RFP No. NHLBI-RR-02-02

"Caenorhabditis Genetics Center"

Request for Proposal No.: NHLBI-RR-02-02
 
Issue Date: May 17, 2001
 
Issued By: Patricia A. Smith
Contracting Officer
NIH/NHLBI
Contracts Operations Branch
6701 Rockledge Drive  MSC 7902
Bethesda MD 20892-7902
 
Purchase Authority: 42 USC 201, Public Health Service Act
 
Small Business Set-Aside: No; NAICS Code 541710
 
Proposal Intent Due Date: June 18, 2001
 
Proposal Due Date: August 07, 2001, 4:30 PM (Eastern Time)


Ladies and Gentlemen:

The National Heart, Lung, and Blood Institute (NHLBI) is soliciting proposals on behalf of the National Center For Research Resources (NCRR) for services to provide a Caenorhabditis Genetics Center (CGC) for acquisition, storage, characterization, and distribution of wild-type and mutant nematodes, primarily of the species Caenorhabditis elegans. In addition, the Contractor shall provide services of maintaining and distributing the genetic map of C. elegans, relevant publications, and the development and communication of uniform genetic terminology for this species.

This Streamlined Technical Request For Proposal (RFP) consists of this combined solicitation form and cover letter (PART A), and three additional components, as follows:

  1. Statement of Work/Technical Reporting Requirements;
  2. Deliverables;
  3. Evaluation Factors for Award, including Technical Evaluation Criteria;

These components contain the technical information required for the submission of a proposal for this acquisition. In addition, there are two other sections in this specific RFP. The section entitled "Specific RFP Instructions and Provisions" contains, for example, the proposal intent response form and the address for delivery of your proposal. The section entitled "Applicable RFP References" lists those items in the STREAMLINED RFP REFERENCES directory that apply to this RFP, including forms for submission of the proposal. The Streamlined RFP References directory is located at URL:

http://ocm.od.nih.gov/contracts/rfps/MAINPAGE.HTM

Although these documents contain sufficient information for you or your organization to submit a proposal, if you intend to submit a proposal in response to this RFP, IT IS ESSENTIAL THAT YOU IMMEDIATELY NOTIFY PATRICIA A. SMITH, CONTRACTING OFFICER, AT THE FOLLOWING INTERNET ADDRESS:

ps44b@nih.gov

IF YOU DO NOT NOTIFY THE CONTRACTING OFFICE OF YOUR INTENT TO SUBMIT A PROPOSAL, YOU WILL NOT RECEIVE AN INDIVIDUAL NOTICE OF ANY AMENDMENTS TO THE RFP, IF ANY ARE ISSUED. HOWEVER, ALL AMENDMENTS WILL BE POSTED ON THE NIH WEB SITE.

The original and twenty-five (25) copies of your technical proposal and the original and six (6) copies of your business proposal must be received by the Contracting Office no later than August 7, 2001, at 4:30 p.m. local time at the address listed in the item entitled "Packaging and Delivery of Proposals". Also, please complete the form entitled "Proposal Intent Response Sheet" and send it to the address indicated therein on or before June 18, 2001. This will allow us to expedite preparations for the peer review of proposals. Finally, your proposal must be organized and submitted in accordance with the "Technical Proposal Table of Contents." All three of these items are found under the "Specific RFP Instructions and Provisions" portion of this RFP, which follows the technical evaluation criteria section.

You are reminded that the "Technical Proposal Cover Sheet" must be completed in full detail and used as the cover sheet for each copy of your technical proposal. (This form is contained in this NIH WEB site under the FORMS, FORMATS, AND ATTACHMENTS file found in STREAMLINED RFP REFERENCES.) This information will be used to ensure that there will be no conflict of interest when selecting review committee members.

Offers will be valid for 120 days unless a different period is specified by the offeror on the form entitled, "Proposal Summary and Data Record, NIH 2043" (PDF and MS Word) also located at the site for FORMS, FORMATS, AND ATTACHMENTS.

NOTE: IF YOUR PROPOSAL IS NOT RECEIVED BY THE CONTRACTING OFFICER OR DESIGNEE AT THE PLACE AND TIME SPECIFIED, THEN IT WILL BE CONSIDERED LATE AND HANDLED IN ACCORDANCE WITH THE CLAUSE ENTITLED, "LATE PROPOSALS, MODIFICATIONS OF PROPOSALS, AND WITHDRAWALS OF PROPOSALS". The full text is in the Optional RFP Instructions and Provisions file of the Streamlined RFP References Directory.

If you have any additional questions regarding this RFP, please contact Mrs. Smith through the Internet using the electronic mail address listed above or phone (301) 435-0345, fax (301) 480-3430. COLLECT CALLS WILL NOT BE ACCEPTED.

SUBMISSION OF PROPOSALS USING FACSIMILE OR ELECTRONIC MAIL IS NOT AUTHORIZED.

NOTE: DIRECTIONS FOR ACCESSING THE "STREAMLINED RFP REFERENCES" REFERRED TO THROUGHOUT THIS RFP ARE AS FOLLOWS:

After reviewing this Request For Proposal, return to the original site for the NIH Request For Proposals Directory. In this directory, entitled "NIH Request For Proposals Directory", following the list of NIH Institutes by name, is the section entitled "STREAMLINED RFP REFERENCES". Select (click on) each section you wish to review:

"STANDARD RFP INSTRUCTIONS AND PROVISIONS" for proposal preparation instructions and other standard provisions,

"OPTIONAL RFP INSTRUCTIONS AND PROVISIONS" for the special provisions identified in this specific RFP,

"FORM, FORMATS, AND ATTACHMENTS" to download the forms listed in this specific RFP that you will need to submit a proposal,

"REPRESENTATIONS AND CERTIFICATIONS" (MS Word--WP--PDF to download and complete the representations and certifications that must be submitted with your proposal, and

"SAMPLE CONTRACT FORMAT-GENERAL" to view some of the clauses that are typical for inclusion in a Research and Development type contract issued by NIH.

Sincerely,
/s/
Patricia A. Smith
Contracting Officer


  1. STATEMENT OF WORK/REPORTING REQUIREMENTS

    ARTICLE C.1. STATEMENT OF WORK

    1. Background

      The Biological Models and Materials Program (BMMP) in the Division of Comparative Medicine, National Center for Research Resources (NCRR), was established in October 1989 to provide for the development and support of cell systems, lower organisms and nonbiological models for biomedical research, and to provide critical biological materials for the research community. The NCRR recognizes the importance of high quality biomaterials and genetically defined animal models. The Caenorhabditis Genetics Center (CGC) is part of an overall NCRR strategy to provide model systems that facilitate research in many areas of biomedical research. The CGC is used by extramural grantees of several NIH Institutes and Centers (ICs). The CGC is the major resource for the acquisition, storage, and distribution of genetic stocks of Caenorhabditis elegans (a nematode). It is also a major source of bibliographic and genetic information related to C. elegans. Because of the multidisciplinary nature of the users' research, the NCRR co-funded the CGC during the contract period 1984-1986, with the National Institute on Aging (NIA). In 1986, the major portion of the support for the CGC was transferred to NCRR under Contract No. N01-RR-4-2111. The contract was recompeted, and awarded to the University of Missouri, Columbia (N01-RR-9-2113). That contract expired on September 30, 1992. The contract was recompeted and contract N01-RR-2-2101 was awarded by the NCRR to the University of Minnesota, St. Paul, with an expiration date of May 31, 1997. The contract was recompeted by NHLBI, on behalf of NCRR, and the award was made to the University of Minnesota, St. Paul. Contract N01-RR-22101 with the University of Minnesota was extended to continue the services through May 31, 2002.

      Objectives

      The objectives of this contract are to acquire and distribute wild-type and mutant strains of C. elegans and related nematode species, to characterize these strains, and to stimulate research using C. elegans as a model system. The CGC is expected to provide a genetic resource to investigators using C. elegans as a model in biological research. The CGC also receives reprints of publications and data (raw and analyzed), stores these materials, verifies genetic status and/or scientific accuracy and distributes mutant strains, bibliographic and genetic information to individual scientists and the scientific public at large. This contract requires that the Contractor perform these activities for a five-year period. The principal objective of the Government is the continuation of the C. elegans resource through the operation of a CGC that acquires, maintains and distributes mutant strains of the nematode C. elegans for biological/biomedical research.

      Work to be Performed

      Independently, and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment and facilities, not otherwise provided by the Government as needed to perform the statement of work below.

      The Contractor, acting as the CGC, shall perform the following tasks:

      1. The Contractor shall acquire, maintain, and distribute wild-type and mutant strains of C. elegans and related nematode species for biomedical research. The Contractor shall inform potential collaborating laboratories, that is, all known laboratories involved in C. elegans research, of the CGC's existence, its objectives and activities by announcements in the C. elegans newsletter, and journals such as Science and Nature. The initial announcement shall be approved by the Project Officer prior to placement. Any substantive changes to the initial announcement or to acquisition or distribution policies of strains of nematodes shall be approved by the Project Officer.

        Approximately 200-400 strains of C. elegans shall be acquired each year from collaborating laboratories. The originating laboratory shall be encouraged to provide information on acquired strains, including: strain name, description of mutant phenotype, name of contained mutation(s), mutagen used to produce mutation, whether back-crossed and if so, how many times, genes affected by contained mutation(s), map location(s) of contained mutation(s), and data used to determine the map. Shipping costs for C. elegans acquisitions shall be borne by the donating laboratory. The Contractor shall exert best effort to assure that the strain collection will include minimally one allele of each identified gene, all available chromosomal rearrangements, knock-out mutants as they become available, available closely-linked double mutants and other multiple mutants useful for mapping, and stable transgenic lines carrying sequences from other species. Novel alleles of well-characterized genes, such as temperature-sensitive alleles, dominant alleles, and nonsense suppressible alleles shall also be collected. Acquisitions shall be subcultured, cleaned of contaminants, stored as frozen replicates, and, if necessary, as active stocks. Precautions shall be established to maximize safety of frozen stocks from accidental loss. At the time of contract award, the Contractor shall have in place an acceptable plan for assuring safety from accidental loss due to power failure or other foreseeable accidents.

      2. The Contractor shall determine that the nematodes for distribution are free from contamination and conform to the visible phenotypes described by the contributing laboratories.

      3. The Contractor shall conduct yearly survival tests on a limited number (approximately 10 to 50) of frozen strains to ensure that long-term storage of strains does not result in strain loss.

      4. The Contractor shall test potentially advantageous new methods for strain storage and/or distribution as needed to ensure the survival of strains.

      5. The Contractor shall ship nematodes to scientists who will utilize the material in research and/or training. The Contractor shall assure that requests for cultures include a brief statement of research and/or training activity for which the culture is intended, that recipients of cultures agree to acknowledge the CGC in publications and to supply the center with two reprints of all resultant publications. Educational/nonprofit institutions shall not be charged a fee for nematode shipments. Shipping costs to educational/nonprofit institutions shall be borne by the Contractor.

      6. In the case of shipments to commercial organizations, a $100.00 fee per strain shall be paid by the recipient in addition to shipping costs. The fee is subject to change and shall be established unilaterally by the Government. Whenever possible, commercial recipients shall be billed directly on a prepaid or COD basis in order to facilitate bookkeeping and to avoid extensive follow-up of delinquent payments. The Contractor shall be responsible for collection of all fees and recovery of all shipping costs (payments made by check shall be made payable to the Contractor). Fees and recovered shipping costs received from commercial recipients shall be used to offset the cost of contract performance (reference ARTICLE G.__. of the contract Schedule, Contract-Related Income Reimbursement Procedures). The Project Officer may direct the Contractor to make gratis shipments to commercial organizations when it is determined to be scientifically desirable. All users of CGC materials from the commercial sector shall inform the CGC of the purpose and commercial status of each request before shipment can be made, and provide, without charge, any published strains derived from CGC stocks to the CGC upon request. A commercial recipient of CGC strains or mutants shall not be permitted to claim any specific authorization from the Government or the CGC for distribution of CGC strains, mutants or derived products. Voluntary compliance with these conditions shall be obtained from commercial recipients before shipments are made to the commercial sector.

      7. The Contractor shall announce the availability of CGC cultures and information in professional genetics journals (e.g., Genetics, Trends in Genetics, etc.) and in widely read journals of a more general scope (e.g., Science and Nature). The Government estimates that two to four announcements will be made annually.

      8. The Contractor shall construct and distribute a detailed genetic map based on all currently available genetic and physical data acquired from the research community to all subscribers of the C. elegans newsletter, the Worm Breeder's Gazette (WBG). The complete genetic map shall be distributed biennially as a part of the WBG. Regular revisions of the map shall be integrated into updates of the publicly available ACeDB (a C. elegans Data Base) or other databases that supercede ACeDB.

        1. Serious discrepancies (such as mapping conflicts or placement of genes on the map) shall be noted and information shall be sought in an attempt to resolve these discrepancies. The CGC's role shall be as facilitator of resolution, not as arbitrator of scientific differences of opinion.

        2. The genetic and physical maps shall be aligned. Genetic and physical mapping data shall be integrated so that genes located by means of hybridization, DNA transformation, physical linkage to deficiency endpoints, DNA sequencing or other physical methods will be included with genetic loci.

      9. The Contractor shall act as a clearinghouse for C. elegans genetic nomenclature, including uppercase strain prefixes, lowercase allele prefixes, and three-letter gene names. This shall be done to avoid duplication or inconsistency in strain or gene names. The Contractor shall maintain lists of all gene names and codes assigned to C. elegans laboratories and new gene name assignments shall be made on request. The Contractor shall distribute these lists with the genetic map and at other times upon request from the research community.

      10. Computerized data on the genetic map, bibliography, and the strain collection shall be made available for integration into other government-funded database systems, including ACeDB, that are designed to disseminate information on C. elegans to the research community.

      11. The Contractor shall maintain the current computer-based storage and retrieval system which shall contain all relevant data in the following areas:

        1. Data on mutant collection itself. Data shall include all CGC strain holdings, how often particular strains are requested, and when and where they are sent.

        2. Data on individual wild-type and mutant strains in the CGC collection. This information shall include gene and chromosomal assignment, mutagen and dose used, by whom isolated, temperature sensitivity, dominance, developmental time of onset, sex-limitation, if any, a description of phenotype, and bibliographic references, to the extent this information is available. This information, updated approximately monthly, shall be made accessible via the Internet.

        3. Data on map location of mutants. Original mapping data (e.g., name of mapper; parental genotype, including alleles; numbers of each scored progeny class; and in the case of three-factor crosses, the genotypes of recombinant animals, etc.) shall be obtained by perusal of the relevant literature and by direct requests to the mapping investigator. This stored database information shall be integrated into ACeDB or other suitable databases.

        4. A list of publications (a complete CGC bibliography) concerning C. elegans. This information, updated approximately monthly, shall be made generally available via the Internet.

        5. A list of individuals using the resource. For each name, the list shall include the individual's organization, address, phone number and e-mail address. A directory of subscribers to the WBG, updated approximately monthly, shall be made accessible via the Internet.

      12. The Contractor shall produce and distribute the C. elegans newsletter, the WBG, at regular intervals (approximately every 3 to 6 months) to subscribers worldwide. The newsletter shall be the main vehicle by which the CGC disseminates bibliographic updates, information about CGC services, including how to access electronic information, general announcements of interest to the field of C. elegans (e.g., meetings, postdoctoral openings, etc.) WBG Subscriber Directory, and (every two years) an updated genetic map. Information from the CGC for the newsletter shall be computer generated from CGC databases and from abstracts submitted by researchers. The Government estimates the number of subscribers to be approximately 750-800. Each newsletter is approximately 30 to 50 photocopied pages. The WBG is also available in electronic form on the World Wide Web. All subscribers to the hard-copy version of the WBG shall be charged for their subscriptions in order to offset copying and associated production costs. The subscription rate shall be established by the contractor, with Project Officer approval. The Contractor shall be responsible for collection of all subscription payments (payments made by check shall be made payable to the Contractor). All revenue received from subscriptions shall be used to offset the cost of contract performance (reference ARTICLE G.__. of the contract Schedule, Contract-Related Income Reimbursement Procedures. Any plans to discontinue publication of the hard-copy version of the WBG must be approved by the Project Officer.

      13. The Contractor shall attend the International C. elegans Meeting each year and shall provide information to the research community regarding CGC activities.

      14. All data accumulated as a result of the activities of items C1.-C13., above, are to be maintained by the Contractor for analysis by, and distribution to, any or all interested scientists. The Project Office is to have access to all data, including computer programs, at any time.

      15. The Contractor shall develop a plan to assure an orderly transition at the time of contract expiration in the event that there is a follow-on contract and the Contractor is replaced by a successor, either the Government or another contractor. To effect an orderly and timely transfer of genetic stocks and computer-based information to any such successor, the Contractor shall perform the following activities (estimated to take place during the last two months of the contract):

        1. The Contractor shall cooperate fully with the successor.

        2. The Contractor shall participate in meetings and/or telephone conversations with the Project Officer and the successor in which current procedures and activities are discussed in detail.

        3. The Contractor shall deliver to the successor the following in accordance with the delivery schedule and shipping procedures specified by the Contracting Officer: all genetic stocks, all computer-based information, and any Government furnished equipment. All delivery costs shall be borne by the Contractor.

      ARTICLE C.2. TECHNICAL REPORTING REQUIREMENTS

      Quarterly and Annual Progress Reports and a Final Report will be required in this project.

      1. Quarterly Progress Report . This report shall consist of a description of the activities performed during the reporting period. It shall include a short narrative summary and tabular presentation of: a) nematode mutants acquired by the CGC, b) number and types of mutants distributed and the recipient laboratories, c) bibliographic references collected by the CGC, including the journal citation, complete list of authors and complete title, d) list of articles acknowledging the CGC, including the information for citations as in item c), above, e) a summation of the number of subscribers to the WBG, including the number of hard-copy and electronic subscribers, and f) one copy of each reprint submitted by the user laboratories. The reporting period shall consist of three full calendar months. Reports shall be due on or before the tenth working day following the reporting period.

      2. Annual Progress Report. This report shall consist of a summation of previously submitted progress reports plus information for the quarter preceding the submission date of the yearly report. The yearly report shall contain a short narrative summary and tabular presentation of: a) nematode mutants acquired by the CGC, b) number and types of mutants distributed and the recipient laboratories, c) bibliographic references collected by the CGC, including the journal citation, complete list of authors and complete title, d) list of articles acknowledging the CGC, including the information for citations as in item c), above, e) a summation of the number of subscribers to the WBG, including the number of hard-copy and electronic subscribers, f) one copy of each reprint submitted by the user laboratories that has not been submitted in previous quarterly reports, g) a summation of the data on the genetic map of C. elegans, h) a complete list of all assigned CGC strain and allele designations, i) a cumulative list of named genes of C. elegans, j) a copy of journal announcements or other publications used to publicize the existence and functions of the resource, k) a summary of fee/payment collections, l) an account of all authorized travel to attend scientific meetings, and m) results of yearly survival tests on frozen strains. The reporting period shall consist of 12 full calendar months. The first report shall cover the period June 1, 2002 to May 31, 2003 of this contract and shall be due on or before the tenth working day following the reporting period. A quarterly report shall not be submitted when the annual report is due.

      3. Final Report. This report shall consist of a summation of the work performed and results obtained for the entire contract period of performance. It shall be in sufficient detail to describe comprehensively the results achieved. The final report shall be submitted on or before the last day of the contract performance period. In addition to the information for the entire contract period, the Final Report shall contain the information required for the annual report for the last contract year.

        Copies of the progress and final reports shall be sent to the following addresses:

        Project Officer

        Number of Copies
         
        Project Officer
        Division of Comparative Medicine
        National Center for Research Resources
        National Institutes of Health
        6705 Rockledge Drive Suite 6050  MSC 7965
        Bethesda MD 20892-7965


        2


        Contracting Officer

         
        Number of Copies
         
        Contracting Officer
        Contracts Operations Branch, NHLBI
        National Institutes of Health
        Rockledge Building  MSC 7902
        6701 Rockledge Dr
        Bethesda MD 20817

        1


  1. DELIVERABLES

    ARTICLE F.1. DELIVERABLES

    Item No. Description Quantity Delivery
     
    1.
     
    Genetic Map of C. Elegans
     
    1
     
    Approximately 5/31/03
    2. C. Elegans Newsletter 1 Approximately every 3-6 months after contract award
    3. Suitable WWW access to required data 1 As required in Article C.1.
    4. Transition Plan 3 March 31, 2007
    5. Progress Reports 3 Quarterly Annual
    6. Final Report 3 May 31, 2007
    7. Other Data described in Article C.1. As directed As Required
    8. Financial Report (NIH Form 2706) per Article G.___ 1 Quarterly

    The above items shall be delivered to:

    Addressee Deliverable Item No. Quantity
    Project Officer 1. and 2. 1
    Project Officer 4. through 6. 2
    Contracting Officer 4. through 6. 1
    Contracting Officer 8. 3


  1. EVALUATION FACTORS FOR AWARD

    1. GENERAL

      Selection of an offeror for contract award will be based on an evaluation of proposals against three factors. The factors in order of importance are: technical, cost/price, and small disadvantaged business (SDB) participation. The technical proposal will receive paramount consideration in the selection of the contractor(s) for this acquisition. Past performance is NOT an evaluation factor but will be considered in determining an offeror's responsibility in accordance with FAR 9.104-3(b). (Reference Applicable RFP References, Optional RFP Instructions and Provisions.) All evaluation factors other than cost/price, when combined, are significantly more important than cost/price. The trade-off process described in FAR 15.101-1 will be employed. This process permits tradeoffs among cost/price and non-cost factors and allows the Government to consider award to other than the lowest priced or highest technically rated offeror. In any event, the Government reserves the right to make an award to that offeror whose proposal provides the best value to the Government.

      The evaluation will be based on the demonstrated capabilities of offerors in relation to the needs of the project as set forth in the RFP. The merits of each proposal will be evaluated carefully. Each proposal must document the feasibility of successful implementation of the requirements of the RFP. Offerors must submit information sufficient to evaluate their proposals based on the detailed evaluation criteria/factors listed below.

    2. TECHNICAL EVALUATION FACTORS

      The technical evaluation criteria are used by the technical evaluation committee when reviewing the technical proposals. The criteria below are listed in the order of relative importance with weights assigned for evaluation purposes.

      Criterion 1. PERSONNEL

      TOTAL POSSIBLE POINTS--40

      1. Principal Investigator--30 points

        Professional training and experience should include genetics, biochemistry and molecular genetics. Must have direct experience with C. elegans, including production and selection of mutants; culturing; genetic mapping; and a strong research publication record, including publications in the C. elegans field, as demonstrated by a curriculum vitae. Experience, and/or demonstrated ability to lead and manage an operation involving collection, characterization, storage and distribution to the research community of living organisms.

      2. Curator--10 points

        Technical training and experience in general laboratory procedures and technologies including: a basic understanding of microbiology, biochemistry and genetics; experience in the laboratory management of C. elegans stocks, including culture, transfer, maintenance, freezing, thawing and related record-keeping as demonstrated by a curriculum vitae.

      Criterion 2. APPROACH TO TECHNICAL PROCEDURES

      TOTAL POSSIBLE POINTS--20


      Evidence of recognition and understanding of the objectives of the requirement as demonstrated by a discussion of the approach and procedures for C. elegans culture, and plans for periodic survival testing after storage, storage and prevention from accidental loss, shipping, determination of freedom from contamination, confirmation of visible phenotype and maintenance of the genetic map and bibliographies.

      Criterion 3. CAPACITY TO MANAGE THE CGC

      TOTAL POSSIBLE POINTS--20


      Adequacy of the offeror's proposed method of professional coordination with participating laboratories and the NCRR as demonstrated by a discussion of: data management, including plan for computerization; previous experience in handling C. elegans mutants; long-term plans for periodic survival testing of a sample of strains; plans for announcements of the presence of the resource; reporting plans; and plans for interactions with C. elegans researchers to promote cooperative relationships among the CGC and user laboratories. Experience, and/or demonstrated ability to lead and manage an operation involving collection, characterization, storage and distribution to the research community of living organisms.

      Criterion 4. FACILITIES AND EQUIPMENT

      TOTAL POSSIBLE POINTS--20


      Adequacy of facilities and equipment, including, but not limited to, laboratory and cryogenic space, media kitchen and dishwasher facilities, shipping and receiving facilities, laboratory and office space, research microscopes and equipment for cryopreservation.

    3. COST/PRICE FACTOR

      Price analysis will be used to verify that the overall price offered is fair and reasonable. Cost/price analysis will be used to evaluate the reasonableness of individual cost elements when cost or pricing data are required. Cost analysis may be used to evaluate information other than cost or pricing data to determine cost reasonableness or cost realism.

      Price Evaluation Adjustment for Small Disadvantaged Business Concerns
      In accordance with FAR Clause 52.219-23, Notice of Price Evaluation Adjustment for Small Disadvantaged Business Concerns, offerors will be evaluated by adding a factor of 10 percent to the price of all offers, except offers from small disadvantaged business (SDB) concerns that have not waived the price evaluation adjustment. In addition, offerors that satisfy the exception requirements under subparagraph (b) of FAR Clause 52.219-23 will not have the price evaluation adjustment factor added to their offers.

      A SDB concern may elect to waive the price evaluation adjustment, in which case the factor will be added to its offer for evaluation purposes. (The agreements in paragraph (d) of FAR Clause 52.219-23 do not apply to offerors that waive the price evaluation adjustment.) If the SDB concern elects to waive the price evaluation adjustment, it will be evaluated under the Small Disadvantaged Business Participation Factor cited in this Section, and participation in performance of the resultant contract shall include the work expected to be performed by SDB concerns at the prime contract level. Small businesses, other than SDB concerns, will also be evaluated under the Small Disadvantaged Business Participation Factor cited in this section. Any targets will be incorporated into and become part of the resulting contract. Credit under the small disadvantaged business participation factor is not available to small disadvantaged business concerns that receive a price evaluation adjustment.

      Price Evaluation Preference for HUBZone Small Business Concerns
      In accordance with FAR Clause 52.219-4, Notice of Price Evaluation Preference for HUBZone Small Business Concerns, offers from HUBZone small business concerns will receive a price evaluation preference by adding a factor of 10 percent to all offers except those referenced at FAR Clause 52.219-4. The factor of 10 percent will be applied on a line item basis or to any group of items on which award may be made. Other evaluation factors, such as transportation costs or rent-free use of Government facilities, will be added to the offer to establish the base offer before adding the factor of 10 percent.

    4. SMALL DISADVANTAGED BUSINESS PARTICIPATION FACTOR
      In accordance with FAR part 15.304(c)(4), the extent of participation of Small Disadvantaged Business (SDB) concerns in performance of the contract will be evaluated; however, the evaluation may take place after establishment of the competitive range. This evaluation will not be conducted on any offeror whose proposal would not be selected for award based on the results of the evaluation of factors other than SDB participation.

      The evaluation will be based on information obtained from the Small Disadvantaged Business Participation Plan provided by the offeror, other relevant information obtained from named SDB concerns, any information supplied by the offeror concerning problems encountered in SDB participation, and other references available to the Government. Evaluation of the SDB Participation Plan will be based on consideration of all relevant facts and circumstances; it will not be based on absolute standards of acceptable performance.

      SDB participation will not be scored, but the Government's conclusions about overall commitment and realism of the offeror's SDB Participation Plan will be considered in determining the relative merits of the offeror's proposal and in selecting the offeror whose proposal is considered to offer the best value to the Government. The SDB Participation Plan is a separate requirement from the Small, Small Disadvantaged and Women-Owned Small Business Subcontracting Plan.


THE REMAINDER OF THIS RFP CONSISTS OF THE FOLLOWING SECTIONS:

  1. Specific RFP Instructions and Provisions, and
  2. Applicable RFP References

  1. SPECIFIC RFP INSTRUCTIONS AND PROVISIONS

    NOTICE TO OFFERORS: This section contains proposal instructions and information which are specifically related to this acquisition. The information provided below is only a portion of the instructions and notices required for the submission of a proposal. References to additional, more general, information and forms regarding proposal preparation are contained under Section III. Applicable RFP References.

    The following specific RFP instructions and provisions apply to this Request For Proposal:

    1. Proposal Intent Response Sheet (submit prior to proposal submission on or before June 18, 2001)
    2. Packaging and Delivery of Proposal
    3. NAICS Code and Small Business Size Standard
    4. Number and Type of Award(s)
    5. Estimate of Effort
    6. Service of Protest
    7. Technical Proposal Table of Contents
    8. Other Provisions

  1. PROPOSAL INTENT RESPONSE SHEET

    RFP No. NHLBI-RR-02-02

    TITLE OF RFP: Caenorhabditis Genetics Center

    FURNISH THE INFORMATION REQUESTED BELOW AND RETURN THIS PAGE BY June 18, 2001. YOUR EXPRESSION OF INTENT IS NOT BINDING BUT WILL ASSIST US IN PLANNING FOR PROPOSAL EVALUATION.

    I INTEND TO SUBMIT A PROPOSAL.


    COMPANY/INSTITUTION NAME:


    ADDRESS:


    PROJECT DIRECTOR'S NAME:

    TITLE:

    TELEPHONE NUMBER:

    NAMES OF COLLABORATING INSTITUTIONS AND INVESTIGATORS
    (include Subcontractors and Consultants):





    RETURN TO:
    Review Branch
    NIH, NCRR
    6705 Rockledge Drive, MSC 7965
    Bethesda MD 20892-7965
    Attention: Dr. Charles Hollingsworth                   or  FAX TO:  Dr. Charles Hollingsworth at (301) 480-3660


  1. PACKAGING AND DELIVERY OF THE PROPOSAL

    Your proposal shall be organized as specified in the "Standard RFP Instructions and Provisions." Shipment and marking shall be as follows:

    EXTERNAL PACKAGE MARKING
    In addition to the address cited below, mark each package as follows:

    "RFP NO. NHLBI-RR-02-02 TO BE OPENED BY AUTHORIZED GOVERNMENT PERSONNEL ONLY"

    The number of copies required of each part of your proposal are:
    TECHNICAL PROPOSAL: ORIGINAL* AND TWENTY-FIVE (25) COPIES
    BUSINESS PROPOSAL: ORIGINAL* AND SIX (6) COPIES

    DELIVER PROPOSAL TO:

    National Institutes of Health
    Review Branch
    National Center For Research Resources
    I Rockledge Building, Room 6100
    6705 Rockledge Drive MSC 7965
    Bethesda, MD 20817-7965

    *THE ORIGINAL PROPOSAL MUST BE READILY ACCESSIBLE FOR DATE STAMPING.


  1. NAICS CODE AND SMALL BUSINESS SIZE STANDARD

    NOTE: The following information is to be used by the offeror in preparing its Representations and Certifications, specifically in completing the provisions entitled, SMALL BUSINESS PROGRAM REPRESENTATIONS, FAR 52.219-1:

    The North American Industry Classification System (NAICS) code for this acquisition is 541710. The small business size standard is 500 employees or less.

    THIS REQUIREMENT IS NOT SET-ASIDE FOR SMALL BUSINESS. However, the FAR requires in every solicitation (except for foreign acquisitions) the inclusion of the NAICS code and corresponding size standard which best describes the nature of the requirement in the solicitation.

  2. NUMBER AND TYPE OF AWARD(S)

    It is anticipated that one award will be made from this solicitation and that award will be made in May 2002.

    It is anticipated that the award from this solicitation will be a multiple-year cost reimbursement, completion type contract with a period of performance of five years, and that incremental funding will be used.

  3. ESTIMATE OF EFFORT

    To assist you in the preparation of your proposal, the Government's requirement for the work set forth in the Statement of Work of this solicitation is set forth below (one person working one year at 100% effort equals 2,080 hours). It is estimated that the labor hours are constituted as specified below for each of the five years of the contract period. This estimate is furnished for the offeror's information only and is not to be considered restrictive for proposal purposes.

    Labor Category
     
    Labor Hours/Yr.
     
    Principal Investigator 208
    Curator 2,080
    Other Professional and Support Personnel 1,040

    All staffing levels proposed should be accompanied by specific justifications as to the type and hours of work expected to be performed by all personnel. Offerors will be required to propose levels of commitment whether compensated or donated effort, necessary to complete the work described in their proposals. It is expected that realistic levels of effort will be proposed such that an offeror's understanding of the work will be apparent.

  4. SERVICE OF PROTEST

    In accordance with FAR 52.233-2 SERVICE OF PROTEST (NOV 1988):

    Protests, as defined in Section 33.101 of the Federal Acquisition Regulation, that are filed directly with an agency, and copies of any protests that are filed with the General accounting Office (GAO) shall be served on the Contracting Officer (addressed as follows) by obtaining written and dated acknowledgment of receipt from:

    Patricia A. Smith, Contracting Officer

    Hand-Carried Address:
    National Institutes of Health
    National Heart, Lung, and Blood Institute
    Contracts Operations Branch
    II Rockledge Center, Room 6124
    6701 Rockledge Drive, MSC 7902
    Bethesda MD 20817

    U.S. Postal Service:
    National Institutes of Health
    National Heart, Lung, and Blood Institute
    Contracts Operations Branch
    6701 Rockledge Drive, MSC 7902
    Bethesda MD 20892-7902

    One copy of any protest shall be received in the office designated above within one day of filing a protest with GAO.

  5. TECHNICAL PROPOSAL TABLE OF CONTENTS

    Please number each page of text. Type density and size must be 10-12 points. If constant spacing is used, there should be no more than 15 cpi, whereas proportional spacing should provide an average of no more than 15 cpi. There must be no more than six lines of text within a vertical inch.

    The technical proposal should be organized as follows:

    1. TECHNICAL PROPOSAL COVER SHEET (Form is located in the Streamlined RFP References under "FORMS, FORMATS, & ATTACHMENTS")--Page 1
    2. TECHNICAL PROPOSAL TABLE OF CONTENTS--Page 2
    3. ABSTRACT--Page 3 State the proposal's broad, long-term objectives and specific aims. Briefly and concisely describe the research design and methods for achieving these goals. DO NOT EXCEED one page in providing the abstract. Identify the RFP Number, Institution and Principal Investigator on the abstract.
    4. TECHNICAL PLAN (not to exceed 25 PAGES) Refer to Technical Proposal Instructions located in the Standard RFP Instructions and Provisions under Streamlined RFP References for more detail.
      1. WORK STATEMENT
        1. Objectives--Page #
        2. Approach--Page #
        3. Methods--Page #
        4. Schedule--Page #

      2. PERSONNEL
        1. List of all Personnel in the project including Subcontractors, Consultants/Collaborators, by name, title, department and organization--Page #
          PROVIDE NARRATIVE FOR:
        2. Principal Investigator/Project Director--Page #
        3. Other Investigators--Page #
        4. Additional Personnel--Page #
          [NOTE: For personnel, include a two-page biosketch under APPENDICES below.]

      3. FACILITIES, EQUIPMENT AND OTHER RESOURCES--Page #
        List/describe all facilities, equipment and other resources available for this project.

      4. OTHER CONSIDERATIONS--Page #
        (Use specifically titled subparagraphs, as applicable.)

    5. OTHER SUPPORT--Page #
      Complete the Form "Summary of Current and Proposed Activities." All key personnel must be listed on this form. The form is located in the Streamlined RFP References under "FORMS, FORMATS, &ATTACHMENTS."

    6. TECHNICAL PROPOSAL COST INFORMATION--Page #
      (Form located in the Streamlined RFP References under "FORMS, FORMATS, & ATTACHMENTS.")

    7. LITERATURE CITED--Page #

    8. APPENDICES--Page # List each Appendix and identify the number of pages for each one. Appendices must be clear and legible, and easily located. Include biosketches here. (not to exceed 100 PAGES)

  1. OTHER PROVISIONS

    1. GOVERNMENT FURNISHED FACILITIES AND EQUIPMENT

      The C. elegans strains, stock, mutants and related genetic materials, computer database bibliographic and data information and genetic map data which constitute the current CGC will be provided as Government furnished property to the successful contractor for this acquisition at contract initiation.

    2. INSTRUCTIONS FOR SMALL DISADVANTAGED BUSINESS PARTICIPATION PLAN

      Small Disadvantaged Business Participation Plan
      In accordance with FAR part 15.304(c)(4), the extent of participation of Small Disadvantaged Business (SDB) concerns in performance of the contract in the authorized SIC Major Groups will be evaluated in unrestricted competitive acquisitions expected to exceed $500,000 ($1,000,000 for construction) subject to certain limitations (see FAR 19.1202-1 and 19.1202-2(b). The dollar amounts cited above include any option years/option quantities that may be included in this solicitation. The definition of a "small disadvantaged business" is cited in FAR 19.001.

      NOTE: The SDB Participation Plan is a separate requirement from the Small, Small Disadvantaged and Women-Owned Small Business Subcontracting Plan described elsewhere in this solicitation, if applicable. Offerors shall submit a Small Disadvantaged Business Participation Plan which includes the following information in one clearly marked section of their business proposal:

      A plan on the extent of participation of SDB concerns in performance of the contract. Participation in performance of the contract includes the work expected to be performed by SDB concern(s). This can include SDB (as prime contractor), joint ventures, teaming arrangements, and subcontracts. Include the following information in your SDB participation plans:

      1. The extent of an offeror's commitment to use SDB concerns. Commitment should be as specific as possible, e.g., are subcontract arrangements already in place; are letters of commitment in place. Enforceable commitments will be weighted more heavily than non-enforceable ones;
      2. Specifically identify the SDB concerns with point of contact and telephone number;
      3. The complexity and variety of the work SDB concerns are to perform;.
      4. Realism for the use of SDB in the proposal;
      5. Past performance of the offeror in complying with subcontracting plans for SDB concerns;
      6. Targets expressed as dollars and percentage of total contract value, in each of the applicable authorized SIC Major Group(s). A total target for SDB participation by the prime contractor that includes any joint ventures and team members* shall be provided, as well as a total target for SDB participation by subcontractors. Targets may be incorporated into and become part of any resulting contract; and
      7. The extent of participation of SDB concerns in terms of the value of the total acquisition.

      *NOTE: FAR Subpart 9.6 defines "Contractor team arrangements" to include two or more companies forming a partnership or joint venture to act as a potential prime contractor, or a potential prime contractor who agrees with one or more companies to have them act as its subcontractors on a specific contract or acquisition program. For purposes of evaluation of the SDB participation factor, FAR 19.1202-4 requires that SDB joint ventures and teaming arrangements at the prime level be presented separately from SDB participation by subcontractors.

      SDB participation information furnished in the plan described above will be used as an evaluation factor (see D. Evaluation Factors for Award, Small Disadvantaged Business Participation Factor.) The Government will focus on information that demonstrates realistic commitments to use SDB concerns relative to the size and complexity of the acquisition under consideration. Also, references other than those identified by the offeror may be contacted by the Government to obtain additional information that will be used in the evaluation of the offeror's commitment to SDB participation.

      The Government is seeking to determine whether the offeror has demonstrated a commitment to use SDB concerns for the work that it intends to perform as the prime contractor. The assessment of the offeror's SDB Participation Plan will be used as a means of evaluating the relative capability and commitment of the offeror and the other competitors, e.g., an offeror with an exceptional record of participation with SDB concerns may receive a more favorable evaluation than another whose record of participation with SDB concerns is acceptable, even though both may have acceptable technical proposals.

      NOTE: Offers to rely on SDB concerns merely for such activities as provision of supplies and basic services such as travel arrangements, unless such supplies and arrangements are of significant value and are an integral part of contract performance, will be considered of negligible value for the purposes of evaluating the SDB participation plan.

    3. UNIFORM RESOURCE LOCATORS (URLs) IN CONTRACT PROPOSALS

      Uniform Resource Locators (URLs) in Contract Proposals
      All proposals must be self-contained within the specific page limitations cited elsewhere in this solicitation. Unless otherwise specified, URLs/Internet addresses shall not be used to provide information necessary to the review because reviewers are under no obligation to review the Internet sites.

    4. INSTRUCTIONS FOR PAST PERFORMANCE INFORMATION

      Past Performance Information

      1. Offerors shall submit the following information as part of their business proposals (for both the offeror and proposed major subcontractors): A list of the contracts completed during the past three years and all contracts currently in progress for products or services similar to the solicitation workscope. Contracts listed may include those entered into with the Federal Government, agencies of state and local governments and commercial customers. Offerors that are newly formed entities without prior contracts should list contracts and subcontracts as required above for all key personnel. Include the following information for each contract or subcontract:
        1. Name of Contracting Organization
        2. Contract Number (for subcontracts, provide the prime contract number and subcontract number)
        3. Contract Type
        4. Total Contract Value
        5. Description of Requirement
        6. Contracting Officer's Name and Telephone Number
        7. Project Officer's Name and Telephone Number

      2. Each offeror will be evaluated on its performance under existing and prior contracts for similar products or services. Performance information will be used for responsibility determinations. The Government will focus on information that demonstrates quality of performance relative to the size and complexity of the acquisition under consideration. The Government is not required to contact all references provided by the offeror, References other than those identified by the offeror may be contacted by the Government to obtain additional information that will be used in the evaluation of an offeror's past performance.

    5. CONTRACT CLAUSE . IT IS ANTICIPATED THAT THE CONTRACT WILL CONTAIN A SPECIAL CLAUSE COVERING INCOME REIMBURSEMENT, SUBSTANTIALLY AS FOLLOWS:

      ARTICLE G.___CONTRACT-RELATED INCOME REIMBURSEMENT PROCEDURES

      1. The Contractor shall keep an accurate account of all fees and recovered, shipping costs received from commercial organizations for shipments of nematodes, and all subscription payments received from subscribers of the C. elegans newsletter separate from other fiscal aspects of the contract. When billing the Government for payment by invoice or letter of credit, the contractor shall include all fees, recovered shipping costs, and subscription payments received during a given billing period. This information shall be used to offset the costs of performance; thus leaving a net amount due the Contractor.

      2. The Contractor shall account for the contract-related income separately in accordance with its own accounting system. The Contractor shall submit to the Government a summary sheet of sales, along with the financial report or invoice. The administration of the contract-related income shall be subject to the terms of this contract, including specifically and without limitation, the "Audit and Records Negotiation" clause (FAR 52.215-2) of the General Contract Clauses, and the applicable cost principles of the Federal Acquisition Regulation.

      3. Should the amount of contract-related income exceed the total cost of performance, the excess monies shall be refunded to the DHHS, NIH, in accordance with the Contracting Officer's instructions for transmittal to the United States Treasury.

  1. APPLICABLE RFP REFERENCES

This section identifies the items located in the Streamlined RFP References that are applicable to this Request For Proposal (RFP).

The entire file entitled "STANDARD RFP INSTRUCTIONS AND PROVISIONS" is applicable to this RFP, except as modified by the inclusion of items from the "OPTIONAL RFP INSTRUCTIONS AND PROVISIONS" listed below, and except that the following sections are deleted from the Standard RFP Instructions and Provisions: delete Standard RFP Instructions and Provisions, G. General Instruction "19. Small Disadvantaged Business Participation" and delete Standard RFP Instructions and Provisions, I. Business Proposal Instruction "3. Qualifications of the Offeror". (These 2 topics are covered under Part II. SPECIFIC RFP INSTRUCTIONS AND PROVISIONS of this solicitation.)

The following items are applicable from the file entitled "OPTIONAL RFP INSTRUCTIONS AND PROVISIONS". The full text of the provisions is available in the file.

List of provisions which apply to this specific RFP:

  1. Notice: This requirement is Not Set-Aside for Small Business
  2. Late Proposals, Modifications of Proposal, and Withdrawal of Proposals
  3. Small Business Subcontracting Plan
  4. "Just in Time"

The following items are applicable to this specific RFP and are located in the file entitled "FORMS, FORMATS, AND ATTACHMENTS", under Streamlined RFP References:

SUBMIT WITH TECHNICAL PROPOSAL (with original and every copy of technical proposal)

  1. Technical Proposal Cover Sheet
  2. Summary of Current and Proposed Activities
  3. Technical Proposal Cost Information

SUBMIT WITH BUSINESS PROPOSAL:

  1. Business Proposal Cost Information, with every copy of business proposal. If possible, please submit a computer disk with the cost proposal in ExcelŽ format.
  2. Proposal Summary and Data Record, NIH-2043 (PDF----MS Word), with every copy of business proposal.
  3. Disclosure of Lobbying Activities, OMB SF-LLL (PDF) only one completed and signed original.
  4. Representations and Certifications (MS Word--WP--PDF), only one completed and signed original.

OTHER--TO BE SUBMITTED LATER:

  1. Certificate of Current Cost or Pricing Data, NIH-1397, to be submitted with Final Proposal Revision, if required by the Contracting Officer.
  2. Small Business Subcontracting Plan (PDF--MS Word), to be submitted as directed by the Contracting Officer.

ANTICIPATED TO BE INCLUDED AS CONTRACT ATTACHMENTS:

  1. Invoice/Financing Requests Instructions for NIH Cost-Reimbursement Type Contracts, NIH(RC)-1 (PDF)
  2. NIH 2706, Financial Report of Individual Project/Contract, the form (PDF) with instructions
  3. Procurement of Certain Equipment, NIH(RC)-7

The "SAMPLE CONTRACT FORMAT-GENERAL" under the Streamlined RFP References is applicable to this RFP. Selected clauses applicable to this acquisition will be included in the contract.


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