|Broad Agency Announcement (BAA):||BAA-HL-02-04|
|Issue Date:||September 17, 2001|
|Issued By:||Joanne Deshler, Contracting Officer|
National Heart, Lung, and Blood Institute
Contracts Operations Branch
Rockledge II, Room 6100
6701 ROCKLEDGE DR MSC 7902
BETHESDA MD 20892-7902
|Telephone Number:||(301) 435-0340|
|Fax Number:||(301) 480-3338|
|Purchase Authority:||45USC201, Public Health Service Act of 1944|
|Small Business Set-Aside:||No; NAICS 541710|
|Pre-Proposal Conference:||November 2, 2001, 11:00 am to 1:00 pm|
|Proposal Intent Due Date:||December 15, 2001 (See Proposal Instructions and Information)|
|Proposal Due Date:||February 27, 2002, 4:30 pm (Eastern Time)|
COMBINED SOLICITATION FORM AND COVER LETTER
Ladies and Gentlemen:
The National Heart, Lung, and Blood Institute (NHLBI) is soliciting proposals to establish local, highly interactive, multi-disciplinary Centers to enhance and develop innovative proteomic technologies and apply them to relevant biological questions that will advance knowledge of heart, lung, blood, and sleep health and disease.
Pre-proposal Conference: Prospective offerors are invited to attend a pre-proposal conference on November 2, 2001 at the Natcher Building on the NIH Campus in Bethesda, Maryland. NHLBI staff will explain the purpose of the Proteomics Initiative, provide instructions about the proposal process, and answer questions. Questions provided prior to the conference will be answered at the meeting. Please provide such questions by October 26 to the above contact point. Questions asked at the meeting may have to be researched and answered after the meeting. Offeror institutions are urged to send a representative to this conference, both to gather information and to exchange ideas with other potential offerors. All attendees, as well as anyone who cannot attend the pre-proposal conference, will be given access to any distributed materials, questions and answers, and a summary of the discussion. These materials will be posted with the BAA through the NHLBI Research Funding web site. Attendance at the pre-proposal conference is recommended; however, attendance is not a prerequisite for proposal submission and will not be considered a factor in proposal evaluation.
This Broad Agency Announcement (BAA) consists of this combined solicitation form and cover letter, and the components identified in the Table of Contents below. This BAA contains sufficient information for you or your organization to submit a proposal.
If you intend to submit a proposal in response to this BAA, it is important that you notify Joanne Deshler, Contracting Officer. If you do not notify the contracting office of your intent to submit a proposal, you will not receive an individual notice of any amendments to the BAA, if any are issued. However, all amendments will be posted on the NHLBI web site.
Proposals must be received by the Contracting Office no later than February 27, 2002, 4:30 P.M. (Eastern Time) at the address listed in the item entitled "Packaging and Delivery of the Proposal". Also, please complete the form entitled "Proposal Intent Response Sheet" and submit as specified on or before December 15, 2002. This will allow us to prepare for the review of proposals. Your proposal must be organized and submitted in accordance with the "Proposal Format." These items are found under the "Proposal Instructions and Information" portion of this BAA, which follows the technical evaluation criteria section. Note that submission of proposals using facsimile or electronic mail is not authorized.
Please contact me if you have any additional questions regarding this BAA.
Joanne C. Deshler
|TABLE OF CONTENTS|
|BACKGROUND AND TECHNICAL OBJECTIVES|
|EVALUATION FACTORS FOR AWARD|
|Technical Evaluation Criteria—Proteomics Center|
Evaluation Criteria—Administrative Center|
|PROPOSAL INSTRUCTIONS AND INFORMATION|
|NAICS Code and Size Standard|
|Proposals Must be in Two Parts|
|Progress Review Panel|
|Programmatic and Progress Review Meetings|
|Salary Rate Limitations on Contracts, Grants and Cooperative Agreements|
|Technical Proposal (Separate Volume)|
Proposal (Separate Volume)|
|ADDITIONAL INFORMATION, INSTRUCTIONS, PROVISIONS, AND CLAUSES|
BAAs are used by agencies to fulfill their requirements for scientific study and experimentation directed toward advancing the state-of-the-art or increasing knowledge or understanding rather than focusing on a specific system or hardware solution. Proposals received as a result of the BAA will be evaluated in accordance with evaluation criteria specified herein through a peer review process. Proposals will not be evaluated against a specific Government need, as in the case of a conventional RFP, as they are not submitted in accordance with a common work statement.
It is anticipated that multiple awards will result from this announcement. The length of time for which funding is requested should be consistent with the nature and complexity of the proposed research. The maximum period acceptable for a research proposal is seven (7) years. Awards are expected to be made on or about September 30, 2002. The NHLBI anticipates awarding approximately 10 contracts, based on technical merit, available funds, and programmatic balance. Program staff estimates the average total annual cost (direct and indirect costs) for these contracts to be $2,100,000 per year per award. It is anticipated that the individual award total costs for each award will vary depending upon the scope and capacity of the technical objectives of the award. One Proteomics Center will also be selected to serve as the Administrative Center. This Center will facilitate and be responsible for the study meetings, common web site, and other activities involving all 10 Proteomics Centers.
This BAA is open to all domestic sources; however, subcontracts to foreign institutions will be considered, but only in exceptional circumstances.
Award documents will be tailored to the final negotiations with the selected offeror(s) and modified, as necessary, for the type of organization, cost or price arrangements, and other elements as negotiated prior to award.
This Proteomics Initiative will be funding proposals at the cutting edge of science. Thus, it is important that the funded Proteomic Centers interact to share information on technical objectives, progress and impediments, as well as exchange ideas, and, where appropriate, establish collaborations. In addition, as the proteomics and related fields are advancing quickly, the NHLBI will rely on a Proteomics Progress Review Panel to help advise the Institute on the progress and goals of the funded Proteomic Centers. More information about Programmatic Meetings and the Progress Review Panel Meetings is provided in Proposal Instructions and Information.
BACKGROUND AND TECHNICAL OBJECTIVES
This section presents the background for this announcement and the technical objectives that the Government seeks to achieve through this BAA. Proposals should explain how the offeror will contribute to these overall objectives. In contracts awarded as a result of this BAA, the Statement of Work will be the Statement of Work proposed by the offeror and negotiated and accepted by the Government.
This BAA will establish local, highly interactive, multi-disciplinary Centers to enhance and develop innovative proteomic technologies and apply them to relevant biological questions in a manner that will advance our knowledge of heart, lung, blood, and sleep health and disease. This BAA is intended to complement and enhance the NHLBI's ongoing research programs, which involve a substantial investment in clinical research, genomic research, basic biology, and training and education programs.
The accelerating science of genomics has made a major impact on the practice of biomedical research. New genomic tools, particularly DNA microarrays, provide a previously unattainable global view of how gene expression patterns respond to various physiological stimuli, to mutations, and in disease states. Such knowledge provides a basis for insights into cellular metabolism that were not possible by studies of a few selected genes at a time. However, a DNA microarray, or any nucleic acid-based methodology, is blind to many events that occur at the protein level. Therefore, they provide an indirect and incomplete picture of cellular function and hence additional information is needed for advancing human medicine and health care. The field of proteomics seeks to supply this knowledge by revealing the levels, activities, regulation, and interactions of every protein in the cell and how these quantities respond to a particular stimulus (e.g. drug, food, infection) or disease state or DNA alteration. In essence, proteomics builds on and complements the knowledge gained from genomics.
This significant effort in proteomics will provide discoveries about the cells' protein machinery that will likely yield important clinical applications. Such knowledge could provide an understanding of the molecular basis of the cause and progression of heart, lung, blood, and sleep disorders, identify targets for new therapeutic interventions, and lead to new methods for early detection and diagnosis. For example, analyzing patterns of protein expression from tissues or fluids over the course of disease progression could reveal proteome-level "biosignatures" indicative of specific disease status. Such "biosignatures" may be used extensively in 21st century medical diagnostics. Similarly, analyses of protein profiles before and after pharmacological treatments could provide vital clues regarding drug effectiveness and toxicity. In addition, particular "biosignatures" may be used to customize therapeutic strategies for individual patients.
Proteomics is much more complex than genomics, not only because there are so many possible interactions among proteins, but because there are so many more proteins than genes. Current estimates are that organisms have over an order of magnitude more proteins than genes. In addition, expressed proteins are typically modified in a variety of ways by post translational modifications (PTM), such as phosphorylation and glycosylation. Furthermore, the proteome is highly dynamic, responding to the cellular microenvironment and the physiological state of the animal.
There are many areas of proteomics that are in need of technological and methodological advances. These areas include, but are not limited to the following.
In order to overcome technological barriers and promote biological discoveries with clinical benefit, an environment is needed in which innovative approaches are developed in concert with studies of important biological problems. Hence, this BAA will establish local, highly interactive, multi-disciplinary groups (possibly with expertise in medicine, biological sciences, chemistry, physics, engineering, proteomics, bioinformatics, and statistics) to enhance and develop innovative proteomic technologies and apply them to critical biological questions. In order to develop truly innovative technologies and apply them to biological issues, the BAA provides for a sustained period of substantial, uninterrupted support. It is recognized that proposed approaches may very well be outdated within a few years, thus flexibility allowing updating approaches are part of this BAA and any subsequent contract. In order to insure maximum benefit from this investment, the products (reagents, techniques, methods, documentation, information, etc.) of this effort will be made readily available to the scientific community.
The NHLBI Proteomics Program is seeking proposals to establish local, highly interactive, multi-disciplinary groups bringing together scientific expertise from diverse areas such as heart, lung, blood, sleep, chemistry, physics, engineering, proteomics, bioinformatics, and statistics, to enhance and develop innovative proteomic technologies and apply them to biological questions relevant to heart, lung, blood, and sleep. Proteomics Centers funded through this announcement will be expected to accomplish major research and development objectives in this field. The ultimate long term goal of all Centers should be the development of new approaches to understanding heart, lung, blood, and/or sleep disease through basic scientific discovery and the development of new means to influence protein states and function. Examples of areas of proteomic research that might be appropriate for support through this initiative include, but are not limited to, the development and application of:
Each Proteomics Center is expected to focus on a specific, physiologically relevant area of heart, lung, blood, and/or sleep research. Technology development in the absence of biology is not responsive to this BAA. Technological developments made within the Center should be coupled to studies that involve application to the Center's stated area of biological focus. For instance, a proposal having as its central theme a specific pathophysiological condition and proposing to develop novel methods for characterizing protein-protein interactions might include specific studies of the processing, subcellular localization, and physiological functions of key proteins and their functional partners in cells, tissues and/or organs in animal models and in humans with this pathophysiological condition. Other organizational and scientific structures are also appropriate.
A distinctive feature of this program is that the work of each Center should involve innovation and continual improvements. Offerors are encouraged to propose both 1) feasible objectives, possibly involving adaptation or augmentation of existing approaches and 2) "far-sighted; high-risk" such as the creation of entirely new approaches or technologies, that has the potential of advancing the field substantially beyond its current status. A mixture of innovative science within each Center of "approachable" and "high-risk" endeavors is desired.
Innovative Technology and Biology
The objectives of this Program are to support proposed plans that include innovative work that is both 1) feasible by adaptation or augmentation of existing approaches, and 2) "far-sighted; high-risk" such as the creation of entirely new approaches or technologies that has the potential of advancing the field substantially beyond its current status. Proposals that can be accomplished through the standard investigator initiated review process will receive lower programmatic priority. Innovative technology development should be conceived and developed with the goal of a biological application. Proposed study plans should be concisely presented. As technology and scientific advances are expected over the next several years, a discussion of study objectives and evaluation of those study objectives will be important. Thought should be given to how plans and approaches will be re-evaluated as technologies advance over the seven year funding period.
The proposed Centers should be local, highly interactive, multi-disciplinary groups (heart, lung, blood, and/or sleep, chemistry, physics, engineering, proteomics, bioinformatics, statistics, etc.) with the purpose to enhance and develop innovative proteomic technologies and apply them to relevant heart, lung, blood, and sleep biological questions. Synergy among the investigators and the proposed science is critical. It is anticipated that all the expertise will be local and highly interactive. If the offeror finds that critical expertise needed for the success of the Center must be found outside the local geographic area, a thoughtful and detailed discussion must be presented.
In order for new technologies, approaches, and applications to be broadly useful and portable to other applications, detailed quality control and quality assurance is required. The technical proposal should include a description of quality control and quality assurance methods and applications. Where relevant, system and design controls, including calibration, validation, and fabrication specifications, should be discussed.
As the NHLBI plans to make a significant investment of time and funds in the Proteomics Program so that truly innovative technologies can be developed and applied to biological areas of interest to NHLBI, the products (reagents, techniques, methods, documentation, information, etc.) of this effort must be made readily available to the scientific community in order to insure maximum benefit from this investment. The proposed plan should include a discussion of intellectual property and patenting and specific plans for dissemination of the products of the Center, which should include a time line. A separate spreadsheet or table is acceptable.
The technical proposal should include scientific milestones and time-line for implementation of those milestones for each aim, goal, objective, and study proposed.
Awards under this solicitation will be made only to offerors located in the continental United States, Alaska, and Hawaii.
In addition to the Proteomic Center proposal, the offeror may also submit a proposal for an Administrative Center. One Proteomics Center will be selected to serve as the Administrative Center. This Center will facilitate and be responsible for the study meetings, common web site, and other administrative activities involving all 10 Proteomics Centers. It is anticipated that the Proteomics Centers will likely be in geographically diverse locations, therefore, effective communication is an important component of this Initiative. Administrative Center staff should demonstrate experience coordinating the administrative functions for a multi-center program and have experience working with multiple investigators with varying experiences. More information about Administrative Center functions is provided in Proposal Instructions and Information.
EVALUATION FACTORS FOR AWARD
The Government will make awards to the responsible offeror(s) whose proposals provide the best value to the Government. For this solicitation, the technical proposal shall receive paramount consideration in the selection of the contractor(s). However, cost realism and reasonableness shall also be considered to the extent appropriate.
The evaluation will be based on the demonstrated capabilities of the prospective offerors in relation to the evaluation criteria as set forth herein. Each proposal must document the feasibility of successful implementation of the requirements of the BAA. The estimated cost of an offer must be reasonable for the tasks to be performed, and, in accordance with FAR 15.305, will be subject to a cost realism analysis by the Government.
All technical proposals will undergo evaluation by a peer review group also known as the Technical Evaluation Panel (TEP). It is anticipated that following this, discussions will be held with any offeror whose proposal remains under consideration. Questions arising from the TEP will be sent to offerors for response. Cost negotiations may be necessary as well.
Final selection of awards will depend upon scientific merit, the proposed costs in relation to availability of funds, and program balance within the NHLBI at the time of award selection. The NHLBI reserves the right to select a variety of technical approaches. Please note that no award will be made solely for the Administrative Center. That award would only go to an otherwise successful offeror.
TECHNICAL EVALUATION CRITERIA PROTEOMICS
The evaluation criteria are used by the Technical Evaluation Panel when reviewing the technical proposals. The criteria below are listed in relative importance with weights assigned for evaluation purposes.
|Extent to which novel and innovative concepts, approaches,
methods, and technologies are employed. Extent to which existing paradigms
are challenged, or new methodologies or technologies are
|SCIENTIFIC AND TECHNICAL APPROACH||30 Points|
|Extent to which proposed plans accomplish the scientific
goals of the Center. Merit of the technical plan within the context of the
goals of the Proteomics Program. Appropriateness of the milestones, time
lines, and products of the Proteomics Center. Suitability of proposed plan
for data, resources, and tool dissemination to the broader scientific
community. Suitability of the quality control and quality assurance
|Adequacy of plans to advance the state of proteomic science.
Extent to which the proposal effectively ties in significant biological
queries with technological application and advances. Extent to which the
proposed Proteomics Center advances, or paves the way to advance,
approaches to diagnosis, detection, and/or new therapeutic interventions
in heart, lung, blood, and sleep diseases.|
|OFFEROR'S CAPABILITIES||20 Points|
|Documented training, experience, expertise, and availability of the Principal Investigator for planning and directing the proposed Proteomics Center. Adequacy of plans describing the synergy of the proposed team of researchers. Documented training, experience, and availability of all personnel in conducting the proposed technical procedures. Adequacy of the organizational and administrative structure of the proposed Proteomics Center. Availability and adequacy of the facilities and resources necessary to meet the objective of the proposed Proteomics Center, including institutional commitment to the Center.|
TECHNICAL EVALUATION CRITERIA ADMINISTRATIVE
The evaluation criteria are used by the technical evaluation committee when reviewing the technical proposals. Only proposals offering to be the Administrative Center will be evaluated against these criteria. The criteria below are listed in the order of relative importance with weights assigned for evaluation purposes:
|TECHNICAL APPROACH||35 Points|
|Merit of the proposed plan to support the administrative
activities of the Proteomics Initiative. Merit of the proposed plan of the
Proteomics Administrative Center to facilitate interactions among the
|OFFEROR'S CAPABILITIES||35 Points|
|Documented experience, expertise, and availability of staff
in conducting the proposed Proteomics Administrative
|INSTITUTIONAL EXPERIENCE AND FACILITIES||30 Points|
|Adequacy of the organizational and administrative structure of the proposed Proteomics Administrative Center. Availability and adequacy of the facilities and resources necessary to meet the objective of the proposed Proteomics Administrative Center, including institutional commitment to the Center.|
PROPOSAL INSTRUCTIONS AND INFORMATION
The proposal must be signed by an individual authorized to bind the organization to a Government contract.
NAICS Code and Size Standard
This requirement is not set-aside for small business. However, the FAR requires in every solicitation (except for foreign acquisitions) the inclusion of the NAICS code and corresponding size standard which best describes the nature of the requirement in the solicitation.
This information is to be used by the offeror in preparing its Representations and Certifications, specifically in completing the provision entitled, SMALL BUSINESS PROGRAM REPRESENTATION, FAR Clause 52.219-1.
Proposals Must be in Two Parts
The proposal must be prepared in two parts: a "Technical Proposal" and a "Business Proposal." Each part shall be separate and complete in itself so that evaluation of one may be accomplished independently of, and concurrently with, evaluation of the other. The technical proposal should disclose your technical approach in as much detail as possible, including, but not limited to, the requirements of the technical proposal instructions. Offerors should realize that the clarity of the presentation is important in communicating their project ideas to reviewers, and that a concise and well formulated proposal is usually more effective in that respect than a voluminous proposal that lacks effective distillation of ideas.
This proposal includes data that shall not be disclosed outside the Government and shall not be duplicated, used, or disclosed—in whole or in part—for any purpose other than to evaluate this proposal. If, however, a contract is awarded to this offeror as a result of, or in connection with, the submission of this data, the Government shall have the right to duplicate, use, or disclose the data to the extent provided in the resulting award. This restriction does not limit the Government's right to use information contained in this data if it is obtained from another source without restriction. The data subject to this restriction are contained in sheets (on pages) [insert numbers or other identification of sheets/pages].
Use or disclosure of data contained on this sheet is subject to the restriction on the title page of this proposal.
NOTE: THE FOLLOWING ARE UNIFORM ASSUMPTIONS TO ASSIST IN PREPARATION OF YOUR PROPOSED BUDGET
Progress Review Panel
The NHLBI will establish a scientific Progress Review Panel to monitor progress, review study findings/data and safety, and advise the NHLBI when changes should be made to the Initiative. The panel will be composed of a Chairman and additional members appointed by the NHLBI. Additional panel members or consultants may be appointed if deemed necessary by the NHLBI or in response to recommendations made by panel members.
Programmatic and Progress Review
In performance of the work, investigators will be expected to attend two programmatic meetings per year. At these meetings each Proteomics Center shall present information on technical objectives, progress, and impediments. The participants at these semi-annual meetings will include Center investigators, Government program officials, and Government contracting officials. For the purposes of estimating costs, offerors should assume two, two-day meetings per year will be conducted in the Washington metropolitan area with attendance by the Principal Investigator as well as the senior investigators on each component project. Post-doctoral and pre-doctoral fellows are encouraged to attend and present, but not as a replacement for key investigators. The purpose of these meetings will be to present information on technical objectives, progress, and impediments, exchange ideas, and, where appropriate, establish collaborations.
In addition to the Programmatic Meetings described above, there will be three Progress Review Meetings with the Progress Review Panel convened by the NHLBI. The Progress Review Panel will meet with the Center investigators, Government program officials, and Government contracting officials. This Progress Review Panel will meet during years 2, 4, and 6 of the Initiative. The purpose of these meetings is to discuss progress and re-evaluate goals.
In addition to the Proteomic Center proposal, the offeror may also submit a proposal for an Administrative Center. One Proteomics Center will be selected to serve as the Administrative Center. This Center will facilitate and be responsible for certain administrative activities involving all 10 Proteomics Centers. Effective communication is an important component of this Initiative, since it is anticipated that the Proteomics Centers will likely be in geographically diverse locations. Administrative Center staff should demonstrate experience coordinating the administrative functions for a multi-center program and have experience working with multiple investigators with varying experiences.
Meetings of the Proteomics Centers and Progress Review Panel will be a key part of the communication network. This Center would coordinate the twice yearly meetings of the Proteomics Centers and meetings of the Progress Review Panel in years 2, 4, and 6. Meetings require the completion of a number of logistical tasks; such as, selection of dates and scheduling; preparation of meeting agendas; collection, organization, and dissemination of materials needed for the meeting; provisions of supporting materials for each agenda topic so that associated issues are articulated and discussions are focused; coordinating travel arrangements; preparation and distribution of correspondence and minutes related to the meetings; when appropriate, use of slides and presentations to help guide meetings, and, completing arrangements with the hotels regarding sleeping rooms and meeting facilities, coffee breaks, luncheons, acquisition of meeting equipment, i.e., overhead and slide projectors, etc.
In addition, other types of communication will also be needed. Working groups may need to meet in person or more likely, via conference telephone calls. The Administrative Center will prepare and distribute program documents, develop and maintain a unified directory of telephone numbers, fax numbers, and e-mail addresses for all Proteomic Center investigators, Progress Review Panel members, NHLBI Program and Contracts staff. In addition, it is expected that the products (reagents, techniques, methods, documentation, information, etc.) from this initiative will be made readily available to the scientific community. In order to insure maximum benefit from this investment offerors should give consideration to the most effective means of making this information available, i.e. via the internet. Maintenance and enhancements of the proposed system will be a part of the Administrative Center's responsibilities. It will be important for the Administrative Center to establish predictable channels for distribution of memos to all Proteomics Centers. Distribution lists and mailing lists will be maintained as part of the functions of the Administrative Center.
The Administrative Center will be responsible for taking and distributing minutes of meetings and conference calls.
If an offeror wishes to propose as an Administrative Center, technical and business proposals should be provided as a separate part of the overall proposal. For the purposes of estimating costs there will be two 2-day programmatic meetings per year (assume 75 attendees) and one 2-day Progress Review Panel meeting in years 2, 4, and 6 (assume 40 attendees). Meetings will take place in the Washington metropolitan area. Center investigators will pay their own travel costs out of their contracts; Progress Review Panel members (assume 10) will have their travel and honorarium ($200/meeting) paid by the Administrative Center.
In performance of the work, the following reporting requirements should be assumed:
A Program Plan shall be submitted 30 days after contract award for review and approval. The plan shall identify technical risks and critical decision points that are expected to result, and include a one page graphic that reflects, task-by-task, when the key milestones of the Center will be met. All revisions to the approved plan shall be submitted to the NHLBI for review and approval.
Abstracts and Manuscripts
Abstracts and Manuscripts in progress and proposed for publication shall be provided to the NHLBI for review and comment 30 days prior to submission for publication. Copies of manuscripts (published or unpublished) derived from research under the contract and copies of all abstracts, manuscripts, reprints and publications that resulted from work conducted or any protocol or method developed specifically under this contract during the performance period. Manuscripts and publications will only be judged as resulting from this work if they cite the support received from this award.
This report shall document and summarize all work results for the period covered. This report shall be in sufficient detail to explain comprehensively the results achieved. The report should be in letter form (2-3 pages) to both the Contracting and Project Officers. The report should include progress for the quarter, problems encountered during the quarter, a discussion of milestones met or missed, a summary of activities planned for the next quarter, manuscripts in progress, submitted or published, and disclosure of intent to file patent applications.
The first reporting period consists of the first full three months of performance including any fractional part of the initial month. Thereafter, the reporting period shall consist of three full calendar months. A Quarterly Progress report is not required for periods in which an annual or final report is due.
Annual Technical Reports—This report shall document and summarize all work results for the period covered. Specifically, the report shall include:
Progress Review Panel Reports
A report will be required one month prior to the Progress Review Panel meeting. This report will be an update to the Annual Report and should be in the same format as the Annual Report. The Project Officer may request, on an as needed basis, additional information not included in the Annual Report or the Progress Review Panel Report.
This report shall consist of the work performed and results obtained for the entire contract period of performance. This report shall be in sufficient detail to describe comprehensively the results achieved, and the final Dissemination Plan including dissemination to date. The final report shall be submitted on or before the last day of the contract performance period.
Salary Rate Limitations on Contracts, Grants and
Pursuant to Public Law, no NIH extramural funds may be used to pay the direct salary of an individual through this contract at a rate in excess the salary rate ceiling established in DHHS appropriation acts. Currently this rate is $161,200. Updates of this rate may be found at: http://ocm.od.nih.gov/contracts/rfps/MAINPAGE.HTM
Your proposal should be organized according to the following outline.
Technical Proposal (Separate
This volume provides the detailed discussion of the proposed work necessary to enable an in-depth review of the specific technical and managerial issues. Specific attention must be given to addressing both risk and payoff of the proposed work and relevance to the specific technical objectives of the NHLBI Proteomics Initiative as outlined in the BACKGROUND AND TECHNICAL OBJECTIVES section.
The technical proposal should be organized as follows: (Number each page of text. Type density and size must be 10-12 points. If constant spacing is used, there should be no more than 15 cpi, whereas proportional spacing should provide an average of no more than 15 cpi. There must be no more than six lines of text within a vertical inch.)
|TECHNICAL PROPOSAL COVER SHEET||Page 1|
|The Technical Proposal Cover Sheet is a form that must be
completed in full detail and used as the cover sheet for each copy of your
technical proposal. It may be accessed at http://ocm.od.nih.gov/contracts/rfps/FORMS1.HTM.
The information contained in the form will be used to insure that there
will be no conflicts of interest when selecting review committee
|TECHNICAL PROPOSAL TABLE OF CONTENTS
|Identify the BAA Number, Institution and Principal
Investigator on the abstract. State the proposal's broad, long-term
objectives and specific aims. Briefly and concisely describe the research
design and methods for achieving these goals. DO NOT EXCEED one page in
providing the abstract. Also indicate in the abstract whether you
are proposing to perform as the Administrative
|MILESTONE PLAN||Page 4|
|This plan should include scientific milestones and time-line
for implementation of those milestones for each aim, goal, objective, and
study proposed. The plan should include a one page graphic that reflects,
task-by-task, when the key milestones of the Center will be
|TECHNICAL PLAN (LIMIT 50 double spaced pages of text)||Page #|
|Refer to the Sections below and the BACKGROUND
AND TECHNICAL OBJECTIVES above for further details.
Section One—Detailed Technical Plan and Proposed Statement of
This section should address the project's potential for contribution to the technological objectives of the NHLBI Proteomics Initiative. The following items should be addressed; the ultimate anticipated utility of the technology; the general applicability of the technology; and the ultimate dissemination of the technology and its application.
A description of the quality control and quality assurance measures used in both the development/enhancement of the proposed technology and the application of that technology to the chosen biological question(s).
In addition, the detailed technical plan will result in the Statement of Work to be used in the contract. Specific technical tasks to be undertaken, specific decision point, and any deliverables to be provided, in addition to the reporting requirements specified in this BAA, will be part of the Statement of Work. The contract Statement of Work will include language that recognizes the proposed approaches may need to be updated to keep pace with state-of-the-art changes that are anticipated under this initiative.
The relevance of the proposal to this Initiative will be judged on the basis of the justification provided in the proposal.
Section Two—Offeror's Qualifications, Project Team, and
Include a detailed listing of the time commitments of the Principal Investigator(s), Co-Investigator(s) and other Key Personnel using the form Summary of Related and Proposed Activities found at: http://ocm.od.nih.gov/contracts/rfps/summact.htm
Section Four—Dissemination and Use of Results
Section Five—Administrative Center
|LITERATURE CITED||Page #|
|The proposal may contain a brief bibliography of relevant
technical papers and research notes (published and unpublished) which
document the technical ideas upon which the proposal is based. Proposals
may include copies of not more than three (3) relevant papers in the
|List each Appendix and identify the number of pages for each
one. Appendices must be clear and legible, and easily located. Include
Include Animal Assurances/Human Subjects Assurances: If animals are proposed, include, in the appendices, a detailed plan for maintaining the animals under the contract in accordance to the requirements of NIH, PHS and AALAC. Provide the date of the last AALAC review and your Animal Assurance number.
Provide a copy of the DHHS Human Subjects Assurance Number if the proposed work involves Human Subjects. Address the timeline for approval by the Institutional Review Board of your organization.
Provide a detailed description of the proposed costs using the Technical Proposal Cost Information form found at: http://ocm.od.nih.gov/contracts/rfps/techcst5.htm. This information will be used by the technical reviewers to assess your understanding of the project.
Provide, in the appendices, letters of commitment for proposed consultants.
Business Proposal (Separate Volume)
|PROPOSAL SUMMARY AND DATA RECORD, NIH-2043||Page 1|
|Form located at: http://ocm.od.nih.gov/contracts/rfps/FORMS1.HTM|
|BUSINESS PROPOSAL COVER SHEET||Page 2|
|The cover sheet shall provide the following information:|
|BUSINESS PROPOSAL TABLE OF CONTENTS||Page 3|
|Section One—Budget Proposal|
Section Two—Budget Justification and Documentation
Section Three—Additional Business Data
Section Four—Small Disadvantaged Business Participation Plan
Section Five—Representations and Certifications
Section One—Budget Proposal
Section Two—Budget Justification and
Provide the following supporting documentation:
Section Three—Additional Business Data
Section Four—Small Disadvantaged Business Participation
Evaluation of the Plan will be performed only on those offerors being considered for award. SDB participation will not be scored, but the Government's conclusions about overall commitment and realism of the offeror's SDB Participation Plan will be considered in determining the relative merits of the offeror's proposal.
The SDB Participation Plan should address the extent of participation of SDB concerns in performance of the contract. Participation in performance of the contract includes the work expected to be performed by SDB concern(s). This can include SDB (as prime contractor), joint ventures, teaming arrangements, and subcontracts. Include the following information in your SDB participation plan:
Section Five—Representations and
ADDITIONAL INFORMATION, INSTRUCTIONS, PROVISIONS, AND REQUIRED CLAUSES
Furnish the information requested below and return this page by December 15, 2001. Your expression of intent is not binding but will assist us in planning for proposal evaluation.
BAA No.: BAA-HL-02-04
TITLE OF BAA: National Heart, Lung, and Blood Institute Proteomics
I INTEND TO SUBMIT A PROPOSAL
NAMES OF COLLABORATING INSTITUTIONS AND INVESTIGATORS
(include Subcontractors and Consultants):
Attention: Dr. Valerie Prenger
Scientific Review Administrator
Review Branch, Division of Extramural Affairs
6701 ROCKLEDGE DR MSC 7924
BETHESDA MD 20892-7924
|or fax to:
or e-mail to:
|Dr. Valerie Prenger at (301)
Shipment and marking shall be as follows:
EXTERNAL PACKAGE MARKING
In addition to the address cited below, mark each package as follows:
"BAA NO.: BAA-HL-02-04
TO BE OPENED BY AUTHORIZED GOVERNMENT PERSONNEL ONLY"
The number of copies required of each part of your proposal
TECHNICAL PROPOSAL: ORIGINAL* AND Forty-Five (45) COPIES
BUSINESS PROPOSAL: ORIGINAL* AND Six (6) COPIES
An electronic version of:
Budget Proposal Spread Sheet (Microsoft EXCEL Spread Sheet)
DELIVER PROPOSAL TO:
If hand delivered or delivery service:
Division of Extramural Affairs
National Heart, Lung, and Blood Institute
Rockledge Building, Room 7091
6701 ROCKLEDGE DRIVE MSC 7924
BETHESDA, MD 20817-7924
If using U.S. Postal Service:
Review Branch, Division of Extramural Affairs
National Institutes of Health
National Heart, Lung, and Blood Institute
6701 ROCKLEDGE DRIVE MSC 7924
BETHESDA, MD 20892-7924
*THE ORIGINAL PROPOSAL MUST BE READILY ACCESSIBLE FOR DATE STAMPING.
Alternate I (October 1997). As prescribed in 15.408(l), substitute the
following paragraph (b)(1) for paragraph (b)(1) of the basic
(b)(1) The offeror shall submit cost or pricing data and supporting attachments using an Excel spreadsheet. Please submit using the guidance set forth under Sections One and Two of the Business Proposal (Separate Volume), above, and in this clause, Requirements for Cost or Pricing Data or Information Other than Cost and Pricing Data.
Contracts Operations Branch
Division of Extramural Affairs
National Heart, Lung, and Blood Institute
Rockledge II, Room 6100
6701 ROCKLEDGE DRIVE, MSC 7902
BETHESDA MD 20892-7902
A small disadvantaged business concern may elect to waive the adjustment, in which case the factor will be added to its offer for evaluation purposes. The agreements in paragraph (d) of FAR Clause 52.219-23 do not apply to offerors that waive the adjustment.
AN OFFEROR WHO ELECTS TO WAIVE THIS EVALUATION ADJUSTMENT MUST SPECIFICALLY INDICATE WITH A STATEMENT TO THIS EFFECT ON THE COVER PAGE OF ITS BUSINESS PROPOSAL