RFP No. NIH-NHLBI-HC-99-19

"Iron Overload and Hereditary Hemochromatosis Study--Coordinating Center

Request for Proposal No.: NIH-NHLBI-HC-99-19
Amendment No.: One (1)
Amendment Date: August 11, 1999
RFP Issue Date:
July 12, 1999
Issued By: Lisa T. O'Neill
Contracting Officer
NIH/NHLBI
Contracts Operations Branch
II Rockledge Centre, RM 6122
6701 Rockledge Drive, MSC 7902
Bethesda, Maryland 20892-7902
Name and Address of Offeror(s): To all interested recipients of RFP Number NIH-NHLBI-HC-99-19

The purpose of this amendment is to clarify the dates in the time line and deliverables set forth in the original RFP. Accordingly,

  1. Revise ATTACHMENT A, II. INTRODUCTION TO THE STATEMENT OF WORK, Table 1. Time line for the Iron Overload and Hereditary Hemochromatosis Study, to revise the dates depicted in bold type only:

    Activity Time Period
    Protocol Development December 31, 1999-December 31, 2000
    (12 months)
    OMB Clearance July 1, 2000-December 31, 2000
    (6 months)
    Training, Pilot Testing
    Protocol Modification    		 October 15, 2000-December 31, 2000
    (2.5 months)
    Initial Transferrin Saturation Screen January 2, 2001-December 31, 2002
    (24 months)
    Random Subgroup Genotyping
    Initial ELSI Assessment    		 January 2, 2001-December 31, 2002
    (24 months)
    Repeat Transferrin Saturation Screen
    Serum Ferritin Assay    		 January 2, 2001-December 31, 2002
    (24 months)
    Comprehensive Clinical Examination
    Genotyping, Extended ELSI Assessment    		 April 1, 2001-December 31, 2003
    (33 months)
    Family Study, ELSI Assessment June 1, 2001-December 31, 2003
    (31 months)
    Follow-up for ELSI, Morbidity and
    Mortality    		 April 1, 2001-December 31, 2004
    (45 months)
    Final Data Analysis and Close-out January 1, 2003-December 31, 2004
    (12 months)

  2. Revise ATTACHMENT B, DELIVERABLES/REPORTING REQUIREMENTS, I. DELIVERABLES, item #10 "Schedule", as follows:

    Item # Description Quantity Schedule Delivery Information
    10. Web Site for Public 1 April 1, 2001 Notify Project Office and
    Steering Committee of
    Operationalization

    NAME AND TITLE OF CONTRACTING OFFICER:
              /s/
    Lisa O'Neill, Contracting Officer, NHLBI
    United States of America

    Date Signed: August 11, 1999

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