also be included.
  11. Q. What are the maximum allowable direct costs for the PEG?
    A. The maximum allowable direct costs are $1.6 million per year for each P01, not including facilities and administrative [F&A] costs associated with consortia.
  12. Q. Does the P01 Program Director or a sub-project PI need to direct one of the mandatory cores?
    A. No, Core Directors are investigators with the appropriate and relevant expertise to lead the particular core. These individuals do not have to be sub-project PIs. Core leaders should dedicate time and effort commensurate with the complexity of the core unit’s function.
  13. Q. Can the mandatory Cores also serve as a “Fee-for-Service” facilities to NIH/NHLBI investigators that may require glyco-analytical tools but are not funded by the PEG program?
    A. Yes, the Cores may provide a Fee-for-Service to any NIH funded investigator. However, services will be free to all investigators funded within the PEGs.
  14. Q. Are the two mandatory PEG Cores (Glycosciences Skills Development Core and Shared Resources Core) synonymous with Program Specific Cores?
    A. No. Program Specific Cores are optional and will only service members of their respective P01 application. Applications without the mandatory cores are considered incomplete.
  15. Q. Since the RFA uses the P01 mechanism, will prior collaboration be a requirement between investigators planning to form a new PEG team?
    A. Prior collaborations are not a requirement. New partnerships are encouraged to bring together the necessary combinations of expertise and technologies to achieve the goals of the PEG. However, the new team should describe how their skills are complementary and how they plan to interact to accomplish their goals.
  16. Q. What is the minimum level of effort for the P01 Program Director and for a sub-project PI?
    A. The minimum level of effort for both the P01 Program Director and the sub-project PIs is 20% time commitment to the PEG grant.
  17. Q. Since the RFA uses a P01 mechanism, will individual research projects receive a separate score?
    A. Individual research projects will not receive a separate score. Each application will be reviewed in its entirety and receive a single impact/priority score.
  18. Q. Since the RFA uses a P01 mechanism, will the review be done by a tailored review committee and the NHLBI PPG Parent Review Committee?
    A. PEG applications will be reviewed by an NHLBI-convened Special Emphasis Panel. There will be no review by the NHLBI PPG Parent Review Committee. The applications will receive a second level of review by the NHLBI Advisory Council.

Scientific/Research Contact:
Rita Sarkar, Ph.D
Division of Blood Diseases and Resources
National Heart, Lung, and Blood Institute
6701 Rockledge Drive, Room 9161
Bethesda MD 20892-7950
Bethesda, MD 20817 (for courier service)
Telephone: 301-435-1324
Fax: 301-480-1046

Last updated: December 23, 2009

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